{"id":229,"date":"2023-11-17T02:46:54","date_gmt":"2023-11-16T18:46:54","guid":{"rendered":"http:\/\/39.105.184.3\/?p=229"},"modified":"2025-12-21T01:06:17","modified_gmt":"2025-12-20T17:06:17","slug":"glp-1%e5%8f%97%e4%bd%93%e6%bf%80%e5%8a%a8%e5%89%82%e7%9a%84%e5%8c%bb%e5%ad%a6%e8%bd%ac%e5%8c%96","status":"publish","type":"post","link":"https:\/\/fanyiming.life\/?p=229","title":{"rendered":"GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u7684\u533b\u5b66\u8f6c\u5316"},"content":{"rendered":"\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\u665a\u4e0a\u8001\u677f\u50ac\u6211\u8bfe\u9898\uff0c\u6211\u8bf4\u6211\u8fd8\u6709\u4e00\u4e2a\u5c0f\u65f6\u5c31\u8981\u53bb\u8bfe\u4e0a\u505aPresentation\u4e86\uff0c\u4ed6\u9707\u60ca\u4e8e\u6211\u600e\u4e48\u4e8c\u5e74\u7ea7\u4e86\u8fd8\u5728\u4e0a\u8bfe\uff0c\u4ed6\u8981\u662f\u77e5\u9053\u6211\u4e00\u5e74\u7ea7\u6709\u4e00\u95e8\u8bfe\u6302\u4e86\u8fd8\u5728\u91cd\u4fee\u4f30\u8ba1\u4f1a\u66f4\u9707\u60ca\u3002\u8fd9\u95e8\u8bfe\u53eb\u201c\u8f6c\u5316\u533b\u5b66\u548c\u836f\u7269\u7814\u53d1\u201d\uff0c\u662f\u7f57\u6c38\u7ae0\u8001\u5e08\u4e0a\u7684\u3002\u4ed6\u725b\u903c\u7684\u5730\u65b9\u5728\u4e8e\u4e03\u6b21\u8bfe\u57fa\u672c\u4e0a\u6bcf\u8282\u8bfe\u8bb2\u7684\u4e1c\u897f\u90fd\u662f\u81ea\u5df1\u7684\u7814\u7a76\u548c\u8f6c\u5316\u7ecf\u5386\uff0c\u5185\u5bb9\u4e30\u5bcc\u3002\u8ba9\u6211\u60f3\u8d77\u6765\u5927\u4e09\u4e0a\u9057\u4f20\u5b66\u7684\u65f6\u5019\u6731\u6b63\u8302\u8001\u5e08\u8bb2\u7684\u67d0\u4e00\u4f4d\u9057\u4f20\u5b66\u5bb6\uff08\u4e0d\u597d\u610f\u601d\u6211\u5fd8\u8bb0\u540d\u5b57\u4e86\uff09\u5728\u5341\u591a\u5e74\u6f5c\u5fc3\u7814\u7a76\u4e00\u7bc7\u6587\u7ae0\u6ca1\u53d1\u4e4b\u540e\uff0c\u88abNature\u7ea6\u7a3f\u5199\u4e86\u4e00\u7bc7\u5de8\u957f\u7684\u7efc\u8ff0\u6027\u7684Research Article\uff0c\u610f\u601d\u5c31\u662f\u5b83\u8fd9\u5341\u51e0\u5e74\u505a\u7684\u4e1c\u897f\u62fc\u4e00\u5757\u5c31\u662f\u4e00\u7bc7\u7efc\u8ff0\u4e86\u3002\u7f57\u8001\u5e08\u8bb2\u4e86\u8fd9\u51e0\u4e2a\u5b9e\u4f8b\uff1aHsp90\u03b1\u80bf\u7624\u6807\u5fd7\u7269\u3001\u6297\u80bf\u7624\u836f\u7269Endostar\u3001\u521b\u65b0\u836f\u7269\u7814\u53d1VEGF\u3001Insulin\u5927\u89c4\u6a21\u9ad8\u7eaf\u5236\u5907\u9020\u5382\u5b50\u3001Albumin\u5927\u89c4\u6a21\u9ad8\u7eaf\u5236\u5907\u9020\u5382\u5b50\u2026\u2026\u6700\u540e\u4e00\u8282\u8bfe\u8bf7\u4e86\u4e13\u5229\u65b9\u9762\u7684\u884c\u5bb6\u4ed8\u5f66\u8001\u5e08\u8bb2\u4e13\u5229\u76f8\u5173\u77e5\u8bc6\u3002\u4ed8\u5f66\u8001\u5e08\u662f\u4f4d\u5973\u58eb\uff0c\u770b\u8d77\u6765\u8d3c\u6709\u6c14\u8d28\uff0c\u636e\u8bf4\u4e94\u5341\u591a\u4e86\uff0c\u4f46\u770b\u7740\u50cf\u4e09\u5341\u591a\u2026\u2026<\/p>\n\n\n\n<p>\u7136\u540e\u8fd9\u4e2a\u5c0f\u7ec4\u5c55\u793a\u51c6\u5907\u7684\u4e5f\u6bd4\u8f83\u4ed3\u4fc3\uff0c\u56e0\u4e3a\u968f\u624b\u5728\u670b\u53cb\u5708\u770b\u5230\u836f\u660e\u5eb7\u5fb7\u53d1\u7684\u4e00\u4e2a\u63a8\u9001\u662f\u6709\u5173GLP-1\u7684\u7814\u7a76\u5386\u7a0b\u7684\uff0c\u5c31\u987a\u624b\u8f6c\u53d1\u5230\u4e86\u5c0f\u7ec4\u7fa4\u91cc\uff0c\u540e\u6765\u5c31\u53d8\u6210\u6211\u4eec\u7684\u9009\u9898\u4e86\u3002\u867d\u7136\u662f\u6211\u9009\u7684\u4f46\u662f\u51c6\u5907\u7684\u4e5f\u4e0d\u5145\u5206\uff0c\u4e09\u4e2a\u4eba\u5206\u4e86\u4e09\u4e2a\u90e8\u5206\uff0c\u8bf4\u5b9e\u8bdd\u6211\u90fd\u6ca1\u770b\u5979\u4eec\u4fe9\u90a3\u4e24\u90e8\u5206\u8bb2\u7684\u5565\uff0c\u751a\u81f3PPT\u662f\u5728\u6211\u4eec\u4ee8\u4e0a\u53f0\u524d10\u5206\u949f\u624d\u505a\u597d\u5408\u8d77\u6765\u7684\u3002\u3002\u3002\u3002\u3002<\/p>\n\n\n\n<p>\u884c\u5e9f\u8bdd\u5b8c\u4e86\uff0c\u4e0b\u9762\u662f\u77e5\u8bc6\u5907\u5fd8\u90e8\u5206\u3002\u6211\u5c31\u60f3\u8d77\u6765\u5565\u5199\u5565\u4e86\u3002<\/p>\n<\/blockquote>\n\n\n\n<h2 