{"id":12658,"date":"2025-09-26T10:44:31","date_gmt":"2025-09-26T02:44:31","guid":{"rendered":"https:\/\/fanyiming.life\/?p=12658"},"modified":"2025-12-21T01:02:34","modified_gmt":"2025-12-20T17:02:34","slug":"slc7a5%e4%b8%8e%e4%ba%ba%e7%b1%bb%e7%96%be%e7%97%85","status":"publish","type":"post","link":"https:\/\/fanyiming.life\/?p=12658","title":{"rendered":"SLC7A5\u4e0e\u4eba\u7c7b\u75be\u75c5"},"content":{"rendered":"\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>By ChatGPT GPT-5 Deep Research<\/p>\n<cite>2025.9.26<\/cite><\/blockquote>\n\n\n\n<h1 class=\"wp-block-heading\"><a><\/a><a><\/a><a>\u4eba\u7c7bSLC7A5\u57fa\u56e0\u4e0e\u4eba\u7c7b\u75be\u75c5\u7684\u5173\u7cfb<\/a><\/h1>\n\n\n\n<h2 class=\"wp-block-heading\"><a><\/a>\u57fa\u56e0\u80cc\u666f\u4e0e\u529f\u80fd<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>SLC7A5\u57fa\u56e0\u7f16\u7801\u7684\u86cb\u767d<\/strong>\u00a0\u2013\u00a0SLC7A5\u53c8\u540dLAT1\uff0c\u662f\u6eb6\u8d28\u8f7d\u4f53\u5bb6\u65cf7\u6210\u54585\uff0c\u5b83\u4e0eSLC3A2\u7f16\u7801\u76844F2hc\u7ec4\u88c5\u6210\u5f02\u6e90\u4e8c\u805a\u4f53\uff0c\u5f62\u6210\u4e00\u79cd\u5927\u578b\u4e2d\u6027\u6c28\u57fa\u9178\u8f6c\u8fd0\u5668\u3002LAT1\/4F2hc\u8d1f\u8d23\u80de\u5916\u5fc5\u9700\u6c28\u57fa\u9178\uff08BCAA\u548c\u82b3\u9999\u65cf\u6c28\u57fa\u9178\uff09\u7684\u5165\u80de\u4ea4\u6362\uff0c\u540c\u65f6\u8f93\u51fa\u9a71\u52a8\u529b\u8f83\u5c0f\u7684\u6c28\u57fa\u9178\uff0c\u5982\u7ec4\u6c28\u9178<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2018.00243\/full\">[1]<\/a>\u3002LAT1\u5e7f\u6cdb\u5206\u5e03\u4e8e\u80ce\u76d8\u3001\u8111\u8840\u7ba1\u5185\u76ae\u548c\u514d\u75ab\u7ec6\u80de\u7b49\u7ec4\u7ec7\uff0c\u5728\u6b63\u5e38\u7ec4\u7ec7\u4e2d\u8868\u8fbe\u8f83\u4f4e\uff0c\u4f46\u5728\u8bb8\u591a\u80bf\u7624\u548c\u6d3b\u5316\u7684\u514d\u75ab\u7ec6\u80de\u4e2d\u663e\u8457\u4e0a\u8c03<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2018.00243\/full#:~:text=2017%29,Tissue%20Localization%20of%20LAT1%20and\">[2]<\/a>\u3002\u5176\u529f\u80fd\u4e0e\u7ec6\u80de\u6444\u53d6\u6c28\u57fa\u9178\u3001mTOR\u4fe1\u53f7\u3001\u86cb\u767d\u8d28\u5408\u6210\u548c\u80fd\u91cf\u4ee3\u8c22\u5bc6\u5207\u76f8\u5173<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=LAT1%20is%20located%20on%20cell,components%20as%20substitute%20sources%20of\">[3]<\/a>\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><a><\/a>SLC7A5\u4e0e\u80bf\u7624<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8fc7\u8868\u8fbe\u4e0e\u80bf\u7624\u4ee3\u8c22<\/strong>\u00a0\u2013\u00a0\u80bf\u7624\u7ec6\u80de\u5bf9\u8425\u517b\u9700\u6c42\u9ad8\uff0c\u7279\u522b\u9700\u8981\u8461\u8404\u7cd6\u3001\u5fc5\u9700\u6c28\u57fa\u9178\u548c\u8c37\u6c28\u9170\u80fa<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2018.00243\/full#:~:text=The%20link%20of%20LAT1%20with,is%20also%20a%20positive%20allosteric\">[4]<\/a>\u3002LAT1\u5728\u5927\u591a\u6570\u4eba\u7c7b\u80bf\u7624\u4e2d\u9ad8\u8868\u8fbe\uff0c\u63d0\u4f9b\u8db3\u591f\u7684\u4eae\u6c28\u9178\u548c\u5176\u4ed6\u5fc5\u9700\u6c28\u57fa\u9178\uff0c\u4ece\u800c\u4fc3\u8fdbmTOR\u6fc0\u6d3b\u548c\u80bf\u7624\u4ee3