{"id":11833,"date":"2025-08-29T18:10:10","date_gmt":"2025-08-29T10:10:10","guid":{"rendered":"https:\/\/fanyiming.life\/?p=11833"},"modified":"2025-12-21T01:02:54","modified_gmt":"2025-12-20T17:02:54","slug":"slc7a5%e5%9f%ba%e5%9b%a02023-2025%e5%b9%b4%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95%e7%bb%bc%e8%bf%b0","status":"publish","type":"post","link":"https:\/\/fanyiming.life\/?p=11833","title":{"rendered":"SLC7A5\u57fa\u56e02023\u20132025\u5e74\u7814\u7a76\u8fdb\u5c55\u7efc\u8ff0"},"content":{"rendered":"\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>By GPT-5 Deep Research<\/p>\n<\/blockquote>\n\n\n\n<h2 class=\"wp-block-heading\"><a>\u5f15\u8a00<\/a><\/h2>\n\n\n\n<p>SLC7A5\u57fa\u56e0\u7f16\u7801L\u578b\u4e2d\u6027\u6c28\u57fa\u9178\u8f6c\u8fd0\u86cb\u767d1\uff08LAT1\uff09\uff0c\u4e3b\u8981\u8d1f\u8d23\u8f6c\u8fd0\u4eae\u6c28\u9178\u3001\u82ef\u4e19\u6c28\u9178\u3001\u8272\u6c28\u9178\u7b49\u5fc5\u9700\u4e2d\u6027\u6c28\u57fa\u9178\uff0c\u5728\u80ce\u76d8\u53d1\u80b2\u548c\u8840\u8111\u5c4f\u969c\u7b49\u751f\u7406\u8fc7\u7a0b\u4e2d\u53d1\u6325\u4f5c\u7528<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=tyrosine,SLC7A5%20promoted%20cell\"><em>[1]<\/em><\/a>\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cLAT1\u5728\u591a\u79cd\u80bf\u7624\u4e2d\u9ad8\u5ea6\u8868\u8fbe\uff0c\u4e0e\u80bf\u7624\u7ec6\u80de\u7684\u4ee3\u8c22\u91cd\u7f16\u7a0b\u3001\u5feb\u901f\u751f\u957f\u548c\u4fb5\u88ad\u6027\u5bc6\u5207\u76f8\u5173<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=placenta%20development%20,studies%20on%20the%20role%20of\"><em>[2]<\/em><\/a>\u3002\u9ad8\u6c34\u5e73\u7684SLC7A5\u5e38\u4e0e\u60a3\u8005\u9884\u540e\u4e0d\u826f\u76f8\u5173<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=expression%20and%20is%20overexpressed%20in,studies%20on%20the%20role%20of\"><em>[3]<\/em><\/a>\u3002\u8fd1\u5e74\u6765\uff082023\u20132025\uff09\uff0c\u9488\u5bf9SLC7A5\u5728\u80bf\u7624\u3001\u751f\u7269\u4ee3\u8c22\u3001\u514d\u75ab\u8c03\u63a7\u3001\u65b0\u836f\u5f00\u53d1\u4ee5\u53ca\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7b49\u65b9\u9762\u7684\u7814\u7a76\u53d6\u5f97\u4e86\u4e00\u7cfb\u5217\u8fdb\u5c55\u3002\u672c\u6587\u5c06\u4ece\u4ee5\u4e0b\u51e0\u4e2a\u65b9\u9762\u8fdb\u884c\u7efc\u8ff0\uff1aSLC7A5\u5728\u5404\u7c7b\u80bf\u7624\u4e2d\u7684\u4f5c\u7528\u673a\u5236\uff0cSLC7A5\u4e0e\u7ec6\u80de\u4ee3\u8c22\u53ca\u514d\u75ab\u8c03\u63a7\u7684\u5173\u7cfb\uff0c\u4ee5SLC7A5\u4e3a\u9776\u70b9\u7684\u6cbb\u7597\u7b56\u7565\u8fdb\u5c55\uff0cSLC7A5\u5728\u5176\u4ed6\u75be\u75c5\uff08\u5c24\u5176\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\uff09\u4e2d\u7684\u4f5c\u7528\uff0c\u4ee5\u53caSLC7A5\u4e0eRNA\u8fde\u63a5\/\u8f6c\u5f55\u540e\u8c03\u63a7\u4e4b\u95f4\u7684\u6f5c\u5728\u5173\u8054\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><a>SLC7A5<\/a>\u5728\u80bf\u7624\u4e2d\u7684\u4f5c\u7528\u4e0e\u673a\u5236<\/h2>\n\n\n\n<p><strong>\u603b\u4f53\u6982\u51b5\uff1a<\/strong> SLC7A5\u5728\u591a\u79cd\u5b9e\u4f53\u7624\u4e2d\u5448\u9ad8\u8868\u8fbe\uff0c\u5305\u62ec\u80ba\u764c\u3001\u80c3\u764c\u3001\u524d\u5217\u817a\u764c\u3001\u80f0\u817a\u764c\u3001\u809d\u764c\u7b49<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=placenta%20development%20,12%5D.%20SLC7A5%20promoted%20cell\"><em>[4]<\/em><\/a>\u3002\u5176\u8fc7\u5ea6\u8868\u8fbe\u4fc3\u8fdb\u80bf\u7624\u7ec6\u80de\u6444\u53d6\u5927\u91cf\u5fc5\u9700\u6c28\u57fa\u9178\u4ee5\u6ee1\u8db3\u5feb\u901f\u589e\u6b96\u7684\u9700\u6c42\u3002\u4e0d\u5c11\u4e34\u5e8a\u75c5\u7406\u7814\u7a76\u8868\u660e\uff0c\u80bf\u7624\u7ec4\u7ec7\u4e2dLAT1\u8868\u8fbe\u6c34\u5e73\u8d8a\u9ad8\uff0c\u60a3\u8005\u751f\u5b58\u9884\u540e\u8d8a\u5dee<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=expression%20and%20is%20overexpressed%20in,studies%20on%20the%20role%20of\"><em>[3]<\/em><\/a>\u3002\u5728\u4e73\u817a\u764c\u4e2d\uff0cLAT1\u7684\u9ad8\u8868\u8fbe\u4e0e\u5185\u5206\u6ccc\u6cbb\u7597\u62b5\u6297\u548c\u590d\u53d1\u76f8\u5173<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=studies%20revealed%20a%20positive%20correlation,to%20the%20pathogenesis%20of%20cancer\"><em>[5]<\/em><\/a>\u3002\u603b\u4f53\u800c\u8a00\uff0cSLC7A5\u901a\u8fc7\u589e\u5f3a\u80bf\u7624\u7ec6\u80de\u7684\u8425\u517b\u6444\u53d6\uff0c\u4ece\u4ee3\u8c22\u5c42\u9762\u63a8\u52a8\u80bf\u7624\u7684\u751f\u957f\u3001\u4fb5\u88ad\u548c\u8010\u836f\u3002<\/p>\n\n\n\n<p><strong>\u809d\u7ec6\u80de\u764c\uff08HCC<\/strong><strong>\uff09\uff1a<\/strong> \u5728\u539f\u53d1\u6027\u809d\u764c\u4e2d\uff0cSLC7A5\u88ab\u9274\u5b9a\u4e3a\u6700\u663e\u8457\u4e0a\u8c03\u7684\u6c28\u57fa\u9178\u8f6c\u8fd0\u86cb\u767d\u4e4b\u4e00\uff0c\u5bf9\u809d\u764c\u53d1\u751f\u53d1\u5c55\u5177\u6709\u5173\u952e\u652f\u6301\u4f5c\u7528<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10253063\/#:~:text=Through%20a%20comprehensive%20analysis%20of,proliferation%20upon%20LAT1%20KO%2C%20we\"><em>[6]<\/em><\/a>\u3002\u901a\u8fc7CRISPR\/Cas9\u6572\u9664HCC\u7ec6\u80de\u7cfb\uff08Huh7\uff09\u4e2d\u7684SLC7A5\uff0c\u53ef\u663e\u8457\u964d\u4f4e\u652f\u94fe\u6c28\u57fa\u9178\uff08BCAA\uff0c\u5982\u4eae\u6c28\u9178\u7b49\uff09\u7684\u6444\u5165\uff0c\u6291\u5236\u7ec6\u80de\u589e\u6b96\uff0c\u5e76\u5728\u88f8\u9f20\u5f02\u79cd\u79fb\u690d\u6a21\u578b\u4e2d\u660e\u663e\u5ef6\u7f13\u80bf\u7624\u751f\u957f<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10253063\/#:~:text=Through%20a%20comprehensive%20analysis%20of,proliferation%20upon%20LAT1%20KO%2C%20we\"><em>[6]<\/em><\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10253063\/#:~:text=performed%20RNA,therapeutic%20angles%20against%20liver%20cancer\"><em>[7]<\/em><\/a>\u3002\u673a\u5236\u4e0a\uff0cLAT1\u7f3a\u5931\u5bfc\u81f4mTORC1\u4fe1\u53f7\u901a\u8def\u4e0b\u6e38\u7684p70 S6\u6fc0\u9176\u548cS6\u6838\u7cd6\u4f53\u86cb\u767d\u78f7\u9178\u5316\u6c34\u5e73\u663e\u8457\u4e0b\u964d\uff0c\u4ece\u800c\u6291\u5236\u80bf\u7624\u7ec6\u80de\u7684\u86cb\u767d\u5408\u6210\u548c\u589e\u6b96\u4fe1\u53f7<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10253063\/#:~:text=performed%20RNA,therapeutic%20angles%20against%20liver%20cancer\"><em>[7]<\/em><\/a>\u3002\u8fd9\u4e00\u6548\u5e94\u53ef\u88abLAT1\u8fc7\u8868\u8fbe\u90e8\u5206\u633d\u6551\uff0c\u8868\u660eLAT1\u4ecb\u5bfc\u7684\u6c28\u57fa\u9178\u8f93\u5165\u5bf9\u4e8e\u7ef4\u6301\u809d\u764c\u7ec6\u80de\u751f\u957f\u548cmTORC1\u6d3b\u6027\u662f\u5fc5\u9700\u7684<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10253063\/#:~:text=suppression%20of%20tumor%20growth%20in,therapeutic%20angles%20against%20liver%20cancer\"><em>[8]<\/em><\/a>\u3002\u56e0\u6b64\uff0cSLC7A5\u88ab\u89c6\u4e3a\u809d\u764c\u6f5c\u5728\u7684\u4ee3\u8c22\u6cbb\u7597\u9776\u70b9\uff0c\u5176\u6291\u5236\u53ef\u963b\u65ad\u80bf\u7624\u5bf9\u5fc5\u9700\u6c28\u57fa\u9178\u7684\u4f9d\u8d56\u6027\u4f9b\u7ed9\u3002<\/p>\n\n\n\n<p><strong>\u4e73\u817a\u764c\uff1a<\/strong> \u5728\u4e73\u817a\u764c\u5c24\u5176\u662f\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\u7684\u7c7b\u578b\u4e2d\uff0cSLC7A5\u9ad8\u8868\u8fbe\u4e0e\u60a3\u8005\u751f\u5b58\u4e0d\u826f\u548c\u5185\u5206\u6ccc\u6cbb\u7597\u8010\u53d7\u76f8\u5173<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=studies%20revealed%20a%20positive%20correlation,to%20the%20pathogenesis%20of%20cancer\"><em>[5]<\/em><\/a>\u3002\u4f8b\u5982\uff0c\u5728\u96cc\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\u7684MCF-7\u4e73\u817a\u764c\u7ec6\u80de\u4e2d\uff0cSLC7A5\u4fc3\u8fdb\u7ec6\u80de\u589e\u6b96\uff0c\u5176\u673a\u5236\u6d89\u53ca\u6fc0\u6d3bAKT\/mTORC1\u901a\u8def<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=studies%20revealed%20a%20positive%20correlation,to%20the%20pathogenesis%20of%20cancer\"><em>[5]<\/em><\/a>\u3002\u5bf9\u4e8e\u4fb5\u88ad\u6027\u66f4\u5f3a\u7684\u4e09\u9634\u6027\u4e73\u817a\u764c\uff08TNBC\uff09\uff0c\u8fd1\u671f\u7814\u7a76\u63ed\u793aLAT1\u5728\u8be5\u4e9a\u578b\u4e2d\u626e\u6f14\u4e86\u91cd\u8981\u7684\u4ee3\u8c22\u201c\u52a0\u901f\u5668\u201d\u89d2\u8272\uff1aTNBC\u60a3\u8005\u80bf\u7624\u4e2dLAT1\u86cb\u767d\u6c34\u5e73\u663e\u8457\u5347\u9ad8\uff0c\u4e14\u9ad8\u8868\u8fbeLAT1\u4e0e\u8f83\u5dee\u7684\u603b\u751f\u5b58\u7387\u76f8\u5173<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=The%20LAT1%20protein%20levels%20were,NAD%2B%2FNADH%20ratio%2C%20which%20enhanced%20the\"><em>[9]<\/em><\/a>\u3002\u529f\u80fd\u5b9e\u9a8c\u8868\u660e\uff0c\u4e0b\u8c03\u6216\u6291\u5236LAT1\u53ef\u51cf\u5c11TNBC\u7ec6\u80de\u7684\u6d3b\u529b\u3001\u589e\u6b96\u548c\u8fc1\u79fb\u4fb5\u88ad\u80fd\u529b\uff0c\u5e76\u80fd\u6291\u5236\u5c0f\u9f20\u6a21\u578b\u4e2d\u7684\u80bf\u7624\u751f\u957f<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=The%20LAT1%20protein%20levels%20were,LDHA\"><em>[10]<\/em><\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=thus%20promoting%20TNBC%20tumor%20progression,of%20doxorubicin%20in%20TNBC%20cells\"><em>[11]<\/em><\/a>\u3002\u673a\u5236\u65b9\u9762\uff0cLAT1\u4e3b\u8981\u901a\u8fc7\u4fc3\u8fdb\u8272\u6c28\u9178\u7b49\u5fc5\u9700\u6c28\u57fa\u9178\u6444\u5165\uff0c\u9a71\u52a8\u80bf\u7624\u7ec6\u80de\u7684\u7cd6\u4ee3\u8c22\u91cd\u7f16\u7a0b\uff1aLAT1\u4e0a\u8c03\u63d0\u9ad8\u4e86\u80de\u5185\u8272\u6c28\u9178\u53ca\u5176\u4ee3\u8c22\u4ea7\u7269\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178\uff08NAD^+\uff09\u7684\u5408\u6210\uff0c\u5bfc\u81f4\u7ec6\u80de\u8d28\u4e2dNAD^+\/NADH\u6bd4\u4f8b\u4e0a\u5347<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=growth%20in%20vivo,resistant%20TNBC%20patient\"><em>[12]<\/em><\/a>\u3002\u8fd9\u8fdb\u4e00\u6b65\u589e\u5f3a\u4e86\u7cd6\u9175\u89e3\u901a\u8def\u4e2d\u5173\u952e\u9176PKM2\u548cLDHA\u7684\u9176\u6d3b\uff08\u78f7\u9178\u5316\u6c34\u5e73\u5347\u9ad8\uff09\uff0c\u4ece\u800c\u52a0\u901f\u4e73\u764c\u7ec6\u80de\u7684\u201cWarburg\u6548\u5e94\u201d\uff08\u504f\u597d\u4e8e\u7cd6\u9175\u89e3\u4ea7\u4e73\u9178\uff09\u5e76\u4fc3\u8fdb\u80bf\u7624\u8fdb\u5c55<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=growth%20in%20vivo,resistant%20TNBC%20patient\"><em>[12]<\/em><\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=growth,reversed%20the%20enhanced%20sensitivity%20to\"><em>[13]<\/em><\/a>\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5728\u5bf9\u963f\u9709\u7d20\uff08doxorubicin\uff09\u8010\u836f\u7684TNBC\u7ec6\u80de\u7cfb\u53ca\u60a3\u8005\u6e90\u6027\u5f02\u79cd\u79fb\u690d\u6a21\u578b\u4e2d\uff0cLAT1-\u8272\u6c28\u9178-NAD^+\u901a\u8def\u5448\u73b0\u4e0a\u8c03\uff0c\u63d0\u793aLAT1\u8fc7\u8868\u8fbe\u662f\u5316\u7597\u8010\u836f\u7ec6\u80de\u901a\u8fc7\u4ee3\u8c22\u9014\u5f84\u83b7\u5f97\u5b58\u6d3b\u4f18\u52bf\u7684\u539f\u56e0\u4e4b\u4e00<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=thus%20promoting%20TNBC%20tumor%20progression,of%20doxorubicin%20in%20TNBC%20cells\"><em>[11]<\/em><\/a>\u3002LAT1\u7684\u6291\u5236\u53ef\u91cd\u65b0\u654f\u5316\u8010\u836f\u7ec6\u80de\u5bf9\u963f\u9709\u7d20\u7684\u654f\u611f\u6027\uff0c\u800c\u5916\u6e90\u8865\u5145\u8272\u6c28\u9178\u6216NAD^+\u5219\u53ef\u90e8\u5206\u9006\u8f6cLAT1\u6572\u4f4e\u6240\u81f4\u7684\u654f\u611f\u6027\u589e\u52a0<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=thus%20promoting%20TNBC%20tumor%20progression,of%20doxorubicin%20in%20TNBC%20cells\"><em>[11]<\/em><\/a>\u3002\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u63ed\u793a\uff0c\u5728\u8fd9\u4e9bTNBC\u7ec6\u80de\u4e2d\u5b58\u5728\u4e00\u4e2a<strong>\u201c<\/strong><strong>SLC7A5\/E2F1\/PTBP1\/PKM2<\/strong><strong>\u8f74\u201d<\/strong>\uff1a\u7531\u4e8emiR-152\u7684\u4e0b\u8c03\uff0cSLC7A5\u5728TNBC\u4e2d\u8fc7\u5ea6\u8868\u8fbe\uff0c\u8fdb\u800c\u8bf1\u5bfcE2F1\u8f6c\u5f55\u56e0\u5b50\u4e0a\u8c03\u5e76\u6fc0\u6d3b\u4e86\u526a\u63a5\u56e0\u5b50PTBP1\u7684\u8868\u8fbe\uff0c\u4fc3\u4f7f\u4e19\u916e\u9178\u6fc0\u9176PKM\u57fa\u56e0\u7684\u526a\u63a5\u4ece\u9ad8\u6d3b\u6027\u7684PKM1\u5f02\u6784\u4f53\u8f6c\u5411\u6709\u5229\u4e8e\u80bf\u7624\u4ee3\u8c22\u7684PKM2\u5f02\u6784\u4f53<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40054655\/#:~:text=SLC7A5%20expression%20activated%20the%20amino,that%20E2F1%20transcriptionally%20activated%20PTBP1\"><em>[14]<\/em><\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40054655\/#:~:text=of%20PTBP1%2C%20which%20maintains%20the,targets%20for%20future%20therapeutic%20interventions\"><em>[15]<\/em><\/a>\u3002\u8fd9\u4e00\u8f6c\u53d8\u589e\u52a0\u4e86PKM2\u7684\u8868\u8fbe\uff0c\u5f3a\u5316\u4e86\u80bf\u7624\u7ec6\u80de\u5bf9\u5fc5\u9700\u6c28\u57fa\u9178\u548c\u8461\u8404\u7cd6\u7684\u5229\u7528\uff0c\u65e2\u6ee1\u8db3\u4e86\u751f\u7269\u5408\u6210\u9700\u6c42\u53c8\u652f\u6301\u4e86\u66f4\u5f3a\u7684\u589e\u6b96\u548c\u5b58\u6d3b\u80fd\u529b<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40054655\/#:~:text=that%20SLC7A5%2C%20a%20key%20amino,and%20PKM2%2C%20linking%20amino%20acid\"><em>[16]<\/em><\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40054655\/#:~:text=signaling%20with%20the%20glycolysis%20pathway,targets%20for%20future%20therapeutic%20interventions\"><em>[17]<\/em><\/a>\u3002\u540c\u65f6\uff0cPKM2\u4ecb\u5bfc\u7684\u4ee3\u8c22\u91cd\u5851\u4e5f\u88ab\u8bc1\u660e\u4e0e\u6cbb\u7597\u6297\u6027\u8868\u578b\u7684\u51fa\u73b0\u6709\u5173<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40054655\/#:~:text=SLC7A5%20expression%20activated%20the%20amino,that%20E2F1%20transcriptionally%20activated%20PTBP1\"><em>[14]<\/em><\/a>\u3002\u56e0\u6b64\uff0c\u5728\u4e73\u817a\u764c\u5c24\u5176\u662fTNBC\u4e2d\uff0cSLC7A5\u901a\u8fc7\u4ee3\u8c22\u91cd\u7f16\u7a0b\u548c\u5f71\u54cd\u4fe1\u53f7\u7f51\u7edc\uff08\u5982AKT\/mTOR\u3001E2F1\/PTBP1\u8f74\uff09\u63a8\u52a8\u4e86\u80bf\u7624\u589e\u6b96\u3001\u8f6c\u79fb\u80fd\u529b\u63d0\u5347\uff0c\u5e76\u4fc3\u8fdb\u5bf9\u5316\u7597\u548c\u5185\u5206\u6ccc\u6cbb\u7597\u7684\u8010\u53d7<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=studies%20revealed%20a%20positive%20correlation,to%20the%20pathogenesis%20of%20cancer\"><em>[5]<\/em><\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=was%20observed%20in%20primary%20cells,of%20doxorubicin%20in%20TNBC%20cells\"><em>[18]<\/em><\/a>\u3002<\/p>\n\n\n\n<p><strong>\u8111\u80f6\u8d28\u7624\uff1a<\/strong> LAT1\u5728\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u80bf\u7624\uff08\u5982\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\uff09\u4e2d\u540c\u6837\u626e\u6f14\u91cd\u8981\u89d2\u8272\u3002\u7531\u4e8e\u5927\u8111\u5bf9\u5fc5\u9700\u6c28\u57fa\u9178\u7684\u4e25\u683c\u9700\u6c42\uff0c\u80f6\u8d28\u7624\u7ec6\u80de\u7cfb\u666e\u904d\u4e0a\u8c03LAT1\u4ee5\u5145\u5206\u83b7\u53d6\u8425\u517b\u3002\u5728\u9ad8\u7ea7\u522b\u80f6\u8d28\u7624\u4e2d\uff0cLAT1\u9ad8\u8868\u8fbe\u4e0e\u6076\u6027\u7a0b\u5ea6\u548c\u60a3\u8005\u