{"id":11840,"date":"2025-08-29T18:14:26","date_gmt":"2025-08-29T10:14:26","guid":{"rendered":"https:\/\/fanyiming.life\/?p=11840"},"modified":"2025-12-21T01:02:51","modified_gmt":"2025-12-20T17:02:51","slug":"atad5%e5%9f%ba%e5%9b%a0%e5%9c%a8%e7%99%8c%e7%97%87%e4%b8%8e%e7%bb%86%e8%83%9e%e7%94%9f%e7%89%a9%e5%ad%a6%e4%b8%ad%e7%9a%84%e6%9c%80%e6%96%b0%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95%e7%bb%bc%e8%bf%b0","status":"publish","type":"post","link":"https:\/\/fanyiming.life\/?p=11840","title":{"rendered":"ATAD5\u57fa\u56e0\u5728\u764c\u75c7\u4e0e\u7ec6\u80de\u751f\u7269\u5b66\u4e2d\u7684\u6700\u65b0\u7814\u7a76\u8fdb\u5c55\u7efc\u8ff0"},"content":{"rendered":"\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>By GPT-5 Deep Research<\/p>\n<\/blockquote>\n\n\n\n<h2 class=\"wp-block-heading\"><a>ATAD5<\/a>\u57fa\u56e0\u6982\u8ff0\u53ca\u5206\u5b50\u529f\u80fd<\/h2>\n\n\n\n<p><strong>\u57fa\u56e0\u80cc\u666f\uff1a<\/strong>ATAD5\uff08ATPase family AAA domain-containing protein 5\uff09\u57fa\u56e0\u7f16\u7801\u4e00\u79cdAAA&lt;sup&gt;+&lt;\/sup&gt; ATP\u9176\u5bb6\u65cf\u86cb\u767d\uff0c\u5728\u9175\u6bcd\u4e2d\u79f0\u4e3aElg1\uff0c\u5728\u4ece\u9175\u6bcd\u5230\u4eba\u7c7b\u7684\u771f\u6838\u751f\u7269\u4e2d\u9ad8\u5ea6\u4fdd\u5b88<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=ATAD5%20is%20important%20for%20maintaining,We\"><em>[1]<\/em><\/a>\u3002ATAD5\u662f\u7ef4\u6301\u57fa\u56e0\u7ec4\u7a33\u5b9a\u6027\u7684\u91cd\u8981\u56e0\u5b50\uff0c\u529f\u80fd\u7f3a\u5931\u4f1a\u5bfc\u81f4\u67d3\u8272\u4f53\u4e0d\u7a33\u5b9a\u3002ATAD5\u86cb\u767d\u662f\u590d\u5236\u56e0\u5b50C\uff08RFC\uff09\u5bb6\u65cf\u7684\u4e00\u4e2a\u53d8\u4f53\u590d\u5408\u7269\u7684\u5927\u4e9a\u57fa\uff1a\u4e0eRFC2-5\u4e9a\u57fa\u5f62\u6210\u4e94\u805a\u4f53\u7684\u201cRFC\u6837\u590d\u5408\u7269\u201d\uff08RLC\uff09\uff0c\u5176\u4e2dATAD5\u53d6\u4ee3\u4e86\u5e38\u89c4RFC\u590d\u5408\u7269\u4e2d\u7684RFC1\uff0c\u7528\u4e8e\u7279\u6b8a\u529f\u80fd<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=the%20ATAD5%20locus%20confers%20enhanced,bypass%20pathway%20by%20recruiting%20the\"><em>[2]<\/em><\/a>\u3002\u5176\u4e3b\u8981\u5206\u5b50\u529f\u80fd\u662f<strong>\u5378\u8f7d<\/strong><strong>PCNA<\/strong>\uff08\u589e\u6b96\u7ec6\u80de\u6838\u6297\u539f\uff09\u2014\u2014PCNA\u662fDNA\u590d\u5236\u65f6\u5305\u88f9DNA\u7684\u6ed1\u52a8\u5939\uff0c\u9700\u8981\u5728\u590d\u5236\u5b8c\u6210\u540e\u4eceDNA\u4e0a\u79fb\u9664\uff0c\u800cATAD5-RLC\u6b63\u662f\u8d1f\u8d23\u8fd9\u4e00\u5378\u8f7d\u8fc7\u7a0b<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=replication%20factor%20C%20%28RFC%29,It%20is%20still%20unclear\"><em>[3]<\/em><\/a>\u3002\u7b80\u800c\u8a00\u4e4b\uff0cATAD5\u5145\u5f53<strong>\u201c\u590d\u5236\u6ed1\u52a8\u5939\u5378\u8f7d\u9176\u201d<\/strong>\uff0c\u786e\u4fdd\u590d\u5236\u540e\u7684PCNA\u73af\u53ca\u65f6\u4eceDNA\u8131\u843d\uff0c\u4ee5\u7ed3\u675f\u590d\u5236\u8fc7\u7a0b\u5e76\u91cd\u7f6e\u590d\u5236\u673a\u5668\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cATAD5\u86cb\u767d\u542b\u67091844\u4e2a\u6c28\u57fa\u9178\uff0c\u7531\u4e24\u4e2a\u529f\u80fd\u533a\u57df\u7ec4\u6210\uff1a<strong>N<\/strong><strong>\u7aef\uff08\u7ea61<\/strong><strong>\u2013600 aa<\/strong><strong>\uff09<\/strong>\u4e0e\u53bb\u6cdb\u7d20\u5316\u590d\u5408\u7269USP1\/UAF1\u7ed3\u5408\uff0c\u8c03\u63a7PCNA\u7684\u6cdb\u7d20\u72b6\u6001\uff1b<strong>C<\/strong><strong>\u7aef\u4e3b\u4f53\uff08\u7ea6812<\/strong><strong>\u20131844 aa<\/strong><strong>\uff09<\/strong>\u5305\u542bAAA&lt;sup&gt;+&lt;\/sup&gt; ATP\u9176\u57df\uff0c\u6267\u884cPCNA\u5378\u8f7d\u529f\u80fd<a href=\"https:\/\/www.nature.com\/articles\/s41594-024-01332-4?error=cookies_not_supported&amp;code=f34d4a1d-769f-49a0-ae4b-3d6f70386c4d#:~:text=is%20a%20large%20protein%20with,an%20extended%20lifespan%20for%20DNA\"><em>[4]<\/em><\/a>\u3002\u7ed3\u6784\u751f\u7269\u5b66\u7814\u7a76\u63ed\u793aATAD5\u5177\u6709\u533a\u522b\u4e8e\u5176\u5b83RFC\u4e9a\u57fa\u7684\u72ec\u7279\u7ed3\u6784\u5143\u4ef6\uff08\u5982\u201c\u53cc\u9501\u73af\u201d\u548c\u201c\u63d2\u5165\u585e\u201d\uff09\uff0c\u4f7f\u5176\u5f62\u6210\u66f4\u521a\u6027\u7684\u590d\u5408\u7269\u6784\u578b\uff0c\u53ef\u6709\u6548\u7ed3\u5408\u5e76\u6253\u5f00PCNA\u73af\uff0c\u4ece\u800c\u4e13\u804c\u4e8ePCNA\u5378\u8f7d<a href=\"https:\/\/www.nature.com\/articles\/s41594-024-01332-4?error=cookies_not_supported&amp;code=f34d4a1d-769f-49a0-ae4b-3d6f70386c4d#:~:text=PCNA%20loaders%20also%20unload%20PCNA,that%20is%20crucial%20for%20PCNA\"><em>[5]<\/em><\/a><a href=\"https:\/\/www.nature.com\/articles\/s41594-024-01332-4?error=cookies_not_supported&amp;code=f34d4a1d-769f-49a0-ae4b-3d6f70386c4d#:~:text=revealed%20that%20it%20unloads%20PCNA,RFC%E2%80%93PCNA%20from%20DNA16\"><em>[6]<\/em><\/a>\u3002\u8fd9\u4e00\u7cfb\u5217\u5206\u5b50\u7279\u5f81\u4f7fATAD5\u6210\u4e3a\u590d\u5236\u8fc7\u7a0b\u4e2dPCNA\u5faa\u73af\u52a8\u6001\u7684\u5173\u952e\u8c03\u63a7\u8005\u3002<\/p>\n\n\n\n<p><strong>PCNA<\/strong><strong>\u5378\u8f7d\u4e0e\u590d\u5236\u5b8c\u6210\uff1a<\/strong>\u5728\u6b63\u5e38\u7ec6\u80de\u5468\u671fS\u671f\uff0cRFC\u590d\u5408\u7269\u5c06PCNA\u52a0\u8f7d\u5230DNA\u4e0a\u4ee5\u63d0\u9ad8DNA\u805a\u5408\u9176\u8fc7\u7a0b\u6027\uff0c\u800cATAD5-RLC\u5219\u5728\u590d\u5236\u5b8c\u6210\u65f6\u8d1f\u8d23\u6253\u5f00PCNA\u73af\u5e76\u5c06\u5176\u4eceDNA\u4e0a\u79fb\u9664<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=replication%20factor%20C%20%28RFC%29,It%20is%20still%20unclear\"><em>[3]<\/em><\/a>\u3002\u8fd9\u79cd\u52a0\u8f7d-\u5378\u8f7d\u673a\u5236\u4fdd\u8bc1\u4e00\u4e2aPCNA\u5728\u5b8c\u6210\u5176\u5de5\u4f5c\u540e\u80fd\u91ca\u653e\u51fa\u6765\u5e76\u7528\u4e8e\u4e0b\u4e00\u4e2a\u5faa\u73af\uff0c\u4ece\u800c\u5728\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u4e2d\u652f\u6301\u6570\u4ee5\u767e\u4e07\u8ba1\u5188\u5d0e\u7247\u6bb5\u7684\u9ad8\u6548\u590d\u5236<a href=\"https:\/\/www.nature.com\/articles\/s41594-024-01332-4?error=cookies_not_supported&amp;code=f34d4a1d-769f-49a0-ae4b-3d6f70386c4d#:~:text=machine,in%20a%20human%20cell%2037%2C12\"><em>[7]<\/em><\/a><a href=\"https:\/\/www.nature.com\/articles\/s41594-024-01332-4?error=cookies_not_supported&amp;code=f34d4a1d-769f-49a0-ae4b-3d6f70386c4d#:~:text=hydrolysis9%20%2C%2036%2C11%20,in%20a%20human%20cell%2037%2C12\"><em>[8]<\/em><\/a>\u3002ATAD5\u7f3a\u5931\u4f1a\u5bfc\u81f4PCNA\u65e0\u6cd5\u53ca\u65f6\u5378\u8f7d\uff0c\u7ed3\u679cPCNA\u5f02\u5e38\u6ede\u7559\u5728\u590d\u5236\u8fc7\u7684\u67d3\u8272\u8d28\u4e0a<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=ATAD5,starting%20with%20RAD51%20recruitment%20and\"><em>[9]<\/em><\/a>\u3002\u8fd9\u4f1a\u5ef6\u957fDNA\u590d\u5236\u5de5\u5382\u7684\u5bff\u547d\uff0c\u5e72\u6270\u540e\u7eed\u7684\u67d3\u8272\u8d28\u7ec4\u88c5\u548c\u590d\u5236\u5b8c\u6210\u8fc7\u7a0b<a href=\"https:\/\/www.nature.com\/articles\/s41594-024-01332-4?error=cookies_not_supported&amp;code=f34d4a1d-769f-49a0-ae4b-3d6f70386c4d#:~:text=revealed%20that%20it%20unloads%20PCNA,RFC%E2%80%93PCNA%20from%20DNA16\"><em>[6]<\/em><\/a>\u3002\u56e0\u6b64\uff0cATAD5\u901a\u8fc7\u53ca\u65f6\u5378\u8f7dPCNA\u6765<strong>\u9632\u6b62\u590d\u5236\u8fc7\u5ea6\u5ef6\u957f\u548c\u590d\u5236\u538b\u529b<\/strong>\uff0c\u4fdd\u969c\u7ec6\u80de\u5468\u671f\u4eceS\u671f\u987a\u5229\u8fc7\u6e21\u5230G2\/M\u671f\u3002\u7814\u7a76\u8868\u660e\uff0c\u76f8\u6bd4\u4e8e\u5e38\u89c4RFC\u590d\u5408\u7269\uff0cATAD5-RLC\u5378\u8f7dPCNA\u7684\u6548\u7387\u66f4\u9ad8<a href=\"https:\/\/www.nature.com\/articles\/s41594-024-01332-4?error=cookies_not_supported&amp;code=f34d4a1d-769f-49a0-ae4b-3d6f70386c4d#:~:text=specific,loaded\"><em>[10]<\/em><\/a>\uff1b\u800cATAD5\u4e0b\u8c03\u65f6\uff0cPCNA\u5728\u67d3\u8272\u8d28\u4e0a\u7684\u6ede\u7559\u65f6\u95f4\u663e\u8457\u5ef6\u957f\uff0c\u63d0\u793aATAD5\u662fPCNA\u5378\u8f7d\u7684\u4e3b\u8981\u6267\u884c\u8005<a href=\"https:\/\/www.nature.com\/articles\/s41594-024-01332-4?error=cookies_not_supported&amp;code=f34d4a1d-769f-49a0-ae4b-3d6f70386c4d#:~:text=region%20,RFC%E2%80%93PCNA%20from%20DNA16\"><em>[11]<\/em><\/a>\u3002\u603b\u7684\u6765\u8bf4\uff0cATAD5\u5728\u590d\u5236\u5b8c\u6210\u9636\u6bb5\u626e\u6f14\u201c\u5584\u540e\u201d\u89d2\u8272\uff0c\u786e\u4fdd\u590d\u5236\u673a\u5668\u6b63\u786e\u5378\u8f7d\u548c\u91cd\u7f6e\uff0c\u4e3a\u57fa\u56e0\u7ec4\u590d\u5236\u7684\u4fdd\u771f\u5ea6\u4fdd\u9a7e\u62a4\u822a\u3002<\/p>\n\n\n\n<p><strong>PCNA<\/strong><strong>\u6cdb\u7d20\u5316\u8c03\u63a7\u4e0eDNA<\/strong><strong>\u635f\u4f24\u5e94\u7b54\uff1a<\/strong>PCNA\u4e0d\u4ec5\u53c2\u4e0e\u590d\u5236\uff0c\u4e5f\u662f\u4e00\u79cd\u8c03\u8282DNA\u635f\u4f24\u5e94\u7b54\u7684\u4e2d\u5fc3\u652f\u67b6\u86cb\u767d\u3002\u5f53\u590d\u5236\u9047\u5230DNA\u635f\u4f24\u963b\u6ede\u65f6\uff0cPCNA\u7684\u7b2c164\u4f4d\u8d56\u6c28\u9178\u53ef\u88ab\u5355\u6cdb\u7d20\u5316\uff08Ub-PCNA\uff09\uff0c\u4ece\u800c\u62db\u52df\u4f4e\u4fdd\u771f\u5ea6\u7684\u8de8\u635f\u4f24\u5408\u6210\uff08TLS\uff09DNA\u805a\u5408\u9176\u6765\u7ed5\u8fc7\u635f\u4f24<a href=\"https:\/\/www.nature.com\/articles\/s41467-024-55005-3?error=cookies_not_supported&amp;code=47f8f193-4049-4741-8361-2af5617ac35c#:~:text=Mono,binding\"><em>[12]<\/em><\/a><a href=\"https:\/\/www.nature.com\/articles\/s41467-024-55005-3?error=cookies_not_supported&amp;code=47f8f193-4049-4741-8361-2af5617ac35c#:~:text=During%20unchallenged%20DNA%20synthesis%2C%20PCNA,RAD18\"><em>[13]<\/em><\/a>\u3002\u635f\u4f24\u7ed5\u8fc7\u5b8c\u6210\u540e\uff0c\u7ec6\u80de\u9700\u8981\u79fb\u9664PCNA\u4e0a\u7684\u6cdb\u7d20\u5e76\u5378\u8f7dPCNA\uff0c\u4ee5\u6062\u590d\u9ad8\u4fdd\u771f\u590d\u5236<a href=\"https:\/\/www.nature.com\/articles\/s41467-024-55005-3?error=cookies_not_supported&amp;code=47f8f193-4049-4741-8361-2af5617ac35c#:~:text=Abstract\"><em>[14]<\/em><\/a><a href=\"https:\/\/www.nature.com\/articles\/s41467-024-55005-3?error=cookies_not_supported&amp;code=47f8f193-4049-4741-8361-2af5617ac35c#:~:text=and%20error,activities%2C%20respectively%2057%2C29%20%2C%2059%2C31\"><em>[15]<\/em><\/a>\u3002ATAD5\u5728\u8fd9\u4e00\u8fc7\u7a0b\u4e2d\u5177\u6709\u5173\u952e\u8c03\u8282\u4f5c\u7528\uff1a\u5176N\u7aef\u7ed3\u6784\u57df\u88ab\u8bc1\u660e\u53ef\u4ee5\u4f5c\u4e3a<strong>Ub-PCNA<\/strong><strong>\u53bb\u6cdb\u7d20\u5316\u7684\u5e73\u53f0<\/strong>\uff0c\u8d1f\u8d23\u62db\u52dfUSP1\/UAF1\u53bb\u6cdb\u7d20\u5316\u9176\u590d\u5408\u7269\uff0c\u5bf9PCNA\u8fdb\u884c\u53bb\u6cdb\u7d20\u4fee\u9970<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=replication%20during%20the%20S%20phase,role%20as%20a%20tumor%20suppressor\"><em>[16]<\/em><\/a><a href=\"https:\/\/www.researchgate.net\/figure\/ATAD5-recognizes-Ub-PCNA-for-deubiquitination-A-ATAD5-1-to-500-binds-to-Ub-PCNA_fig2_383154647#:~:text=for%20regulating%20DNA%20lesion%20bypass,unloading%20complex%2C%20functi\"><em>[17]<\/em><\/a>\u3002Ryu\u7b49\u4eba\u5728PNAS 