class=\"wp-block-heading\">GLP-1\u7684\u201c\u8461\u8404\u7cd6\u4f9d\u8d56\u6027\u201d\u964d\u7cd6(\u4fc3insulin)\u4f5c\u7528<\/h2>\n\n\n\n<p>\u7cd6\u5c3f\u75c5\u4e3b\u8981\u5206\u4e24\u578b\uff0cType I\u662f\u5206\u6ccc\u80f0\u5c9b\u7d20\u7684\u80f0\u5c9bB\u7ec6\u80de\u53d7\u635f\u5bfc\u81f4\u4ea7\u751f\u4e0d\u4e86\u80f0\u5c9b\u7d20\u4e86\uff0cType II\u662f\u80f0\u5c9b\u7d20\u7684\u53d7\u4f53\u5bf9\u80f0\u5c9b\u7d20\u654f\u611f\u6027\u4e0b\u964d\u4e86\uff0c\u7136\u540e\u80f0\u5c9bB\u7ec6\u80de\u53ef\u80fd\u5c31\u4e00\u76f4\u4f7f\u52b2\u513f\u751f\u4ea7\u80f0\u5c9b\u7d20\u6700\u540e\u628a\u81ea\u5df1\u4e5f\u7ed9\u7d2f\u574f\u4e86\u529f\u80fd\u53d7\u635f\u4e86\u3002Type II\u5360\u7684\u6bd4\u4f8b\u5927\u4e00\u70b9\u3002\u4eba\u4eec\u4e00\u76f4\u5728\u7814\u7a76\u600e\u4e48\u66f4\u597d\u5730\u6cbb\u7597\u7cd6\u5c3f\u75c5\u3002<\/p>\n\n\n\n<p>\u7cd6\u5c3f\u75c5\u6700\u4e3b\u8981\u7684\u4e00\u4e2a\u75c7\u72b6\u662f\u9ad8\u8840\u7cd6\u3002\u4e3a\u4e86\u964d\u7cd6\uff0c\u6700\u76f4\u63a5\u7684\u65b9\u6cd5\u662f\u6ce8\u5c04\u5916\u6e90\u7684\u80f0\u5c9b\u7d20\u3002\u7136\u800c\u76f4\u63a5\u6ce8\u5c04\u80f0\u5c9b\u7d20\u6709\u53ef\u80fd\u4f1a\u77eb\u6789\u8fc7\u6b63\uff0c\u5373\u53cd\u800c\u5728\u4e00\u4e9b\u65f6\u5019\u5f15\u8d77\u4f4e\u8840\u7cd6\u75c7\u72b6\u3002GLP-1\u8fd9\u4e2a\u86cb\u767d\u5c31\u6bd4\u8f83\u795e\u5947\uff0c\u5b83\u7684\u5168\u79f0\u53eb\u201c\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd-1\u201d\uff0c\u662f\u4e00\u79cd\u80a0\u9053\u4e2d\u4ea7\u751f\u7684\u6fc0\u7d20\uff0c\u80fd\u591f\u5728\u9ad8\u8840\u7cd6\u65f6\u523a\u6fc0\u80f0\u5c9b\u7d20\u5927\u91cf\u5206\u6ccc\uff0c\u6ce8\u610f\u662f\u5728\u201c\u9ad8\u8840\u7cd6\u201d\u7684\u65f6\u5019\uff0c\u6240\u4ee5\u5c31\u6bd4\u5355\u7eaf\u6ce8\u5c04\u80f0\u5c9b\u7d20\u597d\u4e86\u5f88\u591a\uff0c\u56e0\u4e3a\u5f53\u8840\u7cd6\u4e0b\u964d\u5230\u6b63\u5e38\u6c34\u5e73\u540e\u518d\u6fc0\u6d3bGLP-1\u7684\u53d7\u4f53\u4e5f\u4e0d\u4f1a\u7ee7\u7eed\u589e\u52a0\u80f0\u5c9b\u7d20\u7684\u5206\u6ccc\u4e86\uff0c\u5c31\u4e0d\u4f1a\u5f15\u8d77\u4f4e\u8840\u7cd6\u3002\u4eba\u4eec\u81ea\u7136\u5c31\u60f3\u7528\u8fd9\u4e2a\u6027\u8d28\u5f00\u53d1\u80fd\u591f\u6fc0\u6d3bGLP-1\u53d7\u4f53\u7684\u836f\u7269\uff08\u5c31\u662f\u6807\u9898\u201cGLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u201d\uff09\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" decoding=\"async\" src=\"https:\/\/eamonimgbed.oss-cn-beijing.aliyuncs.com\/img\/202311170507416.png?x-oss-process=style\/screenshots\" alt=\"image-20231117050655805\" \/><\/figure>\n\n\n\n<p>\u867d\u7136\u7406\u8bba\u4e0a\u975e\u5e38\u4e4b\u5b8c\u7f8e\uff0c\u4f46\u662fGLP-1\u8fd9\u4e2a\u86cb\u767d\u672c\u8eab\u6709\u4e00\u4e2a\u5f88\u4e25\u91cd\u7684\u95ee\u9898\u5c31\u662f\u5b83\u5728\u8840\u6d46\u4e2d\u7684\u534a\u8870\u671f\u975e\u5e38\u4e4b\u77ed\uff0c\u901a\u5e38\u53ea\u67092~3\u5206\u949f\u3002\u6240\u4ee5\u901a\u8fc7\u4eba\u5de5\u6ce8\u5c04GLP-1\u6765\u6fc0\u6d3bGLP-1\u53d7\u4f53\u8fd9\u79cd\u7b80\u5355\u65e0\u8111\u7684\u64cd\u4f5c\u662f\u4e0d\u53ef\u884c\u7684\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" decoding=\"async\" src=\"https:\/\/eamonimgbed.oss-cn-beijing.aliyuncs.com\/img\/202311170508674.png?x-oss-process=style\/screenshots\" alt=\"image-20231117050748061\" \/><\/figure>\n\n\n\n<p>\u4e3a\u4ec0\u4e48GLP-1\u7684\u534a\u8870\u671f\u8fd9\u4e48\u77ed\u5462\uff1f\u56e0\u4e3a\u4eba\u4f53\u4e2d\u5b58\u5728\u4e00\u79cd\u53ebDPP-4\u7684\u9176\uff0c\u662f\u4e13\u95e8\u964d\u89e3GLP-1\u7684\uff0c\u56e0\u6b64\uff0c\u836f\u7269\u5f00\u53d1\u7684\u65b9\u5411\u5c31\u8f6c\u5230\u5982\u4f55\u80fd\u591f\u6291\u5236DPP-4\u5bf9GLP-1\u7684\u964d\u89e3\u3002\u65b9\u6cd5\u6709\u5f88\u591a\uff0c\u6bd4\u5982\u627e\u5230\u5728GLP-1\u4e0a\u627e\u5230DPP-4\u8bc6\u522b\u7684\u90a3\u4e2a\u6c28\u57fa\u9178\u4f4d\u70b9\u628a\u5b83\u7a81\u53d8\u6389\uff0c\u5728\u4e0d\u5f71\u54cd\u5bf9GLP-1\u53d7\u4f53\u6fc0\u6d