751f\u5b58\u671f\u77ed\u5bc6\u5207\u76f8\u5173<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10496141\/#:~:text=l,1\"><em>[19]<\/em><\/a>\u3002LAT1\u4e0d\u4ec5\u4e3a\u80bf\u7624\u7ec6\u80de\u63d0\u4f9b\u6c28\u57fa\u9178\u4ee5\u7ef4\u6301\u4e09\u7fa7\u9178\u5faa\u73af\u548c\u751f\u7269\u5408\u6210\uff0c\u5176\u4ecb\u5bfc\u7684\u652f\u94fe\u6c28\u57fa\u9178\u5206\u89e3\u8fd8\u4ea7\u751f\u6d3b\u6027\u4ee3\u8c22\u4ea7\u7269\u5f71\u54cd\u80bf\u7624\u5fae\u73af\u5883\u3002\u4f8b\u5982\uff0cLAT1\u6444\u5165\u7684\u4eae\u6c28\u9178\u3001\u5f02\u4eae\u6c28\u9178\u3001\u7f2c\u6c28\u9178\u7b49BCAA\u53ef\u5728\u80bf\u7624\u7ec6\u80de\u5185\u88ab\u4ee3\u8c22\u4e3a\u4e59\u9170\u8f85\u9176A\u548c\u7425\u73c0\u9170\u8f85\u9176A\u6295\u5165TCA\u5faa\u73af\uff0c\u4e3a\u80bf\u7624\u63d0\u4f9bATP\u548c\u751f\u7269\u5408\u6210\u524d\u4f53\uff0c\u540c\u65f6\u4ea7\u751f\u916e\u4f53\uff08\u5982\u4e19\u916e\u548c3-\u7f9f\u57fa\u4e01\u9178\uff09\u91ca\u653e\u5230\u80bf\u7624\u5fae\u73af\u5883<a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-025-03721-1#:~:text=Branched,provides%20biosynthetic%20precursors%20essential%20for\"><em>[20]<\/em><\/a><a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-025-03721-1#:~:text=sustaining%20the%20rapid%20proliferation%20and,cells%20promotes%20tumor%20progression%20by\"><em>[21]<\/em><\/a>\u3002\u8fd9\u4e9b\u916e\u4f53\u4f1a\u589e\u52a0\u80bf\u7624\u5c40\u90e8\u7684\u9178\u6027\uff0c\u4ece\u800c\u6291\u5236\u514d\u75ab\u7ec6\u80de\u7684\u6d78\u6da6\u548c\u541e\u566c\u6d3b\u6027\uff0c\u4fc3\u8fdb\u514d\u75ab\u9003\u9038<a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-025-03721-1#:~:text=,cells%20promotes%20tumor%20progression%20by\"><em>[22]<\/em><\/a>\u3002\u56e0\u6b64\uff0c\u9ad8\u6c34\u5e73LAT1\u4e0d\u4ec5\u76f4\u63a5\u6ecb\u517b\u80f6\u8d28\u7624\u7ec6\u80de\uff0c\u8fd8\u901a\u8fc7\u4ee3\u8c22\u4ea7\u7269\u8425\u9020\u514d\u75ab\u6291\u5236\u73af\u5883\uff0c\u52a9\u957f\u80bf\u7624\u751f\u5b58\u4e0e\u4fb5\u88ad\u30022024\u5e74\u7684\u4e00\u9879\u65b0\u53d1\u73b0\u8fdb\u4e00\u6b65\u63ed\u793a\u4e86\u80f6\u8d28\u7624\u83b7\u53d6LAT1\u7684\u65b0\u9014\u5f84\uff1a<strong>\u80bf\u7624\u7ec6\u80de\u4e0e\u5de8\u566c\u7ec6\u80de\u878d\u5408<\/strong>\u3002\u7814\u7a76\u8005\u5728\u80f6\u8d28\u7624\u60a3\u8005\u6837\u672c\u548c\u4f53\u5916\u5b9e\u9a8c\u4e2d\u8bc1\u5b9e\uff0c\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\uff08TAM\uff09\u53ef\u4e0e\u80f6\u8d28\u7624\u7ec6\u80de\u53d1\u751f\u7ec6\u80de\u878d\u5408\uff0c\u5f62\u6210\u5177\u6709\u53cc\u91cd\u8868\u578b\u7684\u6742\u5408\u7ec6\u80de<a href=\"https:\/\/sciety.org\/articles\/activity\/10.21203\/rs.3.rs-4281982\/v1#:~:text=of%20M%D0%A4,orchestrates%20the%20augmented%20proliferative%20and\"><em>[23]<\/em><\/a><a href=\"https:\/\/sciety.org\/articles\/activity\/10.21203\/rs.3.rs-4281982\/v1#:~:text=mechanistic%20investigations%20have%20elucidated%20that,the%20malignant%20biology%20of%20gliomas\"><em>[24]<\/em><\/a>\u3002\u8fd9\u4e9b\u878d\u5408\u7ec6\u80de\u7531\u4e8e\u7ee7\u627f\u4e86\u5de8\u566c\u7ec6\u80de\u6765\u6e90\u7684SLC7A5\u57fa\u56e0\uff0c\u9ad8\u5ea6\u8868\u8fbeLAT1\uff0c\u8868\u73b0\u51fa\u663e\u8457\u589e\u5f3a\u7684\u589e\u6b96\u548c\u4fb5\u88ad\u80fd\u529b<a href=\"https:\/\/sciety.org\/articles\/activity\/10.21203\/rs.3.rs-4281982\/v1#:~:text=Research%20on%20the%20biological%20characteristics,associated%20gene%20SLC7A5%20through%20fusion\"><em>[25]<\/em><\/a>\u3002\u673a\u5236\u4e0a\uff0cLAT1\u8fc7\u8868\u8fbe\u901a\u8fc7\u6fc0\u6d3bmTOR-RPS6\u4fe1\u53f7\u901a\u8def\u4fc3\u8fdb\u6742\u5408\u7ec6\u80de\u7684\u751f\u957f\u548c\u8fd0\u52a8\u6027<a href=\"https:\/\/sciety.org\/articles\/activity\/10.21203\/rs.3.rs-4281982\/v1#:~:text=mechanistic%20investigations%20have%20elucidated%20that,the%20malignant%20biology%20of%20gliomas\"><em>[24]<\/em><\/a>\u3002\u66f4\u6709\u610f\u4e49\u7684\u662f\uff0c\u8fd9\u7c7b\u878d\u5408\u7ec6\u80de\u5bf9LAT1\u7279\u5f02\u6027\u6291\u5236\u5242JPH203\u9ad8\u5ea6\u654f\u611f\uff0c\u663e\u793a\u51fa\u660e\u663e\u7684\u589e\u6b96\u6291\u5236\u548c\u4fb5\u88ad\u53d7\u963b<a href=\"https:\/\/sciety.org\/articles\/activity\/10.21203\/rs.3.rs-4281982\/v1#:~:text=mechanistic%20investigations%20have%20elucidated%20that,the%20malignant%20biology%20of%20gliomas\"><em>[24]<\/em><\/a>\u3002\u8fd9\u4e00\u53d1\u73b0\u4e3a\u80f6\u8d28\u7624\u6076\u6027\u8fdb\u5c55\u63d0\u4f9b\u4e86\u65b0\u7684\u89c6\u89d2\uff1a\u80f6\u8d28\u7624\u7ec6\u80de\u53ef\u80fd\u901a\u8fc7\u878d\u5408\u83b7\u53d6LAT1\u4ee5\u63d0\u9ad8\u6076\u6027\u8868\u578b\uff0c\u540c\u65f6\u63d0\u793aLAT1\u6291\u5236\u5728\u6b64\u80cc\u666f\u4e0b\u5177\u6709\u66f4\u5f3a\u7684\u6cbb\u7597\u6f5c\u529b<a href=\"https:\/\/sciety.org\/articles\/activity\/10.21203\/rs.3.rs-4281982\/v1#:~:text=invasive%20capabilities%20of%20hybrid%20cells,the%20malignant%20biology%20of%20gliomas\"><em>[26]<\/em><\/a><a href=\"https:\/\/sciety.org\/articles\/activity\/10.21203\/rs.3.rs-4281982\/v1#:~:text=sensitivity%20to%20a%20specific%20inhibitor,on%20the%20malignant%20biology%20of\"><em>[27]<\/em><\/a>\u3002<\/p>\n\n\n\n<p><strong>\u4fb5\u88ad\u4e0e\u8f6c\u79fb\uff1a<\/strong> \u9664\u4e0a\u8ff0\u7279\u5b9a\u764c\u79cd\u5916\uff0cSLC7A5\u5728\u80bf\u7624\u4fb5\u88ad\u8f6c\u79fb\u4e2d\u7684\u4f5c\u7528\u4e5f\u5907\u53d7\u5173\u6ce8\u3002\u9ad8LAT1\u8868\u8fbe\u5e38\u4e0e\u80bf\u7624\u7684\u8f6c\u79fb\u503e\u5411\u76f8\u5173\uff0c\u4f46\u5176\u673a\u5236\u76f4\u5230\u8fd1\u671f\u624d\u9010\u6b65\u660e\u6670<a href=\"https:\/\/www.nature.com\/articles\/s41598-023-41096-3?error=cookies_not_supported&amp;code=e83f04ff-1a6a-475e-8a4c-071699e5be0b#:~:text=Metastasis%20is%20the%20leading%20cause,F10%20lung%20metastasis\"><em>[28]<\/em><\/a><a href=\"https:\/\/www.nature.com\/articles\/s41598-023-41096-3?error=cookies_not_supported&amp;code=e83f04ff-1a6a-475e-8a4c-071699e5be0b#:~:text=transporter%20highly%20expressed%20in%20various,Furthermore%2C%20nanvuranlat%20and%20LAT1%20knockdown\"><em>[29]<\/em><\/a>\u3002\u5728\u9ed1\u8272\u7d20\u7624B16-F10\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0cLAT1\u6291\u5236\u663e\u793a\u51fa\u663e\u8457\u7684\u6297\u8f6c\u79fb\u6548\u679c\uff1a\u5e94\u7528\u9ad8\u4eb2\u548c\u529bLAT1\u9009\u62e9\u6027\u6291\u5236\u5242nanvuranlat\uff08JPH203\uff09\u53ef\u964d\u4f4e\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u7684\u589e\u6b96\u3001\u8fc1\u79fb\u548c\u4fb5\u88ad\u80fd\u529b\uff0cLAT1\u57fa\u56e0\u6572\u4f4e\u4ea6\u4ea7\u751f\u7c7b\u4f3c\u6548\u679c<a href=\"https:\/\/www.nature.com\/articles\/s41598-023-41096-3?error=cookies_not_supported&amp;code=e83f04ff-1a6a-475e-8a4c-071699e5be0b#:~:text=of%20LAT1%20inhibition%20on%20cancer,the%20downregulation%20of%20the%20mTOR\"><em>[30]<\/em><\/a>\u3002\u5728\u8377\u7624\u5c0f\u9f20\u7684\u80ba\u8f6c\u79fb\u6a21\u578b\u4e2d\uff0c\u65e0\u8bba\u836f\u7269\u6291\u5236\u8fd8\u662f\u57fa\u56e0\u6572\u4f4eLAT1\uff0c\u90fd\u663e\u8457\u51cf\u5c11\u4e86\u80bf\u7624\u7ec6\u80de\u5bf9\u80ba\u7684\u8f6c\u79fb\u7076\u5f62\u6210<a href=\"https:\/\/www.nature.com\/articles\/s41598-023-41096-3?error=cookies_not_supported&amp;code=e83f04ff-1a6a-475e-8a4c-071699e5be0b#:~:text=LAT1,These%20results\"><em>[31]<\/em><\/a>\uff1b\u5728\u539f\u4f4d\u79fb\u690d\u6a21\u578b\u4e2d\uff0cJPH203\u5904\u7406\u7ec4\u7684\u80bf\u7624\u5bf9\u80ba\u3001\u813e\u548c\u6dcb\u5df4\u7ed3\u7684\u8f6c\u79fb\u8d1f\u8377\u4e5f\u5927\u5e45\u4e0b\u964d<a href=\"https:\/\/www.nature.com\/articles\/s41598-023-41096-3?error=cookies_not_supported&amp;code=e83f04ff-1a6a-475e-8a4c-071699e5be0b#:~:text=LAT1,These%20results\"><em>[31]<\/em><\/a><a href=\"https:\/\/www.nature.com\/articles\/s41598-023-41096-3?error=cookies_not_supported&amp;code=e83f04ff-1a6a-475e-8a4c-071699e5be0b#:~:text=invasion,metastasis%20cancer%20therapy\"><em>[32]<\/em><\/a>\u3002\u673a\u5236\u7814\u7a76\u53d1\u73b0\uff0cLAT1\u6291\u5236\u4f1a\u964d\u4f4e\u80bf\u7624\u7ec6\u80de\u8868\u9762\u7684\u6574\u5408\u7d20\u03b1v\u03b23\u6c34\u5e73<a href=\"https:\/\/www.nature.com\/articles\/s41598-023-41096-3?error=cookies_not_supported&amp;code=e83f04ff-1a6a-475e-8a4c-071699e5be0b#:~:text=in%20a%20lung%20metastasis%20model,metastasis%20cancer%20therapy\"><em>[33]<\/em><\/a>\u3002\u6574\u5408\u7d20\u03b1v\u03b23\u662f\u4ecb\u5bfc\u7ec6\u80de\u9ecf\u9644\u548c\u4fb5\u88ad\u7684\u91cd\u8981\u5206\u5b50\uff0c\u5176\u4e0b\u8c03\u4e0e\u80bf\u7624\u7ec6\u80de\u8fc1\u79fb\u80fd\u529b\u51cf\u5f31\u6709\u5173\u3002\u8fdb\u4e00\u6b65\u5206\u6790\u8868\u660e\uff0cLAT1\u88ab\u6291\u5236\u540emTOR\u4fe1\u53f7\u901a\u8def\u53d7\u5230\u4e0b\u8c03\uff0c\u7ee7\u800c\u5bfc\u81f4\u03b1v\u03b23\u8868\u8fbe\u51cf\u5c11\uff0c\u6291\u5236\u4e86\u80bf\u7624\u7ec6\u80de\u7684\u9ecf\u9644\u4fb5\u88ad\u548c\u8f6c\u79fb\u6f5c\u80fd<a href=\"https:\/\/www.nature.com\/articles\/s41598-023-41096-3?error=cookies_not_supported&amp;code=e83f04ff-1a6a-475e-8a4c-071699e5be0b#:~:text=suppressed%20lung%2C%20spleen%2C%20and%20lymph,metastasis%20cancer%20therapy\"><em>[34]<\/em><\/a><a href=\"https:\/\/www.nature.com\/articles\/s41598-023-41096-3?error=cookies_not_supported&amp;code=e83f04ff-1a6a-475e-8a4c-071699e5be0b#:~:text=of%20integrin%20%CE%B1v%CE%B23,metastasis%20cancer%20therapy\"><em>[35]<\/em><\/a>\u3002\u53ef\u89c1\uff0cLAT1\u901a\u8fc7\u652f\u6301mTOR\u6d3b\u6027\u7ef4\u6301\u6574\u5408\u7d20\u7b49\u4fc3\u4fb5\u88ad\u5206\u5b50\u7684\u8868\u8fbe\uff0c\u4ece\u800c\u5728\u80bf\u7624\u8f6c\u79fb\u8fdb\u7a0b\u4e2d\u626e\u6f14\u4e86\u5173\u952e\u89d2\u8272\u3002\u603b\u7684\u6765\u8bf4\uff0c\u8fd9\u4e9b\u7814\u7a76\u5c06SLC7A5\u5b9a\u4f4d\u4e3a\u80bf\u7624\u4ee3\u8c22-\u4fe1\u53f7\u7f51\u7edc\u7684\u4e2d\u5fc3\u8282\u70b9\uff1a\u5b83\u65e2\u4e3a\u80bf\u7624\u7ec6\u80de\u63d0\u4f9b\u7269\u8d28\u57fa\u7840\uff0c\u53c8\u901a\u8fc7\u4fe1\u53f7\u901a\u8def\u8c03\u63a7\u589e\u6b96\u3001\u4fb5\u88ad\u548c\u8010\u836f\u7b49\u8868\u578b\u3002\u56e0\u6b64\uff0c\u963b\u65adSLC7A5\u529f\u80fd\u6709\u671b\u5728\u591a\u79cd\u80bf\u7624\u4e2d\u4ea7\u751f\u6291\u5236\u751f\u957f\u3001\u6297\u4fb5\u88ad\u548c\u589e\u654f\u6cbb\u7597\u7684\u591a\u91cd\u6548\u679c<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=derived%20xenograft%20,of%20doxorubicin%20in%20TNBC%20cells\"><em>[36]<\/em><\/a><a href=\"https:\/\/www.nature.com\/articles\/s41598-023-41096-3?error=cookies_not_supported&amp;code=e83f04ff-1a6a-475e-8a4c-071699e5be0b#:~:text=of%20integrin%20%CE%B1v%CE%B23,metastasis%20cancer%20therapy\"><em>[35]<\/em><\/a>\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><a>SLC7A5<\/a>\u4e0e\u7ec6\u80de\u4ee3\u8c22\u53ca\u514d\u75ab\u8c03\u63a7<\/h2>\n\n\n\n<p><strong>\u4ee3\u8c22\u65b9\u9762\uff1a<\/strong> SLC7A5\u4f5c\u4e3a\u5927\u578b\u4e2d\u6027\u6c28\u57fa\u9178\u8f6c\u8fd0\u8f7d\u4f53\uff0c\u5728\u7ec6\u80de\u4ee3\u8c22\u8c03\u63a7\u4e2d\u5360\u636e\u4e3e\u8db3\u8f7b\u91cd\u7684\u5730\u4f4d\u3002\u5b83\u4ecb\u5bfc\u4eae\u6c28\u9178\u3001\u5f02\u4eae\u6c28\u9178\u3001\u82ef\u4e19\u6c28\u9178\u3001\u8272\u6c28\u9178\u7b49\u5fc5\u9700\u6c28\u57fa\u9178\u8fdb\u5165\u7ec6\u80de\uff0c\u4e0e\u80de\u5185\u8c37\u6c28\u9170\u80fa\u7b49\u5e95\u7269\u8fdb\u884c\u4ea4\u6362\uff0c\u4ece\u800c\u7ef4\u6301\u7ec6\u80de\u8425\u517b\u7a33\u6001<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=tyrosine,SLC7A5%20promoted%20cell\"><em>[1]<\/em><\/a>\u3002\u4eae\u6c28\u9178\u662fmTORC1\u901a\u8def\u7684\u91cd\u8981\u6fc0\u6d3b\u4fe1\u53f7\u4e4b\u4e00\uff0c\u800cLAT1\u6b63\u662f\u7ec6\u80de\u6444\u53d6\u4eae\u6c28\u9178\u7684\u4e3b\u8981\u901a\u9053<a href=\"https:\/\/www.nature.com\/articles\/cddis2016222?error=cookies_not_supported&amp;code=2f8829ef-3af2-4585-a184-2d79cbd92b38#:~:text=match%20at%20L642%20focus%20on,cell%20activation%2C%20as\"><em>[37]<\/em><\/a>\u3002\u5f53LAT1\u5c06\u4eae\u6c28\u9178\u7b49\u5fc5\u9700\u6c28\u57fa\u9178\u8f93\u5165\u7ec6\u80de\u540e\uff0c\u53ef\u5728\u6eb6\u9176\u4f53\u8868\u9762\u4e0eRag GTP\u9176\u7b49\u611f\u5e94\u673a\u5236\u534f\u540c\uff0c\u6fc0\u6d3bmTORC1\uff0c\u5f15\u53d1\u86cb\u767d\u8d28\u5408\u6210\u548c\u7ec6\u80de\u751f\u957f\u76f8\u5173\u7684\u7ea7\u8054\u53cd\u5e94<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10253063\/#:~:text=performed%20RNA,therapeutic%20angles%20against%20liver%20cancer\"><em>[7]<\/em><\/a><a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-025-03721-1#:~:text=Branched,provides%20biosynthetic%20precursors%20essential%20for\"><em>[20]<\/em><\/a>\u3002\u5728\u80bf\u7624\u7ec6\u80de\u4e2d\uff0cSLC7A5\u4ecb\u5bfc\u7684\u6c28\u57fa\u9178\u5927\u91cf\u6444\u5165\u662f\u4ee3\u8c22\u91cd\u7f16\u7a0b\u7684\u4e00\u90e8\u5206\uff1a\u4e0e\u6b63\u5e38\u7ec6\u80de\u4e3b\u8981\u4f9d\u8d56\u8461\u8404\u7cd6\u4e0d\u540c\uff0c\u589e\u6b96\u4e2d\u7684\u80bf\u7624\u7ec6\u80de\u7ea6\u4e00\u534a\u4ee5\u4e0a\u7684\u4ee3\u8c22\u8d28\u91cf\u6765\u6e90\u4e8e\u6c28\u57fa\u9178<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10253063\/#:~:text=Emerging%20evidence%20suggests%20that%20targeting,bearing%20mice%20%5B7\"><em>[38]<\/em><\/a>\u3002\u4f8b\u5982\uff0c\u7cbe\u6c28\u9178\u53ef\u901a\u8fc7mTOR\u901a\u8def\u4fc3\u8fdb\u80bf\u7624\u7ec6\u80de\u86cb\u767d\u8d28\u5408\u6210\uff0c\u9650\u5236\u7cbe\u6c28\u9178\u6444\u53d6\u80fd\u6291\u5236\u80bf\u7624\u751f\u957f<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10253063\/#:~:text=of%20carbon%20in%20cancer%20cells,functions%20in%20HCC%20remain%20unclear\"><em>[39]<\/em><\/a>\uff1bBCAA\u5219\u662f\u80bf\u7624\u91cd\u8981\u7684\u6c2e\u6e90\u548c\u78b3\u6e90\uff0c\u53c2\u4e0e\u591a\u79cd\u751f\u7269\u5408\u6210\u9014\u5f84\u4e14\u80fd\u6fc0\u6d3bmTOR\u4fe1\u53f7<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10253063\/#:~:text=Arginine%20stimulates%20protein%20synthesis%20through,38%2C13%20%2C%2040\"><em>[40]<\/em><\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10253063\/#:~:text=The%20roles%20of%20numerous%20amino,causes%20significant%20inhibition%20of\"><em>[41]<\/em><\/a>\u3002LAT1\u5728\u8fd9\u4e00\u8fc7\u7a0b\u4e2d\u81f3\u5173\u91cd\u8981\uff0c\u5b83\u662f\u80bf\u7624\u7ec6\u80deBCAA\u8fdb\u5165\u7ec6\u80de\u7684\u4e3b\u8981\u9014\u5f84\u4e4b\u4e00<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10253063\/#:~:text=The%20roles%20of%20numerous%20amino,causes%20significant%20inhibition%20of\"><em>[41]<\/em><\/a>\u3002\u6709\u7814\u7a76\u663e\u793a\uff0c\u6572\u964dLAT1\u4f1a\u9020\u6210\u7ec6\u80de\u5185BCAA\u6c34\u5e73\u9aa4\u964d\uff0c\u4ece\u800c\u963b\u788d\u7ec6\u80de\u5468\u671f\u8fdb\u7a0b\u548c\u589e\u6b96<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10253063\/#:~:text=,and%20lymphoblastoid%20cells\"><em>[42]<\/em><\/a>\u3002\u76f8\u53cd\uff0c\u8425\u517b\u5145\u8db3\u65f6LAT1\u5c06\u5927\u91cfBCAA\u8f93\u5165\u7ec6\u80de\uff0c\u4e0d\u4ec5\u4e3aTCA\u5faa\u73af\u63d0\u4f9b\u539f\u6599\u4ea7\u751fATP\uff0c\u8fd8\u4e3a\u8102\u8d28\u3001\u6838\u82f7\u9178\u7b49\u5408\u6210\u63d0\u4f9b\u524d\u4f53\u7269\u8d28<a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-025-03721-1#:~:text=amino%20acid%20transporter%201%20,119%5D.