\u8c22\u91cd\u7f16\u7a0b\u3002\u5bf9\u80c3\u80a0\u9053\u3001\u80ba\u3001\u4e73\u817a\u3001\u809d\u764c\u548c\u80f0\u817a\u764c\u7b49\u591a\u79cd\u80bf\u7624\uff0cLAT1\u7684\u9ad8\u8868\u8fbe\u88ab\u8ba4\u4e3a\u662f\u6076\u6027\u8fdb\u5c55\u548c\u8f6c\u79fb\u7684\u9884\u540e\u6807\u5fd7<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2018.00243\/full#:~:text=2017%29,expression%20is%20also%20a%20prognostic\">[5]<\/a>\u3002\u5728\u7f3a\u6c27\u6761\u4ef6\u4e0b\uff0cHIF\u20112\u03b1\u548cc\u2011Myc\u7b49\u8f6c\u5f55\u56e0\u5b50\u76f4\u63a5\u7ed3\u5408LAT1\u542f\u52a8\u5b50\u63d0\u9ad8\u5176\u8868\u8fbe<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=inducible%20factor%202%CE%B1%20%28HIF,gene%20expression%20and%20activating%20mTORC1\">[6]<\/a>\u3002<\/li>\n\n\n\n<li><strong>\u6cbb\u7597\u9776\u70b9<\/strong>\u00a0\u2013\u00a0\u5c0f\u5206\u5b50\u6291\u5236\u5242\u5982JPH203\u80fd\u9009\u62e9\u6027\u6291\u5236LAT1\uff0c\u963b\u6b62\u80bf\u7624\u7ec6\u80de\u6444\u53d6\u6c28\u57fa\u9178\u5e76\u6291\u5236mTORC1\u4fe1\u53f7\uff0c\u4ece\u800c\u5bfc\u81f4\u80bf\u7624\u7ec6\u80de\u5468\u671f\u505c\u6ede\u548c\u6b7b\u4ea1<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11497297\/#:~:text=required%20for%20cancer%20cell%20growth,115%20%2094\">[7]<\/a>\u3002\u76ee\u524dJPH203\u6b63\u5728\u80c6\u7ba1\u764c\u548c\u5176\u4ed6\u5b9e\u4f53\u7624\u4e2d\u8fdb\u884cII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002LAT1\u8fd8\u53ef\u4ee5\u4f5c\u4e3a\u836f\u7269\u8f93\u9001\u7684\u901a\u9053\uff0c\u5c06\u6297\u764c\u836f\u3001\u6297\u708e\u836f\u6216\u795e\u7ecf\u836f\u7269\u4e0eLAT1\u5e95\u7269\u8fde\u63a5\u6210\u524d\u836f\uff0c\u63d0\u9ad8\u8fd9\u4e9b\u836f\u7269\u8de8\u8d8a\u8840\u8111\u5c4f\u969c\u6216\u8fdb\u5165\u80bf\u7624\u7684\u6548\u7387<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full\">[8]<\/a>\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><a><\/a>\u514d\u75ab\u548c\u708e\u75c7\u76f8\u5173\u75be\u75c5<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u514d\u75ab\u6fc0\u6d3b<\/strong>\u00a0\u2013\u00a0LAT1\u662fT\u7ec6\u80de\u6fc0\u6d3b\u540e\u7684\u5fc5\u9700\u6c28\u57fa\u9178\u5165\u53e3\u3002T\u7ec6\u80de\u53d7\u4f53\u6fc0\u6d3b\u540e\u9700\u8981\u4e0a\u8c03LAT1\u4ee5\u6ee1\u8db3\u86cb\u767d\u5408\u6210\u548c\u80fd\u91cf\u9700\u6c42\uff1b\u7f3a\u5931LAT1\u7684CD4+\u6216CD8+\u00a0T\u7ec6\u80de\u65e0\u6cd5\u6709\u6548\u4e0a\u8c03\u7ec6\u80de\u5185\u6c28\u57fa\u9178\uff0c\u5bfc\u81f4IL\u201117\u3001IL\u20111\u03b2\u548cIL\u201123\u7b49\u708e\u75c7\u7ec6\u80de\u56e0\u5b50\u4ea7\u751f\u51cf\u5c11<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=amino%20acids%20are%20not%20only,These%20results%20indicate%20that\">[9]<\/a>\u3002IL\u201123\/IL\u20111\u03b2\/IL\u201117\u8f74\u53ef\u523a\u6fc0LAT1\u8868\u8fbe\uff0c\u4fc3\u8fdb\u76ae\u80a4\u708e\u75c7\u53cd\u5e94\uff0c\u800cLAT1\u7684\u9ad8\u4eb2\u548c\u529b\u5e95\u7269\u7ec4\u6c28\u9178\u80fd\u591f\u6291\u5236NF\u2011\u03baB\u6fc0\u6d3b\u5e76\u51cf\u5c11\u4eba\u51a0\u72b6\u52a8\u8109\u5185\u76ae\u7ec6\u80de\u4e2d\u7684TNF\u2011\u03b1\u548cIL\u20116\u751f\u6210\uff0c\u63d0\u793aLAT1\