{"id":3210,"date":"2024-04-30T16:36:11","date_gmt":"2024-04-30T08:36:11","guid":{"rendered":"https:\/\/fanyiming.life\/?p=3210"},"modified":"2025-12-21T01:05:09","modified_gmt":"2025-12-20T17:05:09","slug":"science-crispr-guided-rna-breaks","status":"publish","type":"post","link":"https:\/\/fanyiming.life\/?p=3210","title":{"rendered":"Science: CRISPR-guided RNA breaks"},"content":{"rendered":"\n<p><a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.adk5518\">Repair of CRISPR-guided RNA breaks enables site-specific RNA excision in human cells | Science<\/a><\/p>\n\n\n\n<p>\u8ddf\u6211\u4eec\u7ec4\u5f88\u50cf\u7684\u7814\u7a76<\/p>\n\n\n\n<p>\u8fd9\u7bc7\u6587\u7ae0\u5e26\u7ed9\u6211\u4e00\u4e2a\u542f\u53d1\u3002\u6211\u4eec\u7ec4\u7684\u5b9e\u9a8c\u4e00\u76f4\u6709\u4e2a\u88ab\u8d28\u7591\u7684\u95ee\u9898\u5728\u4e8e\uff0c\u53d1\u73b0\u7684RNA ligation\u73b0\u8c61\u53d1\u751f\u5728\u4eba\u4e3a\u5f15\u5165Cas13d\u5207\u5272\u540e\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u4e00\u76f4\u5728\u601d\u8003\u600e\u4e48\u627e\u5230\u81ea\u7136\u754c\u4e2d\u672c\u8eab\u5b58\u5728\u800c\u975e\u4eba\u4e3a\u5f15\u5165\u7684RNA cleavage\u3002\u800c\u8fd9\u7bc7\u6587\u7ae0\u5c31\u6ca1\u6709\u5f80\u8fd9\u4e2a\u65b9\u5411\u601d\u8003\uff0c\u800c\u662f\u76f4\u63a5\u628a\u201c\u76ee\u7684\u201d\u8bf4\u6210\u6cbb\u75c5\uff0c\u4ed6\u4eec\u662f\u5229\u7528sthCsm\u505a\u4e86\u4e00\u4e2a\u6cbb\u75c5\u7684\u201c\u5de5\u5177\u201d\uff0c\u8fd9\u6837\u5c31\u4e0d\u4f1a\u88ab\u8d28\u7591\u662f\u4e0d\u662f\u201c\u6ca1\u6709\u751f\u7269\u5b66\u610f\u4e49\u201d\uff0c\u6bd5\u7adf\u7b97\u4e00\u4e2a\u201c\u53d1\u660e\u201d\u800c\u4e0d\u662f\u201c\u53d1\u73b0\u201d\u3002\u8fd9\u4e2a\u601d\u8def\u503c\u5f97\u501f\u9274\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u8fd9\u7bc7\u53d1\u8868\u4e8e\u300aScience\u300b\u7684\u7814\u7a76\uff0c\u5f00\u53d1\u4e86\u57fa\u4e8eCRISPR-Cas\u7cfb\u7edf\uff08\u5982Csm\u590d\u5408\u7269\uff09\u7684RNA\u9776\u5411\u4e0e\u4fee\u590d\u5de5\u5177\uff0c\u5b9e\u73b0\u4e86\u5728\u4eba\u7c7b\u7ec6\u80de\u4e2d\u8fdb\u884c\u4f4d\u70b9\u7279\u5f02\u6027RNA\u5207\u9664\u3002\u4f5c\u8005\u4ece\u4e2d\u83b7\u5f97\u542f\u53d1\uff0c\u63a2\u8ba8\u4e86\u5982\u4f55\u5c06\u7c7b\u4f3c\u7684RNA\u8fde\u63a5\u73b0\u8c61\uff0c\u4ece\u9a8c\u8bc1\u751f\u7269\u5b66\u610f\u4e49\u7684\u57fa\u7840\u7814\u7a76\uff0c\u8f6c\u5316\u4e3a\u4ee5\u6cbb\u7597\u5e94\u7528\u4e3a\u660e\u786e\u76ee\u6807\u7684\u5de5\u5177\u5f00\u53d1\u601d\u8def\u3002<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[18],"tags":[20,19],"class_list":["post-3210","post","type-post","status-publish","format-standard","hentry","category-18","tag-crispr","tag-rna"],"_links":{"self":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts\/3210","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3210"}],"version-history":[{"count":2,"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts\/3210\/revisions"}],"predecessor-version":[{"id":14008,"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts\/3210\/revisions\/14008"}],"wp:attachment":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3210"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3210"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3210"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}