%20Leucine%2C%20isoleucine\"><em>[43]<\/em><\/a><a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-025-03721-1#:~:text=catabolism%20by%20a%20series%20of,The%20release%20of%20these%20ketone\"><em>[44]<\/em><\/a>\u3002\u540c\u65f6\uff0cBCAA\u4ee3\u8c22\u4ea7\u751f\u7684\u916e\u4f53\u7b49\u526f\u4ea7\u7269\u4f1a\u9178\u5316\u5fae\u73af\u5883\uff0c\u5f71\u54cd\u90bb\u8fd1\u7ec6\u80de\u884c\u4e3a<a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-025-03721-1#:~:text=are%20activated%20in%20the%20hypoxic,and%20contributing%20to%20immune%20suppression\"><em>[45]<\/em><\/a>\u3002\u56e0\u6b64\uff0cSLC7A5\u5b9e\u8d28\u4e0a\u8fde\u63a5\u4e86\u7ec6\u80de\u8425\u517b\u4f9b\u5e94\u4e0e\u4fe1\u53f7\u611f\u5e94\uff1a\u901a\u8fc7\u8c03\u63a7mTORC1\u7b49\u4ee3\u8c22\u901a\u8def\uff0c\u5b83\u4f7f\u7ec6\u80de\u80fd\u591f\u6839\u636e\u6c28\u57fa\u9178\u4f9b\u7ed9\u60c5\u51b5\u8c03\u6574\u751f\u957f\u548c\u4ee3\u8c22\u6a21\u5f0f\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0cSLC7A5\u5bf9<strong>\u6c28\u57fa\u9178<\/strong><strong>&#8211;<\/strong><strong>\u78b3\u9aa8\u67b6\u4e92\u8865\u5229\u7528<\/strong>\u7684\u652f\u6301\u5728\u7f3a\u8425\u517b\u6761\u4ef6\u4e0b\u5c24\u4e3a\u91cd\u8981\u3002\u4f8b\u5982\uff0c\u4e00\u9879\u7814\u7a76\u53d1\u73b0\uff0c\u5f53\u7ec6\u80de\u5904\u4e8e\u7cbe\u6c28\u9178\u532e\u4e4f\u4f46\u6709\u74dc\u6c28\u9178\uff08citrulline\uff09\u53ef\u5229\u7528\u7684\u73af\u5883\u65f6\uff0cSLC7A5\u662f\u7ef4\u6301\u7ec6\u80de\u589e\u6b96\u6240\u5fc5\u9700\u7684\uff0c\u56e0\u4e3a\u5b83\u53c2\u4e0e\u652f\u6301\u7cbe\u6c28\u9178\u518d\u751f\u548c\u5229\u7528\u7684\u4ee3\u8c22\u9014\u5f84<a href=\"https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(24)01481-5#:~:text=SLC7A5%20is%20required%20for%20cancer,SLC7A5%20loss%20impairs%20arginine%20metabolism\"><em>[46]<\/em><\/a>\uff08\u8be5\u673a\u5236\u6d89\u53ca\u7cbe\u6c28\u9178\u4ee3\u8c22\u4e0e\u5c3f\u7d20\u5faa\u73af\u7684\u65c1\u8def\uff0c\u76f8\u5e94\u7814\u7a76\u6df1\u5165\u4e86\u89e3\u4e86LAT1\u5bf9\u80bf\u7624\u7ec6\u80de\u8010\u53d7\u6c28\u57fa\u9178\u532e\u4e4f\u7684\u8d21\u732e\uff09\u3002\u603b\u4e4b\uff0c\u5728\u7ec6\u80de\u4ee3\u8c22\u5c42\u9762\uff0cSLC7A5\u5145\u5f53\u201c\u8425\u517b\u4f20\u611f\u5668\u201d\u548c\u201c\u4f9b\u5e94\u8005\u201d\uff0c\u5176\u6d3b\u6027\u76f4\u63a5\u5f71\u54cdmTORC1\u4fe1\u53f7\u3001\u7cd6\u9175\u89e3\u9014\u5f84\u548c\u6c28\u57fa\u9178\u5206\u89e3\u5408\u6210\u5e73\u8861\u7b49\uff0c\u4ece\u800c\u51b3\u5b9a\u4e86\u7ec6\u80de\u7684\u751f\u957f\u72b6\u6001\u548c\u4ee3\u8c22\u547d\u8fd0<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10253063\/#:~:text=performed%20RNA,therapeutic%20angles%20against%20liver%20cancer\"><em>[7]<\/em><\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=growth%20in%20vivo,resistant%20TNBC%20patient\"><em>[12]<\/em><\/a>\u3002<\/p>\n\n\n\n<p><strong>\u514d\u75ab\u8c03\u63a7\u65b9\u9762\uff1a<\/strong> SLC7A5\u4e0d\u4ec5\u5728\u80bf\u7624\u548c\u4ee3\u8c22\u6027\u7ec6\u80de\u4e2d\u91cd\u8981\uff0c\u5728\u514d\u75ab\u7ec6\u80de\uff08\u7279\u522b\u662fT\u6dcb\u5df4\u7ec6\u80de\uff09\u4e2d\u4e5f\u53d1\u6325\u5173\u952e\u529f\u80fd\u3002\u9759\u606f\u72b6\u6001\u7684\u4eba\u521d\u7ea7T\u7ec6\u80de\u51e0\u4e4e\u4e0d\u8868\u8fbeLAT1\u86cb\u767d\uff0c\u4f46\u5728T\u7ec6\u80de\u53d7\u5230\u6297\u539f\u523a\u6fc0\u6fc0\u6d3b\u540e\uff0c\u4f1a\u8fc5\u901f\u5927\u5e45\u4e0a\u8c03LAT1\uff08\u4ee5\u53ca\u5176\u4f34\u4fa3\u91cd\u94feCD98\uff09\u8868\u8fbe<a href=\"https:\/\/www.nature.com\/articles\/cddis2016222?error=cookies_not_supported&amp;code=2f8829ef-3af2-4585-a184-2d79cbd92b38#:~:text=l,43%20Although%20naive%20human\"><em>[47]<\/em><\/a><a href=\"https:\/\/www.nature.com\/articles\/cddis2016222?error=cookies_not_supported&amp;code=2f8829ef-3af2-4585-a184-2d79cbd92b38#:~:text=primary%20T%20cells%20express%20an,is%20required%20for%20the%20full\"><em>[48]<\/em><\/a>\u3002\u8fd9\u79cd\u8bf1\u5bfc\u4f9d\u8d56\u4e8eT\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u4e0b\u6e38\u7684\u8f6c\u5f55\u56e0\u5b50AP-1\u548cNF-\u03baB\u4fe1\u53f7\uff0c\u63d0\u793aLAT1\u7684\u5b58\u5728\u662f<em>T<\/em>\u7ec6\u80de\u5b8c\u5168\u6d3b\u5316\u6240\u5fc5\u9700\u7684<a href=\"https:\/\/www.nature.com\/articles\/cddis2016222?error=cookies_not_supported&amp;code=2f8829ef-3af2-4585-a184-2d79cbd92b38#:~:text=primary%20T%20cells%20express%20an,is%20required%20for%20the%20full\"><em>[49]<\/em><\/a>\u3002LAT1\u4e3a\u6d3b\u5316T\u7ec6\u80de\u63d0\u4f9b\u4e86\u5927\u91cf\u7684\u4eae\u6c28\u9178\u7b49\u5fc5\u9700\u6c28\u57fa\u9178\uff0c\u7ef4\u6301\u4e86mTORC1\u7684\u6301\u7eed\u6d3b\u8dc3\uff0c\u4ece\u800c\u652f\u6301T\u7ec6\u80de\u5feb\u901f\u589e\u6b96\u548c\u5206\u6ccc\u7ec6\u80de\u56e0\u5b50\u7684\u9700\u8981<a href=\"https:\/\/www.nature.com\/articles\/cddis2016222?error=cookies_not_supported&amp;code=2f8829ef-3af2-4585-a184-2d79cbd92b38#:~:text=l,43%20Although%20naive%20human\"><em>[50]<\/em><\/a><a href=\"https:\/\/www.nature.com\/articles\/cddis2016222?error=cookies_not_supported&amp;code=2f8829ef-3af2-4585-a184-2d79cbd92b38#:~:text=match%20at%20L414%20activation%20of,17.20%20Although\"><em>[51]<\/em><\/a>\u3002\u7814\u7a76\u8bc1\u636e\u663e\u793a\uff0c\u7528LAT1\u7279\u5f02\u6027\u6291\u5236\u5242JPH203\u5904\u7406\u6216\u6572\u4f4eSLC7A5\u57fa\u56e0\uff0c\u90fd\u4f1a<strong>\u663e\u8457\u6291\u5236<\/strong>\u4eba\u521d\u7ea7T\u7ec6\u80de\u5bf9\u4eae\u6c28\u9178\u7684\u6444\u53d6\uff0c\u5e76\u964d\u4f4e\u5176\u5206\u6ccc\u5173\u952e\u7ec6\u80de\u56e0\u5b50\uff08\u5982IFN-\u03b3\u3001IL-4\u3001IL-17\uff09\u7684\u80fd\u529b<a href=\"https:\/\/www.nature.com\/articles\/cddis2016222?error=cookies_not_supported&amp;code=2f8829ef-3af2-4585-a184-2d79cbd92b38#:~:text=match%20at%20L414%20activation%20of,17.20%20Although\"><em>[51]<\/em><\/a><a href=\"https:\/\/www.nature.com\/articles\/cddis2016222?error=cookies_not_supported&amp;code=2f8829ef-3af2-4585-a184-2d79cbd92b38#:~:text=activation%20of%20T%20cells,17.20%20Although\"><em>[52]<\/em><\/a>\u3002\u6b64\u5916\uff0c<strong>Slc7a5<\/strong><strong>\u57fa\u56e0\u6572\u9664<\/strong>\u7684\u5c0f\u9f20T\u7ec6\u80de\u529f\u80fd\u5b58\u5728\u4e25\u91cd\u7f3a\u9677\uff1a\u7f3a\u4e4fLAT1\u7684CD4^+ T\u7ec6\u80de\u65e0\u6cd5\u5bf9\u6297\u539f\u523a\u6fc0\u505a\u51fa\u6b63\u5e38\u589e\u6b96\u5e94\u7b54\uff0cSlc7a5\u7f3a\u5931\u7684CD8^+ T\u7ec6\u80de\u4e5f\u51e0\u4e4e\u4e27\u5931\u4e86\u5bf9\u7279\u5f02\u6027\u6297\u539f\u7684\u6740\u4f24\u53cd\u5e94<a href=\"https:\/\/www.nature.com\/articles\/cddis2016222?error=cookies_not_supported&amp;code=2f8829ef-3af2-4585-a184-2d79cbd92b38#:~:text=expression%20of%20Slc3a2%20and%20Slc7a5%2C,11\"><em>[53]<\/em><\/a>\u3002\u8fd9\u8868\u660eLAT1\u4ecb\u5bfc\u7684\u6c28\u57fa\u9178\u4f9b\u5e94\u5bf9<em>T<\/em>\u7ec6\u80de\u514d\u75ab\u5e94\u7b54\u7684\u80fd\u91cf\u548c\u7269\u8d28\u652f\u6301\u4e0d\u53ef\u6216\u7f3a\uff0c\u5176\u4f5c\u7528\u76f8\u5f53\u4e8e\u514d\u75ab\u7ec6\u80de\u7684\u201c\u6cb9\u95e8\u8e0f\u677f\u201d\u3002\u9664\u6dcb\u5df4\u7ec6\u80de\u5916\uff0cLAT1\u5728\u5148\u5929\u514d\u75ab\u7ec6\u80de\u4e2d\u4e5f\u6709\u76f8\u5173\u62a5\u9053\u3002\u4f8b\u5982\uff0c\u5de8\u566c\u7ec6\u80de\u7684M1\/M2\u6781\u5316\u53ef\u80fd\u53d7\u4ee3\u8c22\u5e95\u7269\u7684\u5f71\u54cd\uff0c\u800cLAT1\u5f71\u54cd\u8272\u6c28\u9178-\u72ac\u5c3f\u9178\u901a\u8def\u53ef\u80fd\u8c03\u8282\u5de8\u566c\u7ec6\u80de\u7684\u6d3b\u5316\u72b6\u6001\uff08\u95f4\u63a5\u5f71\u54cd\u514d\u75ab\u53cd\u5e94\u5f3a\u5ea6\uff09<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=tryptophan,also%20recently%20considered%20to%20be\"><em>[54]<\/em><\/a><a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=2015%29,in%20the%20LAT1%20and%20are\"><em>[55]<\/em><\/a>\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u80bf\u7624\u7ec6\u80de\u9ad8\u8868\u8fbeLAT1\u9020\u6210\u7684\u5fae\u73af\u5883\u53d8\u5316\u4e5f\u4f1a\u5f71\u54cd\u514d\u75ab\u7ec6\u80de\u529f\u80fd\u3002\u4e0a\u6587\u63d0\u53ca\u7684\u80f6\u8d28\u7624\u6848\u4f8b\u4e2d\uff0c\u8fc7\u5ea6\u6444\u53d6BCAA\u4ea7\u751f\u7684\u916e\u4f53\u9178\u5316\u73af\u5883\uff0c\u53ef\u524a\u5f31\u5de8\u566c\u7ec6\u80de\u7684\u541e\u566c\u6d3b\u6027<a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-025-03721-1#:~:text=and%20valine%20also%20exhibit%20ketogenic,cells%20promotes%20tumor%20progression%20by\"><em>[56]<\/em><\/a>\u5e76\u963b\u788d\u6dcb\u5df4\u7ec6\u80de\u6e17\u5165\uff0c\u4ece\u800c\u5f62\u6210\u514d\u75ab\u6291\u5236\u5c4f\u969c<a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-025-03721-1#:~:text=,cells%20promotes%20tumor%20progression%20by\"><em>[22]<\/em><\/a>\u3002\u6b64\u5916\uff0c\u6162\u6027\u708e\u75c7\u73af\u5883\u4e0b\uff0c\u708e\u75c7\u4ecb\u8d28\u4e5f\u80fd\u53cd\u8fc7\u6765\u523a\u6fc0\u57fa\u8d28\u7ec6\u80de\u6216\u514d\u75ab\u7ec6\u80de\u4e0a\u8c03LAT1\u3002\u5982\u5728\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u6ed1\u819c\u4e2d\uff0c\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50IL-1\u03b2\u901a\u8fc7NF-\u03baB\u901a\u8def\u8bf1\u5bfc\u6ed1\u819c\u6210\u7ea4\u7ef4\u6837\u7ec6\u80de\u9ad8\u8868\u8fbeSLC7A5\uff0c\u4ee5\u589e\u5f3a\u7ec6\u80de\u4ee3\u8c22\u6d3b\u6027\u548c\u86cb\u767d\u5408\u6210\uff0c\u7ed3\u679c\u662f\u52a0\u5267\u4e86\u81f4\u75c5\u6027\u7684\u57fa\u8d28\u964d\u89e3\u9176\uff08MMP3\/13\uff09\u7684\u4ea7\u751f<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7457370\/#:~:text=The%20present%20study%20highlights%20the,the%20treatment%20of%20the%20disease\"><em>[57]<\/em><\/a>\uff08\u8be6\u89c1\u4e0b\u6587\u5176\u4ed6\u75be\u75c5\u90e8\u5206\uff09\u3002\u603b\u800c\u8a00\u4e4b\uff0cSLC7A5\u5728\u514d\u75ab\u8c03\u63a7\u4e2d\u5177\u6709<strong>\u53cc\u91cd\u89d2\u8272<\/strong>\uff1a\u4e00\u65b9\u9762\uff0c\u5b83\u4f5c\u4e3a\u8425\u517b\u8f6c\u8fd0\u8005\u76f4\u63a5\u51b3\u5b9a\u514d\u75ab\u7ec6\u80de\u7684\u4ee3\u8c22\u6d3b\u6027\u548c\u6548\u5e94\u529f\u80fd\uff1b\u53e6\u4e00\u65b9\u9762\uff0c\u80bf\u7624\u7b49\u7ec6\u80de\u5229\u7528LAT1\u91cd\u5851\u5fae\u73af\u5883\uff0c\u53ef\u4ee5\u95f4\u63a5\u5f71\u54cd\u514d\u75ab\u7ec6\u80de\u7684\u529f\u80fd\u72b6\u6001\u3002\u9274\u4e8e\u6b64\uff0c\u8c03\u6574SLC7A5\u7684\u6d3b\u6027\u6709\u671b\u6210\u4e3a\u5f71\u54cd\u514d\u75ab\u53cd\u5e94\u7684\u65b0\u7b56\u7565\u2014\u2014\u65e2\u53ef\u4ee5\u901a\u8fc7\u4e0a\u8c03\u589e\u5f3aT\u7ec6\u80de\u7b49\u6297\u80bf\u7624\u514d\u75ab\u7ec6\u80de\u7684\u4ee3\u8c22\u9002\u5e94\u6027<a href=\"https:\/\/www.nature.com\/articles\/cddis2016222?error=cookies_not_supported&amp;code=2f8829ef-3af2-4585-a184-2d79cbd92b38#:~:text=l,43%20Although%20naive%20human\"><em>[47]<\/em><\/a><a href=\"https:\/\/www.nature.com\/articles\/cddis2016222?error=cookies_not_supported&amp;code=2f8829ef-3af2-4585-a184-2d79cbd92b38#:~:text=primary%20T%20cells%20express%20an,is%20required%20for%20the%20full\"><em>[48]<\/em><\/a>\uff08\u5982\u6709\u7814\u7a76\u63d0\u51fa\u5728\u8fc7\u7ee7\u7ec6\u80de\u6cbb\u7597\u4e2d\u4e0a\u8c03\u8425\u517b\u8f6c\u8fd0\u4ee5\u63d0\u9ad8T\u7ec6\u80de\u6d3b\u529b<a href=\"https:\/\/www.frontiersin.org\/journals\/immunology\/articles\/10.3389\/fimmu.2021.624324\/full#:~:text=Targeting%20SLC1A5%20and%20SLC3A2%2FSLC7A5%20as,of%20nutrient%20transporters%2C%20specifically\"><em>[58]<\/em><\/a>\uff09\uff0c\u4e5f\u53ef\u4ee5\u901a\u8fc7\u6291\u5236\u80bf\u7624\u7ec6\u80de\u7684LAT1\u6765\u7f13\u89e3\u514d\u75ab\u6291\u5236\u6027\u4ee3\u8c22\u5c4f\u969c\uff0c\u4ece\u800c\u6539\u5584\u6297\u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><a>\u4ee5SLC7A5<\/a>\u4e3a\u9776\u70b9\u7684\u6cbb\u7597\u7b56\u7565\u53ca\u836f\u7269\u8fdb\u5c55<\/h2>\n\n\n\n<p>\u9274\u4e8eSLC7A5\u5728\u764c\u75c7\u548c\u4ee3\u8c22\u8c03\u63a7\u4e2d\u7684\u5173\u952e\u4f5c\u7528\uff0c\u8fd1\u5e74\u6765\u5f00\u53d1\u4e86\u591a\u79cd\u4ee5LAT1\u4e3a\u9776\u6807\u7684\u6cbb\u7597\u7b56\u7565\uff0c\u5305\u62ec\u5c0f\u5206\u5b50\u6291\u5236\u5242\u3001\u8bca\u65ad\u663e\u50cf\u63a2\u9488\u548c\u524d\u836f\u9012\u9001\u7cfb\u7edf\u7b49\u3002\u4ee5\u4e0b\u603b\u7ed32023\u20132025\u5e74\u8be5\u9886\u57df\u7684\u4e3b\u8981\u8fdb\u5c55\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>LAT1<\/strong><strong>\u7279\u5f02\u6027\u5c0f\u5206\u5b50\u6291\u5236\u5242\uff1a<\/strong> <strong>JPH203<\/strong><strong>\uff08nanvuranlat<\/strong><strong>\uff09<\/strong>\u662f\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u7684LAT1\u9ad8\u9009\u62e9\u6027\u6291\u5236\u5242\uff0c\u901a\u8fc7\u7ade\u4e89\u6027\u963b\u65ad\u5927\u578b\u4e2d\u6027\u6c28\u57fa\u9178\u8fdb\u5165\u7ec6\u80de\u6765\u201c\u997f\u6b7b\u201d\u764c\u7ec6\u80de<a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-023-02957-z#:~:text=targeted%20drugs%20have%20been%20pursued,nanvuranlat%20and%20cytotoxic%20anticancer%20drugs\"><em>[59]<\/em><\/a><a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-023-02957-z#:~:text=SLC7A5,nanvuranlat%20and%20cytotoxic%20anticancer%20drugs\"><em>[60]<\/em><\/a>\u3002\u5728<strong>\u4e34\u5e8a\u8bd5\u9a8c<\/strong>\u65b9\u9762\uff0cJPH203\u5df2\u5b8c\u6210\u7528\u4e8e\u665a\u671f\u80c6\u9053\u764c\u60a3\u8005\u7684\u968f\u673a\u5bf9\u7167\u2161\u671f\u8bd5\u9a8c\u3002\u7ed3\u679c\u663e\u793a\uff0c\u5728\u63a5\u53d7\u8fc7\u6807\u51c6\u6cbb\u7597\u540e\u8fdb\u5c55\u7684\u80c6\u9053\u764c\u60a3\u8005\u4e2d\uff0cJPH203\u5355\u836f\u4f7f\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u663e\u8457\u5ef6\u957f\uff0c\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\u98ce\u9669\u6bd4HR\u4e3a0.557\uff0895% CI 0.34\u20130.90\uff0cP=0.016\uff09\uff0c\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9<a href=\"https:\/\/www.onclive.com\/view\/nanvuranlat-significantly-improves-pfs-in-pretreated-advanced-biliary-tract-cancer#:~:text=Image\"><em>[61]<\/em><\/a><a href=\"https:\/\/www.onclive.com\/view\/nanvuranlat-significantly-improves-pfs-in-pretreated-advanced-biliary-tract-cancer#:~:text=Nanvuranlat%2C%20%28JPH203%29%2C%20a%20first,UMIN000034080\"><em>[62]<\/em><\/a>\u3002\u5c24\u5176\u5728\u90e8\u5206\u4e9a\u578b\uff08\u5982\u809d\u5916\u80c6\u7ba1\u764c\u548c\u80c6\u56ca\u764c\uff09\u4e2d\uff0cJPH203\u7ec4\u7684\u75be\u75c5\u63a7\u5236\u7387\u660e\u663e\u9ad8\u4e8e\u5bf9\u7167\u7ec4\uff0c\u800c\u4e0d\u826f\u53cd\u5e94\u53ef\u901a\u8fc7\u7b5b\u9009\u4e59\u9170\u8f6c\u79fb\u9176\u8868\u578b\u800c\u964d\u4f4e<a href=\"https:\/\/www.onclive.com\/view\/nanvuranlat-significantly-improves-pfs-in-pretreated-advanced-biliary-tract-cancer#:~:text=Data%20presented%20at%20the%202023,n%20%3D%2035\"><em>[63]<\/em><\/a><a