3b\u6d3b\u6027\u7684\u60c5\u51b5\u4e0b\u6291\u5236DPP-4\u5bf9\u5b83\u7684\u8bc6\u522b\uff1b\u518d\u6bd4\u5982\u628aGLP-1\u8ddf\u767d\u86cb\u767dAlbumin\u76f4\u63a5\u878d\u5408\u5728\u4e00\u8d77\u2026\u2026<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\u63d2\u64ad\uff1a\u767d\u86cb\u767dAlbumin\u662f\u8840\u6d46\u4e2d\u6700\u4e30\u5bcc\u7684\u86cb\u767d\u8d28\uff0c\u5360\u8840\u6d46\u86cb\u767d\u542b\u91cf\u768460%\u3002\u628a\u591a\u80bd\u7c7b\u836f\u7269\u8ddfAlbumin\u878d\u5408\u4eff\u4f5b\u662f\u4e00\u79cd\u633a\u5e38\u7528\u7684\u5ef6\u957f\u534a\u8870\u671f\u7684\u7b56\u7565\u3002\u9996\u5148Albumin\u672c\u8eab\u7684\u534a\u8870\u671f\u5c31\u6bd4\u8f83\u957f\uff0c\u5927\u698221\u5929\u597d\u50cf\u3002\u539f\u56e0\u4e4b\u4e00\u662f\u5b83\u80fd\u8ddfFc receptor\u7ed3\u5408\uff0c\u5229\u7528\u4e00\u79cd\u6211\u61d2\u5f97\u67e5\u7684\u673a\u5236\u7ed5\u8fc7endosome\u7684\u964d\u89e3\u9014\u5f84\u3002\u836f\u7269\u878d\u5408Albumin\u4e4b\u540e\u4e5f\u80fd\u901a\u8fc7\u8fd9\u4e2a\u9014\u5f84\u51cf\u5c11\u964d\u89e3\u3002\u540c\u65f6\uff0c\u836f\u7269\u878d\u5408Albumin\u4e4b\u540e\u5206\u5b50\u91cf\u53d8\u5927\uff0c\u751a\u81f3\u53ef\u80fd\u5bb9\u6613\u591a\u805a\u5316\uff0c\u800c\u5206\u5b50\u8d8a\u5927\u8d8a\u4e0d\u5bb9\u6613\u900f\u8fc7\u80be\u5c0f\u7403\u88abrenal elimination\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" decoding=\"async\" src=\"https:\/\/eamonimgbed.oss-cn-beijing.aliyuncs.com\/img\/202311170508577.png?x-oss-process=style\/screenshots\" alt=\"image-20231117050811362\" \/><\/figure>\n<\/blockquote>\n\n\n\n<h2 class=\"wp-block-heading\">\u4e24\u79cd\u836f\u7269\u8f6c\u5316\u5b9e\u4f8b\u2014\u2014Exenatide\u548cLiraglutide<\/h2>\n\n\n\n<p>\u57fa\u4e8eGLP-1\u7c7b\u4f3c\u7269\u7684\u6709\u5f88\u591a\u5f88\u591a\u836f\u54c8\uff0c\u4e0a\u5e02\u7684\u90fd\u6709\u5341\u51e0\u79cd\u4e86\u3002\u8fd9\u91cc\u5c31\u662f\u968f\u4fbf\u9009\u4e86\u4fe9\u4e3e\u4f8b\u5b50\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Exenatide\uff08\u827e\u585e\u90a3\u80bd\uff09<\/h3>\n\n\n\n<p>\u4e00\u4e2a\u53ebEng John\u7684\u79d1\u5b66\u5bb6\u57281992\u4ece\u7f8e\u56fd\u6bd2\u8725\uff08Gila Monster\uff09\u7684\u6bd2\u6db2\u4e2d\u53d1\u73b0\u4e00\u79cd\u53ebExtendin-4\u7684\u7269\u8d28\u3002\u8fd9\u662f\u4e00\u79cd\u4e0e\u4eba\u6e90GLP-1\u5177\u670953%\u540c\u6e90\u6027\u7684Homologue\uff0c\u4f46\u662fEng John\u535a\u58eb\u5f53\u65f6\u5e76\u4e0d\u662f\u4ee5\u627eGLP-1\u540c\u6e90\u86cb\u767d\u7684\u76ee\u7684\u53d1\u73b0Extendin-4\u7684\u3002\u800c\u662f\u53d1\u73b0\u4e86Extendin-4\u4e4b\u540e\u624d\u53d1\u73b0\u5b83\u8ddfGLP-1\u5f88\u50cf\u3002\u968f\u540e\u4ed6\u53c8\u505a\u4e86\u4e00\u4e9b\u5b9e\u9a8c\uff0c\u8bc1\u660e\u4e86Extendin-4\u4e0d\u4f46\u5e8f\u5217\u8ddfGLP-1\u76f8\u4f3c\uff0c\u800c\u4e14\u786e\u5b9e\u4e5f\u80fd\u591f\u6fc0\u6d3b\u4eba\u7c7b\u7684GLP-1 receptor. \u90a3\u8fd9\u6837\u5b83\u5c31\u5177\u6709\u5de8\u5927\u7684\u836f\u7269\u7814\u53d1\u4ef7\u503c\u4e86\uff0cExtendin-4\u662f\u5316\u5b66\u5206\u5b50\u7684\u540d\u5b57\uff0cExenatide\u662f\u628a\u5b83\u5236\u5907\u7eaf\u5316\u5f97\u5230\u7684\u836f\u7269\u7684\u540d\u5b57\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Exenatide\u7684\u533b\u5b66\u8f6c\u5316\u8fc7\u7a0b<\/h4>\n\n\n\n<p>Extendin-4\u5728\u4eba\u8840\u6d46\u4e2d\u7684\u534a\u8870\u671f\u5927\u6982\u57282.4h\uff0c\u6bd4native