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u5177\u6709\u6297\u708e\u4f5c\u7528<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=the%20following%20phenomena,in%20an%20in%20vitro%20pancreatitis\">[10]<\/a>\u3002<\/li>\n\n\n\n<li><strong>\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\uff08RA\uff09<\/strong>\u00a0\u2013\u00a0\u7814\u7a76\u663e\u793aRA\u60a3\u8005\u5916\u5468\u8840\u5355\u6838\u7ec6\u80de\u4e2d\u7684SLC7A5\u8868\u8fbe\u663e\u8457\u5347\u9ad8\uff1b\u7528LPS\u523a\u6fc0\u5065\u5eb7\u4f9b\u4f53\u7684\u5355\u6838\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\u4ea6\u80fd\u8bf1\u5bfcSLC7A5\u8868\u8fbe<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29422900\/#:~:text=activated%20human%20monocytes%2Fmacrophages,is%20related%20to%20inflammatory%20conditions\">[11]<\/a>\u3002\u836f\u7269\u6291\u5236\u6216\u6c89\u9ed8SLC7A5\u4f1a\u964d\u4f4e\u4eae\u6c28\u9178\u4ecb\u5bfc\u7684mTORC1\u6fc0\u6d3b\u548cIL\u20111\u03b2\u4ea7\u751f\uff0c\u4e14SLC7A5\u8868\u8fbe\u4e0eRA\u4e34\u5e8a\u6307\u6807\u5448\u6b63\u76f8\u5173<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29422900\/#:~:text=activated%20human%20monocytes%2Fmacrophages,is%20related%20to%20inflammatory%20conditions\">[11]<\/a>\u3002\u5728RA\u60a3\u8005\u7684\u6ed1\u819c\u4e2d\uff0cIL\u201117\u53ef\u523a\u6fc0LAT1\u4e0a\u8c03\u5e76\u589e\u52a0\u6ed1\u819c\u6210\u7ea4\u7ef4\u6837\u7ec6\u80de\u8fc1\u79fb\uff1b\u5e72\u6270SLC7A5\u8868\u8fbe\u663e\u8457\u51cf\u5c11\u4eae\u6c28\u9178\u6444\u53d6\u3001mTOR\u78f7\u9178\u5316\u548c\u7ec6\u80de\u8fc1\u79fb<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=rheumatoid%20arthritis%20,mediated%20leucine%20absorption%20and%20cell\">[12]<\/a>\u3002<\/li>\n\n\n\n<li><strong>\u80f0\u817a\u708e\u548c\u5176\u4ed6\u708e\u75c7<\/strong>\u00a0\u2013\u00a0\u5728\u80f0\u817a\u5916\u5206\u6ccc\u817a\u6ce1\u7ec6\u80de\u4e2d\uff0cLAT1\u8d1f\u8d23\u79ef\u7d2f\u6c28\u57fa\u9178\u4ee5\u5408\u6210\u6d88\u5316\u9176\u3002\u5728\u4f53\u5916\u80f0\u817a\u708e\u6a21\u578b\u4e2dLAT1\u8868\u8fbe\u51cf\u5c11\uff0c\u53ef\u80fd\u5bfc\u81f4\u7ec6\u80de\u5185\u6c28\u57fa\u9178\u4e0b\u964d\u3001\u6d88\u5316\u9176\u5408\u6210\u4e0d\u8db3\u5e76\u52a0\u91cd\u80f0\u817a\u708e\u75c7\uff1b\u4f53\u5185\u6a21\u578b\u4e2d\u67d0\u4e9b\u7ec6\u80de\u7fa4\u589e\u9ad8\u7684LAT1\u8868\u8fbe\u53ef\u80fd\u63a9\u76d6\u4e86\u817a\u6ce1\u7ec6\u80de\u7684\u4e0b\u964d<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=model%20and%20is%20associated%20with,provides%20cells%20with%20the%20most\">[13]<\/a>\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><a><\/a>\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5e15\u91d1\u68ee\u75c5<\/strong>\u00a0\u2013\u00a0LAT1\u4ecb\u5bfcL\u2011DOPA\u8de8\u8d8a\u8840\u8111\u5c4f\u969c\u3002\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u4e2d\u8111\u8840\u7ba1\u5185\u76aeLAT1\u8868\u8fbe\u51cf\u5c11\uff0c\u5bfc\u81f4L\u2011DOPA\u8fd0\u9001\u548c\u591a\u5df4\u80fa\u751f\u6210\u4e0b\u964d\uff0c\u88ab\u8ba4\u4e3a\u662f\u75be\u75c5\u53d1\u751f\u548c\u8fdb\u5c55\u7684\u539f\u56e0\u4e4b\u4e00<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=%28Duelli%20et%20al,the%20cause%20of%20Parkinson%27s%20disease\">[14]<\/a>\u3002<\/li>\n\n\n\n<li><strong>\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\uff08ASD\uff09<\/strong>\u00a0\u2013\u00a0\u5c0f\u9f20\u7814\u7a76\u8868\u660e\uff0c\u7279\u5f02\u6027\u6572\u9664\u8840\u8111\u5c4f\u969c\u4e2d\u7684Slc7a5\u4f1a\u5bfc\u81f4\u8111\u5185\u6c28\u57fa\u9178\u8c31\u5f02\u5e38\u3001mRNA\u7ffb\u8bd1\u51cf\u5c11\u548c\u660e\u663e\u7684\u795e\u7ecf\u884c\u4e3a\u7f3a\u9677<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5554935\/#:~:text=cause%20of%20ASD,Our%20data%20elucidate%20a\">[15]<\/a>\u3002\u7814\u7a76\u8005\u5728\u6570\u540d\u60a3\u6709\u81ea\u95ed\u75c7\u548c\u8fd0\u52a8\u53d1\u80b2\u8fdf\u7f13\u7684\u60a3\u8005\u4e2d\u53d1\u73b0SLC7A5\u7684\u81f4\u75c5\u6027\u7eaf\u5408\u7a81\u53d8\uff08Ala246Val\u548cPro375Leu\uff09\uff1b\u8fd9\u4e9b\u7a81\u53d8\u964d\u4f4e\u4e86Leu\u7b49\u6c28\u57fa\u9178\u8de8BBB\u7684\u8fd0\u8f93\uff0c\u5bfc\u81f4\u8111\u5185\u4eae\u6c28\u9178\u548c\u5f02\u4eae\u6c28\u9178\u51cf\u5c11\u3001\u7ec4\u6c28\u9178\u5806\u79ef<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full\">[16]<\/a>\u3002\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u901a\u8fc7\u8111\u5ba4\u5185\u6ce8\u5c04BCAA\u53ef\u9006\u8f6c\u884c\u4e3a\u5f02\u5e38\uff0c\u63d0\u793a\u9002\u5f53\u8865\u5145\u5fc5\u9700\u6c28\u57fa\u9178\u53ef\u80fd\u5bf9\u8fd9\u7c7b\u60a3\u8005\u6709\u7597\u6548<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5554935\/#:~:text=cause%20of%20ASD,and%20support%20an%20essential%20role\">[17]<\/a>\u3002<\/li>\n\n\n\n<li><strong>\u5176\u4ed6\u795e\u7ecf\u548c\u5fc3\u7406\u75be\u75c5<\/strong>\u00a0\u2013\u00a0LAT1\u662f\u82ef\u4e19\u6c28\u9178\u548c\u8272\u6c28\u9178\u7684\u4e3b\u8981\u8111\u8840\u7ba1\u8f6c\u8fd0\u86cb\u767d\u3002\u8272\u6c28\u9178\u662f\u8840\u6e05\u7d20\u548c\u892a\u9ed1\u7d20\u7684\u524d\u4f53\uff1bLAT1\u8868\u8fbe\u4e0b\u964d\u4f1a\u51cf\u5c11\u8272\u6c28\u9178\u8de8BBB\u7684\u8f6c\u8fd0\u5e76\u5f71\u54cd\u7126\u8651\u548c\u8ba4\u77e5\u8868\u73b0<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=function%20of%20LAT1%20in%20BBB,Asor%20et%20al\">[18]<\/a>\u3002\u82ef\u4e19\u916e\u5c3f\u75c7(PKU)\u60a3\u8005\u8840\u4e2d\u82ef\u4e19\u6c28\u9178\u8fc7\u591a\u53ef\u80fd\u901a\u8fc7LAT1\u8fdb\u5165\u8111\u5185\u5bfc\u81f4\u8ba4\u77e5\u635f\u5bb3\uff0c\u5c3d\u7ba1\u76ee\u524d\u5c1a\u672a\u53d1\u73b0LAT1\u57fa\u56e0\u7684\u81f4\u75c5\u7a81\u53d8<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=%28Duelli%20et%20al,Therefore%2C%20the%20exactly\">[19]<\/a>\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><a><\/a>\u4ee3\u8c22\u6027\u75be\u75c5\u4e0e\u80f0\u5c9b\u7d20\u62b5\u6297<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7cd6\u5c3f\u75c5\u548c\u80a5\u80d6<\/strong>\u00a0\u2013\u00a0LAT1\/4F2hc\u8d1f\u8d23BCAA\u6444\u53d6\uff1b\u7a7a\u8179\u65f6\u8840\u6d46BCAA\u901a\u5e38\u4e0b\u964d\uff0c\u4f46\u5728\u80a5\u80d6\u548c2\u578b\u7cd6\u5c3f\u75c5(T2DM)\u60a3\u8005\u4e2d\u8840\u6d46BCAA\u5f02\u5e38\u5347\u9ad8<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11497297\/#:~:text=6,T2DM\">[20]<\/a>\u3002\u4e00\