href=\"https:\/\/www.onclive.com\/view\/nanvuranlat-significantly-improves-pfs-in-pretreated-advanced-biliary-tract-cancer#:~:text=%E2%80%9CThe%20forest%20plot%20of%20PFS,%E2%80%9D\"><em>[64]<\/em><\/a>\u3002\u8fd9\u662fLAT1\u6291\u5236\u5242\u9996\u6b21\u5728\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8bc1\u660e\u7597\u6548\uff0c\u5bf9\u4e8e\u5f00\u53d1\u540c\u7c7b\u836f\u7269\u5177\u6709\u91cc\u7a0b\u7891\u610f\u4e49<a href=\"https:\/\/www.onclive.com\/view\/nanvuranlat-significantly-improves-pfs-in-pretreated-advanced-biliary-tract-cancer#:~:text=%E2%80%9CThe%20forest%20plot%20of%20PFS,%E2%80%9D\"><em>[64]<\/em><\/a>\u3002\u5728<strong>\u4e34\u5e8a\u524d<\/strong>\u65b9\u9762\uff0cJPH203\u5bf9\u591a\u79cd\u80bf\u7624\u7ec6\u80de\u5c55\u73b0\u5e7f\u8c31\u6297\u589e\u6b96\u4f5c\u7528\uff0c\u5305\u62ec\u80f0\u817a\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u4e73\u817a\u764c\u7b49<a href=\"https:\/\/www.nature.com\/articles\/s41598-023-41096-3?error=cookies_not_supported&amp;code=e83f04ff-1a6a-475e-8a4c-071699e5be0b#:~:text=of%20LAT1%20inhibition%20on%20cancer,the%20downregulation%20of%20the%20mTOR\"><em>[30]<\/em><\/a>\u3002\u4f8b\u5982\uff0c\u5728\u5c0f\u9f20TNBC\u6a21\u578b\u4e2d\uff0cJPH203\u4e0e\u963f\u9709\u7d20\u8054\u5408\u53ef\u534f\u540c\u589e\u5f3a\u80bf\u7624\u6740\u4f24\u6548\u679c<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=was%20observed%20in%20primary%20cells,of%20doxorubicin%20in%20TNBC%20cells\"><em>[18]<\/em><\/a>\u3002\u5728\u80f0\u817a\u764c\u548c\u80c6\u9053\u764c\u7ec6\u80de\u4e2d\uff0cJPH203\u4e0e\u6807\u51c6\u5316\u7597\u836f\u7269\u5409\u897f\u4ed6\u6ee8\u8054\u5408\u663e\u793a\u4e86\u66f4\u5f3a\u7684\u6291\u7624\u4f5c\u7528\uff1a\u76f8\u6bd4\u5355\u836f\uff0c\u8054\u5408\u5904\u7406\u5728\u591a\u682a\u7ec6\u80de\u7cfb\u4e2d\u5747\u663e\u8457\u6291\u5236\u7ec6\u80de\u751f\u957f\uff0c\u8bf1\u5bfc\u66f4\u660e\u663e\u7684\u7ec6\u80de\u5468\u671f\u505c\u6ede\u548c\u51cb\u4ea1<a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-023-02957-z#:~:text=All%20the%20tested%20seven%20types,anticancer%20drug%20basically%20exerted%20its\"><em>[65]<\/em><\/a><a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-023-02957-z#:~:text=Our%20study%20demonstrates%20the%20potential,pancreatic%20and%20biliary%20tract%20cancers\"><em>[66]<\/em><\/a>\u3002\u867d\u7136\u6709\u62a5\u9053\u5176\u8054\u5408\u6548\u679c\u4e3a\u52a0\u6210\u800c\u975e\u771f\u6b63\u534f\u540c<a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-023-02957-z#:~:text=PaCa,although%20gemcitabine%20more%20strongly%20influenced\"><em>[67]<\/em><\/a>\uff0c\u4f46\u8fd9\u4ecd\u63d0\u793aLAT1\u6291\u5236\u5242\u53ef\u4f5c\u4e3a\u5316\u7597\u589e\u654f\u5242\u4f7f\u7528\uff0c\u63d0\u9ad8\u5bf9\u6c28\u57fa\u9178\u4f9d\u8d56\u6027\u5f3a\u7684\u80bf\u7624\u7684\u6cbb\u7597\u6548\u679c<a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-023-02957-z#:~:text=All%20the%20tested%20seven%20types,anticancer%20drug%20basically%20exerted%20its\"><em>[65]<\/em><\/a><a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-023-02957-z#:~:text=Our%20study%20demonstrates%20the%20potential,pancreatic%20and%20biliary%20tract%20cancers\"><em>[66]<\/em><\/a>\u3002\u76ee\u524d\uff0cJPH203\u6b63\u7531\u65e5\u7f8e\u7b49\u7814\u7a76\u56e2\u961f\u63a8\u8fdb\u66f4\u591a\u764c\u79cd\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u540c\u65f6\u5176\u4ed6\u65b0\u578bLAT1\u5c0f\u5206\u5b50\u6291\u5236\u5242\uff08\u4f8b\u5982\u4f18\u5316\u7684Phe\u884d\u751f\u7269\uff09\u4e5f\u5728\u836f\u7406\u548c\u7ed3\u6784\u5c42\u9762\u5f97\u5230\u6539\u8fdb<a href=\"https:\/\/www.nature.com\/articles\/s41598-023-41096-3?error=cookies_not_supported&amp;code=e83f04ff-1a6a-475e-8a4c-071699e5be0b#:~:text=of%20LAT1%20inhibition%20on%20cancer,the%20downregulation%20of%20the%20mTOR\"><em>[30]<\/em><\/a><a href=\"https:\/\/www.nature.com\/articles\/s41598-023-41096-3?error=cookies_not_supported&amp;code=e83f04ff-1a6a-475e-8a4c-071699e5be0b#:~:text=suppressed%20lung%2C%20spleen%2C%20and%20lymph,metastasis%20cancer%20therapy\"><em>[34]<\/em><\/a>\u3002<\/li>\n\n\n\n<li><strong>\u9776\u5411LAT1<\/strong><strong>\u7684\u836f\u7269\u9012\u9001\u4e0e\u8bca\u65ad\uff1a<\/strong> \u9664\u4e86\u76f4\u63a5\u6291\u5236LAT1\u6d3b\u6027\uff0c\u79d1\u7814\u4eba\u5458\u8fd8\u5229\u7528LAT1\u9ad8\u8868\u8fbe\u4e8e\u80bf\u7624\u548c\u8840\u8111\u5c4f\u969c\u7684\u7279\u6027\u5f00\u53d1\u4e86\u9776\u5411\u9012\u836f\u7cfb\u7edf\u548c\u6210\u50cf\u65b9\u6cd5\u3002\u4f8b\u5982\uff0c<strong>LAT1<\/strong><strong>\u4ecb\u5bfc\u7684\u524d\u4f53\u836f\u7269<\/strong>\u7b56\u7565\u5c06\u6297\u764c\u6216\u795e\u7ecf\u836f\u7269\u4e0eLAT1\u5e95\u7269\u7ed3\u6784\u5076\u8054\uff0c\u4f7f\u5176\u901a\u8fc7LAT1\u6613\u5316\u8fdb\u5165\u80bf\u7624\u7ec6\u80de\u6216\u8111\u7ec4\u7ec7\uff0c\u518d\u5728\u7ec6\u80de\u5185\u91ca\u653e\u6d3b\u6027\u836f\u7269<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=drug%20delivery%20in%20the%20brain,inflammatory%20agent%20ketoprofen\"><em>[68]<\/em><\/a><a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=%28Gynther%20et%20al.%2C%202008%29%2C%20anti,of%20the%20prodrugs%20in%20human\"><em>[69]<\/em><\/a>\u3002\u5df2\u6709\u7814\u7a76\u6210\u529f\u8bbe\u8ba1\u51fa\u591a\u79cdLAT1\u9776\u5411\u524d\u836f\uff0c\u5982LAT1-\u5076\u8054\u916e\u6d1b\u82ac\uff08\u6297\u708e\u9547\u75db\u836f\uff09\u3001\u5de6\u65cb\u591a\u5df4\u524d\u836f\uff08\u6297\u5e15\u91d1\u68ee\u836f\uff09\u7b49\uff0c\u5b83\u4eec\u5728\u7ec6\u80de\u548c\u52a8\u7269\u6a21\u578b\u4e2d\u8868\u73b0\u51fa\u6bd4\u539f\u836f\u66f4\u9ad8\u7684\u8111\u6444\u53d6\u6548\u7387\u6216\u80bf\u7624\u9009\u62e9\u6027<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=selectively%20expressed%20on%20the%20BBB,2018\"><em>[70]<\/em><\/a><a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=and%20natural%20phenolic%20antioxidant%20ferulic,LAT1%20can%20be%20utilized%20to\"><em>[71]<\/em><\/a>\u3002\u4e00\u9879\u7814\u7a76\u540c\u65f6\u6d4b\u8bd5\u4e866\u79cdLAT1\u524d\u836f\uff0c\u53d1\u73b0\u5b83\u4eec\u5728\u7ec6\u80de\u548c\u5c0f\u9f20\u8111\u5185\u7684\u79ef\u7d2f\u663e\u8457\u9ad8\u4e8e\u539f\u836f\uff0c\u5e76\u4e14\u8fd9\u4e00\u6444\u53d6\u53ef\u88abLAT1\u6291\u5236\u5242\u7ade\u4e89\u963b\u65ad\uff0c\u8bc1\u660e\u786e\u5b9e\u662fLAT1\u4ecb\u5bfc\u8fdb\u5165<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=investigational%20immunosuppressive%20perforin%20inhibitors%20,19%29%20cells%20by%2065%E2%80%9393\"><em>[72]<\/em><\/a>\u3002\u8fd9\u79cd\u524d\u836f\u6cd5\u6709\u671b\u63d0\u9ad8\u6cbb\u7597\u836f\u7269\u8de8\u8d8a\u8840\u8111\u5c4f\u969c\u6216\u80bf\u7624\u9776\u5411\u7684\u6548\u7387\uff0c\u51cf\u5c11\u5168\u8eab\u526f\u4f5c\u7528<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=and%20natural%20phenolic%20antioxidant%20ferulic,LAT1%20can%20be%20utilized%20to\"><em>[71]<\/em><\/a><a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=into%20the%20brain%20cells%20comparably,In%20another%20study%20suggested%20the\"><em>[73]<\/em><\/a>\u3002\u5728\u8bca\u65ad\u65b9\u9762\uff0cLAT1\u7684\u9ad8\u9009\u62e9\u6027\u5e95\u7269\u63a2\u9488\u5df2\u7528\u4e8e\u80bf\u7624\u6b63\u7535\u5b50\u53d1\u5c04\u65ad\u5c42\u626b\u63cf\uff08PET\uff09\u6210\u50cf\u548c<strong>\u787c\u4e2d\u5b50\u4fd8\u83b7\u7597\u6cd5\uff08<\/strong><strong>BNCT<\/strong><strong>\uff09<\/strong>\u4e2d\u3002\u4f8b\u5982\uff0c<strong>18F-FAMT<\/strong>\uff0818F\u6807\u8bb0\u7684\u03b1-\u7532\u57fa-Tyrosine\uff09\u662f\u4e00\u79cd\u9009\u62e9\u6027\u7ecfLAT1\u6444\u53d6\u7684PET\u793a\u8e2a\u5242\uff0c\u53ef\u7528\u4e8e\u9274\u522b\u80bf\u7624\u7ec4\u7ec7\u4e0e\u708e\u6027\u75c5\u53d8\uff0c\u56e0\u4e3a\u708e\u75c7\u7ec4\u7ec7LAT1\u8868\u8fbe\u4f4e\u800c\u6444\u53d6\u5f31<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=images%20is%20closely%20related%20to,probe%20that%20can%20be%20applied\"><em>[74]<\/em><\/a><a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=to%20find%20cancer%20through%20PET,BNCT%20is%20a\"><em>[75]<\/em><\/a>\uff1b\u800c\u5728BNCT\u4e2d\uff0c\u5229\u7528LAT1\u9ad8\u8868\u8fbe\u7684\u80bf\u7624\u5bf9\u787c\u836f\u7269\u7684\u5bcc\u96c6\u4f5c\u7528\uff0c\u53ef\u5c06\u5bcc\u542b^&lt;10>B\u7684\u5bf9\u787c\u82ef\u4e19\u6c28\u9178\uff08BPA\uff0c\u4e00\u79cd\u6a21\u62df\u916a\u6c28\u9178\u7684LAT1\u5e95\u7269\uff09\u9009\u62e9\u6027\u8f93\u9001\u8fdb\u5165\u80f6\u8d28\u7624\u7b49\u764c\u7ec6\u80de<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=Glaudemans%20et%20al,mediated%20transmission\"><em>[76]<\/em><\/a>\u3002\u5f53\u53d7\u5230\u4e2d\u5b50\u8f90\u7167\u65f6\uff0c^&lt;10>B\u88c2\u53d8\u91ca\u653e\u7684\u9ad8\u80fd\u03b1\u7c92\u5b50\u7cbe\u51c6\u6740\u4f24\u80bf\u7624\u7ec6\u80de<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=of%20%5B%5E%7B11%7DC%5D,mediated%20transmission\"><em>[77]<\/em><\/a>\u3002LAT1\u4ecb\u5bfc\u7684BPA\u6444\u53d6\u5df2\u88ab\u8bc1\u660e\u4e0e\u80f6\u8d28\u7624\u7ec4\u7ec7\u4e2dLAT1\u7684\u8868\u8fbe\u7a0b\u5ea6\u76f8\u5173<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=%5B%5E%7B11%7DC%5D,10%7DB%20is\"><em>[78]<\/em><\/a>\u3002\u7efc\u4e0a\u6240\u8ff0\uff0c\u65e0\u8bba\u662f\u4f5c\u4e3a\u4ee3\u8c22\u9776\u70b9\u76f4\u63a5\u6291\u5236\uff0c\u8fd8\u662f\u4f5c\u4e3a\u836f\u7269\/\u63a2\u9488\u901a\u9053\u8fdb\u884c\u5229\u7528\uff0cSLC7A5\u5728\u764c\u75c7\u7cbe\u51c6\u6cbb\u7597\u548c\u8bca\u65ad\u4e2d\u7684\u4ef7\u503c\u5f97\u5230\u4e86\u8d8a\u6765\u8d8a\u591a\u7684\u9a8c\u8bc1\u548c\u5e94\u7528\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>SLC7A5<\/strong><strong>\u9776\u5411\u7597\u6cd5\u8fdb\u5c55\u4e00\u89c8\uff1a<\/strong><br>| \u7b56\u7565\/\u836f\u7269 | \u4f5c\u7528\u673a\u5236\u4e0e\u7279\u70b9 | \u6700\u65b0\u8fdb\u5c55\uff082023\u20132025\uff09 | | &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;- | &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;- | &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211; | | <strong>LAT1<\/strong><strong>\u5c0f\u5206\u5b50\u6291\u5236\u5242<\/strong>&lt;br&gt;\uff08\u4ee3\u8868\uff1aJPH203\/nanvuranlat\uff09 | \u9ad8\u9009\u62e9\u6027\u7ade\u4e89\u6027\u6291\u5236LAT1\u8f6c\u8fd0\u529f\u80fd\uff0c\u963b\u65ad\u80bf\u7624\u5fc5\u9700\u6c28\u57fa\u9178\u6444\u53d6<a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-023-02957-z#:~:text=targeted%20drugs%20have%20been%20pursued,nanvuranlat%20and%20cytotoxic%20anticancer%20drugs\"><em>[59]<\/em><\/a><a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-023-02957-z#:~:text=SLC7A5,nanvuranlat%20and%20cytotoxic%20anticancer%20drugs\"><em>[60]<\/em><\/a>\u3002 | \u5b8c\u6210\u80c6\u9053\u764c\u2161\u671f\u4e34\u5e8a\uff1a\u663e\u8457\u5ef6\u957f\u60a3\u8005PFS<a href=\"https:\/\/www.onclive.com\/view\/nanvuranlat-significantly-improves-pfs-in-pretreated-advanced-biliary-tract-cancer#:~:text=Image\"><em>[79]<\/em><\/a><a href=\"https:\/\/www.onclive.com\/view\/nanvuranlat-significantly-improves-pfs-in-pretreated-advanced-biliary-tract-cancer#:~:text=Nanvuranlat%2C%20%28JPH203%29%2C%20a%20first,UMIN000034080\"><em>[62]<\/em><\/a>\uff1b&lt;br&gt;\u5728\u4e73\u817a\u764c\u3001\u9ed1\u8272\u7d20\u7624\u7b49\u6a21\u578b\u663e\u793a\u6291\u7624\u548c\u6297\u8f6c\u79fb\u4f5c\u7528<a href=\"https:\/\/www.nature.com\/articles\/s41598-023-41096-3?error=cookies_not_supported&amp;code=e83f04ff-1a6a-475e-8a4c-071699e5be0b#:~:text=of%20LAT1%20inhibition%20on%20cancer,the%20downregulation%20of%20the%20mTOR\"><em>[30]<\/em><\/a><a href=\"https:\/\/www.nature.com\/articles\/s41598-023-41096-3?error=cookies_not_supported&amp;code=e83f04ff-1a6a-475e-8a4c-071699e5be0b#:~:text=LAT1,These%20results\"><em>[31]<\/em><\/a>\uff1b&lt;br&gt;\u4e0e\u5316\u7597\u8054\u5408\u5728\u80f0\u817a\/\u80c6\u9053\u764c\u7ec6\u80de\u4e2d\u8868\u73b0\u51fa\u589e\u5f3a\u7684\u751f\u957f\u6291\u5236<a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-023-02957-z#:~:text=All%20the%20tested%20seven%20types,anticancer%20drug%20basically%20exerted%20its\"><em>[65]<\/em><\/a><a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-023-02957-z#:~:text=Our%20study%20demonstrates%20the%20potential,pancreatic%20and%20biliary%20tract%20cancers\"><em>[66]<\/em><\/a>\u3002 | | <strong>LAT1<\/strong><strong>\u4ecb\u5bfc\u524d\u836f<\/strong>&lt;br&gt;\uff08\u4ee3\u8868\uff1a\u916e\u6d1b\u82ac-LAT1\u5076\u8054\u7269\u7b49\uff09 | \u5c06\u836f\u7269\u4e0eLAT1\u5e95\u7269\u5171\u4ef7\u5076\u8054\uff0c\u901a\u8fc7LAT1\u8f6c\u8fd0\u8fdb\u5165\u7ec6\u80de\/\u7a7f\u8fc7BBB\u540e\uff0c\u5728\u9776\u70b9\u7ec4\u7ec7\u5185\u91ca\u653e\u6d3b\u6027\u836f\u7269<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=selectively%20expressed%20on%20the%20BBB,2018\"><em>[70]<\/em><\/a><a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=and%20natural%20phenolic%20antioxidant%20ferulic,LAT1%20can%20be%20utilized%20to\"><em>[71]<\/em><\/a>\u3002 | \u591a\u79cdLAT1\u9776\u5411\u524d\u836f\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\u9a8c\u8bc1\uff1a\u8111\u5185\u6444\u53d6\u63d0\u9ad8\uff0c\u53ef\u7528\u4e8e\u5e15\u91d1\u68ee\u7b49\u4e2d\u67a2\u836f\u7269\u9012\u9001<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=%28Gynther%20et%20al.