2024\u5e74\u7684\u7814\u7a76\u4e2d\u8fdb\u4e00\u6b65\u63ed\u793a\uff0cATAD5\u7684N\u7aef\u542b\u6709\u7279\u5b9a\u7684\u201cUB4\u201d\u57fa\u5e8f\u7528\u4e8e\u8bc6\u522b\u7ed3\u5408Ub-PCNA\uff1b\u7a81\u53d8\u8be5\u57fa\u5e8f\u4f1a\u524a\u5f31ATAD5\u4e0eUb-PCNA\u7684\u76f8\u4e92\u4f5c\u7528\u5e76\u4f7fPCNA\u53bb\u6cdb\u7d20\u5316\u53d7\u635f<a href=\"https:\/\/www.researchgate.net\/figure\/ATAD5-recognizes-Ub-PCNA-for-deubiquitination-A-ATAD5-1-to-500-binds-to-Ub-PCNA_fig2_383154647#:~:text=binds%20to%20Ub,n%20%3D%203\"><em>[18]<\/em><\/a><a href=\"https:\/\/www.researchgate.net\/figure\/ATAD5-recognizes-Ub-PCNA-for-deubiquitination-A-ATAD5-1-to-500-binds-to-Ub-PCNA_fig2_383154647#:~:text=ATAD5%20recognizes%20Ub,n%20%3D%203\"><em>[19]<\/em><\/a>\u3002\u6b63\u5e38\u60c5\u51b5\u4e0b\uff0cATAD5\u901a\u8fc7\u540c\u65f6\u7ed3\u5408PCNA\u548cUSP1-UAF1\uff0c<strong>\u534f\u8c03<\/strong><strong>PCNA<\/strong><strong>\u5378\u8f7d\u4e0e\u53bb\u6cdb\u7d20\u5316\u7684\u65f6\u5e8f<\/strong>\uff0c\u786e\u4fdd\u5f53\u590d\u5236\u53c9\u95ee\u9898\u89e3\u51b3\u540e\uff0cPCNA\u53ca\u65f6\u6062\u590d\u672a\u6cdb\u7d20\u5316\u72b6\u6001\u5e76\u4eceDNA\u4e0a\u89e3\u79bb<a href=\"https:\/\/www.researchgate.net\/figure\/ATAD5-recognizes-Ub-PCNA-for-deubiquitination-A-ATAD5-1-to-500-binds-to-Ub-PCNA_fig2_383154647#:~:text=for%20regulating%20DNA%20lesion%20bypass,unloading%20complex%2C%20functi\"><em>[17]<\/em><\/a>\u3002\u8fd9\u4e00\u673a\u5236\u9650\u5236\u4e86\u9519\u8bef\u6613\u53d1\u7684TLS\u9014\u5f84\u6301\u7eed\u6fc0\u6d3b\uff0c\u4ece\u800c\u7ef4\u62a4\u57fa\u56e0\u7ec4\u7a33\u5b9a<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=replication%20during%20the%20S%20phase,role%20as%20a%20tumor%20suppressor\"><em>[16]<\/em><\/a><a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=ATAD5,starting%20with%20RAD51%20recruitment%20and\"><em>[9]<\/em><\/a>\u3002\u6709\u8da3\u7684\u662f\uff0c\u6700\u65b0\u7814\u7a76\u53d1\u73b0<strong>\u67d3\u8272\u8d28\u91cd\u5851\u56e0\u5b50<\/strong><strong>BAZ1B<\/strong><strong>\uff08WSTF<\/strong><strong>\uff09<\/strong>\u662fATAD5\u53bb\u6cdb\u7d20\u5316\u529f\u80fd\u7684\u4e0a\u6e38\u8c03\u8282\u56e0\u5b50\uff1aBAZ1B\u53ef\u7ed3\u5408ATAD5\u7684UAF1\u7ed3\u5408\u533a\u57df\uff0c\u5145\u5f53\u201c\u5239\u8f66\u201d\uff0c\u9632\u6b62ATAD5\u8fc7\u65e9\u5730\u62db\u52dfUSP1\u53bb\u9664PCNA\u4e0a\u7684\u6cdb\u7d20<a href=\"https:\/\/www.nature.com\/articles\/s41467-024-55005-3?error=cookies_not_supported&amp;code=47f8f193-4049-4741-8361-2af5617ac35c#:~:text=ubiquitination,ubiquitination%2C%20thereby%20safeguarding%20genome%20integrity\"><em>[20]<\/em><\/a>\u3002\u5f53ATAD5\u4e0eBAZ1B\u7684\u76f8\u4e92\u4f5c\u7528\u88ab\u7834\u574f\u65f6\uff0c\u7ec6\u80de\u5728\u6c27\u5316\u635f\u4f24\u540e\u51fa\u73b0\u8fc7\u65e9\u7684PCNA\u53bb\u6cdb\u7d20\u5316\uff0c\u5bfc\u81f4DNA\u635f\u4f24\u5e94\u7b54\u5931\u8c03\uff0c\u7ec6\u80de\u5bf9\u6c27\u5316\u5e94\u6fc0\u66f4\u654f\u611f<a href=\"https:\/\/www.nature.com\/articles\/s41467-024-55005-3?error=cookies_not_supported&amp;code=47f8f193-4049-4741-8361-2af5617ac35c#:~:text=subunit%20of%20the%20BAZ1B,ubiquitination%2C%20thereby%20safeguarding%20genome%20integrity\"><em>[21]<\/em><\/a>\u3002\u56e0\u6b64\uff0cBAZ1B-ATAD5\u76f8\u4e92\u4f5c\u7528\u63d0\u4f9b\u4e86\u4e00\u79cd\u7cbe\u7ec6\u8c03\u63a7\uff0c<strong>\u5ef6\u7f13<\/strong><strong>ATAD5<\/strong><strong>\u4ecb\u5bfc\u7684\u53bb\u6cdb\u7d20\u5316\u76f4\u81f3\u9002\u5f53\u7684\u65f6\u95f4\u70b9<\/strong>\uff0c\u4ece\u800c\u786e\u4fddDNA\u635f\u4f24\u8df3\u8dc3\u4fee\u590d\uff08TLS\uff09\u6709\u5145\u88d5\u65f6\u95f4\u5b8c\u6210<a href=\"https:\/\/www.nature.com\/articles\/s41467-024-55005-3?error=cookies_not_supported&amp;code=47f8f193-4049-4741-8361-2af5617ac35c#:~:text=subunit%20of%20the%20BAZ1B,ubiquitination%2C%20thereby%20safeguarding%20genome%20integrity\"><em>[21]<\/em><\/a>\u3002\u8fd9\u4e00\u7cfb\u5217\u53d1\u73b0\u8868\u660e\uff0cATAD5\u4e0d\u4ec5\u901a\u8fc7\u5378\u8f7dPCNA\u76f4\u63a5\u53c2\u4e0e\u590d\u5236\u538b\u529b\u5e94\u5bf9\uff0c\u8fd8\u901a\u8fc7\u8c03\u63a7PCNA\u7684\u6cdb\u7d20\u5316\u72b6\u6001\u5728DNA\u635f\u4f24\u53cd\u5e94\u901a\u8def\u4e2d\u53d1\u6325\u5e73\u53f0\u4f5c\u7528\u3002<\/p>\n\n\n\n<p><strong>\u590d\u5236\u5e94\u6fc0\u4e2d\u7684\u4f5c\u7528\uff1a<\/strong>\u7ef4\u62a4\u590d\u5236\u53c9\u7a33\u5b9a\u6027\u548c\u4fc3\u8fdb\u53d7\u635f\u590d\u5236\u53c9\u91cd\u542f\u662fATAD5\u7684\u91cd\u8981\u804c\u8d23\u4e4b\u4e00<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=Maintaining%20stability%20of%20replication%20forks,slowdown%20of%20fork%20progression%20and\"><em>[22]<\/em><\/a>\u3002\u5728\u590d\u5236\u5e94\u6fc0\u6761\u4ef6\u4e0b\uff08\u5982\u7f9f\u57fa\u8132\u8bf1\u5bfc\u6838\u82f7\u9178\u7f3a\u4e4f\uff09\uff0cATAD5\u8fc5\u901f\u79ef\u805a\u5230\u53d7\u963b\u7684\u590d\u5236\u53c9\u5904\uff0c\u53d1\u6325\u591a\u91cd\u529f\u80fd\u4ee5\u9632\u6b62\u53c9\u5d29\u6e83<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=Maintaining%20stability%20of%20replication%20forks,slowdown%20of%20fork%20progression%20and\"><em>[22]<\/em><\/a>\u3002<strong>\u4e00\u65b9\u9762<\/strong>\uff0cATAD5\u901a\u8fc7\u5176\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u7f51\u7edc\u62db\u52df\u5173\u952e\u7684\u540c\u6e90\u91cd\u7ec4\u56e0\u5b50RAD51\u5230\u53d7\u635f\u590d\u5236\u53c9\u90e8\u4f4d<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=However%2C%20it%20is%20not%20clear,mechanical%20barrier%20to%20fork%20regression\"><em>[23]<\/em><\/a>\u3002RAD51\u5728\u590d\u5236\u53c9\u4fdd\u62a4\u548c\u56de\u5f52\u4e2d\u5fc5\u4e0d\u53ef\u5c11\uff0c\u5b83\u53ef\u4fc3\u8fdb\u590d\u5236\u53c9\u5012\u9000\u5f62\u6210\u56db\u53c9\u7ed3\u6784\uff0c\u4ece\u800c\u907f\u514d\u590d\u5236\u53c9\u76f4\u63a5\u89e3\u4f53<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=delivery%20of%20genetic%20information%20during,restored%20by%20fork%20reversal%20enzymes\"><em>[24]<\/em><\/a><a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=Many%20homologous%20recombination%20,s\"><em>[25]<\/em><\/a>\u3002Park\u7b49\u4eba\u5728Nature Communications\u53d1\u8868\u7684\u7814\u7a76\u8868\u660e\uff1aATAD5\u7f3a\u5931\u4f1a\u524a\u5f31RAD51\u5728\u505c\u6ede\u590d\u5236\u53c9\u5904\u7684\u52df\u96c6\uff0c\u5bfc\u81f4\u590d\u5236\u53c9\u65e0\u6cd5\u53ca\u65f6\u56de\u5f52\uff0c\u7ee7\u7eed\u5411\u524d\u201c\u786c\u63a8\u201d\u800c\u7d2f\u79ef\u66f4\u591a\u635f\u4f24<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=regulating%20activity%20of%20ATAD5%20might,RAD51%20recruitment%20to%20stalled%20forks\"><em>[26]<\/em><\/a><a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=under%20replication%20stress,dependent\"><em>[27]<\/em><\/a>\u3002ATAD5\u901a\u8fc7ATR\u4f9d\u8d56\u7684\u673a\u5236\u589e\u5f3a\u4e0eRAD51\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u5e76<strong>\u79fb\u9664\u5835\u5728\u590d\u5236\u53c9\u4e0a\u7684<\/strong><strong>PCNA<\/strong>\uff0c\u4e3aRAD51\u88c5\u8f7d\u521b\u9020\u7a7a\u95f4<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=However%2C%20it%20is%20not%20clear,mechanical%20barrier%20to%20fork%20regression\"><em>[23]<\/em><\/a><a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=stress.%20We%20find%20that%20ATAD5,RAD51%20recruitment%20to%20stalled%20forks\"><em>[28]<\/em><\/a>\u3002PCNA\u672c\u8eab\u662f\u590d\u5236\u53c9\u7ed3\u6784\u56de\u5f52\u7684\u673a\u68b0\u969c\u788d\uff0c\u5355\u5206\u5b50\u5b9e\u9a8c\u663e\u793aPCNA\u73af\u4f1a\u963b\u6b62\u53c9\u9006\u8f6c<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=in%20fork%20regression%2C%20ATAD5%20depletion,restart%20are%20reduced%20by%20ATAD5\"><em>[29]<\/em><\/a>\uff1bATAD5\u5c06\u5176\u5378\u9664\u540e\uff0cRAD51\u4ecb\u5bfc\u7684\u53c9\u56de\u5f52\u548c\u91cd\u542f\u624d\u80fd\u987a\u5229\u8fdb\u884c<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=match%20at%20L182%20unloading%20by,genome%20stability%2C%20therefore%2C%20extends%20beyond\"><em>[30]<\/em><\/a>\u3002<strong>\u53e6\u4e00\u65b9\u9762<\/strong>\uff0cATAD5\u7f3a\u4e4f\u4f1a\u5bfc\u81f4\u590d\u5236\u5e94\u6fc0\u4e0b\u7684\u53c9\u6062\u590d\u80fd\u529b\u663e\u8457\u4e0b\u964d\u3002ATAD5\u6572\u51cf\u7684\u7ec6\u80de\u5728\u9047\u5230\u590d\u5236\u963b\u6ede\u5242\u65f6\u8868\u73b0\u51fa\u66f4\u6162\u7684\u590d\u5236\u6062\u590d\u548c\u66f4\u591a\u7684DNA\u65ad\u88c2<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=multiple%20functions%20at%20stalled%20forks,important%20role%20of%20ATAD5%20in\"><em>[31]<\/em><\/a><a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=match%20at%20L96%20depletion,genome%20integrity%20during%20replication%20stress\"><em>[32]<\/em><\/a>\u3002\u5c0f\u9f20\u5b9e\u9a8c\u4ea6\u8bc1\u660e\uff0c\u5728\u7f9f\u57fa\u8132\u5904\u7406\u4e0b\uff0cATAD5\u6572\u9664\u5c0f\u9f20\u7684\u57fa\u56e0\u7ec4\u4e0d\u7a33\u5b9a\u6807\u5fd7\uff08\u5982\u65ad\u88c2\u3001\u6613\u4f4d\uff09\u663e\u8457\u589e\u591a<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=multiple%20functions%20at%20stalled%20forks,restart%20are%20reduced%20by%20ATAD5\"><em>[33]<\/em><\/a>\u3002\u7efc\u4e0a\uff0cATAD5\u901a\u8fc7<strong>\u79fb\u9664<\/strong><strong>PCNA<\/strong><strong>\u969c\u788d\u3001\u62db\u52dfRAD51<\/strong><strong>\u4ee5\u53ca\u4fc3\u8fdb\u53d7\u635f\u53c9\u7684\u91cd\u542f<\/strong>\uff0c\u5728\u590d\u5236\u538b\u529b\u73af\u5883\u4e2d\u4fdd\u62a4\u57fa\u56e0\u7ec4\u5b8c\u6574\u6027<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=match%20at%20L182%20unloading%20by,genome%20stability%2C%20therefore%2C%20extends%20beyond\"><em>[30]<\/em><\/a>\u3002<\/p>\n\n\n\n<p><strong>DNA<\/strong><strong>\u4fee\u590d\u901a\u8def\u4e2d\u7684\u4f5c\u7528\uff1a<\/strong>ATAD5\u5f71\u54cd\u591a\u4e2aDNA\u4fee\u590d\u8def\u5f84\uff0c\u7279\u522b\u662f\u5728\u540c\u6e90\u91cd\u7ec4\uff08HR\uff09\u548c\u590d\u5236\u635f\u4f24\u5bb9\u5fcd\u65b9\u9762\u30022023\u5e74\u53d1\u8868\u5728Nucleic Acids Research\u7684\u7814\u7a76\u6307\u51fa\uff1a<strong>ATAD5<\/strong><strong>\u4ecb\u5bfc\u7684PCNA<\/strong><strong>\u5378\u8f7d\u5bf9\u4e8e\u65ad\u88c2DNA<\/strong><strong>\u7684\u77ed\u7a0b\u672b\u7aef\u5207\u9664\uff08short-range end resection<\/strong><strong>\uff09\u662f\u5fc5\u8981\u7684<\/strong>\uff0c\u7f3a\u4e4fATAD5\u4f1a\u5bfc\u81f4HR\u8d77\u59cb\u9636\u6bb5\u7684\u672b\u7aef\u5207\u9664\u53d7\u635f\uff0c\u964d\u4f4e\u540c\u6e90\u91cd\u7ec4\u7684\u53ef\u9760\u6027<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37739427\/#:~:text=...