{"id":124,"date":"2022-10-12T01:31:00","date_gmt":"2022-10-11T17:31:00","guid":{"rendered":"http:\/\/39.105.184.3\/?p=124"},"modified":"2025-12-21T01:06:40","modified_gmt":"2025-12-20T17:06:40","slug":"%e7%94%9f%e7%89%a9%e5%ad%a6%e5%8e%86%e5%8f%b2%e6%a1%86%e6%9e%b6","status":"publish","type":"post","link":"https:\/\/fanyiming.life\/?p=124","title":{"rendered":"\u751f\u7269\u5b66\u5386\u53f2\u6846\u67b6"},"content":{"rendered":"\n

\u7ecf\u5e38\u4f1a\u5728\u4e0a\u8bfe\u548c\u8bfb\u6587\u732e\u7684\u65f6\u5019\u770b\u5230\u5386\u53f2\u4e0a\u7684\u67d0\u5e74\u67d0\u6708\u751f\u7269\u5b66\u4e0a\u6709\u4e86\u4ec0\u4e48\u53d1\u73b0\uff0c\u56e0\u4e3a\u6bd5\u7adf\u662f\u81ea\u5df1\u51fa\u751f\u4ee5\u524d\u7684\u5386\u53f2\uff0c\u6240\u4ee5\u8fd9\u4e9b\u6570\u5b57\u5e38\u5e38\u5728\u6211\u8111\u5b50\u91cc\u662f\u6ca1\u6709\u6982\u5ff5\u7684\uff0c\u65e2\u65e0\u6cd5\u8bb0\u4f4f\uff0c\u4e5f\u65e0\u6cd5\u5e26\u6765\u4fe1\u606f\u3002\u4e3a\u4e86\u6539\u53d8\u8fd9\u79cd\u72b6\u51b5\uff0c\u6211\u51b3\u5b9a\u6b7b\u8bb0\u786c\u80cc\u5c11\u6570\u51e0\u4e2a\u91cd\u8981\u7684\u65f6\u95f4\u8282\u70b9\u4f5c\u4e3a\u751f\u7269\u5b66\u53d1\u5c55\u7684\u951a\u70b9\uff0c\u4ee5\u540e\u518d\u770b\u5230\u201c\u67d0\u5e74\u67d0\u6708\u67d0\u4eba\u53d1\u73b0\u4e86\u67d0\u4e8b\u201d\u5c31\u6709\u4e86\u53c2\u7167\u4e86\u3002 <\/p>\n\n\n\n

2013\u5e74\uff0c\u5f20\u950b\u56e2\u961f\u53d1\u660e\u5728\u54fa\u4e73\u52a8\u7269\u4e2d\u7684CRISPR\/Cas9\u57fa\u56e0\u7f16\u8f91\u6280\u672f<\/p>\n\n\n\n

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Cong L, Ran FA, Cox D, Lin S, Barretto R, Habib N, Hsu PD, Wu X, Jiang W, Marraffini LA, Zhang F. Multiplex genome engineering using CRISPR\/Cas systems. Science. 2013 Feb 15;339(6121):819-23. doi: 10.1126\/science.1231143. Epub 2013 Jan 3. PMID: 23287718; PMCID: PMC3795411.<\/p>\n<\/blockquote>\n\n\n\n

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2001\u5e74\uff0c\u7b2c\u4e00\u4efd\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u8349\u56fe\uff0c\u7531\u201c\u56fd\u9645\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u201d\u548cJohn Craig Venter\u7684\u201c\u585e\u83b1\u62c9\u57fa\u56e0\u516c\u53f8\u201d\u5206\u522b\u516c\u5f00\u53d1\u8868\u3002<\/p>\n\n\n\n

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1984\u5e74\uff0c\u540c\u6e90\u5f02\u5f62\u76d2\uff08Homeobox\uff09\u88ab\u53d1\u73b0\u3002<\/p>\n\n\n\n

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1970\u5e74\uff0cLeland H. Hartwell\u7b49\u5728budding yeast\u4e2d\u7b5b\u9009\u7ec6\u80de\u5468\u671f\u76f8\u5173\u57fa\u56e0\uff0ccdc-1, cdc-2, cdc-3\u3002<\/p>\n\n\n\n

1977\u5e74\uff0csanger\u53d1\u660e\u53cc\u8131\u6c27\u7ec8\u6b62\u6cd5\u7684DNA\u6d4b\u5e8f\u6280\u672f\u3002<\/p>\n\n\n\n

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Sanger F, Nicklen S, Coulson AR (1977) DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A 74:5463\u20135467<\/p>\n<\/blockquote>\n\n\n\n