%2C%202008%29%2C%20anti,of%20the%20prodrugs%20in%20human\"><em>[69]<\/em><\/a><a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=and%20natural%20phenolic%20antioxidant%20ferulic,LAT1%20can%20be%20utilized%20to\"><em>[71]<\/em><\/a>\uff1b&lt;br&gt;\u5bf9\u80bf\u7624\u7ec6\u80de\u6444\u53d6\u663e\u8457\u9ad8\u4e8e\u6b63\u5e38\u7ec4\u7ec7\uff0c\u6709\u671b\u51cf\u5c11\u5168\u8eab\u526f\u4f5c\u7528\uff08\u524d\u4e34\u5e8a\u9636\u6bb5\uff09\u3002 | | <strong>LAT1<\/strong><strong>\u9776\u5411\u8bca\u65ad\/<\/strong><strong>\u653e\u7597<\/strong>&lt;br&gt;\uff08\u4ee3\u8868\uff1a&lt;sup&gt;18&lt;\/sup&gt;F-FAMT PET\u3001&lt;br&gt;BPA-BNCT\uff09 | \u5229\u7528LAT1\u9ad8\u8868\u8fbe\u80bf\u7624\u6444\u53d6\u03b1-\u7532\u57fa\u6c28\u57fa\u9178\u63a2\u9488\u8fdb\u884c\u6210\u50cf\uff0c\u6216\u5bcc\u96c6\u787c-10\u4e8e\u80bf\u7624\u5b9e\u73b0\u4e2d\u5b50\u4fd8\u83b7\u6cbb\u7597<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=images%20is%20closely%20related%20to,probe%20that%20can%20be%20applied\"><em>[74]<\/em><\/a><a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=Glaudemans%20et%20al,mediated%20transmission\"><em>[76]<\/em><\/a>\u3002 | FAMT\u5df2\u7528\u4e8e\u533a\u5206\u80bf\u7624\u4e0e\u708e\u75c7\u75c5\u7076\uff0c\u6444\u53d6\u5f3a\u5ea6\u4e0eLAT1\u8868\u8fbe\u76f8\u5173<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=human%20cancers,and%20strong%20specificity%2C%20and%20has\"><em>[80]<\/em><\/a><a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=%5B%5E%7B11%7DC%5D,10%7DB%20is\"><em>[78]<\/em><\/a>\uff1b&lt;br&gt;BNCT\u4e34\u5e8a\u5e94\u7528\u663e\u793a\u9ad8LAT1\u7684\u80f6\u8d28\u7624\u5bf9BPA\u6444\u53d6\u826f\u597d\uff0c\u63d0\u9ad8\u7597\u6548\uff08\u6301\u7eed\u7814\u7a76\u4e2d\uff09\u3002 |<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><a>SLC7A5<\/a>\u5728\u795e\u7ecf\u7cfb\u7edf\u53ca\u5176\u4ed6\u75be\u75c5\u4e2d\u7684\u8868\u8fbe\u4e0e\u529f\u80fd<\/h2>\n\n\n\n<p><strong>\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\uff08ASD<\/strong><strong>\uff09\u7b49\u795e\u7ecf\u53d1\u80b2\u75be\u75c5\uff1a<\/strong> SLC7A5\u5728\u5927\u8111\u4e2d\u7684\u529f\u80fd\u4e3b\u8981\u4f53\u73b0\u5728\u8840\u8111\u5c4f\u969c\uff08BBB\uff09\u5bf9\u5fc5\u9700\u6c28\u57fa\u9178\u7684\u8f6c\u8fd0\u4e0a\u30022016\u5e74\u7684\u7814\u7a76\u9996\u6b21\u5c06<em>SLC7A5<\/em>\u57fa\u56e0\u7a81\u53d8\u4e0e\u4e00\u79cd\u53ef\u81f4\u6cbb\u7597\u7684\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u8054\u7cfb\u8d77\u6765\uff1a\u4e24\u7ec4\u6709\u591a\u4e2a\u5b69\u5b50\u60a3\u81ea\u95ed\u75c7\u548c\u8fd0\u52a8\u53d1\u80b2\u8fdf\u7f13\u7684\u5bb6\u65cf\u4e2d\u53d1\u73b0\u4e86SLC7A5\u7684\u529f\u80fd\u4e27\u5931\u7a81\u53d8\uff0c\u8fd9\u4e9b\u60a3\u513f\u8111\u810a\u6db2\u4e2d\u7684\u652f\u94fe\u6c28\u57fa\u9178\uff08BCAA\uff09\u6c34\u5e73\u663e\u8457\u964d\u4f4e<a href=\"https:\/\/www.sfari.org\/2016\/12\/30\/a-potentially-treatable-form-of-autism-caused-by-impaired-brain-transport-of-amino-acids\/#:~:text=amino%20acid%20transporter%20LAT1%2C%20located,in%20several%20individuals%20with%20ASD\"><em>[81]<\/em><\/a><a href=\"https:\/\/www.sfari.org\/2016\/12\/30\/a-potentially-treatable-form-of-autism-caused-by-impaired-brain-transport-of-amino-acids\/#:~:text=studied%20a%20mouse%20model%20in,Combined%2C%20these%20findings\"><em>[82]<\/em><\/a>\u3002\u5c0f\u9f20\u6a21\u578b\u8bc1\u5b9e\uff0c<strong>\u9009\u62e9\u6027\u6572\u9664<\/strong><strong>BBB<\/strong><strong>\u5185\u76ae\u7ec6\u80de<\/strong>\u7684Slc7a5\u57fa\u56e0\u4f1a\u5bfc\u81f4\u65b0\u751f\u5c0f\u9f20\u8111\u5185BCAA\u542b\u91cf\u4e0b\u964d\uff0c\u5f15\u53d1\u5c0f\u8111\u53d1\u80b2\u4e0d\u5168\u3001\u795e\u7ecf\u5143\u9ad3\u9798\u5316\u5f02\u5e38\u7b49\uff0c\u8fdb\u800c\u51fa\u73b0\u8fd0\u52a8\u53d1\u80b2\u8fdf\u6ede\u548c\u7c7b\u4f3c\u81ea\u95ed\u75c7\u7684\u793e\u4f1a\u884c\u4e3a\u7f3a\u9677<a href=\"https:\/\/www.sfari.org\/2016\/12\/30\/a-potentially-treatable-form-of-autism-caused-by-impaired-brain-transport-of-amino-acids\/#:~:text=critical%20role%20in%20transporting%20BCAAs,In%20the%20current%20study%2C%20they\"><em>[83]<\/em><\/a><a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=The%20study%20by%20T%C4%83rlungeanu%20et,in%20their%20BBBs%20will%20show\"><em>[84]<\/em><\/a>\u3002\u4ee4\u4eba\u9f13\u821e\u7684\u662f\uff0c\u5411\u6210\u5e74\u5c0f\u9f20\u8111\u5ba4\u5185\u76f4\u63a5\u6ce8\u5c04BCAA\uff0c\u53ef\u4ee5\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a<strong>\u6539\u5584<\/strong>\u56e0LAT1\u7f3a\u4e4f\u5bfc\u81f4\u7684\u5f02\u5e38\u884c\u4e3a<a href=\"https:\/\/www.sfari.org\/2016\/12\/30\/a-potentially-treatable-form-of-autism-caused-by-impaired-brain-transport-of-amino-acids\/#:~:text=the%20blood%20brain%20barrier,Combined%2C%20these%20findings\"><em>[85]<\/em><\/a>\u3002\u8fd9\u63d0\u793a\u6211\u4eec\uff1a\u901a\u8fc7\u6062\u590d\u8111\u5185\u6c28\u57fa\u9178\u5e73\u8861\uff0c\u6709\u671b\u7f13\u89e3\u6b64\u7c7b\u7531SLC7A5\u7f3a\u9677\u5f15\u8d77\u7684\u795e\u7ecf\u53d1\u80b2\u969c\u788d\u75c7\u72b6<a href=\"https:\/\/www.sfari.org\/2016\/12\/30\/a-potentially-treatable-form-of-autism-caused-by-impaired-brain-transport-of-amino-acids\/#:~:text=the%20blood%20brain%20barrier,levels%20of%20BCAAs%20could%20potentially\"><em>[86]<\/em><\/a>\u30022023\u5e74\uff0c\u5965\u5730\u5229ISTA\u7814\u7a76\u6240Novarino\u56e2\u961f\u7684\u6700\u65b0\u5c0f\u9f20\u7814\u7a76\u8fdb\u4e00\u6b65\u52a0\u6df1\u4e86\u5bf9\u8be5\u673a\u5236\u7684\u7406\u89e3\uff1a\u4ed6\u4eec\u53d1\u73b0\u5728\u56f4\u4ea7\u671f\u5982\u679c<strong>\u795e\u7ecf\u5143\u7f3a\u4e4f\u5927\u4e2d\u6027\u6c28\u57fa\u9178\uff08<\/strong><strong>LNAA<\/strong><strong>\uff09\u4f9b\u7ed9<\/strong>\uff0c\u4f1a\u9020\u6210\u4e25\u91cd\u7684\u8111\u53d1\u80b2\u969c\u788d<a href=\"https:\/\/www.genengnews.com\/topics\/translational-medicine\/amino-acid-deficit-impacts-perinatal-mouse-brain-development-leading-to-microcephaly-autism-behaviors\/#:~:text=A%20study%20in%20mice%20by,ASD\"><em>[87]<\/em><\/a>\u3002\u8fd9\u4e9b\u5c0f\u9f20\u5728\u51fa\u751f\u540e\u8111\u4f53\u79ef\u663e\u8457\u51cf\u5c0f\uff08\u5c0f\u5934\u75c7\uff09\uff0c\u8fd9\u4e00\u7f3a\u9677\u4f1a\u6301\u7eed\u81f3\u6210\u5e74\u5e76\u5bfc\u81f4\u957f\u671f\u884c\u4e3a\u6539\u53d8\u2014\u2014\u5305\u62ec\u793e\u4ea4\u969c\u788d\u548c\u91cd\u590d\u523b\u677f\u52a8\u4f5c\u7b49\uff0c\u5747\u4e0e\u81ea\u95ed\u75c7\u8c31\u7cfb\u884c\u4e3a\u7c7b\u4f3c<a href=\"https:\/\/www.genengnews.com\/topics\/translational-medicine\/amino-acid-deficit-impacts-perinatal-mouse-brain-development-leading-to-microcephaly-autism-behaviors\/#:~:text=A%20study%20in%20mice%20by,ASD\"><em>[87]<\/em><\/a>\u3002\u8be5\u56e2\u961f\u901a\u8fc7\u4ee3\u8c22\u7ec4\u5b66\u5206\u6790\u53d1\u73b0\uff0c\u6b63\u5e38\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u8111\u5185LNAA\u6c34\u5e73\u5728\u5173\u952e\u65f6\u95f4\u7a97\u53e3\u9700\u8981\u7ef4\u6301\u5728\u4e00\u5b9a\u8303\u56f4\uff0c\u4ee5\u4fdd\u969c\u795e\u7ecf\u5143\u5174\u594b\u6027\u548c\u5b58\u6d3b\u7684\u7cbe\u7ec6\u8c03\u63a7\uff1b\u800cSLC7A5\u6b63\u662f\u534f\u8c03\u8fd9\u4e00\u8fc7\u7a0b\u7684\u91cd\u8981\u201c\u8425\u517b\u95f8\u95e8\u201d<a href=\"https:\/\/www.genengnews.com\/topics\/translational-medicine\/amino-acid-deficit-impacts-perinatal-mouse-brain-development-leading-to-microcephaly-autism-behaviors\/#:~:text=The%20Novarino%20group%20had%20previously,and%20doctoral%20student%20Lisa%20Knaus\"><em>[88]<\/em><\/a>\u3002\u5f53SLC7A5\u529f\u80fd\u53d7\u635f\u65f6\uff0c\u8111\u5185LNAA\u4f9b\u5e94\u4e0d\u8db3\uff0c\u5f15\u53d1\u53d1\u80b2\u671f\u795e\u7ecf\u5143\u5174\u594b\u6027\u5f02\u5e38\u548c\u6b7b\u4ea1\u589e\u52a0\uff0c\u6700\u7ec8\u5bfc\u81f4\u4e0d\u53ef\u9006\u7684\u76ae\u5c42\u56de\u8def\u7f3a\u9677<a href=\"https:\/\/www.genengnews.com\/topics\/translational-medicine\/amino-acid-deficit-impacts-perinatal-mouse-brain-development-leading-to-microcephaly-autism-behaviors\/#:~:text=The%20researchers%20reported%20on%20their,%E2%80%9D\"><em>[89]<\/em><\/a><a href=\"https:\/\/www.genengnews.com\/topics\/translational-medicine\/amino-acid-deficit-impacts-perinatal-mouse-brain-development-leading-to-microcephaly-autism-behaviors\/#:~:text=The%20Novarino%20group%20had%20previously,and%20doctoral%20student%20Lisa%20Knaus\"><em>[88]<\/em><\/a>\u3002\u4ed6\u4eec\u7684\u7ed3\u8bba\u662f\uff1a\u201c\u5728\u5173\u952e\u53d1\u80b2\u9636\u6bb5\u6270\u4e71\u8425\u517b\u76f8\u5173\u57fa\u56e0\uff08\u5982SLC7A5\uff09\u7684\u8868\u8fbe\u4f1a\u5bfc\u81f4\u6c38\u4e45\u7684\u5927\u8111\u56de\u8def\u53d1\u80b2\u7f3a\u9677\u201d<a href=\"https:\/\/www.genengnews.com\/topics\/translational-medicine\/amino-acid-deficit-impacts-perinatal-mouse-brain-development-leading-to-microcephaly-autism-behaviors\/#:~:text=neutral%20amino%20acid%20levels%20tune,%E2%80%9D\"><em>[90]<\/em><\/a><a href=\"https:\/\/www.genengnews.com\/topics\/translational-medicine\/amino-acid-deficit-impacts-perinatal-mouse-brain-development-leading-to-microcephaly-autism-behaviors\/#:~:text=The%20Novarino%20group%20had%20previously,and%20doctoral%20student%20Lisa%20Knaus\"><em>[88]<\/em><\/a>\u3002\u8fd9\u4e00\u7cfb\u5217\u7814\u7a76\u5c06LAT1\u7f3a\u9677\u578b\u81ea\u95ed\u75c7\u5b9a\u4e49\u4e3a\u4e00\u79cd\u6f5c\u5728<strong>\u53ef\u5e72\u9884<\/strong>\u7684\u4ee3\u8c22\u578b\u8111\u75c5\uff0c\u5e76\u63d0\u793a\u901a\u8fc7\u8865\u5145\u5927\u4e2d\u6027\u6c28\u57fa\u9178\u6216\u52a0\u5f3aBBB\u8f6c\u8fd0\u529f\u80fd\uff0c\u6709\u671b\u6539\u5584\u6b64\u7c7b\u60a3\u8005\u7684\u9884\u540e<a href=\"https:\/\/www.sfari.org\/2016\/12\/30\/a-potentially-treatable-form-of-autism-caused-by-impaired-brain-transport-of-amino-acids\/#:~:text=the%20blood%20brain%20barrier,levels%20of%20BCAAs%20could%20potentially\"><em>[86]<\/em><\/a>\u3002\u76ee\u524d\uff0c\u76f8\u5173\u7684\u4e34\u5e8a\u524d\u63a2\u7d22\uff08\u5982LNAA\u8865\u5145\u7597\u6cd5\uff09\u6b63\u5728\u8fdb\u884c\u4e2d\u3002<\/p>\n\n\n\n<p><strong>\u5176\u5b83\u75be\u75c5\u4e0e\u75c5\u7406\u72b6\u6001\uff1a<\/strong> \u9664\u795e\u7ecf\u7cfb\u7edf\u5916\uff0cSLC7A5\u5728\u67d0\u4e9b\u4ee3\u8c22\u6027\u548c\u514d\u75ab\u6027\u75be\u75c5\u4e2d\u4e5f\u8868\u73b0\u51fa\u5f02\u5e38\u8868\u8fbe\u548c\u529f\u80fd\u6539\u53d8\u3002\u4f8b\u5982\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u708e\u75c7\u4e0e\u81ea\u8eab\u514d\u75ab\uff08\u7c7b\u98ce\u6e7f\u5173\u8282\u708eRA<\/strong><strong>\uff09\uff1a<\/strong> \u5728RA\u60a3\u8005\u7684\u6ed1\u819c\u7ec4\u7ec7\u4e2d\uff0c\u7814\u7a76\u53d1\u73b0LAT1\u8868\u8fbe\u663e\u8457\u9ad8\u4e8e\u9aa8\u5173\u8282\u708e\u7b49\u826f\u6027\u5bf9\u7167\uff0c\u4e14\u4e3b\u8981\u7531\u6ed1\u819c\u6210\u7ea4\u7ef4\u6837\u7ec6\u80de\uff08FLS\uff09\u8868\u8fbe<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7457370\/#:~:text=The%20present%20study%20highlights%20the,the%20treatment%20of%20the%20disease\"><em>[57]<\/em><\/a>\u3002\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\uff08\u5982IL-1\u03b2\uff09\u80fd\u901a\u8fc7\u6fc0\u6d3bNF-\u03baB\u901a\u8def\u4e0a\u8c03FLS\u7684SLC7A5\u8868\u8fbe<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7457370\/#:~:text=The%20present%20study%20highlights%20the,the%20treatment%20of%20the%20disease\"><em>[57]<\/em><\/a>\u3002\u9ad8\u8868\u8fbe\u7684LAT1\u589e\u5f3a\u4e86FLS\u7684\u4ee3\u8c22\u6d3b\u6027\uff0c\u5c24\u5176\u662f\u6fc0\u6d3bmTOR-P70S6K\u4fe1\u53f7\u901a\u8def\uff0c\u4fc3\u8fdb\u86cb\u767d\u5408\u6210\u901a\u8def\u7684\u8fc7\u5ea6\u6d3b\u8dc3<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7457370\/#:~:text=The%20present%20study%20highlights%20the,the%20treatment%20of%20the%20disease\"><em>[57]<\/em><\/a>\u3002\u8fd9\u76f4\u63a5\u5bfc\u81f4\u4e86RA\u75c5\u53d8\u4e2d\u7834\u574f\u5173\u8282\u7684\u5173\u952e\u9176\u2014\u2014\u57fa\u8d28\u91d1\u5c5e\u86cb\u767d\u9176MMP3\u548cMMP13\u7684\u8fc7\u91cf\u4ea7\u751f<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7457370\/#:~:text=The%20present%20study%20highlights%20the,the%20treatment%20of%20the%20disease\"><em>[57]<\/em><\/a>\u3002\u529f\u80fd\u5b9e\u9a8c\u663e\u793a\uff0c\u5e94\u7528LAT1\u529f\u80fd\u963b\u65ad\u6297\u4f53\u6216siRNA\u6c89\u9ed8SLC7A5\uff0c\u53ef\u660e\u663e\u6291\u5236RA-FLS\u5728\u708e\u75c7\u523a\u6fc0\u4e0bMMP3\u548cMMP13\u7684\u5206\u6ccc<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7457370\/#:~:text=The%20present%20study%20highlights%20the,the%20treatment%20of%20the%20disease\"><em>[57]<\/em><\/a>\u3002\u76f8\u53cd\uff0c\u8fc7\u8868\u8fbeLAT1\u4f1a\u52a0\u5267\u8fd9\u4e24\u79cdMMP\u7684\u4ea7\u751f\u548c\u91ca\u653e<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7457370\/#:~:text=The%20present%20study%20highlights%20the,the%20treatment%20of%20the%20disease\"><em>[57]<\/em><\/a>\u3002\u7531\u6b64\u53ef\u89c1\uff0cSLC7A5\u5728RA\u6ed1\u819c\u4e2d\u5145\u5f53\u4e86\u708e\u75c7\u201c\u52a9\u63a8\u5668\u201d\u7684\u89d2\u8272\uff1a\u5b83\u653e\u5927\u4e86\u708e\u75c7\u4fe1\u53f7\u5bf9\u7ec6\u80de\u964d\u89e3\u9176\u8868\u8fbe\u7684\u4fc3\u8fdb\u4f5c\u7528\uff0c\u8fdb\u800c\u52a0\u91cd\u5173\u8282\u7ec4\u7ec7\u7834\u574f\u3002\u8be5\u7814\u7a76\u63d0\u793a\uff0c\u901a\u8fc7\u5e72\u9884LAT1\uff08\u5982\u5c40\u90e8\u5e94\u7528LAT1\u6291\u5236\u5242\uff09\uff0c\u6709\u671b\u51cf\u8f7bRA\u5173\u8282\u7684\u7834\u574f\u6027\u708e\u75c7\u53cd\u5e94<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7457370\/#:~:text=The%20present%20study%20highlights%20the,the%20treatment%20of%20the%20disease\"><em>[57]<\/em><\/a>\u3002\u8fd9\u4e00\u53d1\u73b0\u4e3aRA\u7b49\u708e\u75c7\u75be\u75c5\u63d0\u4f9b\u4e86\u65b0\u7684\u6cbb\u7597\u601d\u8def\u3002<\/li>\n\n\n\n<li><strong>\u80ce\u76d8\u529f\u80fd\u4e0e\u53d1\u80b2\u969c\u788d\uff1a<\/strong> LAT1\u5728\u80ce\u76d8\u6bcd\u80ce\u754c\u9762\u9ad8\u5ea6\u8868\u8fbe\uff0c\u8d1f\u8d23\u6bcd\u4f53\u4e0e\u80ce\u513f\u95f4\u5fc5\u9700\u6c28\u57fa\u9178\u7684\u4ea4\u6362\uff0c\u662f\u7ef4\u6301\u80ce\u513f\u6b63\u5e38\u751f\u957f\u53d1\u80b2\u7684\u5173\u952e\u8f6c\u8fd0\u4f53<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=In%20placentas%2C%20chorionic%20trophoblast%20cells,risk%20of%20suffering%20cardiovascular%20and\"><em>[91]<\/em><\/a><a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=plays%20a%20key%20part%20in,Given%20that%20the\"><em>[92]<\/em><\/a>\u3002\u7814\u7a76\u663e\u793a\uff0c\u5728\u80ce\u513f\u5bab\u5185\u53d1\u80b2\u53d7\u9650\uff08IUGR\uff09\u7684\u5b55\u5987\u80ce\u76d8\u4e2d\uff0cLAT1\u8868\u8fbe\u6c34\u5e73\u663e\u8457\u964d\u4f4e\uff0c\u5bfc\u81f4\u6c28\u57fa\u9178\u7ecf\u80ce\u76d8\u8f6c\u8fd0\u4e0d\u8db3\uff0c\u88ab\u8ba4\u4e3a\u662f\u80ce\u513f\u751f\u957f\u53d7\u9650\u7684\u539f\u56e0\u4e4b\u4e00<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=expressed%20on%20the%20maternal%20and,of%20normal%20LAT1%20expression%20in\"><em>[93]<\/em><\/a><a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=plays%20a%20key%20part%20in,Given%20that%20the\"><em>[92]<\/em><\/a>\u3002\u76f8\u53cd\uff0c\u5bf9\u4e8e\u6bcd\u4f53\u80a5\u80d6\u5bfc\u81f4\u7684\u80ce\u513f\u8fc7\u5ea6\u751f\u957f\u75c5\u4f8b\uff0c\u80ce\u76d8LAT1\u5f80\u5f80\u8fc7\u5ea6\u8868\u8fbe\uff0c\u52a0\u5267\u4e86\u8425\u517b\u8fc7\u5269\u5411\u80ce\u513f\u7684\u4f20\u9012<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=intrauterine%20growth%20restriction%20,found%20so%20far%2C%20the%20role\"><em>[94]<\/em><\/a>\u3002\u56e0\u6b64\uff0c\u6b63\u5e38\u7684LAT1\u529f\u80fd\u5bf9\u7ef4\u6301\u80ce\u513f\u8425\u517b\u4f9b\u7ed9\u5e73\u8861\u81f3\u5173\u91cd\u8981\uff0c\u5176\u5f02\u5e38\u4e0e\u591a\u79cd\u598a\u5a20\u5e76\u53d1\u75c7\u53ca\u8fdc\u671f\u4ee3\u8c22\u75be\u75c5\u98ce\u9669\u76f8\u5173\u3002\u8fd9\u63d0\u793a\u5728\u56f4\u4ea7\u671f\u533b\u5b66\u4e2d\uff0c\u8c03\u8282LAT1\u8868\u8fbe\u53ef\u80fd\u5177\u6709\u5e72\u9884\u80ce\u513f\u751f\u957f\u5f02\u5e38\u7684\u6f5c\u529b<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=plays%20a%20key%20part%20in,Given%20that%20the\"><em>[92]<\/em><\/a>\u3002<\/li>\n\n\n\n<li><strong>\u5176\u5b83\u4ee3\u8c22\u75be\u75c5\uff1a<\/strong> \u521d\u6b65\u7814\u7a76\u8fd8\u5c06LAT1\u4e0e\u4ee3\u8c22\u7efc\u5408\u5f81\u4e2d\u7684\u80f0\u5c9b\u03b2\u7ec6\u80de\u529f\u80fd\u8054\u7cfb\u8d77\u6765\u3002\u6709\u52a8\u7269\u5b9e\u9a8c\u53d1\u73b0\uff0c\u7ed9\u2161\u578b\u7cd6\u5c3f\u75c5\u6a21\u578b\u5c0f\u9f20\u4f7f\u7528LAT1\u6291