%20pubmed.ncbi.nlm.nih.gov%20%20Short,10535\"><em>[34]<\/em><\/a>\u3002\u8fd9\u6697\u793a\u5728DNA\u53cc\u94fe\u65ad\u88c2\u4fee\u590d\u4e2d\uff0cATAD5\u53ef\u80fd\u901a\u8fc7\u6e05\u9664\u635f\u4f24\u4f4d\u70b9\u9644\u8fd1\u7684PCNA\u6216\u5176\u4ed6\u5939\u86cb\u767d\uff0c\u4e3a\u6838\u9178\u5916\u5207\u9176\uff08\u5982CtIP\u3001MRE11\u7b49\uff09\u521b\u9020\u7a7a\u95f4\u4ee5\u8fdb\u884c5\u2019\u7aef\u5207\u9664\uff0c\u4ece\u800c\u786e\u4fdd\u540e\u7eed\u7684RAD51\u4ecb\u5bfc\u7684\u94fe\u4fb5\u5165\u53d1\u751f\u987a\u5229\u3002\u9664\u4e86HR\uff0cATAD5\u5bf9<strong>\u8de8\u635f\u4f24\u5408\u6210<\/strong>\uff08TLS\uff09\u4e5f\u6709\u8c03\u63a7\u4f5c\u7528\uff1aATAD5\u62db\u52dfUSP1\u53bb\u9664PCNA\u7684\u5355\u6cdb\u7d20\uff0c\u9650\u5236TLS\u9014\u5f84\u65f6\u95f4\u7a97<a href=\"https:\/\/www.nature.com\/articles\/s41467-024-55005-3?error=cookies_not_supported&amp;code=47f8f193-4049-4741-8361-2af5617ac35c#:~:text=Mono,binding\"><em>[12]<\/em><\/a><a href=\"https:\/\/www.nature.com\/articles\/s41467-024-55005-3?error=cookies_not_supported&amp;code=47f8f193-4049-4741-8361-2af5617ac35c#:~:text=translesion%20synthesis%20,RFC2%E2%80%935\"><em>[35]<\/em><\/a>\u3002\u5982\u679cATAD5\u529f\u80fd\u7f3a\u5931\uff0cPCNA\u6cdb\u7d20\u5316\u548cTLS\u4fe1\u53f7\u5c06\u8fc7\u5ea6\u6301\u7eed\uff0c\u53ef\u80fd\u5bfc\u81f4\u9519\u8bef\u503e\u5411\u7684\u805a\u5408\u9176\u63d2\u5165\u9519\u8bef\u78b1\u57fa\uff0c\u589e\u52a0\u7a81\u53d8\u98ce\u9669<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=replication%20during%20the%20S%20phase,role%20as%20a%20tumor%20suppressor\"><em>[16]<\/em><\/a><a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=ATAD5,starting%20with%20RAD51%20recruitment%20and\"><em>[9]<\/em><\/a>\u3002\u6b64\u5916\uff0cATAD5\u7f3a\u9677\u7ec6\u80de\u5f80\u5f80\u5448\u73b0\u51fa<strong>\u590d\u5236\u5e94\u6fc0\u548c<\/strong><strong>DNA<\/strong><strong>\u635f\u4f24\u7684\u7279\u5f81\u6027\u6807\u8bb0<\/strong>\uff1a\u590d\u5236\u901f\u7387\u53d8\u6162\u3001S\u671f\u5ef6\u957f\uff0c\u7ec6\u80de\u6838\u5185\u51fa\u73b0\u5927\u91cfDNA\u635f\u4f24\u7126\u70b9\uff08\u5982\u03b3H2AX foci\uff09\u548c\u5355\u94feDNA\u7d2f\u79ef\u7b49<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=ATAD5,starting%20with%20RAD51%20recruitment%20and\"><em>[9]<\/em><\/a>\u3002\u8fd9\u4e9b\u8868\u578b\u4e0ePCNA\u8c03\u63a7\u5931\u8861\u76f4\u63a5\u76f8\u5173\uff0c\u8868\u660eATAD5\u5728\u591a\u4e2a\u5c42\u9762\u5b88\u62a4\u7740DNA\u590d\u5236-\u4fee\u590d\u7684\u5e73\u8861\u3002\u603b\u4e4b\uff0cATAD5\u5728DNA\u635f\u4f24\u4fee\u590d\u7f51\u7edc\u4e2d\u626e\u6f14\u591a\u9762\u624b\u89d2\u8272\uff1a\u65e2\u53c2\u4e0e\u540c\u6e90\u91cd\u7ec4\u4fee\u590d\u8d77\u59cb\uff0c\u53c8\u7ec8\u6b62\u8de8\u635f\u4f24\u5408\u6210\uff0c\u8fd8\u901a\u8fc7\u7ef4\u6301\u590d\u5236\u53c9\u7a33\u5b9a\u6765\u9884\u9632\u635f\u4f24\u53d1\u751f\u3002<\/p>\n\n\n\n<p><strong>\u4e0eRNA<\/strong><strong>\u4ee3\u8c22\u7684\u8054\u7cfb\uff08R-loop <\/strong><strong>\u7b49\uff09\uff1a<\/strong>\u5c3d\u7ba1ATAD5\u672c\u8eab\u4e0d\u76f4\u63a5\u5145\u5f53\u7ecf\u5178\u7684RNA\u4ee3\u8c22\u56e0\u5b50\uff0c\u4f46\u6700\u65b0\u7814\u7a76\u53d1\u73b0\u5b83\u901a\u8fc7\u6291\u5236<strong>R-loop<\/strong><strong>\uff08DNA-RNA<\/strong><strong>\u6742\u4ea4\u73af\uff09<\/strong>\u7684\u5f62\u6210\uff0c\u95f4\u63a5\u7ef4\u7cfb\u7740\u57fa\u56e0\u8868\u8fbe\u4e0e\u590d\u5236\u7684\u534f\u8c03\u3002R-loop\u662f\u5728\u8f6c\u5f55\u8fc7\u7a0b\u4e2d\u5f62\u6210\u7684DNA:RNA\u6742\u5408\u7ed3\u6784\uff0c\u672a\u53ca\u65f6\u79fb\u9664\u7684R-loop\u4f1a\u5f15\u53d1\u590d\u5236\u53c9\u649e\u969c\uff0c\u5bfc\u81f4DNA\u65ad\u88c2\u548c\u57fa\u56e0\u7ec4\u4e0d\u7a33\u5b9a\u3002Kim\u7b49\u4eba\u57282020\u5e74\u7684\u7814\u7a76\u8868\u660e\uff1a<strong>ATAD5<\/strong><strong>\u5177\u6709\u53cc\u91cd\u529f\u80fd\u6765\u51cf\u5c11R-loop<\/strong>\uff0c\u65e2\u4fc3\u8fdbR-loop\u7684\u6e05\u9664\uff0c\u4e5f\u9632\u6b62\u65b0\u7684R-loop\u4ea7\u751f<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32542338\/#:~:text=,normal%20and%20replication%20stress%20conditions\"><em>[36]<\/em><\/a><a href=\"https:\/\/ngdc.cncb.ac.cn\/openlb\/publication\/OLB-PM-32542338#:~:text=,which%2C%20otherwise%2C%20accumulates%20and\"><em>[37]<\/em><\/a>\u3002\u4e00\u65b9\u9762\uff0cATAD5\u901a\u8fc7\u5176\u5408\u4f5c\u56e0\u5b50UAF1\u63d0\u9ad8\u4e86\u4e00\u4e9bRNA\u89e3\u65cb\u9176\uff08DEAD\/DEXH-box RNA helicases\uff0c\u5982Aquarius\u7b49\uff09\u7684\u7a33\u5b9a\u6027\u6216\u6d3b\u6027<a href=\"https:\/\/academic.oup.com\/nar\/article-pdf\/48\/13\/7218\/33507731\/gkaa501.pdf#:~:text=First%2C%20RNA%20processing%20proteins%20limit,Sec\"><em>[38]<\/em><\/a>\u3002\u8fd9\u4e9bRNA\u89e3\u65cb\u9176\u80fd\u591f\u89e3\u5f00DNA-RNA\u6742\u4ea4\uff0c\u4ece\u800c<strong>\u52a0\u901f\u5df2\u6709<\/strong><strong>R-loop<\/strong><strong>\u7684\u89e3\u6790<\/strong>\u3002ATAD5\/UAF1\u590d\u5408\u7269\u4e0eRNA\u89e3\u65cb\u9176\u76f8\u4e92\u4f5c\u7528\u7684\u7f3a\u5931\u4f1a\u5bfc\u81f4\u7ec6\u80de\u5185R-loop\u6c34\u5e73\u5347\u9ad8\u3001\u590d\u5236\u901f\u7387\u964d\u4f4e<a href=\"https:\/\/www.researchgate.net\/figure\/Depletion-of-ATAD5UAF1-interacting-RNA-helicases-reduces-DNA-replication-rate-A-B-D_fig8_342244232#:~:text=Depletion%20of%20ATAD5%2FUAF1,U2OS%20cells%20were%20transfected\"><em>[39]<\/em><\/a>\uff0c\u652f\u6301ATAD5\u5728\u7ef4\u62a4RNA\u89e3\u65cb\u9176\u529f\u80fd\u4e0a\u7684\u4f5c\u7528\u3002\u53e6\u4e00\u65b9\u9762\uff0cATAD5\u901a\u8fc7<strong>\u53ca\u65f6\u5378\u8f7d<\/strong><strong>PCNA<\/strong>\u6765\u9884\u9632\u65b0\u7684R-loop\u5728\u590d\u5236\u53c9\u540e\u5f62\u6210<a href=\"https:\/\/ngdc.cncb.ac.cn\/openlb\/publication\/OLB-PM-32542338#:~:text=,which%2C%20otherwise%2C%20accumulates%20and\"><em>[37]<\/em><\/a>\u3002\u5982\u679cPCNA\u5728\u590d\u5236\u5b8c\u6210\u533a\u57df\u6301\u7eed\u6ede\u7559\uff0c\u4f1a\u5e72\u6270\u8be5\u533a\u57df\u540e\u7eed\u7684\u8f6c\u5f55\u6216RNA\u5904\u7406\uff0c\u5bb9\u6613\u8bf1\u53d1RNA\u94fe\u4fb5\u5165DNA\u5f62\u6210R-loop<a href=\"https:\/\/ngdc.cncb.ac.cn\/openlb\/publication\/OLB-PM-32542338#:~:text=,which%2C%20otherwise%2C%20accumulates%20and\"><em>[37]<\/em><\/a>\u3002ATAD5\u786e\u4fdd\u590d\u5236\u8fc7\u7684\u533a\u57dfPCNA\u6e05\u9664\uff0c\u6709\u52a9\u4e8e\u8f6c\u5f55-\u590d\u5236\u51b2\u7a81\u7684\u7f13\u89e3\u3002\u56e0\u6b64\uff0c\u5728\u6b63\u5e38\u548c\u53d7\u80c1\u8feb\u6761\u4ef6\u4e0b\uff0cATAD5\u5747\u663e\u8457\u964d\u4f4e\u4e86\u5168\u5c40R-loop\u7684\u7d2f\u79ef<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32542338\/#:~:text=,normal%20and%20replication%20stress%20conditions\"><em>[36]<\/em><\/a>\u3002\u9700\u8981\u5f3a\u8c03\u7684\u662f\uff0c\u76ee\u524d<strong>\u5c1a\u65e0\u8bc1\u636e\u8868\u660e<\/strong><strong>ATAD5<\/strong><strong>\u76f4\u63a5\u53c2\u4e0eRNA<\/strong><strong>\u8fde\u63a5\uff08ligation<\/strong><strong>\uff09\u6216\u526a\u63a5\u7b49RNA<\/strong><strong>\u52a0\u5de5\u8fc7\u7a0b<\/strong>\u3002ATAD5\u4e0eRNA\u7684\u5173\u8054\u4e3b\u8981\u4f53\u73b0\u5728\u8f6c\u5f55\u4e0e\u590d\u5236\u51b2\u7a81\u7684\u7ba1\u7406\u4e0a\uff0c\u5373\u901a\u8fc7\u7ef4\u6301R-loop\u52a8\u6001\u5e73\u8861\uff0c\u95f4\u63a5\u4fdd\u8bc1RNA\u751f\u7269\u5408\u6210\u7684\u6b63\u5e38\u8fdb\u884c\u548c\u57fa\u56e0\u7ec4\u7a33\u5b9a<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32542338\/#:~:text=,normal%20and%20replication%20stress%20conditions\"><em>[36]<\/em><\/a><a href=\"https:\/\/ngdc.cncb.ac.cn\/openlb\/publication\/OLB-PM-32542338#:~:text=,which%2C%20otherwise%2C%20accumulates%20and\"><em>[37]<\/em><\/a>\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><a>ATAD5<\/a>\u5728\u764c\u75c7\u4e2d\u7684\u4f5c\u7528\u548c\u673a\u5236<\/h2>\n\n\n\n<p><strong>\u80bf\u7624\u6291\u5236\u56e0\u5b50\u4f5c\u7528\uff1a<\/strong>\u5927\u91cf\u8bc1\u636e\u8868\u660eATAD5\u5145\u5f53\u4e86<strong>\u57fa\u56e0\u7ec4\u7a33\u5b9a\u5b88\u62a4\u8005\u548c\u6f5c\u5728\u80bf\u7624\u6291\u5236\u57fa\u56e0<\/strong>\u3002\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0cATAD5\u7684\u5355\u7b49\u4f4d\u57fa\u56e0\u7f3a\u5931\u5373\u53ef\u5bfc\u81f4\u660e\u663e\u7684\u81f4\u764c\u503e\u5411\uff1aAtad5&lt;sup&gt;+\/-&lt;\/sup&gt;\u6742\u5408\u7a81\u53d8\u5c0f\u9f20\u5728\u751f\u547d\u5468\u671f\u5185\u81ea\u53d1\u80bf\u7624\u7684\u53d1\u751f\u7387\u663e\u8457\u5347\u9ad8<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=ATAD5%20is%20important%20for%20maintaining,We\"><em>[1]<\/em><\/a><a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=underscored%20by%20the%20fact%20that,functions%20of%20the%20eukaryotic%20DNA\"><em>[40]<\/em><\/a>\u3002\u8fd9\u4e00\u73b0\u8c61\u5f3a\u8c03\u4e86ATAD5\u5bf9\u6291\u5236\u80bf\u7624\u53d1\u751f\u7684\u91cd\u8981\u6027\u3002\u4eba\u7fa4\u7814\u7a76\u65b9\u9762\uff0cBell\u7b49\u4eba\u57282011\u5e74\u7684\u7814\u7a76\u9996\u5148\u53d1\u73b0\u4e86\u4eba\u7c7bATAD5\u57fa\u56e0\u7684\u529f\u80fd\u7f3a\u9677\u53ef\u80fd\u5bfc\u81f4\u764c\u75c7\u6613\u611f<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=13,7%2C%20e1002245%20%282011\"><em>[41]<\/em><\/a>\u3002\u968f\u540e\u66f4\u5927\u89c4\u6a21\u7684\u6d4b\u5e8f\u548c\u5173\u8054\u5206\u6790\u8bc1\u5b9e\uff1a<strong>ATAD5<\/strong><strong>\u57fa\u56e0\u5b58\u5728\u4e8e\u82e5\u5e72\u80bf\u7624\u6613\u611f\u4f4d\u70b9<\/strong>\u4e2d\u3002\u4f8b\u5982\uff0cATAD5\u57fa\u56e0\u533a\u57df\u7684\u9057\u4f20\u53d8\u5f02\u4e0e\u5b50\u5bab\u5185\u819c\u764c\u3001\u4e73\u817a\u764c\u548c\u5375\u5de2\u764c\u98ce\u9669\u589e\u52a0\u76f8\u5173<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=tumors13%20,from%20DNA%20upon%20its%20successful\"><em>[42]<\/em><\/a>\uff1b\u5728\u4e73\u817a\u764c\u548c\u5375\u5de2\u764c\u60a3\u8005\u4e2d\u4e5f\u9274\u5b9a\u51fa\u4e86\u7f55\u89c1\u7684ATAD5\u9519\u4e49\u53d8\u5f02<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=14,376%2C%20173%E2%80%93177%20%282016\"><em>[43]<\/em><\/a>\u3002\u8fd9\u4e9b\u53d1\u73b0\u652f\u6301ATAD5\u4f5c\u4e3a<strong>\u9690\u6027\u80bf\u7624\u6291\u5236\u57fa\u56e0<\/strong>\u7684\u89d2\u8272\uff0c\u5373ATAD5\u529f\u80fd\u53d7\u635f\u4f1a\u63d0\u5347\u7ec6\u80de\u53d1\u751f\u6076\u6027\u8f6c\u5316\u7684\u6982\u7387<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=tumors13%20,from%20DNA%20upon%20its%20successful\"><em>[42]<\/em><\/a>\u3002\u81f4\u764c\u673a\u7406\u4e0a\uff0cATAD5\u7f3a\u5931\u5bfc\u81f4\u7684<strong>\u57fa\u56e0\u7ec4\u4e0d\u7a33\u5b9a<\/strong>\u88ab\u8ba4\u4e3a\u662f\u4fc3\u80bf\u7624\u7684\u4e3b\u56e0\uff1aPCNA\u5378\u8f7d\u529f\u80fd\u7684\u4e27\u5931\u4f7f\u590d\u5236\u8fc7\u7a0b\u4e2d\u7d2f\u79ef\u66f4\u591a\u9519\u8bef\u548cDNA\u635f\u4f24\uff0c\u7ec6\u80de\u9010\u6e10\u83b7\u5f97\u9a71\u52a8\u80bf\u7624\u53d1\u751f\u7684\u7a81\u53d8\u96c6\u5408<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=ATAD5,starting%20with%20RAD51%20recruitment%20and\"><em>[9]<\/em><\/a>\u3002\u540c\u65f6\uff0cPCNA\u53bb\u6cdb\u7d20\u5316\u53d7\u963b\u610f\u5473\u7740\u8bef\u5dee\u6613\u53d1\u7684DNA\u635f\u4f24\u5bb9\u5fcd\u8def\u5f84\u6301\u7eed\u5f00\u542f\uff0c\u8fdb\u4e00\u6b65\u63d0\u9ad8\u7a81\u53d8\u8d1f\u8377<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=replication%20during%20the%20S%20phase,role%20as%20a%20tumor%20suppressor\"><em>[16]<\/em><\/a><a