u79cd\u6a21\u578b\u8ba4\u4e3aLAT1\u4ecb\u5bfc\u7684BCAA\u6444\u53d6\u4e0e\u80f0\u5c9b\u7d20\u4fe1\u53f7\u534f\u540c\u6fc0\u6d3bmTORC1\uff1bmTORC1\u7684\u8fc7\u5ea6\u6fc0\u6d3b\u4e0e\u80a5\u80d6\u548c\u80f0\u5c9b\u7d20\u62b5\u6297\u76f8\u5173<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11497297\/#:~:text=6,T2DM\">[20]<\/a>\u3002\u80f0\u5c9b\u7d20\u53ef\u4e0a\u8c03\u808c\u8089\u7ec6\u80de\u4e2dLAT1\u8868\u8fbe\uff0c\u800c\u9ad8\u8461\u8404\u7cd6\u53ef\u80fd\u901a\u8fc7\u6291\u5236AMPK\u4fe1\u53f7\u964d\u4f4eLAT1\u00a0mRNA<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11497297\/#:~:text=increased%20amino%20acid%20uptake%20mediated,reaching%20consequence%20of%20such%20increased\">[21]<\/a>\u3002\u5728\u80f0\u5c9b\u03b2\u7ec6\u80de\u4e2d\uff0cLAT1\u4ecb\u5bfc\u6c28\u57fa\u9178\u6444\u53d6\u589e\u5f3a\u4e86\u80f0\u5c9b\u7d20\u5408\u6210\u548c\u5206\u6ccc<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11497297\/#:~:text=6,T2DM\">[22]<\/a>\u3002\u56e0\u6b64\u8c03\u8282LAT1\u53ef\u80fd\u5f71\u54cdBCAA\u6c34\u5e73\u3001\u80fd\u91cf\u6444\u53d6\u4e0e\u9965\u997f\u4fe1\u53f7\uff0c\u5e76\u4e14\u6709\u52a9\u4e8e\u89e3\u91ca\u80a5\u80d6\u4e0e\u6291\u90c1\u4e4b\u95f4\u7684\u8054\u7cfb<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11497297\/#:~:text=diabetes%20patients,in%20obese%20patients%20or%20to\">[23]<\/a>\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><a><\/a>\u598a\u5a20\u4e0e\u80ce\u513f\u53d1\u80b2<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u80ce\u76d8\u8f6c\u8fd0\u4e0e\u80ce\u513f\u751f\u957f<\/strong>\u00a0\u2013\u00a0LAT1\u5728\u7ed2\u6bdb\u6ecb\u517b\u5c42\u7ec6\u80de\u7684\u6bcd\u4f53\u548c\u80ce\u513f\u4fa7\u5747\u8868\u8fbe\uff0c\u4ecb\u5bfc\u6bcd\u4f53\u4e0e\u80ce\u513f\u4e4b\u95f4\u7684\u6c28\u57fa\u9178\u4ea4\u6362\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u80ce\u76d8LAT1\u8868\u8fbe\u964d\u4f4e\u4e0e\u80ce\u513f\u5bab\u5185\u751f\u957f\u53d7\u9650(IUGR)\u6709\u5173\uff0c\u8fd9\u79cd\u60c5\u51b5\u4e0b\u6bcd\u4f53\u63d0\u4f9b\u7ed9\u80ce\u513f\u7684\u8425\u517b\u4e0d\u8db3\uff0c\u51fa\u751f\u540e\u4f34\u968f\u8f83\u9ad8\u7684\u5fc3\u8840\u7ba1\u548c\u4ee3\u8c22\u75be\u75c5\u98ce\u9669<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=In%20placentas%2C%20chorionic%20trophoblast%20cells,risk%20of%20suffering%20cardiovascular%20and\">[24]<\/a>\u3002\u76f8\u53cd\uff0c\u6bcd\u4f53\u80a5\u80d6\u53ef\u5bfc\u81f4\u80ce\u76d8LAT1\u8fc7\u5ea6\u8868\u8fbe\uff0c\u4f7f\u80ce\u513f\u8fc7\u5ea6\u751f\u957f<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=metabolic%20diseases%20when%20they%20grow,of%20normal%20LAT1%20expression%20in\">[25]<\/a>\u3002\u56e0\u6b64\u7ef4\u6301\u6b63\u5e38\u7684LAT1\u6c34\u5e73\u5bf9\u4e8e\u80ce\u513f\u8425\u517b\u5e73\u8861\u81f3\u5173\u91cd\u8981\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><a><\/a>\u5176\u4ed6\u75be\u75c5\u4e0e\u6bd2\u6027<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u514d\u75ab\u4ee3\u8c22\u6027\u75be\u75c5<\/strong>\u00a0\u2013\u00a0LAT1\u5728\u7ea2\u7ec6\u80de\u53ca\u5176\u4ed6\u7ec4\u7ec7\u4e2d\u5bf9\u6c28\u57fa\u9178\u4f9b\u5e94\u8d77\u5173\u952e