\u5236\u5242BCH\u5904\u7406\u4e00\u6bb5\u65f6\u95f4\u540e\uff0c\u5c0f\u9f20\u7684\u8461\u8404\u7cd6\u8010\u91cf\u548c\u80f0\u5c9b\u7d20\u5206\u6ccc\u6709\u6240\u6539\u5584<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=The%20treatment%20of%20cells%20with,The%20IPGTT%20revealed\"><em>[95]<\/em><\/a><a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=%28El,The%20morphology\"><em>[96]<\/em><\/a>\u3002\u63a8\u6d4b\u5176\u673a\u5236\u4e3a\u6291\u5236LAT1\u964d\u4f4e\u4e86\u9ad8\u7cd6\u9ad8\u8102\u73af\u5883\u4e0b\u80f0\u5c9b\u7ec6\u80de\u7684\u8425\u517b\u5e94\u6fc0\uff0c\u7f13\u89e3\u4e86\u03b2\u7ec6\u80de\u7684\u201c\u8461\u8404\u7cd6-\u8102\u6bd2\u6027\u201d\uff0c\u4ece\u800c\u4fdd\u62a4\u4e86\u80f0\u5c9b\u529f\u80fd<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=The%20treatment%20of%20cells%20with,The%20IPGTT%20revealed\"><em>[95]<\/em><\/a><a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=%28El,The%20morphology\"><em>[96]<\/em><\/a>\u3002\u867d\u7136\u8fd9\u65b9\u9762\u7814\u7a76\u5c1a\u5904\u65e9\u671f\uff0c\u4f46\u4e5f\u63d0\u793aLAT1\u53ef\u80fd\u53c2\u4e0e\u80a5\u80d6\u3001\u7cd6\u5c3f\u75c5\u7b49\u4ee3\u8c22\u75c5\u7406\u8fc7\u7a0b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u603b\u4e4b\uff0cSLC7A5\u9664\u4e86\u5728\u80bf\u7624\u548c\u8111\u53d1\u80b2\u4e2d\u626e\u6f14\u91cd\u8981\u89d2\u8272\u5916\uff0c\u5728\u708e\u75c7\u3001\u81ea\u8eab\u514d\u75ab\u3001\u80ce\u513f\u53d1\u80b2\u4ee5\u53ca\u4ee3\u8c22\u7d0a\u4e71\u7b49\u591a\u79cd\u4eba\u7c7b\u75be\u75c5\u72b6\u6001\u4e0b\u4ea6\u8868\u73b0\u51fa\u529f\u80fd\u5f02\u5e38\u3002\u968f\u7740\u7814\u7a76\u6df1\u5165\uff0c\u6211\u4eec\u6216\u80fd\u53d1\u73b0\u66f4\u591aSLC7A5\u53c2\u4e0e\u7684\u75be\u75c5\u673a\u5236\uff0c\u5e76\u5c06\u5176\u4f5c\u4e3a\u5e72\u9884\u9776\u70b9\u5f00\u62d3\u65b0\u7684\u6cbb\u7597\u8def\u5f84<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7457370\/#:~:text=The%20present%20study%20highlights%20the,the%20treatment%20of%20the%20disease\"><em>[57]<\/em><\/a><a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=plays%20a%20key%20part%20in,Given%20that%20the\"><em>[92]<\/em><\/a>\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><a>SLC7A5<\/a>\u4e0eRNA\u8fde\u63a5\uff08RNA Ligation\uff09\u53ca\u8f6c\u5f55\u540e\u8c03\u63a7\u7684\u6f5c\u5728\u5173\u8054<\/h2>\n\n\n\n<p>SLC7A5\u57fa\u56e0\u4e3b\u8981\u901a\u8fc7\u7f16\u7801\u819c\u8f6c\u8fd0\u86cb\u767d\u53d1\u6325\u4f5c\u7528\uff0c\u672c\u8eab\u4e0d\u76f4\u63a5\u6d89\u53caRNA\u8fde\u63a5\u9176\u7b49\u7ecf\u5178RNA\u4ee3\u8c22\u8fc7\u7a0b\u3002\u7136\u800c\uff0c\u8fd1\u5e74\u6765\u4e00\u4e9b\u7814\u7a76\u63ed\u793a\u4e86<em>SLC7A5<\/em>\u5728<strong>\u8f6c\u5f55\u540e\u8c03\u63a7<\/strong>\u5c42\u9762\u7684\u95f4\u63a5\u5173\u8054\uff0c\u5305\u62ec\u4e0emRNA\u526a\u63a5\u3001\u7a33\u5b9a\u6027\u548c\u7ffb\u8bd1\u6548\u7387\u7b49\u7684\u5173\u7cfb\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5f71\u54cd\u4e0b\u6e38\u57fa\u56e0\u7684\u53ef\u53d8\u526a\u63a5\uff1a<\/strong> \u6b63\u5982\u524d\u6587\u6240\u8ff0\uff0c\u5728TNBC\u4e2d\u53d1\u73b0\u7684SLC7A5\/E2F1\/PTBP1\u8f74\u5373\u4f53\u73b0\u4e86LAT1\u4fe1\u53f7\u5bf9RNA\u526a\u63a5\u7684\u8c03\u63a7<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40054655\/#:~:text=SLC7A5%20expression%20activated%20the%20amino,that%20E2F1%20transcriptionally%20activated%20PTBP1\"><em>[14]<\/em><\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40054655\/#:~:text=signaling%20with%20the%20glycolysis%20pathway,targets%20for%20future%20therapeutic%20interventions\"><em>[17]<\/em><\/a>\u3002\u5177\u4f53\u800c\u8a00\uff0cSLC7A5\u8fc7\u8868\u8fbe\u6fc0\u6d3b\u8f6c\u5f55\u56e0\u5b50E2F1\uff0c\u540e\u8005\u76f4\u63a5\u7ed3\u5408\u5e76\u4e0a\u8c03\u4e86\u526a\u63a5\u56e0\u5b50PTBP1\u7684\u57fa\u56e0\u8f6c\u5f55<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40054655\/#:~:text=of%20PTBP1%2C%20which%20maintains%20the,metabolic%20reprogramming%20and%20highlight%20potential\"><em>[97]<\/em><\/a>\u3002PTBP1\u662f\u4fc3\u8fdb\u4e19\u916e\u9178\u6fc0\u9176\u57fa\u56e0PKM\u4ea7\u751fPKM2\u5f02\u6784\u4f53\u7684\u5173\u952e\u526a\u63a5\u56e0\u5b50\uff0c\u5b83\u4f1a\u8df3\u8fc7PKM\u7684\u5916\u663e\u5b509\u4ee5\u504f\u5411\u5305\u542b\u5916\u663e\u5b5010\u7684PKM2\u526a\u63a5\u5f62\u5f0f\u3002\u5728LAT1\u9ad8\u8868\u8fbe\u7684TNBC\u7ec6\u80de\u4e2d\uff0cPTBP1\u6c34\u5e73\u5347\u9ad8\u5bfc\u81f4PKM<strong>\u524d\u4f53mRNA<\/strong>\u66f4\u591a\u5730\u88ab\u526a\u63a5\u4e3aPKM2\u578b\uff0c\u540c\u6b65\u6291\u5236\u4e86PKM1\u578b\u7684\u751f\u6210<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40054655\/#:~:text=SLC7A5%20expression%20activated%20the%20amino,that%20E2F1%20transcriptionally%20activated%20PTBP1\"><em>[14]<\/em><\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40054655\/#:~:text=from%20PKM1%20to%20PKM2%20expression%2C,between%20amino%20acid%20signaling%20and\"><em>[98]<\/em><\/a>\u3002\u8fd9\u79cd\u526a\u63a5\u91cd\u7f16\u7a0b\u63d0\u9ad8\u4e86PKM2\u7684\u4e30\u5ea6\uff0c\u589e\u5f3a\u4e86\u80bf\u7624\u7ec6\u80de\u7cd6\u9175\u89e3\u548c\u4ee3\u8c22\u9002\u5e94\u6027\uff08\u56e0\u4e3aPKM2\u9176\u6d3b\u53ef\u8c03\u63a7\u4e14\u5229\u4e8e\u80bf\u7624\u751f\u957f\uff09<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40054655\/#:~:text=SLC7A5%20expression%20activated%20the%20amino,that%20E2F1%20transcriptionally%20activated%20PTBP1\"><em>[14]<\/em><\/a>\u3002\u56e0\u6b64\uff0cSLC7A5\u901a\u8fc7\u4fe1\u53f7\u4f20\u5bfc\u7ea7\u8054\uff0c<strong>\u95f4\u63a5\u6539\u53d8<\/strong>\u4e86\u4e0b\u6e38\u57fa\u56e0\u7684mRNA\u526a\u63a5\u6a21\u5f0f\uff0c\u53ef\u89c6\u4e3a\u5176\u5728\u8f6c\u5f55\u540e\u5c42\u9762\u5f71\u54cd\u57fa\u56e0\u8868\u8fbe\u7684\u4e00\u4e2a\u4f8b\u5b50\u3002<\/li>\n\n\n\n<li><strong>SLC7A5 mRNA<\/strong><strong>\u7684\u7a33\u5b9a\u6027\u8c03\u63a7\uff1a<\/strong> SLC7A5\u81ea\u8eab\u7684mRNA\u4e5f\u53d7\u5230\u8f6c\u5f55\u540e\u673a\u5236\u7684\u4e25\u683c\u8c03\u8282\u3002\u4e00\u9879\u9488\u5bf9RNA\u7ed3\u5408\u86cb\u767dYBX3\u7684\u7814\u7a76\u8868\u660e\uff0cYBX3\u53ef\u4ee5\u76f4\u63a5\u4e0eSLC7A5\u548c\u5176\u4f34\u4fa3\u91cd\u94feSLC3A2\u7684mRNA\u76843\u2032UTR\u533a\u57df\u7ed3\u5408\uff0c<strong>\u589e\u5f3a<\/strong>\u8fd9\u4e9b\u8f6c\u8fd0\u4f53mRNA\u7684\u7a33\u5b9a\u6027<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10837625\/#:~:text=We%20recently%20showed%20that%20in,SLC%20amino%20acid%20transporter\"><em>[99]<\/em><\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10837625\/#:~:text=,For%20example\"><em>[100]<\/em><\/a>\u3002\u5728HeLa\u7b49\u4eba\u7c7b\u7ec6\u80de\u4e2d\u6572\u4f4eYBX3\u540e\uff0cSLC7A5\u548cSLC3A2\u7684mRNA\u6c34\u5e73\u663e\u8457\u4e0b\u964d\uff0c\u86cb\u767d\u8868\u8fbe\u968f\u4e4b\u964d\u4f4e\uff0c\u5bfc\u81f4\u7ec6\u80de\u6444\u5165\u7684\u5927\u4e2d\u6027\u6c28\u57fa\u9178\u660e\u663e\u51cf\u5c11<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10837625\/#:~:text=We%20recently%20showed%20that%20in,SLC%20amino%20acid%20transporter\"><em>[99]<\/em><\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10837625\/#:~:text=,For%20example\"><em>[100]<\/em><\/a>\u3002\u8fd9\u4e00\u53d1\u73b0\u8bf4\u660e\uff0c\u5728\u8f6c\u5f55\u548c\u7ffb\u8bd1\u4e4b\u5916\uff0c\u5b58\u5728YBX3\u4ecb\u5bfc\u7684<strong>\u4fdd\u62a4\u673a\u5236<\/strong>\u7ef4\u6301LAT1\u8f6c\u5f55\u672c\u4e0d\u88ab\u964d\u89e3\uff0c\u4ece\u800c\u6301\u7eed\u4fdd\u969c\u7ec6\u80de\u6c28\u57fa\u9178\u4f9b\u7ed9\u3002\u6709\u610f\u601d\u7684\u662f\uff0cYBX3\u5728\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u4e2d\u7684\u8c03\u63a7\u53ef\u80fd\u5b58\u5728\u5dee\u5f02\uff1a\u5728\u4eba\u7c7b\u764c\u7ec6\u80de\u4e2dYBX3\u7a33\u5b9aLAT1 mRNA\uff0c\u800c\u5728\u5c0f\u9f20\u9aa8\u9abc\u808c\u5206\u5316\u8fc7\u7a0b\u4e2d\uff0cYBX3\u66f4\u4e3b\u8981\u7a33\u5b9a\u53e6\u4e00\u79cd\u8f6c\u8fd0\u86cb\u767dSLC1A5\u7684mRNA<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10837625\/#:~:text=We%20recently%20showed%20that%20in,SLC%20amino%20acid%20transporter\"><em>[99]<\/em><\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10837625\/#:~:text=,For%20example\"><em>[100]<\/em><\/a>\u3002\u4f46\u603b\u4f53\u800c\u8a00\uff0cYBX3\u7b49RNA\u7ed3\u5408\u86cb\u767d\u4f5c\u4e3a\u8f6c\u5f55\u540e\u8c03\u63a7\u56e0\u5b50\uff0c\u80fd\u534f\u540c\u51b3\u5b9aSLC7A5\u57fa\u56e0\u7684\u8868\u8fbe\u6c34\u5e73\u3002\u672a\u6765\u5982\u679c\u80fd\u627e\u5230\u66f4\u591a\u53c2\u4e0e\u8c03\u63a7LAT1 mRNA\u7a33\u5b9a\u6027\u6216\u7ffb\u8bd1\u6548\u7387\u7684\u56e0\u5b50\uff0c\u53ef\u80fd\u4e3a\u7cbe\u7ec6\u63a7\u5236LAT1\u529f\u80fd\u63d0\u4f9b\u65b0\u7684\u5207\u5165\u70b9\u3002<\/li>\n\n\n\n<li><strong>microRNA<\/strong><strong>\u4ecb\u5bfc\u7684\u8c03\u63a7\uff1a<\/strong> \u5fae\u5c0fRNA\uff08miRNA\uff09\u901a\u8fc7\u4e0emRNA 3\u2032UTR\u7ed3\u5408\u6765\u6291\u5236\u57fa\u56e0\u8868\u8fbe\u3002SLC7A5\u5df2\u88ab\u8bc1\u5b9e\u662f\u591a\u4e2amiRNA\u7684\u76f4\u63a5\u6216\u95f4\u63a5\u9776\u6807\u3002\u5728TNBC\u4e2d\uff0cmiR-152\u88ab\u9274\u5b9a\u4e3a\u8d1f\u5411\u8c03\u63a7SLC7A5\u7684\u4e0a\u6e38\u5206\u5b50\uff1amiR-152\u6c34\u5e73\u964d\u4f4e\u4f1a\u89e3\u9664\u5176\u5bf9SLC7A5 mRNA\u7684\u6291\u5236\uff0c\u4ece\u800c\u4fc3\u8fdbLAT1\u8fc7\u5ea6\u8868\u8fbe<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40054655\/#:~:text=from%20PKM1%20to%20PKM2%20expression%2C,novel%20SLC7A5%2FE2F1%2FPTBP1%20axis%20plays%20a\"><em>[101]<\/em><\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40054655\/#:~:text=SLC7A5%20resulted%20from%20miR,for%20TNBC%20progression%20and%20therapeutic\"><em>[102]<\/em><\/a>\u3002\u8fd9\u4e5f\u662f\u4e3a\u4f55\u8bb8\u591aTNBC\u80bf\u7624\u4e2dLAT1\u663e\u8457\u4e0a\u8c03\u7684\u539f\u56e0\u4e4b\u4e00\u3002\u540c\u6837\u5730\uff0c\u5728\u5176\u4ed6\u60c5\u5883\u4e0b\uff0c\u4e00\u4e9b\u4e0e\u795e\u7ecf\u7cfb\u7edf\u76f8\u5173\u7684miRNA\u4e5f\u53ef\u80fd\u8c03\u63a7LAT1\u3002\u4f8b\u5982\u6709\u62a5\u544a\u6307\u51fa\uff0c\u5728\u81ea\u95ed\u75c7\u60a3\u8005\u7684\u5916\u5468\u8840\u548c\u8111\u7ec4\u7ec7\u4e2d\uff0c\u6c28\u57fa\u9178\u8f6c\u8fd0\u76f8\u5173\u901a\u8def\uff08\u5305\u62ecLAT1\uff09\u7684\u8f6c\u5f55\u6c34\u5e73\u5f02\u5e38\uff0c\u90e8\u5206\u5f52\u56e0\u4e8emiRNA\u7f51\u7edc\u7684\u5931\u8c03<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=suggests%20that%20the%20decrease%20in,and%20other%20LNAAs%2C%20with%20potential\"><em>[103]<\/em><\/a><a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=2015%29,in%20the%20LAT1%20and%20are\"><em>[55]<\/em><\/a>\u3002\u5c3d\u7ba1\u5177\u4f53miRNA\u79cd\u7c7b\u4ecd\u5728\u7814\u7a76\uff0c\u4f46\u8fd9\u4e9b\u6570\u636e\u63d0\u793a\uff1aSLC7A5\u7684\u8868\u8fbe\u53d7\u590d\u6742\u7684\u8f6c\u5f55\u540e\u7f51\u7edc\u63a7\u5236\uff0cmiRNA\u5931\u8861\u53ef\u80fd\u5bfc\u81f4LAT1\u5f02\u5e38\u9ad8\u8868\u8fbe\u8fdb\u800c\u5f71\u54cd\u795e\u7ecf\u53d1\u80b2\u548c\u529f\u80fd\u3002\u9488\u5bf9\u8fd9\u7c7bmiRNA-SLC7A5\u8f74\uff0c\u6709\u671b\u901a\u8fc7miRNA\u66ff\u4ee3\u6216\u6291\u5236\u6765\u95f4\u63a5\u8c03\u8282LAT1\u6c34\u5e73\uff0c\u4f5c\u4e3a\u6cbb\u7597\u5e72\u9884\u7684\u4e00\u79cd\u65b9\u5411\u3002<\/li>\n\n\n\n<li><strong>RNA<\/strong><strong>\u7ffb\u8bd1\u4e0e\u7a33\u5b9a\u7684\u95f4\u63a5\u5f71\u54cd\uff1a<\/strong> SLC7A5\u529f\u80fd\u7f3a\u5931\u4f1a\u5f15\u53d1\u7ec6\u80de\u5185\u5e7f\u6cdb\u7684\u4ee3\u8c22\u5e94\u6fc0\uff0c\u8fdb\u800c\u95f4\u63a5\u5f71\u54cdRNA\u7684\u7ffb\u8bd1\u548c\u7a33\u5b9a\u6027\u3002\u4f8b\u5982\uff0c\u5728BBB\u7f3a\u4e4fLAT1\u7684\u5c0f\u9f20\u8111\u7ec4\u7ec7\u4e2d\uff0c\u9664\u4e86\u6c28\u57fa\u9178\u7ec4\u6210\u5931\u8861\u5916\uff0c\u8fd8\u89c2\u5bdf\u5230\u4e86<strong>\u5f02\u5e38\u7684<\/strong><strong>mRNA<\/strong><strong>\u7ffb\u8bd1\u6a21\u5f0f<\/strong>\u548c\u6838\u7cd6\u4f53\u529f\u80fd\u969c\u788d<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=The%20study%20by%20T%C4%83rlungeanu%20et,in%20their%20BBBs%20will%20show\"><em>[84]<\/em><\/a>\u3002\u6c28\u57fa\u9178\u4e0d\u8db3\u53ef\u6fc0\u6d3b\u7ec6\u80de\u7684\u7efc\u5408\u5e94\u6fc0\u53cd\u5e94\uff08ISR\uff09\uff0c\u901a\u8fc7\u78f7\u9178\u5316eIF2\u03b1\u6291\u5236\u603b\u4f53\u86cb\u767d\u7ffb\u8bd1\uff0c\u5e76\u9009\u62e9\u6027\u7ffb\u8bd1\u5e94\u6fc0\u76f8\u5173mRNA\uff0c\u540c\u65f6\u53ef\u80fd\u5f71\u54cd\u67d0\u4e9bmRNA\u7684\u7a33\u5b9a\u6027\uff08\u5982\u89e6\u53d1\u7279\u5b9a\u8f6c\u5f55\u672c\u7684\u8870\u51cf\u6216\u50a8\u5b58\uff09\u3002\u867d\u7136\u8fd9\u4e9b\u6548\u5e94\u4e0d\u662fLAT1\u76f4\u63a5\u53c2\u4e0eRNA\u201c\u8fde\u63a5\u201d\u6216\u4fee\u590d\u9020\u6210\u7684\uff0c\u4f46\u5b83\u4f53\u73b0\u4e86SLC7A5\u4ecb\u5bfc\u7684\u4ee3\u8c22\u72b6\u6001\u6539\u53d8\u5982\u4f55<strong>\u95f4\u63a5<\/strong>\u5730\u5728\u8f6c\u5f55\u540e\u5c42\u9762\u5bf9\u7ec6\u80de\u57fa\u56e0\u8868\u8fbe\u4ea7\u751f\u5e7f\u6cdb\u5f71\u54cd\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u76ee\u524d\u5c1a\u672a\u6709\u8d44\u6599\u663e\u793aSLC7A5\u86cb\u767d\u672c\u8eab\u5177\u6709RNA\u8fde\u63a5\u9176\u6216RNA\u4fee\u590d\u9176\u7684\u6d3b\u6027\uff0c\u4e5f\u6ca1\u6709\u8bc1\u636e\u8868\u660eLAT1\u76f4\u63a5\u53c2\u4e0eRNA\u65ad\u88c2\u518d\u8fde\u63a5\u7b49\u8fc7\u7a0b\u3002\u5728\u6211\u4eec\u68c0\u7d22\u76842023\u20132025\u5e74\u6587\u732e\u4e2d\uff0c\u672a\u53d1\u73b0SLC7A5\u4e0e\u7ecf\u5178<strong>RNA<\/strong><strong>\u8fde\u63a5\uff08ligation<\/strong><strong>\uff09\u6216RNA<\/strong><strong>\u4fee\u590d<\/strong>\u901a\u8def\u5b58\u5728\u76f4\u63a5\u5173\u8054\u7684\u62a5\u9053\u3002\u56e0\u6b64\uff0c\u53ef\u4ee5\u8ba4\u4e3aSLC7A5\u5bf9RNA\u4ee3\u8c22\u7684\u5f71\u54cd\u4e3b\u8981\u662f\u901a\u8fc7\u8c03\u63a7\u4e0a\u6e38\u4fe1\u53f7\u548c\u7ec6\u80de\u4ee3\u8c22\u72b6\u6001\uff0c\u8fdb\u800c\u5f71\u54cd\u8f6c\u5f55\u540e\u8c03\u63a7\u7f51\u7edc\u5b9e\u73b0\u7684\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u5c0f\u7ed3\uff1a<\/strong> SLC7A5\u57fa\u56e0\u867d\u4e0d\u662fRNA\u4ee3\u8c22\u56e0\u5b50\uff0c\u4f46\u901a\u8fc7\u4fe1\u53f7\u901a\u8def\u548c\u8c03\u63a7\u5206\u5b50\u7684\u8054\u52a8\uff0c\u8fde\u63a5\u4e86\u7ec6\u80de\u7684\u8425\u517b\u611f\u77e5\u7cfb\u7edf\u4e0e\u57fa\u56e0\u8868\u8fbe\u8c03\u63a7\u7cfb\u7edf\u3002\u5728\u6c28\u57fa\u9178\u5145\u8db3\u65f6\uff0cLAT1\u4e0a\u8c03\u4fc3\u8fdb\u67d0\u4e9b\u81f4\u764c\u57fa\u56e0\u526a\u63a5\u53d8\u5f02\uff08\u5982PKM2\uff09\u548c\u86cb\u767d\u5408\u6210\u901a\u8def\u6d3b\u8dc3<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40054655\/#:~:text=SLC7A5%20expression%20activated%20the%20amino,that%20E2F1%20transcriptionally%20activated%20PTBP1\"><em>[14]<\/em><\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40054655\/#:~:text=signaling%20with%20the%20glycolysis%20pathway,targets%20for%20future%20therapeutic%20interventions\"><em>[17]<\/em><\/a>\uff1b\u5728\u6c28\u57fa\u9178\u7f3a\u4e4f\u6216\