GLP-1\u76842~3min\u9ad8\u4e86\u6570\u500d\u4e0d\u6b62\u3002\u534a\u8870\u671f\u957f\u7684\u539f\u56e0\u6709\u4ee5\u4e0b\u51e0\u70b9\uff1a<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>\u4e0b\u56fe\u4e2dGLP-1\u4eceN\u7aef\u5f00\u59cb\u7684\u7b2c\u4e8c\u4e2a\u6c28\u57fa\u9178(A)\u662fDPP-4\u7684\u8bc6\u522b\u4f4d\u70b9\uff0c\u800cExtendin-4\u7684\u8fd9\u4e00\u4f4d\u6c28\u57fa\u9178\u66ff\u6362\u6210\u4e86Glycine\uff0c\u6240\u4ee5\u6781\u5927\u963b\u788d\u4e86DPP-4\u7684\u8bc6\u522b\uff1b<\/li>\n\n\n\n<li>Extendin-4\u4e2d\u95f4\u90e8\u5206\u7684\u82e5\u5e72\u6c28\u57fa\u9178\u66ff\u6362\u80fd\u591f\u6291\u5236\u5b83\u81ea\u5df1\u88abNEP24.11\uff08\u53e6\u4e00\u79cd\u964d\u89e3GLP-1\u7684\u9176\uff09\u7684\u8bc6\u522b\u548c\u964d\u89e3\uff1b<\/li>\n\n\n\n<li>Extendin-4\u7684C\u7aef\u76849\u4e2a\u6c28\u57fa\u9178\u94fe\u80fd\u591f\u589e\u5f3a\u8fd9\u4e2a\u5206\u5b50\u7684\u5316\u5b66\u7a33\u5b9a\u6027\u3002<\/li>\n<\/ol>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" decoding=\"async\" src=\"https:\/\/eamonimgbed.oss-cn-beijing.aliyuncs.com\/img\/202311170510206.png?x-oss-process=style\/screenshots\" alt=\"image-20231117051046199\" \/><\/figure>\n\n\n\n<p>\u4ece1992\u5e74\u53d1\u73b0\u5f00\u59cb\uff0cEng John\u535a\u58eb\u4e8e1994\u5e74\u6210\u529f\u7533\u8bf7\u5230\u4e86Extendin-4\u7684\u4e13\u5229\u30021996\u5e74\u7684\u65f6\u5019\uff0c\u4ed6\u53bb\u53c2\u52a0\u7f8e\u56fd\u4e00\u4e2a\u7cd6\u5c3f\u75c5\u76f8\u5173\u7684\u5e74\u4f1a\uff0c\u5728\u4f1a\u4e0a\u5c55\u793a\u4e86\u4e00\u4e2aposter\uff0c\u7136\u540e\u5f53\u65f6\u5728\u7814\u7a76\u76f8\u5173\u836f\u7269\u7684Amylin\u516c\u53f8\u7684\u6280\u672f\u4eba\u5458\u770b\u5230\u4e86\uff0c\u4e8e\u662f\u4e00\u62cd\u5373\u5408\u5f00\u59cb\u4ecb\u5165\u8d44\u672c\u7684\u529b\u91cf\u6b63\u5f0f\u5f00\u59cb\u4e86Extendin-4\u7684\u533b\u5b66\u8f6c\u5316\u30022002\u5e74\u7684\u65f6\u5019\uff0c\u4f34\u968f\u7740Amylin\u7684\u8d22\u52a1\u5371\u673a\uff0c\u53e6\u4e00\u4e2a\u66f4\u725b\u903c\u7684\u516c\u53f8Eli Lilly\u52a0\u5165\u4e86Exenatide\u7684\u7814\u53d1\u30022005\u5e74\uff0cExenatide\u88abFDA\u6279\u51c6\u4e0a\u5e02\u3002\u6b64\u65f6\uff0c\u8ddd\u79bbEng John\u4ece\u7f8e\u56fd\u6bd2\u8725\u4e2d\u53d1\u73b0Extendin-4\u5df2\u7ecf\u8fc7\u53bb\u4e8613\u5e74\u30022009\u5e74\uff0cExtenatide\u8fdb\u5165\u4e2d\u56fd\u5e02\u573a\uff0c\u540d\u5b57\u662fByetta\/\u767e\u6ccc\u8fbe\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" decoding=\"async\" src=\"https:\/\/eamonimgbed.oss-cn-beijing.aliyuncs.com\/img\/202311170511858.png?x-oss-process=style\/screenshots\" alt=\"image-20231117051103761\" \/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\">\u957f\u6548Exenatide\u7684\u533b\u5b66\u8f6c\u5316\u8fc7\u7a0b<\/h4>\n\n\n\n<p>2005\u5e74\u4e0a\u5e02\u7684Exenatide\u662fGLP-1\u7c7b\u4f3c\u7269\u76f8\u5173\u836f\u7269\u4e2d\u7684\u7b2c\u4e00\u4e2a\u4e0a\u5e02\u7684\u836f\u7269\uff08First-in-class\uff09\uff0c\u5b83\u9700\u8981\u75c5\u4eba<strong>\u6bcf\u5929\u6253\u4e24\u9488<\/strong>\u624d\u80fd\u7ef4\u6301\u836f\u6548\u3002<\/p>\n\n\n\n<p>\u663e\u7136\uff0c\u5bf9\u4e8e\u4e00\u4e2a\u957f\u671f\u836f\u7269\uff0c\u6bcf\u5929\u6253\u4e24\u9488\u5bf9\u4e8e\u75c5\u4eba\u6765\u8bf4\u662f\u4e00\u4e2a\u5f88\u5927\u7684\u8eab\u4f53\u548c\u7cbe\u795e\u8d1f\u62c5\u3002\u6240\u4ee5Amylin\u6ca1\u6709\u6b62\u6b65\u4e0d\u524d\uff0c\u800c\u662f\u5728Exenatide\u7684\u57fa\u7840\u4e0a\u7ee7\u7eed\u5f00\u53d1\u66f4\u957f\u6548\u7684\u836f\u7269\u3002<\/p>\n\n\n\n<p>2012\u5e74\uff0clong-term Exenatide\u6279\u51c6\u4e0a\u5e02\uff0c\u836f\u540d\u53ebBydureon\uff0c\u5b83\u53ea\u9700\u8981<strong>\u6bcf\u5468\u6253\u4e00\u9488<\/strong>\u3002<\/p>\n\n\n\n<p>Bydureon\u7528\u7684\u5176\u5b9e\u8fd8\u662fExtendin-4\uff0c\u636e\u6211\u7684\u7406\u89e3\u5e94\u8be5\u662f\u5206\u5b50\u5f0f\u4e00\u70b9\u90fd\u6ca1\u53d8\uff0c\u4f46\u662f\u5728\u5916\u9762\u52a0\u4e86\u4e00\u5c42Glycolic acid\u548cLactic