\u4f5c\u7528\uff0c\u53ef\u80fd\u53c2\u4e0e\u8c03\u8282\u7ea2\u7ec6\u80de\u5408\u6210\u3001\u6297\u6c27\u5316\u548c\u4ee3\u8c22\u8fc7\u7a0b\u3002\u67d0\u4e9b\u7814\u7a76\u63d0\u793aLAT1\u8fd8\u53ef\u8f6c\u8fd0\u6c5e\u5316\u5408\u7269\uff0c\u53ef\u80fd\u89e3\u91ca\u6c5e\u5bf9\u80ce\u513f\u6216\u795e\u7ecf\u7cfb\u7edf\u7684\u6bd2\u6027\uff0c\u5176\u6291\u5236\u5242\u53ef\u4ee5\u51cf\u8f7b\u6c5e\u7684\u7ec6\u80de\u6bd2\u6027<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2018.00243\/full#:~:text=LAT1%20in%20acinar%20cells%20that,2005%3B%20Bridges%20and\">[26]<\/a>\u3002<\/li>\n\n\n\n<li><strong>\u6f5c\u5728\u5173\u8054\u75be\u75c5<\/strong>\u00a0\u2013\u00a0LAT1\u53c2\u4e0e\u4fe1\u53f7\u901a\u8def\u548c\u8425\u517b\u611f\u5e94\uff0c\u63d0\u793a\u5176\u53ef\u80fd\u4e0e\u66f4\u591a\u75be\u75c5\u76f8\u5173\uff0c\u5982\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u3001\u8102\u80aa\u7ec4\u7ec7\u708e\u75c7\u7b49<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=in%20LAT1%20levels%20can%20alter,LAT1%20expression%20or%20providing%20LAT1\">[27]<\/a>\u3002\u4e0d\u8fc7\u5c1a\u9700\u66f4\u591a\u7814\u7a76\u786e\u5b9a\u5176\u4f5c\u7528\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><a><\/a>\u603b\u7ed3\u4e0e\u5c55\u671b<\/h2>\n\n\n\n<p>SLC7A5\/LAT1\u662f\u7ef4\u6301\u4eba\u4f53\u5fc5\u9700\u6c28\u57fa\u9178\u4f9b\u5e94\u7684\u5173\u952e\u8f6c\u8fd0\u86cb\u767d\u3002\u5176\u8fc7\u5ea6\u6216\u4e0d\u8db3\u7684\u8868\u8fbe\u6d89\u53ca\u80bf\u7624\u3001\u514d\u75ab\u708e\u75c7\u75be\u75c5\u3001\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u3001\u4ee3\u8c22\u7efc\u5408\u5f81\u4ee5\u53ca\u80ce\u513f\u53d1\u80b2\u5f02\u5e38\u7b49\u591a\u79cd\u4eba\u7c7b\u75be\u75c5\u3002LAT1\u901a\u8fc7\u8c03\u8282\u6c28\u57fa\u9178\u5438\u6536\u548cmTORC1\u4fe1\u53f7\uff0c\u652f\u6301\u7ec6\u80de\u589e\u6b96\u548c\u4ee3\u8c22\u91cd\u7f16\u7a0b\u3002\u9488\u5bf9LAT1\u7684\u836f\u7269\uff08\u5982JPH203\uff09\u5df2\u7ecf\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4e14\u5229\u7528LAT1\u4ecb\u5bfc\u836f\u7269\u8f6c\u8fd0\u4e5f\u662f\u5f00\u53d1\u795e\u7ecf\u7cfb\u7edf\u6cbb\u7597\u836f\u7269\u7684\u65b0\u7b56\u7565\u3002\u7136\u800c\uff0c\u9274\u4e8eLAT1\u5728\u514d\u75ab\u548c\u795e\u7ecf\u7cfb\u7edf\u4e2d\u7684\u5e7f\u6cdb\u4f5c\u7528\uff0c\u5f00\u53d1\u6291\u5236\u5242\u9700\u6743\u8861\u6297\u80bf\u7624\u6548\u5e94\u4e0e\u6f5c\u5728\u7684\u514d\u75ab\u6291\u5236\u548c\u795e\u7ecf\u526f\u4f5c\u7528<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11497297\/\">[28]<\/a>\u3002\u672a\u6765\u7814\u7a76\u5e94\u8fdb\u4e00\u6b65\u9610\u660eLAT1\u5728\u975e\u80bf\u7624\u75be\u75c5\u4e2d\u7684\u5177\u4f53\u673a\u5236\uff0c\u63a2\u7d22\u5176\u4f5c\u4e3a\u6cbb\u7597\u9776\u70b9\u6216\u836f\u7269\u8f93\u8fd0\u901a\u9053\u7684\u66f4\u591a\u53ef\u80fd\u6027\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><a><\/a><a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2018.00243\/full\">[1]<\/a>&nbsp;<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2018.00243\/full#:~:text=2017%29,Tissue%20Localization%20of%20LAT1%20and\">[2]<\/a>&nbsp;<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2018.00243\/full#:~:text=The%20link%20of%20LAT1%20with,is%20also%20a%20positive%20allosteric\">[4]<\/a>&nbsp;<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2018.00243\/full#:~:text=2017%29,expression%20is%20also%20a%20prognostic\">[5]<\/a>&nbsp;<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2018.00243\/full#:~:text=LAT1%20in%20acinar%20cells%20that,2005%3B%20Bridges%20and\">[26]<\/a>&nbsp;Frontiers | The Human SLC7A5 (LAT1): The Intriguing Histidine\/Large Neutral Amino Acid Transporter and Its Relevance to Human Health<\/p>\n\n\n\n<p><a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2018.00243\/full\">https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2018.00243\/full<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=LAT1%20is%20located%20on%20cell,components%20as%20substitute%20sources%20of\">[3]<\/a>&nbsp;<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=inducible%20factor%202%CE%B1%20%28HIF,gene%20expression%20and%20activating%20mTORC1\">[6]<\/a>&nbsp;<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full\">[8]<\/a>&nbsp;<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=amino%20acids%20are%20not%20only,These%20results%20indicate%20that\">[9]<\/a>&nbsp;<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=the%20following%20phenomena,in%20an%20in%20vitro%20pancreatitis\">[10]<\/a>&nbsp;<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=rheumatoid%20arthritis%20,mediated%20leucine%20absorption%20and%20cell\">[12]<\/a>&nbsp;<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=model%20and%20is%20associated%20with,provides%20cells%20with%20the%20most\">[13]<\/a>&nbsp;<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=%28Duelli%20et%20al,the%20cause%20of%20Parkinson%27s%20disease\">[14]<\/a>&nbsp;<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full\">[16]<\/a>&nbsp;<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=function%20of%20LAT1%20in%20BBB,Asor%20et%20al\">[18]<\/a>&nbsp;<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=%28Duelli%20et%20al,Therefore%2C%20the%20exactly\">[19]<\/a>&nbsp;<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=In%20placentas%2C%20chorionic%20trophoblast%20cells,risk%20of%20suffering%20cardiovascular%20and\">[24]<\/a>&nbsp;<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=metabolic%20diseases%20when%20they%20grow,of%20normal%20LAT1%20expression%20in\">[25]<\/a>&nbsp;<a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full#:~:text=in%20LAT1%20levels%20can%20alter,LAT1%20expression%20or%20providing%20LAT1\">[27]<\/a>&nbsp;Frontiers | Review of the Correlation of LAT1 With Diseases: Mechanism and Treatment<\/p>\n\n\n\n<p><a