u5e94\u6fc0\u65f6\uff0cLAT1\u529f\u80fd\u4e0b\u964d\u53c8\u53ef\u5f15\u53d1\u7ffb\u8bd1\u6291\u5236\u7b49\u4fdd\u62a4\u6027\u8f6c\u5f55\u540e\u54cd\u5e94<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=The%20study%20by%20T%C4%83rlungeanu%20et,in%20their%20BBBs%20will%20show\"><em>[84]<\/em><\/a>\u3002\u540c\u65f6\uff0c\u7ec6\u80de\u4e5f\u5229\u7528miRNA\u548cRNA\u7ed3\u5408\u86cb\u767d\u7b49\u7cbe\u7ec6\u63a7\u5236LAT1\u7684mRNA\u547d\u8fd0\uff0c\u4ee5\u9002\u5e94\u4e0d\u540c\u73af\u5883\u9700\u6c42<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10837625\/#:~:text=We%20recently%20showed%20that%20in,SLC%20amino%20acid%20transporter\"><em>[99]<\/em><\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10837625\/#:~:text=,For%20example\"><em>[100]<\/em><\/a>\u3002\u8fd9\u4e9b\u53d1\u73b0\u4e30\u5bcc\u4e86\u6211\u4eec\u5bf9SLC7A5\u4f5c\u7528\u8303\u7574\u7684\u8ba4\u8bc6\uff0c\u63d0\u793a\u672a\u6765\u53ef\u4ee5\u4ece\u8f6c\u5f55\u540e\u5c42\u9762\u5bfb\u627e\u66f4\u591a\u8c03\u63a7LAT1\u6d3b\u6027\u7684\u9014\u5f84\uff0c\u4e3a\u4ee3\u8c22\u76f8\u5173\u75be\u75c5\u548c\u764c\u75c7\u7684\u6cbb\u7597\u63d0\u4f9b\u65b0\u7684\u5207\u5165\u70b9\u3002<\/p>\n\n\n\n<p><strong>\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=expression%20and%20is%20overexpressed%20in,studies%20on%20the%20role%20of\"><em>[3]<\/em><\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=studies%20revealed%20a%20positive%20correlation,to%20the%20pathogenesis%20of%20cancer\"><em>[5]<\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=growth%20in%20vivo,resistant%20TNBC%20patient\"><em>[12]<\/em><\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=thus%20promoting%20TNBC%20tumor%20progression,of%20doxorubicin%20in%20TNBC%20cells\"><em>[11]<\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40054655\/#:~:text=SLC7A5%20expression%20activated%20the%20amino,that%20E2F1%20transcriptionally%20activated%20PTBP1\"><em>[14]<\/em><\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40054655\/#:~:text=signaling%20with%20the%20glycolysis%20pathway,targets%20for%20future%20therapeutic%20interventions\"><em>[17]<\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10253063\/#:~:text=Through%20a%20comprehensive%20analysis%20of,proliferation%20upon%20LAT1%20KO%2C%20we\"><em>[6]<\/em><\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10253063\/#:~:text=performed%20RNA,therapeutic%20angles%20against%20liver%20cancer\"><em>[7]<\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41598-023-41096-3?error=cookies_not_supported&amp;code=e83f04ff-1a6a-475e-8a4c-071699e5be0b#:~:text=of%20LAT1%20inhibition%20on%20cancer,the%20downregulation%20of%20the%20mTOR\"><em>[30]<\/em><\/a><a href=\"https:\/\/www.nature.com\/articles\/s41598-023-41096-3?error=cookies_not_supported&amp;code=e83f04ff-1a6a-475e-8a4c-071699e5be0b#:~:text=of%20integrin%20%CE%B1v%CE%B23,metastasis%20cancer%20therapy\"><em>[35]<\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-025-03721-1#:~:text=,cells%20promotes%20tumor%20progression%20by\"><em>[22]<\/em><\/a><a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-025-03721-1#:~:text=and%20valine%20also%20exhibit%20ketogenic,and%20contributing%20to%20immune%20suppression\"><em>[104]<\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.nature.com\/articles\/cddis2016222?error=cookies_not_supported&amp;code=2f8829ef-3af2-4585-a184-2d79cbd92b38#:~:text=match%20at%20L414%20activation%20of,17.20%20Although\"><em>[51]<\/em><\/a><a href=\"https:\/\/www.nature.com\/articles\/cddis2016222?error=cookies_not_supported&amp;code=2f8829ef-3af2-4585-a184-2d79cbd92b38#:~:text=expression%20of%20Slc3a2%20and%20Slc7a5%2C,11\"><em>[53]<\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.onclive.com\/view\/nanvuranlat-significantly-improves-pfs-in-pretreated-advanced-biliary-tract-cancer#:~:text=Nanvuranlat%2C%20%28JPH203%29%2C%20a%20first,UMIN000034080\"><em>[62]<\/em><\/a><a href=\"https:\/\/www.onclive.com\/view\/nanvuranlat-significantly-improves-pfs-in-pretreated-advanced-biliary-tract-cancer#:~:text=Data%20presented%20at%20the%202023,n%20%3D%2035\"><em>[63]<\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-023-02957-z#:~:text=All%20the%20tested%20seven%20types,anticancer%20drug%20basically%20exerted%20its\"><em>[65]<\/em><\/a><a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-023-02957-z#:~:text=Our%20study%20demonstrates%20the%20potential,pancreatic%20and%20biliary%20tract%20cancers\"><em>[66]<\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.genengnews.com\/topics\/translational-medicine\/amino-acid-deficit-impacts-perinatal-mouse-brain-development-leading-to-microcephaly-autism-behaviors\/#:~:text=A%20study%20in%20mice%20by,ASD\"><em>[87]<\/em><\/a><a href=\"https:\/\/www.genengnews.com\/topics\/translational-medicine\/amino-acid-deficit-impacts-perinatal-mouse-brain-development-leading-to-microcephaly-autism-behaviors\/#:~:text=The%20Novarino%20group%20had%20previously,and%20doctoral%20student%20Lisa%20Knaus\"><em>[88]<\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.sfari.org\/2016\/12\/30\/a-potentially-treatable-form-of-autism-caused-by-impaired-brain-transport-of-amino-acids\/#:~:text=critical%20role%20in%20transporting%20BCAAs,In%20the%20current%20study%2C%20they\"><em>[83]<\/em><\/a><a href=\"https:\/\/www.sfari.org\/2016\/12\/30\/a-potentially-treatable-form-of-autism-caused-by-impaired-brain-transport-of-amino-acids\/#:~:text=the%20blood%20brain%20barrier,Combined%2C%20these%20findings\"><em>[85]<\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7457370\/#:~:text=The%20present%20study%20highlights%20the,the%20treatment%20of%20the%20disease\"><em>[57]<\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=plays%20a%20key%20part%20in,Given%20that%20the\"><em>[92]<\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10837625\/#:~:text=We%20recently%20showed%20that%20in,SLC%20amino%20acid%20transporter\"><em>[99]<\/em><\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10837625\/#:~:text=,For%20example\"><em>[100]<\/em><\/a><\/li>\n<\/ol>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><a><\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=tyrosine,SLC7A5%20promoted%20cell\"><em>[1]<\/em><\/a> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=placenta%20development%20,studies%20on%20the%20role%20of\"><em>[2]<\/em><\/a> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=expression%20and%20is%20overexpressed%20in,studies%20on%20the%20role%20of\"><em>[3]<\/em><\/a> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=placenta%20development%20,12%5D.%20SLC7A5%20promoted%20cell\"><em>[4]<\/em><\/a> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=studies%20revealed%20a%20positive%20correlation,to%20the%20pathogenesis%20of%20cancer\"><em>[5]<\/em><\/a> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=The%20LAT1%20protein%20levels%20were,NAD%2B%2FNADH%20ratio%2C%20which%20enhanced%20the\"><em>[9]<\/em><\/a> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=The%20LAT1%20protein%20levels%20were,LDHA\"><em>[10]<\/em><\/a> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12224598\/#:~:text=thus%20promoting%20TNBC%20tumor%20progression,of%20doxorubicin%20in%20TNBC%20cells\"><em>[11]<\/em><\/a> 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href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10253063\/#:~:text=Through%20a%20comprehensive%20analysis%20of,proliferation%20upon%20LAT1%20KO%2C%20we\"><em>[6]<\/em><\/a> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10253063\/#:~:text=performed%20RNA,therapeutic%20angles%20against%20liver%20cancer\"><em>[7]<\/em><\/a> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10253063\/#:~:text=suppression%20of%20tumor%20growth%20in,therapeutic%20angles%20against%20liver%20cancer\"><em>[8]<\/em><\/a> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10253063\/#:~:text=Emerging%20evidence%20suggests%20that%20targeting,bearing%20mice%20%5B7\"><em>[38]<\/em><\/a> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10253063\/#:~:text=of%20carbon%20in%20cancer%20cells,functions%20in%20HCC%20remain%20unclear\"><em>[39]<\/em><\/a> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10253063\/#:~:text=Arginine%20stimulates%20protein%20synthesis%20through,38%2C13%20%2C%2040\"><em>[40]<\/em><\/a> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10253063\/#:~:text=The%20roles%20of%20numerous%20amino,causes%20significant%20inhibition%20of\"><em>[41]<\/em><\/a> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10253063\/#:~:text=,and%20lymphoblastoid%20cells\"><em>[42]<\/em><\/a>&nbsp; Genetic Ablation of LAT1 Inhibits Growth of Liver Cancer Cells and Downregulates mTORC1 Signaling &#8211; PMC<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10253063\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40054655\/#:~:text=SLC7A5%20expression%20activated%20the%20amino,that%20E2F1%20transcriptionally%20activated%20PTBP1\"><em>[14]<\/em><\/a> <a 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href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40054655\/#:~:text=from%20PKM1%20to%20PKM2%20expression%2C,novel%20SLC7A5%2FE2F1%2FPTBP1%20axis%20plays%20a\"><em>[101]<\/em><\/a> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40054655\/#:~:text=SLC7A5%20resulted%20from%20miR,for%20TNBC%20progression%20and%20therapeutic\"><em>[102]<\/em><\/a> SLC7A5\/E2F1\/PTBP1\/PKM2 axis mediates progression and therapy effect of triple-negative breast cancer through the crosstalk of amino acid metabolism and glycolysis pathway &#8211; PubMed<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/pubmed.ncbi.nlm.nih.gov\/40054655\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10496141\/#:~:text=l,1\"><em>[19]<\/em><\/a> l-Type Amino Acid Transporter 1-Targeted Single Photon Emission &#8230;<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10496141\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-025-03721-1#:~:text=Branched,provides%20biosynthetic%20precursors%20essential%20for\"><em>[20]<\/em><\/a> <a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-025-03721-1#:~:text=sustaining%20the%20rapid%20proliferation%20and,cells%20promotes%20tumor%20progression%20by\"><em>[21]<\/em><\/a> <a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-025-03721-1#:~:text=,cells%20promotes%20tumor%20progression%20by\"><em>[22]<\/em><\/a> <a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-025-03721-1#:~:text=amino%20acid%20transporter%201%20,119%5D.%20Leucine%2C%20isoleucine\"><em>[43]<\/em><\/a> <a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-025-03721-1#:~:text=catabolism%20by%20a%20series%20of,The%20release%20of%20these%20ketone\"><em>[44]<\/em><\/a> <a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-025-03721-1#:~:text=are%20activated%20in%20the%20hypoxic,and%20contributing%20to%20immune%20suppression\"><em>[45]<\/em><\/a> <a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-025-03721-1#:~:text=and%20valine%20also%20exhibit%20ketogenic,cells%20promotes%20tumor%20progression%20by\"><em>[56]<\/em><\/a> <a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-025-03721-1#:~:text=and%20valine%20also%20exhibit%20ketogenic,and%20contributing%20to%20immune%20suppression\"><em>[104]<\/em><\/a> Amino acid metabolism in glioblastoma pathogenesis, immune evasion, and treatment resistance | Cancer Cell International | Full Text<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-025-03721-1\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/sciety.org\/articles\/activity\/10.21203\/rs.3.rs-4281982\/v1#:~:text=of%20M%D0%A4,orchestrates%20the%20augmented%20proliferative%20and\"><em>[23]<\/em><\/a> <a href=\"https:\/\/sciety.org\/articles\/activity\/10.21203\/rs.3.rs-4281982\/v1#:~:text=mechanistic%20investigations%20have%20elucidated%20that,the%20malignant%20biology%20of%20gliomas\"><em>[24]<\/em><\/a> <a href=\"https:\/\/sciety.org\/articles\/activity\/10.21203\/rs.3.rs-4281982\/v1#:~:text=Research%20on%20the%20biological%20characteristics,associated%20gene%20SLC7A5%20through%20fusion\"><em>[25]<\/em><\/a> <a href=\"https:\/\/sciety.org\/articles\/activity\/10.21203\/rs.3.rs-4281982\/v1#:~:text=invasive%20capabilities%20of%20hybrid%20cells,the%20malignant%20biology%20of%20gliomas\"><em>[26]<\/em><\/a> <a href=\"https:\/\/sciety.org\/articles\/activity\/10.21203\/rs.3.rs-4281982\/v1#:~:text=sensitivity%20to%20a%20specific%20inhibitor,on%20the%20malignant%20biology%20of\"><em>[27]<\/em><\/a>&nbsp; Glioma Cells Achieve Malignant Progression&nbsp;by&nbsp;Fusion with Macrophages to Gain High SLC7A5 Expression | Sciety<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/sciety.org\/articles\/activity\/10.21203\/rs.3.rs-4281982\/v1\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41598-023-41096-3?error=cookies_not_supported&amp;code=e83f04ff-1a6a-475e-8a4c-071699e5be0b#:~:text=Metastasis%20is%20the%20leading%20cause,F10%20lung%20metastasis\"><em>[28]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41598-023-41096-3?error=cookies_not_supported&amp;code=e83f04ff-1a6a-475e-8a4c-071699e5be0b#:~:text=transporter%20highly%20expressed%20in%20various,Furthermore%2C%20nanvuranlat%20and%20LAT1%20knockdown\"><em>[29]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41598-023-41096-3?error=cookies_not_supported&amp;code=e83f04ff-1a6a-475e-8a4c-071699e5be0b#:~:text=of%20LAT1%20inhibition%20on%20cancer,the%20downregulation%20of%20the%20mTOR\"><em>[30]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41598-023-41096-3?error=cookies_not_supported&amp;code=e83f04ff-1a6a-475e-8a4c-071699e5be0b#:~:text=LAT1,These%20results\"><em>[31]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41598-023-41096-3?error=cookies_not_supported&amp;code=e83f04ff-1a6a-475e-8a4c-071699e5be0b#:~:text=invasion,metastasis%20cancer%20therapy\"><em>[32]<\/em><\/a> <a 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class=\"wp-block-embed__wrapper\">\nhttps:\/\/www.nature.com\/articles\/s41598-023-41096-3?error=cookies_not_supported&#038;code=e83f04ff-1a6a-475e-8a4c-071699e5be0b\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/cddis2016222?error=cookies_not_supported&amp;code=2f8829ef-3af2-4585-a184-2d79cbd92b38#:~:text=match%20at%20L642%20focus%20on,cell%20activation%2C%20as\"><em>[37]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/cddis2016222?error=cookies_not_supported&amp;code=2f8829ef-3af2-4585-a184-2d79cbd92b38#:~:text=l,43%20Although%20naive%20human\"><em>[47]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/cddis2016222?error=cookies_not_supported&amp;code=2f8829ef-3af2-4585-a184-2d79cbd92b38#:~:text=primary%20T%20cells%20express%20an,is%20required%20for%20the%20full\"><em>[48]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/cddis2016222?error=cookies_not_supported&amp;code=2f8829ef-3af2-4585-a184-2d79cbd92b38#:~:text=primary%20T%20cells%20express%20an,is%20required%20for%20the%20full\"><em>[49]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/cddis2016222?error=cookies_not_supported&amp;code=2f8829ef-3af2-4585-a184-2d79cbd92b38#:~:text=l,43%20Although%20naive%20human\"><em>[50]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/cddis2016222?error=cookies_not_supported&amp;code=2f8829ef-3af2-4585-a184-2d79cbd92b38#:~:text=match%20at%20L414%20activation%20of,17.20%20Although\"><em>[51]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/cddis2016222?error=cookies_not_supported&amp;code=2f8829ef-3af2-4585-a184-2d79cbd92b38#:~:text=activation%20of%20T%20cells,17.20%20Although\"><em>[52]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/cddis2016222?error=cookies_not_supported&amp;code=2f8829ef-3af2-4585-a184-2d79cbd92b38#:~:text=expression%20of%20Slc3a2%20and%20Slc7a5%2C,11\"><em>[53]<\/em><\/a> Amino-acid transporters in T-cell activation and differentiation | Cell Death &amp; Disease<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/www.nature.com\/articles\/cddis2016222?error=cookies_not_supported&#038;code=2f8829ef-3af2-4585-a184-2d79cbd92b38\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(24)01481-5#:~:text=SLC7A5%20is%20required%20for%20cancer,SLC7A5%20loss%20impairs%20arginine%20metabolism\"><em>[46]<\/em><\/a> SLC7A5 is required for cancer cell growth under arginine-limited &#8230;<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(24)01481-5\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=tryptophan,also%20recently%20considered%20to%20be\"><em>[54]<\/em><\/a> <a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=2015%29,in%20the%20LAT1%20and%20are\"><em>[55]<\/em><\/a> <a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=drug%20delivery%20in%20the%20brain,inflammatory%20agent%20ketoprofen\"><em>[68]<\/em><\/a> <a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=%28Gynther%20et%20al.