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=ATAD5,starting%20with%20RAD51%20recruitment%20and\"><em>[9]<\/em><\/a>\u3002\u56e0\u6b64\uff0cATAD5\u7684\u7f3a\u9677\u76f8\u5f53\u4e8e\u79fb\u9664\u4e86\u57fa\u56e0\u7ec4\u7ef4\u62a4\u7684\u91cd\u8981\u201c\u5b89\u5168\u9600\u201d\uff0c\u4f7f\u7ec6\u80de\u66f4\u6613\u8d70\u4e0a\u80bf\u7624\u53d1\u751f\u7684\u9053\u8def\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u5728\u4e00\u4e9b\u4eba\u7c7b\u9057\u4f20\u7efc\u5408\u5f81\u4e2d\u53ef\u80fd\u6d89\u53caATAD5\u7f3a\u5931\uff1a\u4f8b\u5982<strong>NF1<\/strong><strong>\u57fa\u56e0\u5fae\u7f3a\u5931\u7efc\u5408\u5f81<\/strong>\u7684\u60a3\u8005\u4e22\u5931\u5927\u7247\u5305\u542bATAD5\u5728\u5185\u7684\u57fa\u56e0\u7247\u6bb5\uff0c\u636e\u62a5\u9053\u8fd9\u4e9b\u60a3\u8005\u7684\u80bf\u7624\u6613\u611f\u6027\u4e5f\u53ef\u80fd\u5347\u9ad8\uff08\u63d0\u793aATAD5\u7f3a\u5931\u7684\u8d21\u732e\uff09\u3002\u603b\u7684\u6765\u8bf4\uff0c\u4ece\u6a21\u578b\u751f\u7269\u5230\u4eba\u7c7b\u961f\u5217\u7684\u8bc1\u636e\u4e00\u81f4\u8868\u660e\uff1a<strong>ATAD5<\/strong><strong>\u529f\u80fd\u5b8c\u6574\u6027\u5bf9\u4e8e\u9884\u9632\u80bf\u7624\u53d1\u751f\u81f3\u5173\u91cd\u8981<\/strong><a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=tumors13%20,from%20DNA%20upon%20its%20successful\"><em>[42]<\/em><\/a>\u3002<\/p>\n\n\n\n<p><strong>\u7279\u5b9a\u764c\u79cd\u7814\u7a76\u8fdb\u5c55\uff1a<\/strong><br>&#8211; <strong>\u4e73\u817a\u764c\uff1a<\/strong>ATAD5\u5728\u4e73\u817a\u764c\u4e2d\u53d7\u5230\u5173\u6ce8\u3002\u4e00\u65b9\u9762\uff0c\u4e73\u817a\u764c\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u68c0\u6d4b\u5230\u4e86ATAD5\u7684\u4f53\u7ec6\u80de\u7a81\u53d8<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=14,376%2C%20173%E2%80%93177%20%282016\"><em>[43]<\/em><\/a>\uff1b\u53e6\u4e00\u65b9\u9762\uff0c\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76(GWAS)\u5c06ATAD5\u5b9a\u4f4d\u4e3a\u4e73\u817a\u764c\u6613\u611f\u57fa\u56e0\u5ea7\u4e4b\u4e00<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=14,376%2C%20173%E2%80%93177%20%282016\"><em>[43]<\/em><\/a>\u3002\u867d\u7136ATAD5\u7a81\u53d8\u5728\u4e73\u817a\u764c\u4e2d\u4e0d\u662f\u9ad8\u9891\u4e8b\u4ef6\uff0c\u4f46\u7531\u4e8e\u5176\u53c2\u4e0eDNA\u4fee\u590d\uff0c\u4e0eBRCA1\u7b49\u7ecf\u5178\u4e73\u817a\u764c\u6291\u764c\u57fa\u56e0\u53ef\u80fd\u5b58\u5728\u529f\u80fd\u5173\u8054\u3002\u4e00\u9879\u5206\u6790\u53d1\u73b0\uff0c\u5728\u4e73\u817a\u548c\u7ed3\u76f4\u80a0\u80bf\u7624\u4e2d\uff0cATAD5\u7684mRNA\u6c34\u5e73\u4e0eBRCA1\u5448\u6b63\u76f8\u5173\uff08\u5373\u9ad8ATAD5\u8868\u8fbe\u7684\u6837\u672c\u5f80\u5f80BRCA1\u8868\u8fbe\u4e5f\u9ad8\uff09<a href=\"https:\/\/www.researchgate.net\/figure\/TOP2A-and-ATAD5-mRNA-expression-correlates-with-BRCA1-mRNA-expression-in-BC-and-CRC_fig5_354909991#:~:text=TOP2A%20and%20ATAD5%20mRNA%20expression,with%20BRCA1%20expression%20in%20CRC\"><em>[44]<\/em><\/a>\u3002\u8fd9\u63d0\u793aATAD5\u53ef\u80fd\u53d7\u5171\u540c\u7684\u80bf\u7624\u6291\u5236\u901a\u8def\u8c03\u63a7\u3002\u5728BRCA1\u7f3a\u9677\u578b\u4e73\u817a\u764c\u4e2d\uff0cATAD5\u7f3a\u5931\u53ef\u80fd\u8fdb\u4e00\u6b65\u524a\u5f31\u540c\u6e90\u91cd\u7ec4\u4fee\u590d\uff0c\u4f7f\u7ec6\u80de\u66f4\u52a0\u4e0d\u7a33\u5b9a\u5e76\u4f9d\u8d56\u5176\u4ed6\u5bb9\u5fcd\u8def\u5f84\u3002\u603b\u4f53\u6765\u8bf4\uff0cATAD5\u5728\u4e73\u817a\u764c\u4e2d\u7684\u4f5c\u7528\u673a\u5236\u5c1a\u5f85\u6df1\u5165\uff0c\u4f46\u5176\u4f5c\u4e3a\u57fa\u56e0\u7ec4\u7ef4\u62a4\u8005\u7684\u89d2\u8272\u610f\u5473\u7740\u4efb\u4f55\u524a\u5f31ATAD5\u529f\u80fd\u7684\u6539\u53d8\u90fd\u4f1a\u4fc3\u8fdb\u4e73\u817a\u7ec6\u80de\u7684\u6076\u6027\u8f6c\u5316\u548c\u8fdb\u5c55\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7ed3\u76f4\u80a0\u764c\uff1a<\/strong>\u76ee\u524d\u5173\u4e8eATAD5\u5728\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u4e2d\u7684\u76f4\u63a5\u6570\u636e\u6709\u9650\u3002\u4e0d\u8fc7\u9274\u4e8eCRC\u4e2d\u5e38\u89c1\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a(MSI)\u548c\u590d\u5236\u9519\u8bef\u8868\u578b\uff0c\u53ef\u4ee5\u63a8\u6d4bATAD5\u529f\u80fd\u5f02\u5e38\u53ef\u80fd\u4e0e\u6b64\u7c7b\u57fa\u56e0\u7ec4\u4e0d\u7a33\u5b9a\u6709\u5173\u3002\u4e00\u4e9b\u7814\u7a76\u8bd5\u56fe\u5229\u7528\u591a\u57fa\u56e0\u7b7e\u540d\u9884\u6d4bCRC\u9884\u540e\uff0c\u5176\u4e2d\u5305\u542bDNA\u590d\u5236\/\u4fee\u590d\u76f8\u5173\u57fa\u56e0\u7684\u8868\u8fbe\u4fe1\u606f\u3002\u6709\u62a5\u9053\u63d0\u51fa\u4e00\u4e2a\u75314\u4e2aDNA\u4ee3\u8c22\u57fa\u56e0\u7ec4\u6210\u7684\u9884\u540e\u7b7e\u540d\u7528\u4e8e\u9ad8\u7a81\u53d8\u8d1f\u8377CRC\uff0c\u5176\u4e2d\u6216\u6d89\u53caATAD5\u7684\u8868\u8fbe<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6407520\/#:~:text=A%20novel%204,H%20CRC.%20Future\"><em>[45]<\/em><\/a>\u3002\u6b64\u5916\uff0cOncotarget\u520a\u7269\u7684\u4e00\u9879\u7814\u7a76\u6307\u51faATAD5\u5728CRC\u7ec4\u7ec7\u4e2d\u7684\u8868\u8fbe\u6c34\u5e73\u4e0eBRCA1\u6709\u76f8\u5173\u6027<a href=\"https:\/\/www.oncotarget.com\/news\/pr\/brca1-mrna-expression-in-breast-and-colorectal-cancer\/#:~:text=Oncotarget%3A%20BRCA1%20mRNA%20expression%20in,expression%20correlates%20with%20BRCA1\"><em>[46]<\/em><\/a>\uff08\u7c7b\u4f3c\u4e8e\u4e73\u817a\u764c\u60c5\u51b5\uff09\uff0c\u63d0\u793a\u5176\u8868\u8fbe\u53d7DNA\u4fee\u590d\u7f51\u7edc\u6574\u4f53\u8c03\u63a7\u3002\u867d\u7136\u5c1a\u672a\u53d1\u73b0ATAD5\u5728\u7ed3\u76f4\u80a0\u764c\u4e2d\u6709\u70ed\u70b9\u7a81\u53d8\uff0c\u4f46\u4e0d\u80fd\u6392\u9664\u90e8\u5206MSI-H\u4e9a\u578b\u80bf\u7624\u5b58\u5728ATAD5\u7f3a\u9677\uff0c\u4ece\u800c\u52a0\u5267\u590d\u5236\u9519\u8bef\u7684\u53ef\u80fd\u6027\u3002\u672a\u6765\u9488\u5bf9CRC\u7684\u5168\u5916\u663e\u5b50\/\u5168\u57fa\u56e0\u7ec4\u6570\u636e\u6316\u6398\u4e5f\u8bb8\u4f1a\u63ed\u793aATAD5\u5f02\u5e38\u5728\u4e9a\u7fa4\u60a3\u8005\u4e2d\u7684\u610f\u4e49\u3002<\/li>\n\n\n\n<li><strong>\u767d\u8840\u75c5\uff1a<\/strong>\u5173\u4e8eATAD5\u5728\u767d\u8840\u75c5\uff0c\u5c24\u5176\u662f\u6025\u6027\u767d\u8840\u75c5\uff08AML\/ALL\uff09\u4e2d\u7684\u7814\u7a76\u8f83\u5c11\u3002\u76ee\u524d\u5927\u578b\u767d\u8840\u75c5\u6d4b\u5e8f\u9879\u76ee\u5e76\u672a\u5c06ATAD5\u5217\u4e3a\u5e38\u89c1\u7a81\u53d8\u57fa\u56e0\u3002\u7136\u800c\uff0c\u8003\u8651\u5230\u9020\u8840\u7ec6\u80de\u9ad8\u5ea6\u4f9d\u8d56\u51c6\u786e\u7684DNA\u590d\u5236\u548c\u4fee\u590d\uff0cATAD5\u529f\u80fd\u7684\u7f3a\u9677\u53ef\u80fd\u5f71\u54cd\u8840\u6db2\u7cfb\u7edf\u7ec6\u80de\u7684\u57fa\u56e0\u7a33\u6001\u3002\u4e00\u79cd\u53ef\u80fd\u6027\u662fATAD5\u4f4e\u8868\u8fbe\u6216\u529f\u80fd\u53d8\u5f02\u7684\u9020\u8840\u5e72\/\u7956\u7ec6\u80de\u5728\u5e94\u5bf9\u589e\u6b96\u538b\u529b\u65f6\u66f4\u6613\u79ef\u7d2f\u7a81\u53d8\uff0c\u4ece\u800c\u5728\u957f\u671f\u53ef\u80fd\u63a8\u8fdb\u767d\u8840\u75c5\u53d1\u751f\u3002\u53e6\u4e00\u4e2a\u89d2\u5ea6\uff0c\u767d\u8840\u75c5\u7ec6\u80de\u901a\u5e38\u627f\u53d7\u589e\u6b96\u538b\u529b\u4e14DNA\u635f\u4f24\u8d1f\u8377\u9ad8\uff0c\u5982\u679cATAD5\u9ad8\u5ea6\u8868\u8fbe\u5e2e\u52a9\u8fd9\u4e9b\u7ec6\u80de\u5e94\u5bf9\u590d\u5236\u5e94\u6fc0\uff0c\u90a3\u4e48\u6291\u5236ATAD5\u529f\u80fd\u4e5f\u8bb8\u5bf9\u767d\u8840\u75c5\u7ec6\u80de\u662f\u81f4\u547d\u7684\uff08\u89c1\u4e0b\u6587\u6cbb\u7597\u90e8\u5206\uff09\u3002\u603b\u4e4b\uff0c\u76ee\u524d\u7f3a\u4e4f\u76f4\u63a5\u8bc1\u636e\u8bc1\u660eATAD5\u5728\u767d\u8840\u75c5\u53d1\u75c5\u4e2d\u7684\u4f5c\u7528\uff0c\u672a\u6765\u53ef\u80fd\u9700\u8981\u529f\u80fd\u6027\u7814\u7a76\uff08\u5982ATAD5\u5728\u9020\u8840\u7cfb\u7edf\u7684\u6761\u4ef6\u6027\u6572\u9664\u6a21\u578b\uff09\u6765\u8bc4\u4f30\u5176\u5f71\u54cd\u3002<\/li>\n\n\n\n<li><strong>\u5176\u4ed6\u5b9e\u4f53\u7624\uff1a<\/strong>\u5728\u5375\u5de2\u764c\u548c\u5b50\u5bab\u5185\u819c\u764c\u4e2d\uff0cATAD5\u7684\u9057\u4f20\u53d8\u5f02\u548c\u8868\u8fbe\u5931\u8c03\u540c\u6837\u503c\u5f97\u5173\u6ce8\u3002\u524d\u8ff0GWAS\u9274\u5b9a\u4e86ATAD5\u4f4d\u70b9\u4e0e\u5375\u5de2\u764c\u6613\u611f\u6027\u7684\u5173\u8054<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=15,47%2C%20164%E2%80%93171%20%282015\"><em>[47]<\/em><\/a>\uff1bKostovska\u7b49\u4eba\u62a5\u9053\u4e86\u51e0\u4f8b\u5375\u5de2\u764c\/\u4e73\u764c\u60a3\u8005\u643a\u5e26\u7f55\u89c1\u7684ATAD5\u80da\u7cfb\u53d8\u5f02<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=14,376%2C%20173%E2%80%93177%20%282016\"><em>[43]<\/em><\/a>\u3002\u8fd9\u4e9b\u53d8\u5f02\u53ef\u80fd\u524a\u5f31ATAD5\u529f\u80fd\uff0c\u4ece\u800c\u589e\u52a0\u60a3\u764c\u98ce\u9669\u3002\u4e34\u5e8a\u6837\u672c\u5206\u6790\u4e5f\u663e\u793a\u90e8\u5206\u5375\u5de2\u764c\u7ec4\u7ec7\u4e2dATAD5\u8868\u8fbe\u4e0b\u964d\uff0c\u53ef\u80fd\u4e0e\u57fa\u56e0\u62f7\u8d1d\u7f3a\u5931\u6216\u8868\u89c2\u9057\u4f20\u6c89\u9ed8\u6709\u5173\uff08\u63a8\u6d4b\uff09\u3002\u6b64\u5916\uff0cATAD5\u5728<strong>\u66ff\u4ee3\u6027\u7aef\u7c92\u5ef6\u957f\uff08<\/strong><strong>ALT<\/strong><strong>\uff09\u673a\u5236<\/strong>\u9633\u6027\u7684\u80bf\u7624\u4e2d\u5177\u6709\u7279\u6b8a\u610f\u4e49\u3002ALT\u662f\u4e00\u90e8\u5206\u7f3a\u4e4f\u7aef\u7c92\u9176\u7684\u80bf\u7624\u901a\u8fc7\u540c\u6e90\u91cd\u7ec4\u5ef6\u957f\u7aef\u7c92\u7684\u9014\u5f84\uff0c\u800c\u6700\u8fd1\u7814\u7a76\u53d1\u73b0PCNA\u7684\u6cdb\u7d20\u5316\u548c\u5378\u8f7d\u5e73\u8861\u5bf9ALT\u6d3b\u6027\u6709\u8c03\u63a7\u4f5c\u7528<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39291733\/#:~:text=Replication%20stresses%20are%20the%20major,dependent%20manner\"><em>[48]<\/em><\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39291733\/#:~:text=Furthermore%2C%20deficiency%20of%20ATAD5%2C%20which,a%20trigger%20for%20directing%20BIR\"><em>[49]<\/em><\/a>\u3002\u5177\u4f53\u800c\u8a00\uff0c\u5728ALT\u9633\u6027\u7684\u9aa8\u8089\u7624\u7b49\u7ec6\u80de\u4e2d\uff0c<strong>ATAD5<\/strong><strong>\u7f3a\u5931\u4f1a\u5ef6\u957f\u7aef\u7c92\u5e76\u589e\u5f3aALT<\/strong><strong>\u8868\u578b<\/strong>\uff1a\u7531\u4e8eATAD5\u7f3a\u4e4f\uff0cPCNA\u7684\u6cdb\u7d20\u5316\u4e0d\u80fd\u88ab\u53ca\u65f6\u79fb\u9664\u4e14PCNA\u6301\u7eed\u5b58\u5728\u4e8e\u7aef\u7c92\u5904\uff0c\u89e6\u53d1SLX4\u4ecb\u5bfc\u7684BIR\uff08\u65ad\u88c2\u8bf1\u5bfc\u7684\u590d\u5236\uff09\u8def\u5f84\u8fc7\u5ea6\u6fc0\u6d3b\uff0c\u5bfc\u81f4\u7aef\u7c92\u8fc7\u5ea6\u91cd\u7ec4\u5ef6\u957f<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39291733\/#:~:text=deubiquitinating%20enzyme%2C%20results%20in%20an,a%20trigger%20for%20directing%20BIR\"><em>[50]<\/em><\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39291733\/#:~:text=Furthermore%2C%20deficiency%20of%20ATAD5%2C%20which,a%20trigger%20for%20directing%20BIR\"><em>[49]<\/em><\/a>\u3002\u6362\u8a00\u4e4b\uff0c\u6b63\u5e38\u60c5\u51b5\u4e0bATAD5\u901a\u8fc7\u5378\u8f7dPCNA\u5e76\u8f85\u4f50USP1\u9650\u5236ALT\u76f8\u5173\u7684\u7aef\u7c92DNA\u5408\u6210\uff0c\u800c\u4e00\u65e6ATAD5\u529f\u80fd\u53d7\u635f\uff0c\u8fd9\u4e00<strong>\u201c<\/strong><strong>PCNA^<\/strong><strong>\u6cdb\u7d20\u5316\u2013SLX4<\/strong><strong>\u201d\u8f74<\/strong>\u4fbf\u5931\u63a7\uff0c\u53ef\u80fd\u4fc3\u4f7f\u67d0\u4e9b\u80bf\u7624\u83b7\u5f97\u65e0\u9650\u589e\u6b96\u80fd\u529b<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39291733\/#:~:text=Furthermore%2C%20deficiency%20of%20ATAD5%2C%20which,a%20trigger%20for%20directing%20BIR\"><em>[49]<\/em><\/a>\u3002\u7efc\u4e0a\uff0c\u5728\u591a\u79cd\u5b9e\u4f53\u7624\u4e2dATAD5\u7684\u4f4e\u529f\u80fd\u72b6\u6001\u90fd\u503e\u5411\u4e8e\u4fc3\u8fdb\u57fa\u56e0\u7ec4\u4e0d\u7a33\u548c\u80bf\u7624\u8fdb\u5c55\uff0c\u4f46\u4e0d\u540c\u764c\u79cd\u7684\u5177\u4f53\u673a\u5236\u548c\u8868\u578b\u53ef\u80fd\u5404\u6709\u4fa7\u91cd\uff0c\u4ecd\u9700\u8fdb\u4e00\u6b65\u7814\u7a76\u5398\u6e05\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><a>\u4e34\u5e8a\u610f\u4e49\u4e0e\u7cbe\u51c6\u533b\u7597\u524d\u666f<\/a><\/h2>\n\n\n\n<p><strong>\u6f5c\u5728\u751f\u7269\u6807\u5fd7\u7269\uff1a<\/strong>\u57fa\u4e8e\u4e0a\u8ff0\u7814\u7a76\uff0cATAD5\u72b6\u6001\u53ef\u4ee5\u4f5c\u4e3a\u8bc4\u4f30\u80bf\u7624\u6cbb\u7597\u53cd\u5e94\u7684\u4e00\u4e2a\u6f5c\u5728\u751f\u7269\u6807\u5fd7\u7269\u3002ATAD5\u7f3a\u9677\u8d4b\u4e88\u7ec6\u80de\u9ad8\u5ea6\u7684\u590d\u5236\u538b\u529b\u8106\u5f31\u6027\uff0c\u8fd9\u4f7f\u5b83\u4eec\u5bf9\u67d0\u4e9bDNA\u635f\u4f24\u836f\u7269\u66f4\u52a0\u654f\u611f<a