href=\"https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full\">https:\/\/www.frontiersin.org\/journals\/chemistry\/articles\/10.3389\/fchem.2020.564809\/full<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11497297\/#:~:text=required%20for%20cancer%20cell%20growth,115%20%2094\">[7]<\/a>&nbsp;<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11497297\/#:~:text=6,T2DM\">[20]<\/a>&nbsp;<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11497297\/#:~:text=increased%20amino%20acid%20uptake%20mediated,reaching%20consequence%20of%20such%20increased\">[21]<\/a>&nbsp;<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11497297\/#:~:text=6,T2DM\">[22]<\/a>&nbsp;<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11497297\/#:~:text=diabetes%20patients,in%20obese%20patients%20or%20to\">[23]<\/a>&nbsp;<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11497297\/\">[28]<\/a>&nbsp;&nbsp;The human LAT1\u20134F2hc (SLC7A5\u2013SLC3A2) transporter complex: Physiological and pathophysiological implications &#8211; PMC<\/p>\n\n\n\n<p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11497297\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11497297<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29422900\/#:~:text=activated%20human%20monocytes%2Fmacrophages,is%20related%20to%20inflammatory%20conditions\">[11]<\/a>&nbsp;Role of SLC7A5 in Metabolic Reprogramming of Human Monocyte\/Macrophage Immune Responses &#8211; PubMed<\/p>\n\n\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29422900\">https:\/\/pubmed.ncbi.nlm.nih.gov\/29422900<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5554935\/#:~:text=cause%20of%20ASD,Our%20data%20elucidate%20a\">[15]<\/a>&nbsp;<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5554935\/#:~:text=cause%20of%20ASD,and%20support%20an%20essential%20role\">[17]<\/a>&nbsp;&nbsp;Impaired amino acid transport at the blood brain barrier is a cause of autism spectrum disorder &#8211; PMC<\/p>\n\n\n\n<p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5554935\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5554935<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>SLC7A5\uff08LAT1\uff09\u662f\u5927\u578b\u4e2d\u6027\u6c28\u57fa\u9178\u7684\u5173\u952e\u8f6c\u8fd0\u86cb\u767d\uff0c\u5176\u8868\u8fbe\u5f02\u5e38\u5e7f\u6cdb\u53c2\u4e0e\u80bf\u7624\u4ee3\u8c22\u3001\u514d\u75ab\u708e\u75c7\u3001\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u53ca\u4ee3\u8c22\u7efc\u5408\u5f81\u7b49\u591a\u79cd\u75c5\u7406\u8fc7\u7a0b\u3002\u672c\u6587\u7efc\u8ff0\u4e86\u5176\u5728\u75be\u75c5\u53d1\u751f\u53d1\u5c55\u4e2d\u7684\u6838\u5fc3\u673a\u5236\uff0c\u5e76\u63a2\u8ba8\u4e86\u4f5c\u4e3a\u6cbb\u7597\u9776\u70b9\u7684\u6f5c\u529b\u3002<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[18],"tags":[32],"class_list":["post-12658","post","type-post","status-publish","format-standard","hentry","category-18","tag-deep-research"],"_links":{"self":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts\/12658","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=12658"}],"version-history":[{"count":4,"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts\/12658\/revisions"}],"predecessor-version":[{"id":13760,"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts\/12658\/revisions\/13760"}],"wp:attachment":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=12658"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=12658"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=12658"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}