acid\u7684\u805a\u5408\u7269\u5f62\u6210\u7684\u5fae\u56ca\uff0c\u4e8e\u662f\u5236\u6210\u4e86\u7f13\u91ca\u5242\u3002\u8fd9\u4e00\u836f\u7269\u7684\u6210\u529f\u4f9d\u8d56\u4e8eAmylin\u548c\u836f\u7269\u7f13\u91ca\u5242\u4e13\u5bb6Alkermes\u516c\u53f8\u7684\u5408\u4f5c\u3002Bydureon\u5728\u8840\u6d46\u4e2d\u7684\u534a\u8870\u671f\u8fbe\u5230\u4e86\u6050\u6016\u7684\u4ee5\u661f\u671f\u4e3a\u5355\u4f4d\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" decoding=\"async\" src=\"https:\/\/eamonimgbed.oss-cn-beijing.aliyuncs.com\/img\/202311170511255.png?x-oss-process=style\/screenshots\" alt=\"image-20231117051137135\" \/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\">Exenatide\u7684\u7f3a\u70b9<\/h4>\n\n\n\n<p>Exenatide\u6bd5\u7adf\u662f\u8de8\u7269\u79cd\u4ece\u8725\u8734\u90a3\u91cc\u6765\u7684\uff0c\u5b83\u4e0eGLP-1\u7684\u5e8f\u5217\u76f8\u4f3c\u6027\u53ea\u670953%\u3002\u5b9e\u9a8c\u8bc1\u660e\uff0c\u670940%\u7684\u75c5\u4eba\u5728\u7ecf\u8fc7Exenatide\u6cbb\u7597\u540e\u4ea7\u751f\u4e86\u9488\u5bf9\u8fd9\u79cd\u5206\u5b50\u7684\u4e2d\u548c\u6297\u4f53\u3002\u4ea7\u751f\u6297\u4f53\u672c\u8eab\u663e\u7136\u5bf9\u836f\u6548\u6709\u526f\u4f5c\u7528\uff0c\u8fd8\u5b58\u5728\u6f5c\u5728\u7684\u8bf1\u53d1\u514d\u75ab\u53cd\u5e94\u7684\u540e\u679c\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Liraglutide\uff08\u5229\u62c9\u9c81\u80bd\uff09<\/h3>\n\n\n\n<p>\u5728Exenatide\u957f\u8fbe13\u5e74\u7684\u7814\u53d1\u8fc7\u7a0b\u4e2d\uff0c\u8d5b\u9053\u4e2d\u663e\u7136\u4e0d\u53ea\u6709Amylin\u548cEli Lilly\u8fd9\u4e24\u5bb6\u516c\u53f8\uff0c\u53e6\u4e00\u4e2a\u7cd6\u5c3f\u75c5\u5de8\u5934\u516c\u53f8Novo Nordisk\uff08\u8bfa\u548c\u8bfa\u5fb7\uff09\u4e5f\u5728\u4e89\u5206\u593a\u79d2\u7814\u53d1GLP-1\u7c7b\u4f3c\u7269\u836f\u7269\uff0c\u62a2\u5360\u5e02\u573a\u3002\u8bfa\u548c\u8bfa\u5fb7\u7684\u79d1\u5b66\u5bb6\u4e5f\u610f\u8bc6\u5230\u4e86Extendin-4\u5bb9\u6613\u8bf1\u53d1\u514d\u75ab\u53cd\u5e94\u7684\u95ee\u9898\uff0c\u4ed6\u4eec\u575a\u6301\u4ece\u4eba\u6e90GLP-1\u4e3a\u57fa\u7840\uff0c\u5bf9\u5b83\u8fdb\u884c\u6539\u9020\u4fee\u9970\u6765\u5ef6\u957f\u534a\u8870\u671f\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Liraglutide\u7684\u533b\u5b66\u8f6c\u5316\u8fc7\u7a0b<\/h4>\n\n\n\n<p>\u4e00\u53e5\u8bdd\u6982\u62ec\uff1a\u7ed9GLP-1\u52a0\u4e0a\u4e00\u4e2a\u8102\u80aa\u9178\u94fe\uff0c\u540e\u8005\u53ef\u4ee5\u975e\u5171\u4ef7\u5730\u7ed3\u5408Albumin\uff0c\u7136\u540e\u5c31\u8fbe\u5230\u4e86\u7c7b\u4f3c\u4e0a\u9762\u65b9\u6846\u91cc\u5199\u7684\u878d\u5408Albumin\u7684\u5ef6\u957f\u534a\u8870\u671f\u6548\u679c\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" decoding=\"async\" src=\"https:\/\/eamonimgbed.oss-cn-beijing.aliyuncs.com\/img\/202311170512480.png?x-oss-process=style\/screenshots\" alt=\"image-20231117051221079\" \/><\/figure>\n\n\n\n<p>\u7a0d\u5fae\u7ec6\u8282\u4e00\u70b9\u7684\u70b9\uff1a<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>\u8102\u80aa\u9178\u94fe\u901a\u8fc7\u81ea\u5df1\u7684\u7f9f\u57fa\u548cGLP-1\u4e0aLysine\u7684\u4fa7\u94fe\u6c28\u57fa\u53d1\u751f\u9170\u5316\u53cd\u5e94\u8fde\u63a5\u4e0a\u53bb\uff0c\u800cGLP-1\u4e0a\u6709\u4e24\u4e2aLysine\uff0c\u6240\u4ee5\u628a\u7b2c\u4e8c\u4e2aLysine\u7a81\u53d8\u6210\u4e86Arginine\uff08\u636e\u7f57\u8001\u5e08\u8bf4\u8fd9\u662f\u4e2a\u4fdd\u5b88\u7a81\u53d8\uff09\uff0c\u8fd9\u6837\u5c31\u6d88\u9664\u4e86\u9170\u5316\u4f4d\u70b9\u7684\u9009\u62e9\u6027\u3002<\/li>\n\n\n\n<li>\u8102\u80aa\u9178\u94fe\u548cLysine\u4e4b\u95f4\u8fd8\u52a0\u4e86\u4e00\u4e2a\u03b3-Glutamate\uff0c\u636e\u8bf4\u521a\u5f00\u59cb\u6ca1\u52a0\u8fd9\u4e2aglutamate\uff0c\u5206\u5b50\u7279\u522b\u7c98\u7a20\uff0c\u7eaf\u5316\u7684\u65f6\u5019\u65e0\u6cd5\u4ece\u8272\u8c31\u67f1\u4e0a\u6d17\u8131\u4e0b\u6765\u3002\u540e\u6765\u52a0\u4e86\u8fd9\u4e2a\u8c37\u6c28\u9178\u4e4b\u540e\uff0c\u53ef\u80fd\u662f\u56e0\u4e3a\u5f15\u5165\u4e86\u4e00\u4e2a\u7fa7\u57fa\uff08\u8c37\u6c28\u9178\u4fa7\u94fe\u6709\u4e00\u4e2a\u989d\u5916\u7684\u7fa7\u57fa\uff09\uff1f\u6240\u4ee5\u6c34\u6eb6\u6027\u597d\u591a\u4e86\u3002\u540c\u65f6\uff0c\u6709\u6587\u732e\u8868\u660e\uff0c\u589e\u52a0\u4e00\u4e2a\u7fa7\u57fa\u4e5f\u80fd\u589e\u5f3a\u8102\u80aa\u9178\u94fe\u4e0e\u767d\u86cb\u767d\u7684\u975e\u5171\u4ef7\u7ed3\u5408\u80fd\u529b\u3002<\/li>\n<\/ol>\n\n\n\n<p>Liraglutide\u7684\u534a\u8870\u671f\u4ecenative GLP-1\u76842~3min\u5ef6\u957f\u5230\u4e8612h\uff0c\u5b83\u9700\u8981\u75c5\u4eba<strong>\u6bcf\u5929\u6ce8\u5c04\u4e00\u9488<\/strong>\u3002<\/p>\n\n\n\n<p>\u4e00\u4e9b\u65f6\u95f4\u8282\u70b9\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>2009, Liraglutide (1.2\/1.8 mg), approved by EMA (for type II diabetes).