href=\"https:\/\/academic.oup.com\/nar\/article\/49\/20\/11746\/6414590#:~:text=,4939\"><em>[51]<\/em><\/a>\u3002Giovannini\u7b49\u4eba\u57282020\u5e74\u7684\u7814\u7a76\u4e2d\u53d1\u73b0\uff0c<strong>ATAD5<\/strong><strong>\u6572\u51cf\u4f1a\u663e\u8457\u589e\u5f3a\u7ec6\u80de\u5bf9PARP<\/strong><strong>\u6291\u5236\u5242\u7684\u654f\u611f\u6027<\/strong><a href=\"https:\/\/academic.oup.com\/nar\/article\/49\/20\/11746\/6414590#:~:text=,4939\"><em>[51]<\/em><\/a>\u3002PARP\u6291\u5236\u5242\u901a\u5e38\u7528\u4e8eBRCA1\/2\u7a81\u53d8\u5bfc\u81f4HR\u7f3a\u9677\u7684\u80bf\u7624\uff0cATAD5\u7f3a\u9677\u7ec6\u80de\u8868\u73b0\u51fa\u7c7b\u4f3c\u201cHR\u4fee\u590d\u4e0d\u826f\u201d\u7684\u7279\u5f81\uff0c\u56e0\u6b64\u5bf9PARP\u6291\u5236\u4ea7\u751fsynthetic lethal\u6548\u5e94<a href=\"https:\/\/academic.oup.com\/nar\/article\/49\/20\/11746\/6414590#:~:text=,4939\"><em>[51]<\/em><\/a><a href=\"https:\/\/www.researchgate.net\/figure\/Differential-effect-of-ATAD5-depletion-on-chemical-sensitivity-of-A2780-cells-Knock-down_fig1_340717490#:~:text=,Sara%20Giovannini\"><em>[52]<\/em><\/a>\u3002\u540c\u4e00\u7814\u7a76\u8fd8\u62a5\u544a\uff0cATAD5\u7f3a\u4e4f\u4f7f\u7ec6\u80de\u5bf9\u5176\u5b83\u963b\u788dDNA\u590d\u5236\u7684\u8bd5\u5242\uff08\u5982\u70f7\u57fa\u5316\u5242MMS\u3001\u62d3\u6251\u5f02\u6784\u9176I\u6291\u5236\u5242CPT\u3001\u4ea4\u8054\u5242\u4e1d\u88c2\u9709\u7d20C\u7b49\uff09\u66f4\u52a0\u654f\u611f<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32297953\/#:~:text=,agents%20that%20hinder%20the\"><em>[53]<\/em><\/a><a href=\"https:\/\/www.researchgate.net\/figure\/Differential-effect-of-ATAD5-depletion-on-chemical-sensitivity-of-A2780-cells-Knock-down_fig1_340717490#:~:text=,Sara%20Giovannini\"><em>[52]<\/em><\/a>\u3002\u8fd9\u610f\u5473\u7740\u5728\u80bf\u7624\u4e2d\uff0c\u5982\u679c\u68c0\u6d4b\u5230ATAD5\u529f\u80fd\u53d7\u635f\uff08\u4f8b\u5982\u7a81\u53d8\u6216\u4f4e\u8868\u8fbe\uff09\uff0c<strong>\u53ef\u4ee5\u8003\u8651\u4f7f\u7528\u4ee5\u589e\u5f3a\u590d\u5236\u538b\u529b\u4e3a\u673a\u5236\u7684\u836f\u7269<\/strong>\uff0c\u5982\u94c2\u7c7b\u5316\u7597\u3001\u62d3\u6251\u5f02\u6784\u9176\u6291\u5236\u5242\u6216PARP\u6291\u5236\u5242\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u80bf\u7624\u7ec6\u80de\u66f4\u96be\u5e94\u5bf9\u7d2f\u79ef\u7684DNA\u635f\u4f24\u3002\u53cd\u4e4b\uff0c\u5bf9\u4e8eATAD5\u9ad8\u5ea6\u8868\u8fbe\uff08\u53ef\u80fd\u5e2e\u52a9\u80bf\u7624\u7ec6\u80de\u8010\u53d7DNA\u635f\u4f24\uff09\u7684\u60c5\u51b5\uff0c\u5219\u53ef\u80fd\u9700\u8981\u66f4\u5f3a\u7684\u8054\u5408\u6cbb\u7597\u6765\u514b\u670d\u5176\u57fa\u56e0\u7ec4\u7ef4\u62a4\u80fd\u529b\u3002\u603b\u4e4b\uff0cATAD5\u7684\u72b6\u6001\u6709\u6f5c\u529b\u7528\u4e8e\u6307\u5bfc\u4e2a\u4f53\u5316\u6cbb\u7597\u65b9\u6848\u7684\u5236\u5b9a\uff0c\u5e2e\u52a9\u533b\u751f\u9009\u62e9\u6700\u6709\u6548\u7684DNA\u635f\u4f24\u5e94\u5bf9\u7597\u6cd5\u3002<\/p>\n\n\n\n<p><strong>\u836f\u7269\u9776\u70b9\u63a2\u7d22\uff1a<\/strong>\u5c3d\u7ba1\u4f5c\u4e3a\u6291\u764c\u57fa\u56e0\u7684ATAD5\u5728\u4f20\u7edf\u610f\u4e49\u4e0a\u4e0d\u662f\u201c\u81f4\u764c\u9a71\u52a8\u86cb\u767d\u201d\uff0c\u4f46\u9488\u5bf9\u5176\u901a\u8def\u7684\u836f\u7269\u5e72\u9884\u601d\u8def\u6b63\u5728\u840c\u82bd\u3002\u5176\u4e2d\u4e00\u4e2a\u65b9\u5411\u662f<strong>\u5408\u6210\u81f4\u6b7b\u7b56\u7565<\/strong>\uff1a\u5728ATAD5\u7f3a\u9677\u7684\u80bf\u7624\u7ec6\u80de\u4e2d\uff0c\u6291\u5236\u5176\u4f59\u7684DNA\u635f\u4f24\u53cd\u5e94\u9014\u5f84\u4ee5\u8fbe\u5230\u9009\u62e9\u6027\u6740\u4f24\u7684\u76ee\u7684\u3002\u4f8b\u5982\uff0cATR\u548cCHK1\u662f\u590d\u5236\u5e94\u6fc0\u53cd\u5e94\u7684\u6838\u5fc3\u6fc0\u9176\uff0cATAD5\u7f3a\u9677\u7ec6\u80de\u5bf9ATR\u6216CHK1\u6291\u5236\u5242\u53ef\u80fd\u5c24\u4e3a\u8106\u5f31\uff0c\u56e0\u4e3a\u5b83\u4eec\u672c\u5df2\u6709\u590d\u5236\u53c9\u4e0d\u7a33\u5b9a\u7684\u95ee\u9898\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u663e\u793aPARP\u6291\u5236\u4e0eATR\u6291\u5236\u5242\u8054\u7528\u80fd\u591f\u52a0\u901f\u590d\u5236\u707e\u96be\u5e76\u5bfc\u81f4\u764c\u7ec6\u80de\u51cb\u4ea1<a href=\"https:\/\/www.oncologynewscentral.com\/article\/dual-inhibition-of-parp-and-atr-feasible-early-trials-suggest#:~:text=Dual%20Inhibition%20of%20PARP%20and,catastrophe%20and%20unscheduled%20mitosis\"><em>[54]<\/em><\/a><a href=\"https:\/\/www.mdpi.com\/2072-6694\/12\/5\/1095#:~:text=ATR%20Inhibition%20Potentiates%20PARP%20Inhibitor,\"><em>[55]<\/em><\/a>\u2014\u2014\u8fd9\u4e00\u539f\u7406\u540c\u6837\u9002\u7528\u4e8eATAD5\u7f3a\u9677\u60c5\u51b5\u3002\u53e6\u4e00\u4e2a\u65b0\u9896\u65b9\u5411\u662f<strong>\u76f4\u63a5\u9488\u5bf9<\/strong><strong>ATAD5<\/strong><strong>\u672c\u8eab\u8fdb\u884c\u836f\u7269\u5e72\u9884<\/strong>\u3002\u867d\u7136\u4f20\u7edf\u4e0a\u5f88\u96be\u6062\u590d\u80bf\u7624\u7ec6\u80de\u4e2d\u5931\u53bb\u529f\u80fd\u7684\u6291\u764c\u86cb\u767d\uff0c\u4f46\u53ef\u4ee5\u8003\u8651<strong>\u4eba\u4e3a\u6291\u5236<\/strong><strong>ATAD5<\/strong>\u6765\u589e\u52a0\u764c\u7ec6\u80de\u7684\u5e94\u6fc0\uff0c\u4ece\u800c\u4e0e\u5176\u4ed6\u6cbb\u7597\u534f\u540c\u6740\u4f24\u30022019\u5e74\uff0c\u6709\u7814\u7a76\u901a\u8fc7\u9ad8\u901a\u91cf\u7b5b\u9009\u53d1\u73b0\u4e86\u4e00\u4e2a\u5c0f\u5206\u5b50\u63a2\u9488 <strong>ML367<\/strong>\uff0c\u5b83\u80fd\u591f<strong>\u5e72\u6270<\/strong><strong>ATAD5<\/strong><strong>\u86cb\u767d\u7684\u7a33\u6001<\/strong><a href=\"https:\/\/www.cancer-research-network.com\/2019\/08\/03\/ml367-is-an-atad5-stabilization-inhibitor\/#:~:text=Researchers%20carried%20out%20a%20quantitative,an%20inhibitor%20of%20ATAD5%20stabilization\"><em>[56]<\/em><\/a>\u3002ML367\u88ab\u79f0\u4e3a\u201cATAD5\u7a33\u5b9a\u5316\u6291\u5236\u5242\u201d\uff0c\u53ef\u5728\u7ec6\u80de\u4e2d\u8bf1\u5bfcATAD5\u86cb\u767d\u964d\u89e3\u6216\u529f\u80fd\u5931\u6d3b<a href=\"https:\/\/www.cancer-research-network.com\/2019\/08\/03\/ml367-is-an-atad5-stabilization-inhibitor\/#:~:text=ML367%20is%20a%20probe%20molecule%2C,in%20blocking%20DNA%20repair%20pathways\"><em>[57]<\/em><\/a>\u3002\u529f\u80fd\u6d4b\u8bd5\u8868\u660e\uff1aML367\u5904\u7406\u7ec6\u80de\u4f1a<strong>\u524a\u5f31<\/strong><strong>DNA<\/strong><strong>\u635f\u4f24\u5e94\u7b54<\/strong>\uff0c\u6bd4\u5982\u5728\u7d2b\u5916\u7ebf\u7167\u5c04\u540e\uff0c\u53d7\u5230ML367\u9884\u5904\u7406\u7684\u7ec6\u80de\u78f7\u9178\u5316RPA32\u548cCHK1\u7684\u6c34\u5e73\u663e\u8457\u964d\u4f4e<a href=\"https:\/\/www.cancer-research-network.com\/2019\/08\/03\/ml367-is-an-atad5-stabilization-inhibitor\/#:~:text=ML367%20is%20a%20probe%20molecule%2C,in%20blocking%20DNA%20repair%20pathways\"><em>[57]<\/em><\/a>\uff1b\u8fd9\u8868\u660eML367\u6709\u6548\u5730\u963b\u65ad\u4e86\u7ec6\u80de\u5bf9\u4e8e\u590d\u5236\u538b\u529b\u7684\u5e38\u89c4\u53cd\u5e94<a href=\"https:\/\/www.cancer-research-network.com\/2019\/08\/03\/ml367-is-an-atad5-stabilization-inhibitor\/#:~:text=ML367%20is%20a%20probe%20molecule%2C,in%20blocking%20DNA%20repair%20pathways\"><em>[57]<\/em><\/a>\u3002\u66f4\u6709\u8da3\u7684\u662f\uff0cML367\u5bf9<strong>\u672c\u8eab\u7f3a\u4e4f<\/strong><strong>DNA<\/strong><strong>\u4fee\u590d\u86cb\u767d\u7684\u7ec6\u80de<\/strong>\u6bd2\u6027\u66f4\u5f3a<a href=\"https:\/\/www.cancer-research-network.com\/2019\/08\/03\/ml367-is-an-atad5-stabilization-inhibitor\/#:~:text=Image\"><em>[58]<\/em><\/a>\u3002\u6362\u53e5\u8bdd\u8bf4\uff0c\u5728\u4e00\u4e9bDNA\u4fee\u590d\u9014\u5f84\u5df2\u5931\u7075\u7684\u7ec6\u80de\uff08\u5982BRCA\u7f3a\u9677\u6216p53\u7f3a\u9677\uff09\u4e2d\u8fdb\u4e00\u6b65\u6291\u5236ATAD5\uff0c\u4f1a\u5bfc\u81f4\u201c\u53cc\u91cd\u6253\u51fb\u201d\uff0c\u5f3a\u529b\u8bf1\u53d1\u7ec6\u80de\u6b7b\u4ea1<a href=\"https:\/\/www.cancer-research-network.com\/2019\/08\/03\/ml367-is-an-atad5-stabilization-inhibitor\/#:~:text=In%20addition%2C%20ML367%20displays%20excellent,lack%20DNA%20damage%20repair%20proteins\"><em>[59]<\/em><\/a>\u3002\u8fd9\u63d0\u793a\u5c06<strong>ATAD5<\/strong><strong>\u6291\u5236\u5242\u4e0e\u5176\u4ed6DNA<\/strong><strong>\u635f\u4f24\u836f\u7269<\/strong>\u8054\u5408\u4f7f\u7528\uff0c\u53ef\u80fd\u4ea7\u751f\u534f\u540c\u7684\u6297\u764c\u6548\u679c<a href=\"https:\/\/www.cancer-research-network.com\/2019\/08\/03\/ml367-is-an-atad5-stabilization-inhibitor\/#:~:text=in%20HEK293T%20cells,lack%20DNA%20damage%20repair%20proteins\"><em>[60]<\/em><\/a>\u3002\u5f53\u7136\uff0c\u76ee\u524dML367\u4ecd\u662f\u79d1\u7814\u5de5\u5177\u5206\u5b50\uff0c\u9009\u62e9\u6027\u548c\u4f53\u5185\u6548\u679c\u5c1a\u5f85\u4f18\u5316\u3002\u4f46\u5176\u51fa\u73b0\u8bc1\u660e\u4e86ATAD5\u901a\u8def\u7684\u201c\u53ef\u836f\u6027\u201d\uff0c\u672a\u6765\u6709\u671b\u53d1\u5c55\u66f4\u5f3a\u6548\u3001\u66f4\u7279\u5f02\u7684ATAD5\u901a\u8def\u6291\u5236\u5242\u7528\u4e8e\u4e34\u5e8a\u3002<\/p>\n\n\n\n<p><strong>\u7cbe\u51c6\u533b\u7597\u5e94\u7528\u524d\u666f\uff1a<\/strong>\u968f\u7740\u5bf9ATAD5\u4f5c\u7528\u673a\u5236\u548c\u80bf\u7624\u76f8\u5173\u6027\u7684\u6df1\u5165\u4e86\u89e3\uff0c\u5728\u4e34\u5e8a\u4e0a\u53ef\u8003\u8651\u4ee5\u4e0b\u5e94\u7528\u524d\u666f\uff1a\u9996\u5148\uff0c<strong>\u8bca\u65ad<\/strong><strong>\/<\/strong><strong>\u9884\u540e\u65b9\u9762<\/strong>\uff0c\u5c06ATAD5\u7eb3\u5165\u80bf\u7624\u57fa\u56e0\u68c0\u6d4b