{"id":2089,"date":"2024-04-15T03:11:59","date_gmt":"2024-04-14T19:11:59","guid":{"rendered":"https:\/\/fanyiming.life\/?p=2089"},"modified":"2025-12-21T01:05:24","modified_gmt":"2025-12-20T17:05:24","slug":"%e8%bf%87%e8%a1%a8%e8%be%be%e5%ae%9e%e9%aa%8c","status":"publish","type":"post","link":"https:\/\/fanyiming.life\/?p=2089","title":{"rendered":"\u8fc7\u8868\u8fbe\u5b9e\u9a8c"},"content":{"rendered":"\n<p>\u4e00\u4e2aoverexpression\u7684\u4f8b\u5b50<\/p>\n\n\n\n<p>Remarkably, SAFB ChIP-seq peaks, aswell as L1s, are enriched at the strengthened domain boundaries(Figures 2D, 2E, and S5D), suggesting that SAFB KO strengthensdomain boundaries at the SAFB-bound L1s. Interestingly, wefound that SAFB overexpression did not significantly strengthenthe TAD boundaries (Figures S5E and S5F), implying that eitherSAFB levels in wild-type NCCIT cells are enough to constrainthe L1-associated TAD boundaries or that SAFB is required butnot enough to repress TAD formation in human cells<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u8fd9\u7bc7\u7b14\u8bb0\u63a2\u8ba8\u4e86SAFB\u86cb\u767d\u5728\u57fa\u56e0\u7ec4\u4e09\u7ef4\u7ed3\u6784\u8c03\u63a7\u4e2d\u7684\u4f5c\u7528\u3002\u901a\u8fc7ChIP-seq\u6570\u636e\u5206\u6790\u53d1\u73b0\uff0cSAFB\u7f3a\u5931\u4f1a\u589e\u5f3a\u5176\u7ed3\u5408\u4f4d\u70b9\u9644\u8fd1\u7684\u62d3\u6251\u76f8\u5173\u7ed3\u6784\u57df\u8fb9\u754c\uff0c\u800c\u8fc7\u8868\u8fbe\u5b9e\u9a8c\u5219\u663e\u793aSAFB\u6c34\u5e73\u53ef\u80fd\u5df2\u9971\u548c\u6216\u4e0d\u8db3\u4ee5\u5355\u72ec\u6291\u5236\u8fb9\u754c\u5f62\u6210\u3002<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-2089","post","type-post","status-publish","format-standard","hentry","category-note"],"_links":{"self":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts\/2089","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2089"}],"version-history":[{"count":2,"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts\/2089\/revisions"}],"predecessor-version":[{"id":14043,"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts\/2089\/revisions\/14043"}],"wp:attachment":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2089"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2089"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2089"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}