<\/li>\n\n\n\n<li>2010, Liraglutide (1.2\/1.8 mg), approved by FDA (for type II diabetes).<\/li>\n\n\n\n<li>2014, Liraglutide (1.2\/1.8 mg) approved by FDA (for adult obesity). \/\/\u6ca1\u9519GLP-1\u8fd8\u6709\u6291\u5236\u98df\u6b32\u51cf\u8f7b\u4f53\u91cd\u7684\u4f5c\u7528<\/li>\n\n\n\n<li>2020, Liraglutide (3.0 mg) approved by FDA (for obesity of 12-17 year-old patients).<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Liraglutide\u7684\u7f3a\u70b9<\/h4>\n\n\n\n<p>Dominant <strong>gastrointestinal side effects\uff08\u80a0\u80c3\u9053\u526f\u4f5c\u7528\uff09<\/strong>, such as nausea (\u6076\u5fc3), diarrhea (\u8179\u6cfb), vomiting (\u5455\u5410), and constipation (\u4fbf\u79d8).<\/p>\n\n\n\n<p>\u600e\u4e48\u89e3\u51b3\u7684\u8fd9\u4e2a\u95ee\u9898\u5462\uff1f\u7528&#8221;Dose titration&#8221;\u7684\u65b9\u6cd5\uff0c\u5c31\u662f\u4ece\u4f4e\u5242\u91cf\u5f00\u59cb\u8ba9\u75c5\u4eba\u654f\u611f\u6027\u964d\u4f4e\uff0c\u7b49\u75c5\u4eba\u9002\u5e94\u4e86\u8fd9\u4e2a\u5242\u91cf\u4e0d\u4f1a\u4ea7\u751f\u660e\u663e\u526f\u4f5c\u7528\u540e\uff0c\u518d\u4e00\u70b9\u70b9\u63d0\u9ad8\u5242\u91cf\u3002<\/p>\n\n\n\n<p>Dose titration of Liraglutide:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Starting dose: <strong>0.6 mg<\/strong> once daily, <strong>at least 1 week<\/strong>.<\/li>\n\n\n\n<li>Incease dose to <strong>1.2 mg<\/strong> once daily, <strong>at least 1 week<\/strong>.<\/li>\n\n\n\n<li>A further dose to <strong>1.8 mg<\/strong> once daily, higher dose is not recommended.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">\u516b\u5366<\/h2>\n\n\n\n<p>\u4f60\u53ef\u4ee5\u770b\u5230\u4e0a\u9762\u7684\u65f6\u95f4\u8282\u70b9\u662f\u6709\u91cd\u5408\u7684\uff0c\u4f46\u662f\u5e02\u573a\u5c31\u5730\u7403\u4e00\u4e2a\u5e02\u573a\uff0c\u6240\u4ee5\u4e2d\u95f4\u4f1a\u6709\u4e0d\u540c\u516c\u53f8\u7684\u4e4b\u95f4\u7684\u826f\u6027\u6216\u6076\u6027\u7ade\u4e89\uff0c\u6bd4\u5982\u5728\u5bf9\u6bd4\u7597\u6548\u7684\u8bba\u6587\u91cc\u4f7f\u4e00\u70b9\u5fc3\u673a\u628a\u5bf9\u624b\u7684\u5242\u91cf\u964d\u4f4e\u2026\u2026<\/p>\n\n\n\n<p>Exenatide\u81ea1992\u53d1\u73b0\uff0c2005\u5e74\u624d\u8f6c\u5316\u6210\u529f\uff0c\u7136\u800cLiraglutide 2009~2010\u5e74\u5c31\u4e0a\u5e02\u4e86\uff0c\u540e\u6765\u6bd4Exenatide\u66f4\u53d7\u6b22\u8fce\u3002\u6240\u4ee5Exenatide\u7684\u9500\u552e\u9ec4\u91d1\u671f\u53ef\u80fd\u5c314~5\u5e74\u7684\u6837\u5b50\u3002\u540e\u9762Exenatide\u63a8\u51fa\u4e86\u957f\u6548\u7248\u672c\uff0c\u8bfa\u548c\u8bfa\u5fb7\u7684Liraglutide\u4e5f\u63a8\u51fa\u4e86\u957f\u6548\u7248\u672cSemaglutide\u3002<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>Semaglutide\u628aLiraglutide\u7684N\u7aef\u90a3\u4e2a\u6613\u88abDPP-4\u8bc6\u522b\u7684\u6c28\u57fa\u9178\u66ff\u6362\u6210\u4e86\u4e00\u4e2a\u81ea\u7136\u754c\u4e0d\u5b58\u5728\u7684\u4eba\u5de5\u6c28\u57fa\u9178AIB\uff0c\u7136\u540e\u8102\u80aa\u9178\u4ece16\u78b3\u6362\u6210\u4e8618\u78b3\uff0c\u5e76\u5728\u8102\u80aa\u9178\u94fe\u7684\u6e38\u79bb\u7aef\u53c8\u6dfb\u4e86\u4e00\u4e2a\u7fa7\u57fa\u3002\u534a\u8870\u671f\u8fbe\u5230160h\uff0c\u4e8e\u662f\u4e5f\u53ef\u4ee5\u4e00\u5468\u6ce8\u5c04\u4e00\u6b21\u4e86\u3002<\/p>\n<\/blockquote>\n\n\n\n<p>\u5f53\u7136\u8fd8\u6709\u597d\u591aPlayer\uff0cRoche\u3001Pfizer\u3001\u8bda\u76ca\u751f\u7269\u7b49\u7b49\u2026\u2026\u7136\u540e\u6709\u5173\u4e13\u5229\u3001\u7597\u6548\u3001\u5e02\u573a\u7684\u516b\u5366\u6545\u4e8b\u4e5f\u6709\u597d\u591a\u2026\u2026\u8fd9\u90e8\u5206\u662f\u201c\u54e6\u83ab\u201d\u540c\u5b66\u8bb2\u7684\uff0c\u6211\u61d2\u5f97\u6574\u7406\u4e86\u3002\u540e\u9762\u7684\u65b9\u5411\u636e\u8bf4\u662f\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u5982\u679c\u80fd\u627e\u5230\u4e00\u4e2a\u80fd\u591f\u6fc0\u6d3bGLP-1 