panel\uff0c\u8bc4\u4f30\u60a3\u8005\u80bf\u7624\u662f\u5426\u5b58\u5728ATAD5\u7a81\u53d8\u6216\u8868\u8fbe\u4e0b\u8c03\u3002\u5982\u679c\u6709\uff0c\u5219\u63d0\u793a\u8be5\u80bf\u7624\u57fa\u56e0\u7ec4\u7ef4\u62a4\u80fd\u529b\u4e0b\u964d\uff0c\u53ef\u80fd\u5bf9DNA\u635f\u4f24\u7c7b\u7597\u6cd5\u8f83\u4e3a\u654f\u611f\uff0c\u53ef\u9009\u62e9PARP\u6291\u5236\u5242\u3001\u94c2\u7c7b\u6216\u653e\u7597\u7b49\u4f5c\u4e3a\u6cbb\u7597\u65b9\u6848<a href=\"https:\/\/academic.oup.com\/nar\/article\/49\/20\/11746\/6414590#:~:text=,4939\"><em>[51]<\/em><\/a><a href=\"https:\/\/www.researchgate.net\/figure\/Differential-effect-of-ATAD5-depletion-on-chemical-sensitivity-of-A2780-cells-Knock-down_fig1_340717490#:~:text=,Sara%20Giovannini\"><em>[52]<\/em><\/a>\u3002\u76f8\u53cd\uff0c\u5982\u679c\u68c0\u6d4b\u5230ATAD5\u8868\u8fbe\u663e\u8457\u4e0a\u8c03\uff08\u4f5c\u4e3a\u80bf\u7624\u5bf9\u6297\u538b\u529b\u7684\u9002\u5e94\uff09\uff0c\u5219\u53ef\u8003\u8651\u9776\u5411\u8fd9\u4e00\u9002\u5e94\u6027\u8106\u5f31\u6027\uff0c\u4f8b\u5982\u4f7f\u7528ATR\/CHK1\u6291\u5236\u5242\u6216\u672a\u6765\u4e13\u95e8\u7684ATAD5\u6291\u5236\u5242\uff0c\u914d\u5408\u5316\u7597\u4ee5\u514b\u670d\u80bf\u7624\u8010\u53d7\u3002\u5176\u6b21\uff0c<strong>\u6cbb\u7597\u65b9\u9762<\/strong>\uff0c\u5bf9\u4e8eATAD5\u7f3a\u9677\u7684\u80bf\u7624\uff0c\u53ef\u5c1d\u8bd5<strong>\u201c\u8d81\u865a\u800c\u5165\u201d<\/strong>\u2014\u2014\u4f8b\u5982\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u4e2d\uff0c\u5c06ATAD5\u72b6\u6001\u4f5c\u4e3a\u9009\u62e9\u6807\u51c6\uff0c\u7b5b\u9009\u51fa\u53ef\u80fd\u4ecePARP\u6291\u5236\u6216ATR\u6291\u5236\u4e2d\u83b7\u76ca\u7684\u60a3\u8005\u3002\u5bf9\u4e8eATAD5\u6b63\u5e38\u7684\u60a3\u8005\uff0c\u5c24\u5176\u662f\u90a3\u4e9b\u643a\u5e26\u590d\u5236\u538b\u529b\u9ad8\u7684\u80bf\u7624\uff08\u5982MYC\u9ad8\u8868\u8fbe\u80bf\u7624\uff09\uff0c\u5219\u672a\u6765\u53ef\u4ee5\u63a2\u7d22<strong>ATAD5<\/strong><strong>\u5c0f\u5206\u5b50\u6291\u5236\u5242<\/strong>\u4e0e\u6807\u51c6\u6cbb\u7597\u8054\u5408\u7684\u65b9\u6848\uff0c\u5229\u7528\u5176\u6270\u4e71\u764c\u7ec6\u80deDNA\u590d\u5236\u5e94\u6fc0\u5e94\u7b54\u7684\u4f5c\u7528\u6765\u589e\u5f3a\u6cbb\u7597\u6548\u679c<a href=\"https:\/\/www.cancer-research-network.com\/2019\/08\/03\/ml367-is-an-atad5-stabilization-inhibitor\/#:~:text=in%20HEK293T%20cells,lack%20DNA%20damage%20repair%20proteins\"><em>[60]<\/em><\/a>\u3002\u6700\u540e\uff0c\u5728\u7279\u5b9a\u4e9a\u7fa4\u5982ALT\u9633\u6027\u80bf\u7624\uff0cATAD5\u529f\u80fd\u72b6\u6001\u53ef\u80fd\u5f71\u54cd\u7aef\u7c92\u7ef4\u6301\u7597\u6cd5\u7684\u6548\u679c\u2014\u2014\u82e5ATAD5\u4f4e\uff0c\u5219\u8fd9\u4e9b\u80bf\u7624\u4f9d\u8d56ALT\uff0c\u6216\u8bb8\u654f\u611f\u4e8eSLX4\u6216BIR\u901a\u8def\u7684\u6291\u5236\u5242\uff1b\u53cd\u4e4bATAD5\u9ad8\u8868\u8fbe\u7684ALT\u7624\u53ef\u80fd\u9700\u8981\u4e0d\u540c\u7b56\u7565\u3002\u8fd9\u4e9b\u8bbe\u60f3\u9700\u8981\u66f4\u591a\u4e34\u5e8a\u524d\u7814\u7a76\u9a8c\u8bc1\u3002\u4f46\u53ef\u4ee5\u9884\u89c1\uff0c<strong>\u56f4\u7ed5<\/strong><strong>ATAD5<\/strong><strong>\u901a\u8def\u7684\u7cbe\u786e\u533b\u7597\u7b56\u7565<\/strong>\u5c06\u4e0d\u65ad\u6d8c\u73b0\uff0c\u5176\u6838\u5fc3\u601d\u60f3\u662f\u5728\u4e86\u89e3\u80bf\u7624\u7ec6\u80de\u57fa\u56e0\u7ec4\u7a33\u5b9a\u6027\u201c\u963f\u5580\u7409\u65af\u4e4b\u8e35\u201d\u7684\u57fa\u7840\u4e0a\uff0c\u5b9e\u73b0\u66f4\u6709\u9488\u5bf9\u6027\u7684\u6253\u51fb\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><a>\u6700\u8fd12<\/a>\u20133\u5e74\u91cd\u8981\u7814\u7a76\u8bba\u6587\u6982\u89c8<\/h2>\n\n\n\n<p>\u8fd1\u5e74\u6765\u591a\u9879\u53d1\u8868\u5728\u9ad8\u5f71\u54cd\u529b\u671f\u520a\u7684\u7814\u7a76\u663e\u8457\u62d3\u5c55\u4e86\u6211\u4eec\u5bf9ATAD5\u7684\u8ba4\u8bc6\uff0c\u4ee5\u4e0b\u6458\u53d6\u51e0\u9879\u5177\u6709\u4ee3\u8868\u6027\u7684\u6210\u679c\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u590d\u5236\u53c9\u7a33\u5b9a\u4e0e\u91cd\u542f (2019, <em>Nature Communications<\/em>):<\/strong> Park\u7b49\u62a5\u9053\uff0cATAD5\u4f5c\u4e3a<strong>PCNA<\/strong><strong>\u5378\u8f7d\u9176<\/strong>\u5728\u590d\u5236\u53d7\u963b\u65f6\u53d1\u6325\u5173\u952e\u4f5c\u7528\u3002ATAD5\u7f3a\u5931\u4f1a\u5bfc\u81f4\u590d\u5236\u53c9\u65e0\u6cd5\u6b63\u5e38\u505c\u987f\u548c\u5012\u9000\uff0c\u9020\u6210\u57fa\u56e0\u7ec4\u4e0d\u7a33\u5b9a\uff1b\u76f8\u53cd\uff0c\u6709ATAD5\u65f6\uff0cPCNA\u88ab\u53ca\u65f6\u5378\u9664\uff0cRAD51\u5f97\u4ee5\u62db\u52df\u5230\u53d7\u635f\u590d\u5236\u53c9\u4fc3\u8fdb\u53c9\u56de\u5f52\uff0c\u4ece\u800c\u5b9e\u73b0\u590d\u5236\u53c9\u7684\u4fdd\u62a4\u4e0e\u91cd\u542f<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=Maintaining%20stability%20of%20replication%20forks,slowdown%20of%20fork%20progression%20and\"><em>[22]<\/em><\/a><a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=multiple%20functions%20at%20stalled%20forks,important%20role%20of%20ATAD5%20in\"><em>[31]<\/em><\/a>\u3002\u8be5\u7814\u7a76\u9996\u6b21\u76f4\u63a5\u8bc1\u660e\u4e86ATAD5\u5728\u590d\u5236\u5e94\u6fc0\u4e0b\u7ef4\u62a4\u53c9\u7a33\u5b9a\u3001\u9632\u6b62\u67d3\u8272\u4f53\u5d29\u88c2\u7684\u529f\u80fd\u673a\u5236\u3002<\/li>\n\n\n\n<li><strong>R-loop<\/strong><strong>\u6291\u5236 (2020, <em>Nucleic Acids Research<\/em>):<\/strong> Kim\u7b49\u53d1\u73b0\uff0cATAD5\u80fd\u591f<strong>\u9650\u5236<\/strong><strong>R-loop<\/strong><strong>\u5f62\u6210<\/strong>\uff0c\u7ef4\u62a4\u8f6c\u5f55-\u590d\u5236\u534f\u8c03<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32542338\/#:~:text=,normal%20and%20replication%20stress%20conditions\"><em>[36]<\/em><\/a>\u3002\u4ed6\u4eec\u63ed\u793aATAD5\u901a\u8fc7UAF1\u63d0\u9ad8\u4e86\u4e00\u4e9bRNA\u89e3\u65cb\u9176\u6c34\u5e73\u6765\u5e2e\u52a9<strong>\u6e05\u9664\u5df2\u6709<\/strong><strong>R-loop<\/strong>\uff0c\u540c\u65f6ATAD5\u5378\u8f7dPCNA\u9632\u6b62\u65b0\u7684R-loop\u5728\u590d\u5236\u540e\u4ea7\u751f<a href=\"https:\/\/ngdc.cncb.ac.cn\/openlb\/publication\/OLB-PM-32542338#:~:text=,which%2C%20otherwise%2C%20accumulates%20and\"><em>[37]<\/em><\/a>\u3002ATAD5\u6572\u9664\u7ec6\u80de\u4e2dR-loop\u663e\u8457\u79ef\u7d2f\u5e76\u51fa\u73b0\u590d\u5236\u51cf\u7f13\uff0c\u5f3a\u8c03ATAD5\u5728\u9632\u6b62DNA\/RNA\u6742\u4ea4\u5bfc\u81f4\u7684\u57fa\u56e0\u7ec4\u4e0d\u7a33\u4e2d\u4e0d\u53ef\u6216\u7f3a\u3002<\/li>\n\n\n\n<li><strong>\u540c\u6e90\u91cd\u7ec4\u7aef\u5207\u5904\u7406 (2023, <em>Nucleic Acids Research<\/em>):<\/strong> Park\u7b49\u7684\u7814\u7a76\u805a\u7126\u4e8e\u53cc\u94fe\u65ad\u88c2\u7684\u540c\u6e90\u91cd\u7ec4\u4fee\u590d\u8d77\u59cb\u9636\u6bb5\u3002\u4ed6\u4eec\u62a5\u9053<strong>\u77ed\u7a0b\u672b\u7aef\u5207\u9664\u9700\u8981<\/strong><strong>ATAD5<\/strong><strong>\u4ecb\u5bfc\u7684PCNA<\/strong><strong>\u5378\u8f7d<\/strong>\u624d\u80fd\u9ad8\u6548\u8fdb\u884c<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37739427\/#:~:text=...%20pubmed.ncbi.nlm.nih.gov%20%20Short,10535\"><em>[34]<\/em><\/a>\u3002ATAD5\u7f3a\u5931\u7ec6\u80de\u5728\u8bf1\u5bfcDNA\u65ad\u88c2\u540e\u5448\u73b0\u7aef\u9000\u706b\u53d7\u635f\u548c\u540c\u6e90\u91cd\u7ec4\u6548\u7387\u964d\u4f4e\u7684\u8868\u578b\u3002\u8fd9\u4e00\u7ed3\u679c\u5c06ATAD5\u4e0eHR\u4fee\u590d\u76f4\u63a5\u5173\u8054\u8d77\u6765\uff0c\u8868\u660eATAD5\u6709\u52a9\u4e8e\u4e3aMRN\u590d\u5408\u7269\u7b49\u6838\u9178\u5916\u5207\u9176\u6e05\u7406\u65ad\u53e3\u73af\u5883\uff0c\u4ee5\u4fdd\u969c\u7cbe\u51c6\u7684DNA\u4fee\u590d\u3002<\/li>\n\n\n\n<li><strong>ATAD5<\/strong><strong>\u529f\u80fd\u8c03\u63a7 \u2013 BAZ1B<\/strong><strong>\u56e0\u5b50 (2024, <em>Nature Communications<\/em>):<\/strong> \u6765\u81eaMyung\u8bfe\u9898\u7ec4\u7684\u65b0\u53d1\u73b0\uff0cKim\u7b49\u63ed\u793a\u4e86<strong>BAZ1B-ATAD5<\/strong><strong>\u76f8\u4e92\u4f5c\u7528<\/strong>\u5728\u8c03\u8282PCNA\u53bb\u6cdb\u7d20\u5316\u4e2d\u7684\u4f5c\u7528<a href=\"https:\/\/www.nature.com\/articles\/s41467-024-55005-3?error=cookies_not_supported&amp;code=47f8f193-4049-4741-8361-2af5617ac35c#:~:text=ubiquitination,ubiquitination%2C%20thereby%20safeguarding%20genome%20integrity\"><em>[20]<\/em><\/a>\u3002ATAD5\u4e0e\u67d3\u8272\u8d28\u56e0\u5b50BAZ1B\u7ed3\u5408\u4ee5\u5ef6\u8fdfUSP1\u5bf9PCNA\u7684\u53bb\u6cdb\u7d20\u3002\u5f53\u8fd9\u4e00\u4e92\u52a8\u88ab\u7834\u574f\u65f6\uff0c\u7ec6\u80de\u5728\u6c27\u5316\u538b\u529b\u4e0b\u51fa\u73b0PCNA\u8fc7\u65e9\u53bb\u6cdb\u7d20\u5316\uff0c\u5bfc\u81f4\u57fa\u56e0\u7ec4\u635f\u4f24\u79ef\u7d2f\u548c\u7ec6\u80de\u5b58\u6d3b\u7387\u4e0b\u964d<a href=\"https:\/\/www.nature.com\/articles\/s41467-024-55005-3?error=cookies_not_supported&amp;code=47f8f193-4049-4741-8361-2af5617ac35c#:~:text=subunit%20of%20the%20BAZ1B,ubiquitination%2C%20thereby%20safeguarding%20genome%20integrity\"><em>[21]<\/em><\/a>\u3002\u8fd9\u4e00\u7814\u7a76\u63d0\u4f9b\u4e86ATAD5\u6d3b\u6027\u8c03\u63a7\u7684\u65b0\u5c42\u6b21\uff0c\u5373<strong>\u67d3\u8272\u8d28\u73af\u5883\u56e0\u5b50\u53ef\u4ee5\u5f71\u54cd<\/strong><strong>ATAD5<\/strong><strong>\u7684\u65f6\u7a7a\u4f5c\u7528<\/strong>\uff0c\u63d0\u793a\u5728\u4e0d\u540c\u751f\u7406\u6761\u4ef6\u4e0bATAD5\u529f\u80fd\u53ef\u80fd\u53d7\u5230\u7ec6\u80de\u80cc\u666f\u7684\u7cbe\u7ec6\u63a7\u5236\u3002<\/li>\n\n\n\n<li><strong>ATAD5<\/strong><strong>\u4f5c\u4e3a\u53bb\u6cdb\u7d20\u5316\u5e73\u53f0 (2024, <em>PNAS<\/em>):<\/strong> Ryu\u7b49\u8be6\u7ec6\u89e3\u6790\u4e86ATAD5<strong>\u8bc6\u522b\u5e76\u88c5\u914dUb-PCNA<\/strong><strong>\u8fdb\u884c\u53bb\u6cdb\u7d20\u5316<\/strong>\u7684\u5206\u5b50\u673a\u5236<a href=\"https:\/\/www.researchgate.net\/figure\/ATAD5-recognizes-Ub-PCNA-for-deubiquitination-A-ATAD5-1-to-500-binds-to-Ub-PCNA_fig2_383154647#:~:text=for%20regulating%20DNA%20lesion%20bypass,unloading%20complex%2C%20functi\"><em>[17]<\/em><\/a>\u3002\u4ed6\u4eec\u53d1\u73b0ATAD5 N\u7aef\u542b\u6709\u7279\u5b9a\u57fa\u5e8f\u76f4\u63a5\u7ed3\u5408Ub-PCNA\uff0c\u5e76\u5c06USP1-UAF1\u9176\u590d\u5408\u7269\u62db\u52df\u5230PCNA\u9644\u8fd1\uff0c\u4ece\u800c\u5b9e\u73b0PCNA\u53bb\u6cdb\u7d20\u5316\u4e0e\u5378\u8f7d\u7684\u7d27\u5bc6\u8026\u5408<a href=\"https:\/\/www.researchgate.net\/figure\/ATAD5-recognizes-Ub-PCNA-for-deubiquitination-A-ATAD5-1-to-500-binds-to-Ub-PCNA_fig2_383154647#:~:text=binds%20to%20Ub,n%20%3D%203\"><em>[18]<\/em><\/a><a href=\"https:\/\/www.researchgate.net\/figure\/ATAD5-recognizes-Ub-PCNA-for-deubiquitination-A-ATAD5-1-to-500-binds-to-Ub-PCNA_fig2_383154647#:~:text=ATAD5%20recognizes%20Ub,n%20%3D%203\"><em>[19]<\/em><\/a>\u3002\u901a\u8fc7\u7a81\u53d8\u5206\u6790\u8bc1\u660e\uff0c\u5982\u679cATAD5\u4e0d\u80fd\u6709\u6548\u7ed3\u5408Ub-PCNA\uff0cPCNA\u7684\u53bb\u6cdb\u7d20\u5316\u4f1a\u660e\u663e\u5ef6\u8fdf\uff0c\u7ec6\u80de\u5bf9DNA\u635f\u4f24\u5242\u7684\u6297\u6027\u964d\u4f4e<a href=\"https:\/\/www.researchgate.net\/figure\/ATAD5-recognizes-Ub-PCNA-for-deubiquitination-A-ATAD5-1-to-500-binds-to-Ub-PCNA_fig2_383154647#:~:text=that%20is%20coisolated%20with%20ATAD5,n%20%3D%203\"><em>[61]<\/em><\/a><a