%2C%202008%29%2C%20anti,of%20the%20prodrugs%20in%20human\"><em>[69]<\/em><\/a> <a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=selectively%20expressed%20on%20the%20BBB,2018\"><em>[70]<\/em><\/a> <a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=and%20natural%20phenolic%20antioxidant%20ferulic,LAT1%20can%20be%20utilized%20to\"><em>[71]<\/em><\/a> <a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=investigational%20immunosuppressive%20perforin%20inhibitors%20,19%29%20cells%20by%2065%E2%80%9393\"><em>[72]<\/em><\/a> <a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=into%20the%20brain%20cells%20comparably,In%20another%20study%20suggested%20the\"><em>[73]<\/em><\/a> <a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=images%20is%20closely%20related%20to,probe%20that%20can%20be%20applied\"><em>[74]<\/em><\/a> <a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=to%20find%20cancer%20through%20PET,BNCT%20is%20a\"><em>[75]<\/em><\/a> <a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=Glaudemans%20et%20al,mediated%20transmission\"><em>[76]<\/em><\/a> <a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=of%20%5B%5E%7B11%7DC%5D,mediated%20transmission\"><em>[77]<\/em><\/a> <a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=%5B%5E%7B11%7DC%5D,10%7DB%20is\"><em>[78]<\/em><\/a> <a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=human%20cancers,and%20strong%20specificity%2C%20and%20has\"><em>[80]<\/em><\/a> <a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=The%20study%20by%20T%C4%83rlungeanu%20et,in%20their%20BBBs%20will%20show\"><em>[84]<\/em><\/a> <a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=In%20placentas%2C%20chorionic%20trophoblast%20cells,risk%20of%20suffering%20cardiovascular%20and\"><em>[91]<\/em><\/a> <a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=plays%20a%20key%20part%20in,Given%20that%20the\"><em>[92]<\/em><\/a> <a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=expressed%20on%20the%20maternal%20and,of%20normal%20LAT1%20expression%20in\"><em>[93]<\/em><\/a> <a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=intrauterine%20growth%20restriction%20,found%20so%20far%2C%20the%20role\"><em>[94]<\/em><\/a> <a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=The%20treatment%20of%20cells%20with,The%20IPGTT%20revealed\"><em>[95]<\/em><\/a> <a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=%28El,The%20morphology\"><em>[96]<\/em><\/a> <a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=suggests%20that%20the%20decrease%20in,and%20other%20LNAAs%2C%20with%20potential\"><em>[103]<\/em><\/a> Frontiers | Review of the Correlation of LAT1 With Diseases: Mechanism and Treatment<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7457370\/#:~:text=The%20present%20study%20highlights%20the,the%20treatment%20of%20the%20disease\"><em>[57]<\/em><\/a>&nbsp; Intervening upregulated SLC7A5 could mitigate inflammatory mediator by mTOR-P70S6K signal in rheumatoid arthritis synoviocytes &#8211; PMC<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7457370\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/www.frontiersin.org\/journals\/immunology\/articles\/10.3389\/fimmu.2021.624324\/full#:~:text=Targeting%20SLC1A5%20and%20SLC3A2%2FSLC7A5%20as,of%20nutrient%20transporters%2C%20specifically\"><em>[58]<\/em><\/a> Targeting SLC1A5 and SLC3A2\/SLC7A5 as a Potential Strategy to &#8230;<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/www.frontiersin.org\/journals\/immunology\/articles\/10.3389\/fimmu.2021.624324\/full\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-023-02957-z#:~:text=targeted%20drugs%20have%20been%20pursued,nanvuranlat%20and%20cytotoxic%20anticancer%20drugs\"><em>[59]<\/em><\/a> <a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-023-02957-z#:~:text=SLC7A5,nanvuranlat%20and%20cytotoxic%20anticancer%20drugs\"><em>[60]<\/em><\/a> <a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-023-02957-z#:~:text=All%20the%20tested%20seven%20types,anticancer%20drug%20basically%20exerted%20its\"><em>[65]<\/em><\/a> <a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-023-02957-z#:~:text=Our%20study%20demonstrates%20the%20potential,pancreatic%20and%20biliary%20tract%20cancers\"><em>[66]<\/em><\/a> <a href=\"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-023-02957-z#:~:text=PaCa,although%20gemcitabine%20more%20strongly%20influenced\"><em>[67]<\/em><\/a> Combination effects of amino acid transporter LAT1 inhibitor nanvuranlat and cytotoxic anticancer drug gemcitabine on pancreatic and biliary tract cancer cells | Cancer Cell International | Full Text<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-023-02957-z\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/www.onclive.com\/view\/nanvuranlat-significantly-improves-pfs-in-pretreated-advanced-biliary-tract-cancer#:~:text=Image\"><em>[61]<\/em><\/a> <a href=\"https:\/\/www.onclive.com\/view\/nanvuranlat-significantly-improves-pfs-in-pretreated-advanced-biliary-tract-cancer#:~:text=Nanvuranlat%2C%20%28JPH203%29%2C%20a%20first,UMIN000034080\"><em>[62]<\/em><\/a> <a href=\"https:\/\/www.onclive.com\/view\/nanvuranlat-significantly-improves-pfs-in-pretreated-advanced-biliary-tract-cancer#:~:text=Data%20presented%20at%20the%202023,n%20%3D%2035\"><em>[63]<\/em><\/a> <a href=\"https:\/\/www.onclive.com\/view\/nanvuranlat-significantly-improves-pfs-in-pretreated-advanced-biliary-tract-cancer#:~:text=%E2%80%9CThe%20forest%20plot%20of%20PFS,%E2%80%9D\"><em>[64]<\/em><\/a> <a href=\"https:\/\/www.onclive.com\/view\/nanvuranlat-significantly-improves-pfs-in-pretreated-advanced-biliary-tract-cancer#:~:text=Image\"><em>[79]<\/em><\/a> Nanvuranlat Significantly Improves PFS in Pretreated, Advanced Biliary Tract Cancer<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/www.onclive.com\/view\/nanvuranlat-significantly-improves-pfs-in-pretreated-advanced-biliary-tract-cancer\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/www.sfari.org\/2016\/12\/30\/a-potentially-treatable-form-of-autism-caused-by-impaired-brain-transport-of-amino-acids\/#:~:text=amino%20acid%20transporter%20LAT1%2C%20located,in%20several%20individuals%20with%20ASD\"><em>[81]<\/em><\/a> <a href=\"https:\/\/www.sfari.org\/2016\/12\/30\/a-potentially-treatable-form-of-autism-caused-by-impaired-brain-transport-of-amino-acids\/#:~:text=studied%20a%20mouse%20model%20in,Combined%2C%20these%20findings\"><em>[82]<\/em><\/a> <a href=\"https:\/\/www.sfari.org\/2016\/12\/30\/a-potentially-treatable-form-of-autism-caused-by-impaired-brain-transport-of-amino-acids\/#:~:text=critical%20role%20in%20transporting%20BCAAs,In%20the%20current%20study%2C%20they\"><em>[83]<\/em><\/a> <a href=\"https:\/\/www.sfari.org\/2016\/12\/30\/a-potentially-treatable-form-of-autism-caused-by-impaired-brain-transport-of-amino-acids\/#:~:text=the%20blood%20brain%20barrier,Combined%2C%20these%20findings\"><em>[85]<\/em><\/a> <a href=\"https:\/\/www.sfari.org\/2016\/12\/30\/a-potentially-treatable-form-of-autism-caused-by-impaired-brain-transport-of-amino-acids\/#:~:text=the%20blood%20brain%20barrier,levels%20of%20BCAAs%20could%20potentially\"><em>[86]<\/em><\/a> SFARI | A potentially treatable form of autism caused by impaired brain transport of amino acids<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-wp-embed is-provider-sfari wp-block-embed-sfari\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"wp-embedded-content\" data-secret=\"w9INLDQyX7\"><a href=\"https:\/\/www.sfari.org\/2016\/12\/30\/a-potentially-treatable-form-of-autism-caused-by-impaired-brain-transport-of-amino-acids\/\">A potentially treatable form of autism caused by impaired brain transport of amino acids<\/a><\/blockquote><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; visibility: hidden;\" title=\"&#8220;A potentially treatable form of autism caused by impaired brain transport of amino acids&#8221; &#8212; SFARI\" src=\"https:\/\/www.sfari.org\/2016\/12\/30\/a-potentially-treatable-form-of-autism-caused-by-impaired-brain-transport-of-amino-acids\/embed\/#?secret=XfVLGAB9oZ#?secret=w9INLDQyX7\" data-secret=\"w9INLDQyX7\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe>\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/www.genengnews.com\/topics\/translational-medicine\/amino-acid-deficit-impacts-perinatal-mouse-brain-development-leading-to-microcephaly-autism-behaviors\/#:~:text=A%20study%20in%20mice%20by,ASD\"><em>[87]<\/em><\/a> <a href=\"https:\/\/www.genengnews.com\/topics\/translational-medicine\/amino-acid-deficit-impacts-perinatal-mouse-brain-development-leading-to-microcephaly-autism-behaviors\/#:~:text=The%20Novarino%20group%20had%20previously,and%20doctoral%20student%20Lisa%20Knaus\"><em>[88]<\/em><\/a> <a href=\"https:\/\/www.genengnews.com\/topics\/translational-medicine\/amino-acid-deficit-impacts-perinatal-mouse-brain-development-leading-to-microcephaly-autism-behaviors\/#:~:text=The%20researchers%20reported%20on%20their,%E2%80%9D\"><em>[89]<\/em><\/a> <a href=\"https:\/\/www.genengnews.com\/topics\/translational-medicine\/amino-acid-deficit-impacts-perinatal-mouse-brain-development-leading-to-microcephaly-autism-behaviors\/#:~:text=neutral%20amino%20acid%20levels%20tune,%E2%80%9D\"><em>[90]<\/em><\/a> Amino Acid Deficit Impacts Perinatal Mouse Brain Development, Leading to Microcephaly, Autism Behaviors<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-wp-embed is-provider-gen-genetic-engineering-and-biotechnology-news wp-block-embed-gen-genetic-engineering-and-biotechnology-news\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"wp-embedded-content\" data-secret=\"1qgu9dCWp9\"><a href=\"https:\/\/www.genengnews.com\/topics\/translational-medicine\/amino-acid-deficit-impacts-perinatal-mouse-brain-development-leading-to-microcephaly-autism-behaviors\/\">Amino Acid Deficit Impacts Perinatal Mouse Brain Development, Leading to Microcephaly, Autism Behaviors<\/a><\/blockquote><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; visibility: hidden;\" title=\"&#8220;Amino Acid Deficit Impacts Perinatal Mouse Brain Development, Leading to Microcephaly, Autism Behaviors&#8221; &#8212; GEN - Genetic Engineering and Biotechnology News\" src=\"https:\/\/www.genengnews.com\/topics\/translational-medicine\/amino-acid-deficit-impacts-perinatal-mouse-brain-development-leading-to-microcephaly-autism-behaviors\/embed\/#?secret=cYlK85p5tL#?secret=1qgu9dCWp9\" data-secret=\"1qgu9dCWp9\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe>\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10837625\/#:~:text=We%20recently%20showed%20that%20in,SLC%20amino%20acid%20transporter\"><em>[99]<\/em><\/a> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10837625\/#:~:text=,For%20example\"><em>[100]<\/em><\/a>&nbsp; The YBX3 RNA-binding protein posttranscriptionally controls SLC1A5 mRNA in proliferating and differentiating skeletal muscle cells &#8211; PMC<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10837625\n<\/div><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>SLC7A5\u57fa\u56e0\u7f16\u7801\u7684LAT1\u8f6c\u8fd0\u86cb\u767d\uff0c\u5728\u80bf\u7624\u4ee3\u8c22\u91cd\u7f16\u7a0b\u3001\u514d\u75ab\u8c03\u63a7\u53ca\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u4e2d\u626e\u6f14\u5173\u952e\u89d2\u8272\u3002\u672c\u6587\u7efc\u8ff0\u4e862023\u81f32025\u5e74\u95f4\u8be5\u57fa\u56e0\u5728\u591a\u79cd\u764c\u75c7\u4e2d\u7684\u4f5c\u7528\u673a\u5236\u3001\u9776\u5411\u6cbb\u7597\u7b56\u7565\uff08\u5982\u6291\u5236\u5242JPH203\uff09\u7684\u6700\u65b0\u8fdb\u5c55\uff0c\u4ee5\u53ca\u5176\u5728\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u7b49\u75be\u75c5\u4e2d\u7684\u65b0\u53d1\u73b0\u3002<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[18],"tags":[32],"class_list":["post-11833","post","type-post","status-publish","format-standard","hentry","category-18","tag-deep-research"],"_links":{"self":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts\/11833","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=11833"}],"version-history":[{"count":3,"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts\/11833\/revisions"}],"predecessor-version":[{"id":13791,"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts\/11833\/revisions\/13791"}],"wp:attachment":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=11833"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=11833"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=11833"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}