receptor\u7684\u5c0f\u5206\u5b50\uff0c\u5c31\u4e0d\u7528\u53bb\u8003\u8651\u4ec0\u4e48DPP-4\u964d\u89e3\u3001\u514d\u75ab\u539f\u6027\u3001\u80c3\u80a0\u9053\u6d88\u5316\u7b49\u7b49\u95ee\u9898\u4e86\u3002\u8f89\u745e\u6709\u4e2a\u5c0f\u5206\u5b50\u6b63\u5728\u4e8c\u671f\u4e34\u5e8a\u3002\u53e6\u59162019\u5e74\u4e0a\u5e02\u4e86\u53e3\u670d\u7248\u672c\u7684Semaglutide\uff0c\u75c5\u4eba\u4e0d\u7528\u6253\u9488\u4e86\uff0c\u4e0d\u8fc7\u5e02\u573a\u5360\u6709\u7387\u591a\u5c11\u6211\u4e0d\u77e5\u9053\u2026\u2026<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n\n\n<h2 class=\"wp-block-heading\">\u62d3\u5c55\u8d44\u6599<\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li><a href=\"https:\/\/zhuanlan.zhihu.com\/p\/420271868\">GLP-1\u7684\u524d\u4e16\u4eca\u751f\u2014\u2014\u8ffd\u5bfbBest-in-Class GLP-1RA\u7684\u7231\u6068\u60c5\u4ec7 &#8211; \u77e5\u4e4e (zhihu.com)<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/mp.weixin.qq.com\/s\/btkXlBt5qNq4bzssIPVExw\">\u91cd\u78c5GLP-1\u836f\u7269\u8bde\u751f\u8bb0\u2014\u2014\u8fd9\u540d\u5973\u6027\u79d1\u5b66\u5bb6\u5982\u4f55\u5e26\u6765\u51cf\u91cd\u7597\u6cd5\u65b0\u65f6\u4ee3<\/a><\/li>\n\n\n\n<li>\u4e00\u7bc7\u7efc\u8ff0 Tan Q, Akindehin SE, Orsso CE, et al. <strong>Recent Advances in Incretin-Based Pharmacotherapies for the Treatment of Obesity and Diabetes.<\/strong> Front Endocrinol (Lausanne). 2022;13:838410. Published 2022 Mar 1. doi:10.3389\/fendo.2022.838410<\/li>\n\n\n\n<li>Knudsen LB, Lau J. <strong>The Discovery and Development of Liraglutide and Semaglutide.<\/strong> Front Endocrinol (Lausanne). 2019;10:155. Published 2019 Apr 12. doi:10.3389\/fendo.2019.00155<\/li>\n\n\n\n<li>M\u00fcller TD, Clemmensen C, Finan B, DiMarchi RD, Tsch\u00f6p MH. <strong>Anti-Obesity Therapy: from Rainbow Pills to Polyagonists.<\/strong> Pharmacol Rev. 2018 Oct;70(4):712-746. doi: 10.1124\/pr.117.014803. PMID: 30087160.<\/li>\n\n\n\n<li>DeYoung MB, MacConell L, Sarin V, Trautmann M, Herbert P. <strong>Encapsulation of exenatide in poly-(D,L-lactide-co-glycolide) microspheres produced an investigational long-acting once-weekly formulation for type 2 diabetes.<\/strong> Diabetes Technol Ther. 2011 Nov;13(11):1145-54. doi: 10.1089\/dia.2011.0050. Epub 2011 Jul 13. PMID: 21751887; PMCID: PMC3202891.<\/li>\n\n\n\n<li>Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, et al. <strong>Once-Weekly Semaglutide in Adults With Overweight or besity.<\/strong> N Engl J Med (2021) 384(11):989. doi: 10.1056\/NEJMoa2032183<\/li>\n\n\n\n<li>Gough SC. <strong>Liraglutide: from clinical trials to clinical practice.<\/strong> Diabetes Obes Metab. 2012 Apr;14 Suppl 2:33-40. doi: 10.1111\/j.1463-1326.2012.01576.x. PMID: 22405267.<\/li>\n<\/ol>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" decoding=\"async\" src=\"https:\/\/eamonimgbed.oss-cn-beijing.aliyuncs.com\/img\/202311170519109.jpg?x-oss-process=style\/screenshots\" alt=\"cb90515e5096d91d514148336fd6d39\" \/><\/figure>\n\n\n\n<p>\u5c31\u8fd9\u6837\u5427~<\/p>\n\n\n\n<p>\u6536\u7a3f\u65f6\u95f4\uff1a2023\/11\/17 