href=\"https:\/\/www.cancer-research-network.com\/2019\/08\/03\/ml367-is-an-atad5-stabilization-inhibitor\/#:~:text=in%20HEK293T%20cells,lack%20DNA%20damage%20repair%20proteins\"><em>[60]<\/em><\/a>\u3002\u6b64\u9879\u5de5\u4f5c\u5de9\u56fa\u4e86ATAD5\u5728DNA\u635f\u4f24\u5bb9\u5fcd\u540e\u9636\u6bb5\u7684\u4e2d\u5fc3\u5730\u4f4d\uff0c\u5373\u5145\u5f53\u652f\u67b6\u786e\u4fdd\u201c\u505c\u6b62TLS\u4fe1\u53f7\u3001\u6062\u590d\u6b63\u5e38\u590d\u5236\u201d\u8fd9\u4e00\u8f6c\u6362\u8fc7\u7a0b\u987a\u5229\u5b8c\u6210\u3002<\/li>\n\n\n\n<li><strong>PCNA<\/strong><strong>\u6cdb\u7d20\u5316\u4e0e\u7aef\u7c92ALT<\/strong><strong>\u901a\u8def (2024, <em>Nucleic Acids Research<\/em>):<\/strong> Sangin Kim\u7b49\u7814\u7a76\u4e86\u6ca1\u6709\u7aef\u7c92\u9176\u7684ALT\u578b\u764c\u7ec6\u80de\u7ef4\u6301\u7aef\u7c92\u7684\u673a\u5236\uff0c\u53d1\u73b0<strong>PCNA<\/strong><strong>\u591a\u6cdb\u7d20\u5316-<\/strong><strong>\u9a71\u52a8\u7684BIR<\/strong><strong>\u673a\u5236<\/strong>\u5728ALT\u4e2d\u626e\u6f14\u5173\u952e\u89d2\u8272<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39291733\/#:~:text=Replication%20stresses%20are%20the%20major,dependent%20manner\"><em>[48]<\/em><\/a>\u3002\u590d\u5236\u5e94\u6fc0\u53ef\u4ee5\u5f15\u53d1PCNA\u53d1\u751fK63\u94fe\u591a\u6cdb\u7d20\u5316\uff0c\u8fdb\u800c\u62db\u52dfSLX4\u6838\u9178\u9176\u590d\u5408\u7269\u5728\u635f\u4f24\u4f4d\u70b9\u89e6\u53d1\u65ad\u88c2\u8bf1\u5bfc\u7684\u590d\u5236(BIR)\u3002\u5728ALT&lt;sup>+&lt;\/sup>\u80bf\u7624\u7ec6\u80de\u4e2d\uff0c\u8fd9\u4e00\u9014\u5f84\u7279\u522b\u6d3b\u8dc3\u3002\u4f5c\u8005\u8fdb\u4e00\u6b65\u6307\u51fa\uff1a\u6291\u5236PCNA\u53bb\u6cdb\u7d20\u5316\u7684\u56e0\u7d20\uff08\u5982USP1\u6291\u5236\u6216ATAD5\u7f3a\u5931\uff09\u4f1a<strong>\u589e\u5f3a<\/strong><strong>ALT<\/strong><strong>\u8868\u578b<\/strong>\uff0c\u5305\u62ec\u66f4\u591a\u7684APB\uff08ALT\u76f8\u5173PML\u6838\u4f53\uff09\u5f62\u6210\u548c\u7aef\u7c92\u5904\u7684\u5f02\u5e38DNA\u5408\u6210<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39291733\/#:~:text=%28CFS%29,scaffold%2C%20at%20telomeres%20through%20its\"><em>[62]<\/em><\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39291733\/#:~:text=deubiquitinating%20enzyme%2C%20results%20in%20an,a%20trigger%20for%20directing%20BIR\"><em>[50]<\/em><\/a>\u3002\u8fd9\u9879\u7814\u7a76\u63d0\u793aATAD5\u901a\u8fc7\u9650\u5236PCNA\u591a\u6cdb\u7d20\u5316\u7d2f\u79ef\uff0c<strong>\u5728\u6291\u5236\u8fc7\u5ea6\u7684\u7aef\u7c92\u91cd\u7ec4\u65b9\u9762\u6709\u91cd\u8981\u4f5c\u7528<\/strong>\uff0c\u4e3a\u7406\u89e3ALT\u80bf\u7624\u7684\u6cbb\u7597\u5e72\u9884\u63d0\u4f9b\u4e86\u65b0\u601d\u8def\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u603b\u7ed3\uff1a<\/strong>\u8fd12\u20133\u5e74\u7684\u7814\u7a76\u663e\u8457\u52a0\u6df1\u4e86\u6211\u4eec\u5bf9ATAD5\u5728\u57fa\u56e0\u7ec4\u7ef4\u62a4\u4e2d\u7684\u591a\u7ef4\u5ea6\u4f5c\u7528\u7684\u7406\u89e3\u3002\u4ece\u590d\u5236\u53c9\u4fdd\u62a4\u3001PCNA\u5378\u8f7d\u4e0e\u53bb\u6cdb\u7d20\u5316\uff0c\u5230\u6291\u5236R-loop\u548c\u5f02\u5e38\u91cd\u7ec4\uff0c\u8fd9\u4e9b\u53d1\u73b0\u7ed8\u5c31\u4e86ATAD5\u4f5c\u4e3a<strong>\u201c\u57fa\u56e0\u7ec4\u5b88\u95e8\u4eba\u201d<\/strong>\u7684\u5168\u8c8c<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=tumors13%20,from%20DNA%20upon%20its%20successful\"><em>[42]<\/em><\/a>\u3002ATAD5\u65e2\u901a\u8fc7\u81ea\u8eab\u9176\u6d3b\u76f4\u63a5\u7ef4\u62a4\u590d\u5236\u5b8c\u6574\u6027\uff0c\u53c8\u4f5c\u4e3a\u652f\u67b6\u6574\u5408\u53bb\u6cdb\u7d20\u5316\u9176\u548c\u89e3\u65cb\u9176\u7b49\u6765\u534f\u8c03DNA\u635f\u4f24\u6062\u590d\u3002\u5176\u5728\u591a\u79cd\u80bf\u7624\u4e2d\u7684\u6291\u764c\u4f5c\u7528\u4e5f\u5f97\u5230\u9057\u4f20\u548c\u529f\u80fd\u6570\u636e\u7684\u652f\u6491\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u8fd9\u4e9b\u7814\u7a76\u4e3a<strong>\u5c06<\/strong><strong>ATAD5<\/strong><strong>\u901a\u8def\u5f15\u5165\u4e34\u5e8a\u9776\u5411<\/strong>\u94fa\u5e73\u4e86\u9053\u8def\uff1a\u4e0d\u8bba\u662f\u5c06ATAD5\u7f3a\u9677\u4f5c\u4e3a\u6cbb\u7597\u7b56\u7565\u7684\u5207\u5165\u70b9\uff0c\u8fd8\u662f\u5f00\u53d1\u9488\u5bf9ATAD5\u590d\u5408\u7269\u7684\u836f\u7269\uff0c\u5747\u5c55\u73b0\u51fa\u7cbe\u51c6\u533b\u7597\u7684\u5e94\u7528\u6f5c\u529b\u3002\u53ef\u4ee5\u9884\u671f\uff0c\u968f\u7740\u7814\u7a76\u7684\u63a8\u8fdb\uff0cATAD5\u5c06\u4ece\u5b9e\u9a8c\u5ba4\u8d70\u5411\u4e34\u5e8a\uff0c\u6210\u4e3a\u63d0\u5347\u6297\u764c\u7597\u6548\u3001\u4fdd\u969c\u57fa\u56e0\u7ec4\u7a33\u5b9a\u6027\u7684\u5173\u952e\u4e00\u73af\u3002<a href=\"https:\/\/academic.oup.com\/nar\/article\/49\/20\/11746\/6414590#:~:text=,4939\"><em>[51]<\/em><\/a><a href=\"https:\/\/www.cancer-research-network.com\/2019\/08\/03\/ml367-is-an-atad5-stabilization-inhibitor\/#:~:text=in%20HEK293T%20cells,lack%20DNA%20damage%20repair%20proteins\"><em>[60]<\/em><\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><a><\/a><a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=ATAD5%20is%20important%20for%20maintaining,We\"><em>[1]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=the%20ATAD5%20locus%20confers%20enhanced,bypass%20pathway%20by%20recruiting%20the\"><em>[2]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=replication%20factor%20C%20%28RFC%29,It%20is%20still%20unclear\"><em>[3]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=ATAD5,starting%20with%20RAD51%20recruitment%20and\"><em>[9]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=replication%20during%20the%20S%20phase,role%20as%20a%20tumor%20suppressor\"><em>[16]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=Maintaining%20stability%20of%20replication%20forks,slowdown%20of%20fork%20progression%20and\"><em>[22]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=However%2C%20it%20is%20not%20clear,mechanical%20barrier%20to%20fork%20regression\"><em>[23]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=delivery%20of%20genetic%20information%20during,restored%20by%20fork%20reversal%20enzymes\"><em>[24]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=Many%20homologous%20recombination%20,s\"><em>[25]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=regulating%20activity%20of%20ATAD5%20might,RAD51%20recruitment%20to%20stalled%20forks\"><em>[26]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=under%20replication%20stress,dependent\"><em>[27]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=stress.%20We%20find%20that%20ATAD5,RAD51%20recruitment%20to%20stalled%20forks\"><em>[28]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=in%20fork%20regression%2C%20ATAD5%20depletion,restart%20are%20reduced%20by%20ATAD5\"><em>[29]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=match%20at%20L182%20unloading%20by,genome%20stability%2C%20therefore%2C%20extends%20beyond\"><em>[30]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=multiple%20functions%20at%20stalled%20forks,important%20role%20of%20ATAD5%20in\"><em>[31]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=match%20at%20L96%20depletion,genome%20integrity%20during%20replication%20stress\"><em>[32]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=multiple%20functions%20at%20stalled%20forks,restart%20are%20reduced%20by%20ATAD5\"><em>[33]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=underscored%20by%20the%20fact%20that,functions%20of%20the%20eukaryotic%20DNA\"><em>[40]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=13,7%2C%20e1002245%20%282011\"><em>[41]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=tumors13%20,from%20DNA%20upon%20its%20successful\"><em>[42]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=14,376%2C%20173%E2%80%93177%20%282016\"><em>[43]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&amp;code=98011ae5-1706-4887-95fe-071afc5bd6a7#:~:text=15,47%2C%20164%E2%80%93171%20%282015\"><em>[47]<\/em><\/a> ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress | Nature Communications<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/www.nature.com\/articles\/s41467-019-13667-4?error=cookies_not_supported&#038;code=98011ae5-1706-4887-95fe-071afc5bd6a7\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41594-024-01332-4?error=cookies_not_supported&amp;code=f34d4a1d-769f-49a0-ae4b-3d6f70386c4d#:~:text=is%20a%20large%20protein%20with,an%20extended%20lifespan%20for%20DNA\"><em>[4]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41594-024-01332-4?error=cookies_not_supported&amp;code=f34d4a1d-769f-49a0-ae4b-3d6f70386c4d#:~:text=PCNA%20loaders%20also%20unload%20PCNA,that%20is%20crucial%20for%20PCNA\"><em>[5]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41594-024-01332-4?error=cookies_not_supported&amp;code=f34d4a1d-769f-49a0-ae4b-3d6f70386c4d#:~:text=revealed%20that%20it%20unloads%20PCNA,RFC%E2%80%93PCNA%20from%20DNA16\"><em>[6]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41594-024-01332-4?error=cookies_not_supported&amp;code=f34d4a1d-769f-49a0-ae4b-3d6f70386c4d#:~:text=machine,in%20a%20human%20cell%2037%2C12\"><em>[7]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41594-024-01332-4?error=cookies_not_supported&amp;code=f34d4a1d-769f-49a0-ae4b-3d6f70386c4d#:~:text=hydrolysis9%20%2C%2036%2C11%20,in%20a%20human%20cell%2037%2C12\"><em>[8]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41594-024-01332-4?error=cookies_not_supported&amp;code=f34d4a1d-769f-49a0-ae4b-3d6f70386c4d#:~:text=specific,loaded\"><em>[10]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41594-024-01332-4?error=cookies_not_supported&amp;code=f34d4a1d-769f-49a0-ae4b-3d6f70386c4d#:~:text=region%20,RFC%E2%80%93PCNA%20from%20DNA16\"><em>[11]<\/em><\/a> The human ATAD5 has evolved unique structural elements to function exclusively as a PCNA unloader | Nature Structural &amp; Molecular Biology<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/www.nature.com\/articles\/s41594-024-01332-4?error=cookies_not_supported&#038;code=f34d4a1d-769f-49a0-ae4b-3d6f70386c4d\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41467-024-55005-3?error=cookies_not_supported&amp;code=47f8f193-4049-4741-8361-2af5617ac35c#:~:text=Mono,binding\"><em>[12]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41467-024-55005-3?error=cookies_not_supported&amp;code=47f8f193-4049-4741-8361-2af5617ac35c#:~:text=During%20unchallenged%20DNA%20synthesis%2C%20PCNA,RAD18\"><em>[13]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41467-024-55005-3?error=cookies_not_supported&amp;code=47f8f193-4049-4741-8361-2af5617ac35c#:~:text=Abstract\"><em>[14]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41467-024-55005-3?error=cookies_not_supported&amp;code=47f8f193-4049-4741-8361-2af5617ac35c#:~:text=and%20error,activities%2C%20respectively%2057%2C29%20%2C%2059%2C31\"><em>[15]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41467-024-55005-3?error=cookies_not_supported&amp;code=47f8f193-4049-4741-8361-2af5617ac35c#:~:text=ubiquitination,ubiquitination%2C%20thereby%20safeguarding%20genome%20integrity\"><em>[20]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41467-024-55005-3?error=cookies_not_supported&amp;code=47f8f193-4049-4741-8361-2af5617ac35c#:~:text=subunit%20of%20the%20BAZ1B,ubiquitination%2C%20thereby%20safeguarding%20genome%20integrity\"><em>[21]<\/em><\/a> <a