1965\u5e74\uff0c\u6240\u6709\u6c28\u57fa\u9178\u7684\u9057\u4f20\u5bc6\u7801\u7834\u8bd1\u3002<\/p>\n\n\n\n

1967\u5e74\uff0c\u5168\u90e864\u4e2a\u5bc6\u7801\u5b50\u88ab\u89e3\u7801\u3002<\/p>\n\n\n\n

1953\u5e74\uff0cJames D. Watson&Francis Crick\u53d1\u73b0DNA\u53cc\u87ba\u65cb\u7ed3\u6784<\/p>\n\n\n\n

1958\u5e74\uff0cCrick\u5728\u201c\u5b9e\u9a8c\u751f\u7269\u5b66\u4f1a\u8bae\u201d\u4e0a\u9610\u8ff0\u201c\u4e2d\u5fc3\u6cd5\u5219\u201d\u3002<\/p>\n\n\n\n

1944\u5e74\uff0cBarbara McClintock: Jumping genes<\/p>\n\n\n\n

1944\u5e74\uff0cOswald Avery, Colin MacLeod and Maclyn McCarty: DNA transforms cells (following Frederick Griffith’s transformation exp. 1928)<\/p>\n\n\n\n

1945\u5e74\uff0cFrederick Sanger\u53d1\u660e\u86cb\u767d\u8d28\u7684\u6d4b\u5e8f\u65b9\u6cd5\u3002F. Sanger, Biochem. J., 39 (1945) 507.<\/p>\n\n\n\n

1924\u5e74\uff0cHans Spemann\u548cHilde Mangold\u7efc\u5408\u82e5\u5e72\u5e74\u7684\u877e\u8788\u80da\u80ce\u5b9e\u9a8c\uff0c\u53d1\u8868\u8bba\u6587\uff0c\u63d0\u51fa\u201c\u7ec4\u7ec7\u4e2d\u5fc3\u201d\u7684\u6982\u5ff5(The organizer and the organizing center)<\/p>\n\n\n\n

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“\u2026A piece of the upper blastopore lip of an amphibian embryo undergoing gastrulation exerts an organizing effect on its environment in such a way that, if transplanted to an indifferent region of another embryo, it causes the formation of a secondary embryonic anlage. Such a piece can therefore be designated as an Organizer\u2026 “<\/p>\n<\/blockquote>\n\n\n\n

1925\u5e74\uff0c\u7c73-\u66fc\u6c0f\u65b9\u7a0b\uff08Michaelis-Menten equation\uff09\u7684\u6539\u8fdb\u3002<\/p>\n\n\n\n

1927\u5e74\uff0cHermann Joseph Muller\u53d1\u73b0X\u5149\u53ef\u4ee5\u7528\u4e8e\u8bf1\u5bfc\u57fa\u56e0\u7a81\u53d8\u3002<\/p>\n\n\n\n

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1918\u5e74\uff0cMuller\u63d0\u51fa\u548c\u5236\u9020\u5e73\u8861\u81f4\u6b7b\u7cfb\u3002<\/p>\n\n\n\n

1913\u5e74\uff0cAlfred Sturtevant\u53d1\u8868\u4e86\u7b2c\u4e00\u5f20\u9057\u4f20\u56fe\u8c31\u3002 <\/p>\n\n\n\n

1911\u5e74\uff0cTH Morgan: Chromosomes carry genes; genetic linkage<\/p>\n\n\n\n

1900\u5e74\uff0cDeVries, Correns, and von Tschermak: Rediscovery of Mendel’s work<\/p>\n\n\n\n

1880s\uff0cLouis Pasteur\u53d1\u660e\u72c2\u72ac\u75c5\u75ab\u82d7\uff0c\u4ed6\u8fd8\u6307\u51fa\u8fd9\u79cd\u75c5\u539f\u7269\u662f\u67d0\u79cd\u53ef\u4ee5\u901a\u8fc7\u7ec6\u83cc\u6ee4\u5668\u7684\u201c\u8fc7\u6ee4\u6027\u7684\u8d85\u5fae\u751f\u7269\u201d\u3002\u8fd8\u53d1\u660e\u70ad\u75bd\u75c5\u75ab\u82d7\u3001\u9e21\u970d\u4e71\u75ab\u82d7\u7b49\u3002<\/p>\n\n\n\n

1869\u5e74\uff0cFrederick Miescher\u53d1\u73b0\u6838\u9178\uff0cDNA isolated (nuclein) 1866\u5e74\uff0cMendel\u53d1\u8868\u4e86\u4ed6\u7684\u8c4c\u8c46\u6742\u4ea4\u5b9e\u9a8c\u7ed3\u679c <\/p>\n\n\n\n