5:23<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n\n\n<p><\/p>\n\n\n\n<p>\u987a\u4fbf\u8bb0\u4e00\u4e0b\u7ed3\u8bfe\u6536\u83b7\uff1a<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>\u3010\u7533\u8bf7\u4e13\u5229\u3011\u5728\u3010\u53d1\u8868\u6587\u7ae0\u3011\u4e4b\u524d\uff0c\u5982\u679c\u5148\u53d1\u6587\u7ae0\u76f8\u5f53\u4e8e\u5df2\u7ecf\u516c\u5f00\u4e86\uff0c\u5c31\u4e0d\u80fd\u7533\u8bf7\u4e13\u5229\u4e86\u3002\u4e00\u5b9a\u8981\u5728\u4e13\u5229\u6280\u672f\u516c\u5f00\u4e4b\u524d\u63d0\u4ea4\u4e13\u5229\u7533\u8bf7\u3002\u5305\u62ec\u5728\u516c\u5f00\u573a\u5408\u8bb2\u62a5\u544a\u548c\u5c55\u793a\u6d77\u62a5\u90fd\u7b97\u516c\u5f00\uff0c\u5982\u679c\u88ab\u68c0\u4e3e\u90fd\u4e0d\u80fd\u7533\u8bf7\u4e86\uff01<\/li>\n\n\n\n<li>\u64b0\u5199\u9ad8\u6c34\u5e73\u7684\u3010\u4e13\u5229\u8bf4\u660e\u4e66\u3011\u5bf9\u79d1\u5b66\u5bb6\u6765\u8bf4\u662f\u51e0\u4e4e\u4e0d\u53ef\u80fd\u5b8c\u6210\u7684\u4efb\u52a1\uff0c\u4e00\u5b9a\u8981\u59d4\u6258\u4e13\u4e1a\u6cd5\u5f8b\u4eba\u58eb\u3002\u79d1\u5b66\u5bb6\u81ea\u5df1\u9700\u8981\u63d0\u4f9b\u3010\u6280\u672f\u4ea4\u5e95\u4e66\u3011\u2014\u2014\u3010\u4e13\u5229\u4ee3\u7406\u4eba\u3011\u662f\u4e00\u4e2a\u804c\u4e1a\u9009\u62e9\u3002<\/li>\n\n\n\n<li>\u6ce8\u610f\uff1a\u62e5\u6709\u4e13\u5229\uff0c\u4f9d\u7136\u6709\u53ef\u80fd\u5728\u53d8\u6210\u4ea7\u54c1\u7684\u67d0\u4e9b\u73af\u8282\u4e2d\u4fb5\u522b\u4eba\u7684\u6743\u3002<\/li>\n\n\n\n<li>\u4e13\u5229\u6587\u732e\uff0c\u76f8\u6bd4\u5b66\u672f\u8bba\u6587\uff0c\u4e5f\u5f88\u6709\u4ef7\u503c\u3002\n<ul class=\"wp-block-list\">\n<li>\u65b0<\/li>\n\n\n\n<li>\u53ef\u64cd\u4f5c\u6027\u5f3a<\/li>\n\n\n\n<li>\u5e26\u6765\u610f\u60f3\u4e0d\u5230\u7684\u542f\u793a<\/li>\n\n\n\n<li>\u65e0\u6548\u4e13\u5229\u81ea\u7531\u4f7f\u7528<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>\u7f51\u7ad9\uff1a\n<ul class=\"wp-block-list\">\n<li>\u4e2d\u56fd\u53ca\u591a\u56fd\u4e13\u5229\u5ba1\u67e5\u4fe1\u606f\u67e5\u8be2<\/li>\n\n\n\n<li>Ptentics<\/li>\n\n\n\n<li>\u56fd\u77e5\u5c40\u7f51\u7ad9<\/li>\n\n\n\n<li>Soopat<\/li>\n\n\n\n<li>Wipo\u4e16\u754c\u77e5\u8bc6\u4ea7\u6743\u5c40\u6570\u636e\u5e93<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>\u836f\u7269\u8f6c\u5316\u867d\u7136\u8bf4\u6839\u672c\u662f\u79d1\u5b66\uff0c\u4f46\u66f4\u591a\u8f6c\u5316\u8fc7\u7a0b\u4e2d\u7684\u4e13\u5229\u3001\u8d44\u672c\u3001\u8bc9\u8bbc\u3001\u4e34\u5e8a\u5b9e\u9a8c\u3001\u5e02\u573a\u7b49\u7b49\u624d\u662f\u66f4\u8981\u547d\u7684\u4e1c\u897f\u3002<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>\u8fd9\u7bc7\u7b14\u8bb0\u8bb0\u5f55\u4e86\u4f5c\u8005\u5728\u201c\u8f6c\u5316\u533b\u5b66\u548c\u836f\u7269\u7814\u53d1\u201d\u8bfe\u7a0b\u4e2d\u5173\u4e8eGLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u7684\u7cfb\u7edf\u6027\u68b3\u7406\u3002\u6587\u7ae0\u4eceGLP-1\u7684\u201c\u8461\u8404\u7cd6\u4f9d\u8d56\u6027\u201d\u964d\u7cd6\u673a\u5236\u5165\u624b\uff0c\u6df1\u5165\u5256\u6790\u4e86\u5176\u534a\u8870\u671f\u77ed\u7684\u6838\u5fc3\u95ee\u9898\uff0c\u5e76\u8be6\u7ec6\u5bf9\u6bd4\u4e86Exenatide\uff08\u4ece\u8725\u8734\u6bd2\u6db2\u4e2d\u53d1\u73b0\uff09\u4e0eLiraglutide\uff08\u57fa\u4e8e\u4eba\u6e90GLP-1\u6539\u9020\uff09\u4e24\u79cd\u7ecf\u5178\u836f\u7269\u7684\u7814\u53d1\u5386\u7a0b\u3001\u6280\u672f\u7b56\u7565\u4e0e\u5546\u4e1a\u7ade\u4e89\uff0c\u751f\u52a8\u5c55\u73b0\u4e86\u4ece\u57fa\u7840\u53d1\u73b0\u5230\u6210\u529f\u836f\u7269\u7684\u8f6c\u5316\u5168\u8c8c\u3002<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-229","post","type-post","status-publish","format-standard","hentry","category-note"],"_links":{"self":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts\/229","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=229"}],"version-history":[{"count":2,"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts\/229\/revisions"}],"predecessor-version":[{"id":14149,"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts\/229\/revisions\/14149"}],"wp:attachment":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=229"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=229"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=229"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}