href=\"https:\/\/www.nature.com\/articles\/s41467-024-55005-3?error=cookies_not_supported&amp;code=47f8f193-4049-4741-8361-2af5617ac35c#:~:text=translesion%20synthesis%20,RFC2%E2%80%935\"><em>[35]<\/em><\/a> ATAD5-BAZ1B interaction modulates PCNA ubiquitination during DNA repair | Nature Communications<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/www.nature.com\/articles\/s41467-024-55005-3?error=cookies_not_supported&#038;code=47f8f193-4049-4741-8361-2af5617ac35c\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/www.researchgate.net\/figure\/ATAD5-recognizes-Ub-PCNA-for-deubiquitination-A-ATAD5-1-to-500-binds-to-Ub-PCNA_fig2_383154647#:~:text=for%20regulating%20DNA%20lesion%20bypass,unloading%20complex%2C%20functi\"><em>[17]<\/em><\/a> <a href=\"https:\/\/www.researchgate.net\/figure\/ATAD5-recognizes-Ub-PCNA-for-deubiquitination-A-ATAD5-1-to-500-binds-to-Ub-PCNA_fig2_383154647#:~:text=binds%20to%20Ub,n%20%3D%203\"><em>[18]<\/em><\/a> <a href=\"https:\/\/www.researchgate.net\/figure\/ATAD5-recognizes-Ub-PCNA-for-deubiquitination-A-ATAD5-1-to-500-binds-to-Ub-PCNA_fig2_383154647#:~:text=ATAD5%20recognizes%20Ub,n%20%3D%203\"><em>[19]<\/em><\/a> <a href=\"https:\/\/www.researchgate.net\/figure\/ATAD5-recognizes-Ub-PCNA-for-deubiquitination-A-ATAD5-1-to-500-binds-to-Ub-PCNA_fig2_383154647#:~:text=that%20is%20coisolated%20with%20ATAD5,n%20%3D%203\"><em>[61]<\/em><\/a> ATAD5 recognizes Ub-PCNA for deubiquitination. (A) ATAD5 (1 to 500)&#8230; | Download Scientific Diagram<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/www.researchgate.net\/figure\/ATAD5-recognizes-Ub-PCNA-for-deubiquitination-A-ATAD5-1-to-500-binds-to-Ub-PCNA_fig2_383154647\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37739427\/#:~:text=...%20pubmed.ncbi.nlm.nih.gov%20%20Short,10535\"><em>[34]<\/em><\/a> Short-range end resection requires ATAD5-mediated PCNA &#8230;<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/pubmed.ncbi.nlm.nih.gov\/37739427\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32542338\/#:~:text=,normal%20and%20replication%20stress%20conditions\"><em>[36]<\/em><\/a> ATAD5 restricts R-loop formation through PCNA unloading and RNA &#8230;<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/pubmed.ncbi.nlm.nih.gov\/32542338\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/ngdc.cncb.ac.cn\/openlb\/publication\/OLB-PM-32542338#:~:text=,which%2C%20otherwise%2C%20accumulates%20and\"><em>[37]<\/em><\/a> ATAD5 restricts R-loop formation through PCNA unloading and RNA &#8230;<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/ngdc.cncb.ac.cn\/openlb\/publication\/OLB-PM-32542338\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/academic.oup.com\/nar\/article-pdf\/48\/13\/7218\/33507731\/gkaa501.pdf#:~:text=First%2C%20RNA%20processing%20proteins%20limit,Sec\"><em>[38]<\/em><\/a> ATAD5 restricts R-loop formation through PCNA unloading and RNA &#8230;<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/academic.oup.com\/nar\/article-pdf\/48\/13\/7218\/33507731\/gkaa501.pdf\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/www.researchgate.net\/figure\/Depletion-of-ATAD5UAF1-interacting-RNA-helicases-reduces-DNA-replication-rate-A-B-D_fig8_342244232#:~:text=Depletion%20of%20ATAD5%2FUAF1,U2OS%20cells%20were%20transfected\"><em>[39]<\/em><\/a> Depletion of ATAD5\/UAF1-interacting RNA helicases reduces DNA&#8230;<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/www.researchgate.net\/figure\/Depletion-of-ATAD5UAF1-interacting-RNA-helicases-reduces-DNA-replication-rate-A-B-D_fig8_342244232\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/www.researchgate.net\/figure\/TOP2A-and-ATAD5-mRNA-expression-correlates-with-BRCA1-mRNA-expression-in-BC-and-CRC_fig5_354909991#:~:text=TOP2A%20and%20ATAD5%20mRNA%20expression,with%20BRCA1%20expression%20in%20CRC\"><em>[44]<\/em><\/a> TOP2A and ATAD5 mRNA expression correlates with BRCA1 mRNA&#8230;<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/www.researchgate.net\/figure\/TOP2A-and-ATAD5-mRNA-expression-correlates-with-BRCA1-mRNA-expression-in-BC-and-CRC_fig5_354909991\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6407520\/#:~:text=A%20novel%204,H%20CRC.%20Future\"><em>[45]<\/em><\/a> A novel 4-gene prognostic signature for hypermutated colorectal &#8230;<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6407520\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/www.oncotarget.com\/news\/pr\/brca1-mrna-expression-in-breast-and-colorectal-cancer\/#:~:text=Oncotarget%3A%20BRCA1%20mRNA%20expression%20in,expression%20correlates%20with%20BRCA1\"><em>[46]<\/em><\/a> Oncotarget: BRCA1 mRNA expression in breast and colorectal cancer<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/www.oncotarget.com\/news\/pr\/brca1-mrna-expression-in-breast-and-colorectal-cancer\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39291733\/#:~:text=Replication%20stresses%20are%20the%20major,dependent%20manner\"><em>[48]<\/em><\/a> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39291733\/#:~:text=Furthermore%2C%20deficiency%20of%20ATAD5%2C%20which,a%20trigger%20for%20directing%20BIR\"><em>[49]<\/em><\/a> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39291733\/#:~:text=deubiquitinating%20enzyme%2C%20results%20in%20an,a%20trigger%20for%20directing%20BIR\"><em>[50]<\/em><\/a> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39291733\/#:~:text=%28CFS%29,scaffold%2C%20at%20telomeres%20through%20its\"><em>[62]<\/em><\/a> Polyubiquitinated PCNA triggers SLX4-mediated break-induced replication in alternative lengthening of telomeres (ALT) cancer cells &#8211; PubMed<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/pubmed.ncbi.nlm.nih.gov\/39291733\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/academic.oup.com\/nar\/article\/49\/20\/11746\/6414590#:~:text=,4939\"><em>[51]<\/em><\/a> Timely termination of repair DNA synthesis by ATAD5 is important in &#8230;<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/academic.oup.com\/nar\/article\/49\/20\/11746\/6414590\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/www.researchgate.net\/figure\/Differential-effect-of-ATAD5-depletion-on-chemical-sensitivity-of-A2780-cells-Knock-down_fig1_340717490#:~:text=,Sara%20Giovannini\"><em>[52]<\/em><\/a> Differential effect of ATAD5 depletion on chemical sensitivity of &#8230;<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/www.researchgate.net\/figure\/Differential-effect-of-ATAD5-depletion-on-chemical-sensitivity-of-A2780-cells-Knock-down_fig1_340717490\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32297953\/#:~:text=,agents%20that%20hinder%20the\"><em>[53]<\/em><\/a> ATAD5 deficiency alters DNA damage metabolism and sensitizes &#8230;<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/pubmed.ncbi.nlm.nih.gov\/32297953\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/www.oncologynewscentral.com\/article\/dual-inhibition-of-parp-and-atr-feasible-early-trials-suggest#:~:text=Dual%20Inhibition%20of%20PARP%20and,catastrophe%20and%20unscheduled%20mitosis\"><em>[54]<\/em><\/a> Dual Inhibition of PARP and ATR Feasible, Early Trials Suggest<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/www.oncologynewscentral.com\/article\/dual-inhibition-of-parp-and-atr-feasible-early-trials-suggest\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/www.mdpi.com\/2072-6694\/12\/5\/1095#:~:text=ATR%20Inhibition%20Potentiates%20PARP%20Inhibitor,\"><em>[55]<\/em><\/a> ATR Inhibition Potentiates PARP Inhibitor Cytotoxicity in High Risk &#8230;<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/www.mdpi.com\/2072-6694\/12\/5\/1095\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/www.cancer-research-network.com\/2019\/08\/03\/ml367-is-an-atad5-stabilization-inhibitor\/#:~:text=Researchers%20carried%20out%20a%20quantitative,an%20inhibitor%20of%20ATAD5%20stabilization\"><em>[56]<\/em><\/a> <a href=\"https:\/\/www.cancer-research-network.com\/2019\/08\/03\/ml367-is-an-atad5-stabilization-inhibitor\/#:~:text=ML367%20is%20a%20probe%20molecule%2C,in%20blocking%20DNA%20repair%20pathways\"><em>[57]<\/em><\/a> <a href=\"https:\/\/www.cancer-research-network.com\/2019\/08\/03\/ml367-is-an-atad5-stabilization-inhibitor\/#:~:text=Image\"><em>[58]<\/em><\/a> <a href=\"https:\/\/www.cancer-research-network.com\/2019\/08\/03\/ml367-is-an-atad5-stabilization-inhibitor\/#:~:text=In%20addition%2C%20ML367%20displays%20excellent,lack%20DNA%20damage%20repair%20proteins\"><em>[59]<\/em><\/a> <a href=\"https:\/\/www.cancer-research-network.com\/2019\/08\/03\/ml367-is-an-atad5-stabilization-inhibitor\/#:~:text=in%20HEK293T%20cells,lack%20DNA%20damage%20repair%20proteins\"><em>[60]<\/em><\/a> ML367 is an ATAD5 Stabilization Inhibitor &#8211; Network of Cancer Research<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/www.cancer-research-network.com\/2019\/08\/03\/ml367-is-an-atad5-stabilization-inhibitor\n<\/div><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>\u8fd9\u7bc7\u7efc\u8ff0\u7cfb\u7edf\u68b3\u7406\u4e86ATAD5\u57fa\u56e0\u4f5c\u4e3a\u5173\u952ePCNA\u5378\u8f7d\u9176\u5728\u7ef4\u6301\u57fa\u56e0\u7ec4\u7a33\u5b9a\u6027\u4e2d\u7684\u6838\u5fc3\u4f5c\u7528\u3002\u6587\u7ae0\u8be6\u7ec6\u9610\u8ff0\u4e86\u5176\u901a\u8fc7\u8c03\u63a7PCNA\u5faa\u73af\u3001\u534f\u8c03DNA\u635f\u4f24\u5e94\u7b54\u3001\u6291\u5236R-loop\u5f62\u6210\u7b49\u591a\u91cd\u673a\u5236\uff0c\u5728\u590d\u5236\u5e94\u6fc0\u548c\u80bf\u7624\u6291\u5236\u4e2d\u626e\u6f14\u7684\u91cd\u8981\u89d2\u8272\uff0c\u5e76\u63a2\u8ba8\u4e86\u5176\u5728\u764c\u75c7\u4e2d\u7684\u4e34\u5e8a\u610f\u4e49\u4e0e\u7cbe\u51c6\u533b\u7597\u524d\u666f\u3002<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[18],"tags":[32],"class_list":["post-11840","post","type-post","status-publish","format-standard","hentry","category-18","tag-deep-research"],"_links":{"self":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts\/11840","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=11840"}],"version-history":[{"count":3,"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts\/11840\/revisions"}],"predecessor-version":[{"id":13786,"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts\/11840\/revisions\/13786"}],"wp:attachment":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=11840"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=11840"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=11840"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}