1858\u5e74\uff0cRudolph Carl Virchow\u63d0\u51fa\u7ec6\u80de\u53ea\u80fd\u6765\u6e90\u4e8e\u7ec6\u80de\u3002\u5b8c\u5584\u4e86\u201c\u7ec6\u80de\u5b66\u8bf4\uff08Cell Theory\uff09\u201d\uff1a\u6240\u6709\u751f\u7269\u7686\u7531\u7ec6\u80de\u548c\u7ec6\u80de\u4ea7\u7269\u7ec4\u6210\uff0c\u7ec6\u80de\u662f\u751f\u7269\u7684\u57fa\u672c\u5355\u5143\uff0c\u7ec6\u80de\u53ea\u80fd\u7531\u5176\u4ed6\u7ec6\u80de\u5206\u88c2\u800c\u6765\u3002<\/p>\n\n\n\n

1859\u5e74\uff0cDarwin\u7684\u7269\u79cd\u8d77\u6e90\u5728\u4f26\u6566\u51fa\u7248 <\/p>\n\n\n\n

1838\u5e74\uff0cMathias Jacob Schleiden\u53d1\u8868\u8bba\u6587\u63d0\u51fa\u201c\u690d\u7269\u7531\u7ec6\u80de\u7ec4\u6210\u201d\u3002<\/p>\n\n\n\n

1839\u5e74\uff0cTheodor Schwann\u53d1\u8868\u4e13\u8457\u63d0\u51fa\u201c\u52a8\u690d\u7269\u7686\u7531\u7ec6\u80de\u7ec4\u6210\u201d\u3002<\/p>\n\n\n\n

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1809\u5e74\uff0c\u62c9\u9a6c\u514b\u53d1\u8868\u300a\u52a8\u7269\u54f2\u5b66\u300b\u4e00\u4e66\uff0c\u7cfb\u7edf\u5730\u9610\u8ff0\u4e86\u4ed6\u7684\u8fdb\u5316\u7406\u8bba\uff0c\u5373\u901a\u5e38\u6240\u79f0\u7684\u62c9\u9a6c\u514b\u5b66\u8bf4\u3002<\/p>\n\n\n\n

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1798\u5e74\uff0cEdward Jenner\u53d1\u8868\u300a\u79cd\u725b\u75d8\u7684\u539f\u56e0\u4e0e\u6548\u679c\u7684\u63a2\u8ba8\u300b\uff0c\u53d1\u660e\u725b\u75d8\u5929\u82b1\u75ab\u82d7\u3002Edward Jenner\u88ab\u8a89\u4e3a\u514d\u75ab\u5b66\u4e4b\u7236\u3002<\/p>\n\n\n\n

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1753\u5e74\uff0c\u6797\u5948\u51fa\u7248\u300a\u690d\u7269\u79cd\u8d28\u300b\uff0c\u5efa\u7acb\u4e86\u52a8\u690d\u7269\u547d\u540d\u7684\u201c\u53cc\u540d\u6cd5\u201d\uff0c\u4f7f\u7528\u53cc\u547d\u540d\u6cd5\u4e3a7300\u79cd\u5de6\u53f3\u7684\u690d\u7269\u547d\u540d\u3002\u6797\u5948\u9996\u6b21\u63d0\u51fa\u201c\u754c\u3001\u95e8\u3001\u7eb2\u3001\u76ee\u3001\u5c5e\u3001\u79cd\u201d\u7684\u7269\u79cd\u5206\u7c7b\u6cd5\u3002<\/p>\n\n\n\n

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1674\u5e74\uff0cAnton van Leeuwenhoek\u89c2\u5bdf\u5230\u6d3b\u7ec6\u80de\u3002<\/p>\n\n\n\n

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1660\u5e74\uff0cRobert Hooke\u7528\u663e\u5fae\u955c\u89c2\u5bdf\u6728\u585e\u540e\u63d0\u51fa”cell”\u4e00\u8bcd\u3002<\/p>\n\n\n\n

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1651\u5e74\uff0c\u54c8\u7ef4\u5b8c\u6210\u4e86\u4f1f\u5927\u7684\u533b\u5b66\u8457\u4f5c\u300a\u80da\u80ce\u5b66\u300b\u3002<\/p>\n\n\n\n

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1628\u5e74\uff0c\u54c8\u7ef4\u7684\u300a\u5fc3\u8840\u8fd0\u52a8\u8bba\u300b\u5728\u5fb7\u56fd\u51fa\u7248\u3002\u4ed6\u53d1\u73b0\u4e86\u8840\u6db2\u5faa\u73af\u548c\u5fc3\u810f\u7684\u529f\u80fd\u3002<\/p>\n\n\n\n

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