{"id":5952,"date":"2024-09-11T12:52:47","date_gmt":"2024-09-11T04:52:47","guid":{"rendered":"https:\/\/fanyiming.life\/?p=5952"},"modified":"2025-12-21T01:04:28","modified_gmt":"2025-12-20T17:04:28","slug":"pol-ii","status":"publish","type":"post","link":"https:\/\/fanyiming.life\/?p=5952","title":{"rendered":"Pol II"},"content":{"rendered":"\n<p>RNA\u805a\u5408\u9176 II\uff08Pol II\uff09\u662f\u8d1f\u8d23\u771f\u6838\u7ec6\u80de\u4e2dmRNA\u5408\u6210\u7684\u6838\u5fc3\u9176\uff0c\u5176\u5c3e\u90e8\u643a\u5e26\u7684C\u672b\u7aef\u7ed3\u6784\u57df\uff08CTD\uff09\u5728\u8f6c\u5f55\u8fc7\u7a0b\u4e2d\u88ab\u591a\u79cd\u86cb\u767d\u6fc0\u9176\u4fee\u9970\uff0c\u5176\u4e2d\u6700\u91cd\u8981\u7684\u4fee\u9970\u662f\u7b2c2\u4f4d\uff08Ser2\uff09\u548c\u7b2c5\u4f4d\uff08Ser5\uff09\u4e1d\u6c28\u9178\u7684\u78f7\u9178\u5316\uff08p\uff09\uff0c\u5206\u522b\u5f62\u6210Ser2\u78f7\u9178\u5316\uff08Ser2p\uff09\u548cSer5\u78f7\u9178\u5316\uff08Ser5p\uff09\u3002\u8fd9\u4e9b\u78f7\u9178\u5316\u4fee\u9970\u5728\u8c03\u63a7\u8f6c\u5f55\u5468\u671f\u4e2d\u7684\u4e0d\u540c\u9636\u6bb5\u626e\u6f14\u5173\u952e\u89d2\u8272\u3002<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Pol II Ser5p<\/strong><br>Ser5p\u7684\u78f7\u9178\u5316\u901a\u5e38\u53d1\u751f\u5728\u8f6c\u5f55\u8d77\u59cb\u9636\u6bb5\u3002\u5b83\u4e3b\u8981\u7531CDK7\u6fc0\u9176\uff08TFIIH\u590d\u5408\u7269\u7684\u7ec4\u6210\u90e8\u5206\uff09\u4ecb\u5bfc\u3002Ser5p\u4e0e\u8f6c\u5f55\u8d77\u59cb\u3001mRNA 5&#8217;\u7aef\u52a0\u5e3d\u6709\u5173\uff0c\u4fc3\u8fdbmRNA\u76845&#8217;\u5e3d\u5f62\u6210\u9176\u4e0ePol II\u7684\u7ed3\u5408\u3002\u5728\u8f6c\u5f55\u65e9\u671f\uff0cSer5p\u6c34\u5e73\u8f83\u9ad8\uff0c\u4e4b\u540e\u5728\u8f6c\u5f55\u5ef6\u4f38\u8fc7\u7a0b\u4e2d\u9010\u6e10\u4e0b\u964d\u3002<\/li>\n\n\n\n<li><strong>Pol II Ser2p<\/strong><br>Ser2p\u7684\u78f7\u9178\u5316\u4e3b\u8981\u53d1\u751f\u5728\u8f6c\u5f55\u5ef6\u4f38\u548c\u8f6c\u5f55\u7ec8\u6b62\u9636\u6bb5\u3002CDK9\uff08P-TEFb\u590d\u5408\u7269\u7684\u4e00\u90e8\u5206\uff09\u8d1f\u8d23Ser2\u7684\u78f7\u9178\u5316\u3002Ser2p\u6807\u5fd7\u7740Pol II\u8fdb\u5165\u4e86\u6709\u6548\u5ef6\u4f38\u72b6\u6001\uff0c\u5e76\u4e0emRNA\u52a0\u5de5\uff08\u5982\u526a\u63a5\u548c3&#8217;\u7aef\u591a\u805a\u817a\u82f7\u9178\u5316\uff09\u5bc6\u5207\u76f8\u5173\u3002Ser2p\u5728\u57fa\u56e0\u76843&#8217;\u7aef\u9ad8\u5ea6\u79ef\u7d2f\uff0c\u4e0e\u8f6c\u5f55\u7ec8\u6b62\u5bc6\u5207\u914d\u5408\u3002<\/li>\n<\/ol>\n\n\n\n<p>\u7b80\u800c\u8a00\u4e4b\uff0cPol II\u7684Ser5p\u548cSer2p\u5206\u522b\u4e0e\u8f6c\u5f55\u8d77\u59cb\u548c\u5ef6\u4f38\u8fc7\u7a0b\u4e2d\u7684\u4e0d\u540c\u529f\u80fd\u76f8\u5173\uff0c\u8fd9\u4e9b\u78f7\u9178\u5316\u4fee\u9970\u5728\u65f6\u95f4\u548c\u7a7a\u95f4\u4e0a\u88ab\u7cbe\u786e\u8c03\u63a7\uff0c\u786e\u4fdd\u57fa\u56e0\u8868\u8fbe\u7684\u51c6\u786e\u6027\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u8fd9\u7bc7\u7b14\u8bb0\u805a\u7126\u771f\u6838\u8f6c\u5f55\u7684\u6838\u5fc3\u5f15\u64ce\u2014\u2014RNA\u805a\u5408\u9176II\uff08Pol II\uff09\uff0c\u8be6\u7ec6\u89e3\u6790\u4e86\u5176C\u672b\u7aef\u7ed3\u6784\u57df\uff08CTD\uff09\u4e0aSer5\u4e0eSer2\u4f4d\u70b9\u7684\u78f7\u9178\u5316\u4fee\u9970\u3002\u8fd9\u4e9b\u52a8\u6001\u4fee\u9970\u7cbe\u786e\u8c03\u63a7\u7740\u8f6c\u5f55\u8d77\u59cb\u3001\u5ef6\u4f38\u53camRNA\u52a0\u5de5\u7b49\u5173\u952e\u73af\u8282\u3002<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-5952","post","type-post","status-publish","format-standard","hentry","category-note"],"_links":{"self":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts\/5952","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5952"}],"version-history":[{"count":2,"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts\/5952\/revisions"}],"predecessor-version":[{"id":13931,"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts\/5952\/revisions\/13931"}],"wp:attachment":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5952"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5952"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5952"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}