{"id":5978,"date":"2024-09-14T23:20:07","date_gmt":"2024-09-14T15:20:07","guid":{"rendered":"https:\/\/fanyiming.life\/?p=5978"},"modified":"2025-12-21T01:04:29","modified_gmt":"2025-12-20T17:04:29","slug":"protac","status":"publish","type":"post","link":"https:\/\/fanyiming.life\/?p=5978","title":{"rendered":"PROTAC"},"content":{"rendered":"\n
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PROTAC \u5168\u79f0\u4e3aproteolysis-targeting chimeras (\u86cb\u767d\u964d\u89e3\u9776\u5411\u5d4c\u5408\u5206\u5b50)\uff0c\u662f\u4e00\u79cd\u6742\u5408\u53cc\u529f\u80fd\u5c0f\u5206\u5b50\u5316\u5408\u7269\uff0c\u7ed3\u6784\u4e2d\u542b\u6709\u4e24\u79cd\u4e0d\u540c\u914d\u4f53\uff0c\u4e00\u4e2a\u662f\u6cdb\u7d20\u8fde\u63a5\u9176 E3 \u914d\u4f53\uff0c\u53e6\u4e00\u4e2a\u662f\u4e0e\u7ec6\u80de\u4e2d\u76ee\u6807\u9776\u86cb\u767d\u7ed3\u5408\u7684\u914d\u4f53\uff0c\u4e24\u4e2a\u914d\u4f53\u4e4b\u95f4\u901a\u8fc7 linker \u76f8\u8fde\uff0c\u4ece\u800c\u5f62\u6210 \u201c \u4e09\u4f53 \u201d \u805a\u5408\u7269\u2014\u2014\u9776\u86cb\u767d\u914d\u4f53-Linker-E3 \u914d\u4f53\u3002PROTACs\u901a\u8fc7\u5c06\u76ee\u6807\u9776\u86cb\u767d\u548c\u7ec6\u80de\u5185\u7684 E3 \u6cdb\u7d20\u8fde\u63a5\u9176\u7684\u8ddd\u79bb\u62c9\u8fd1\uff0c\u5229\u7528\u201c\u6cdb\u7d20-\u86cb\u767d\u9176\u4f53\u201d\u9014\u5f84\u7279\u5f02\u6027\u7684\u964d\u89e3\u9776\u86cb\u767d\u3002PROTACs\u80fd\u591f\u6539\u5584\u201c\u4e0d\u53ef\u6210\u836f\u201d\u9776\u70b9\u7684\u6210\u836f\u6027\u3002<\/p>\nPROTAC \u9776\u5411\u86cb\u767d\u964d\u89e3 | MCE (medchemexpress.cn)<\/a><\/cite><\/blockquote>\n\n\n\n

\u8001\u677f\u8bf4\u4ed6\u8ddf\u5b5f\u9662\u58eb\u804a\u4e86\u804a\uff0c\u540e\u8005\u63a8\u8350\u5c1d\u8bd5\u7528PROTAC\u7814\u7a76nuclear actin\uff0c\u901a\u8fc7\u5c06PROTAC\u5206\u5b50\u9776\u5411\u5230\u7ec6\u80de\u6838\u4ece\u800c\u5b9e\u73b0\u5bf9nuclear actin\u9009\u62e9\u6027\u5730\u964d\u89e3\u3002\u6211\u76ee\u524d\u53ea\u7b80\u5355\u67e5\u4e86\u67e5\uff0c\u89c9\u5f97\u4e0d\u592a\u53ef\u884c\u3002\u56f0\u96be\u6709\u4e24\u70b9\uff1a<\/p>\n\n\n\n

    \n
  1. PROTAC\u5e76\u4e0d\u662f\u591a\u80bd\uff0c\u5b83\u672c\u8eab\u662f\u4e2a\u5316\u5b66\u5c0f\u5206\u5b50\u3002\u5176\u4e2d\u9776\u5411actin\u7684ligand\u5f88\u96be\u8bbe\u8ba1\uff0c\u9700\u8981\u5316\u5b66\u548c\u751f\u7269\u4e24\u65b9\u9762\u77e5\u8bc6\u80cc\u666f\u7684\u4eba\u6765\u8bbe\u8ba1\uff0c\u800c\u4e14\u542c\u8d77\u6765\u5c31\u5f88\u96be\u3002\u76ee\u524d\u4e5f\u53ea\u6709\u51e0\u79cd\u6210\u529f\u9776\u5411\u67d0\u4e2a\u86cb\u767d\u7684PROTAC\u836f\u7269\u51fa\u73b0\uff0c\u5b83\u8c8c\u4f3c\u5e76\u4e0d\u50cf\u627e\u5230\u4e00\u4e2a\u86cb\u767d\u7684\u6297\u4f53\u90a3\u4e48\u7b80\u5355\u3002<\/li>\n\n\n\n
  2. \u7531\u4e8e\u4e0d\u662f\u591a\u80bd\uff0c\u4e5f\u4e0d\u80fd\u76f4\u63a5\u878d\u5408\u8868\u8fbe\u4e00\u4e2aNLS\uff0c\u90a3\u5b83\u600e\u6837\u5b9e\u73b0\u7ec6\u80de\u6838\u5b9a\u4f4d\u5462\uff1f\u5316\u5b66\u65b9\u6cd5\u6539\u8fdb\u5c31\u662f\u8ba9\u5b83\u6e17\u900f\u6027\u589e\u5f3a\uff0c\u4f46\u8fd9\u5e76\u4e0d\u80fd\u964d\u4f4e\u5bf9cytosolic actin\u7684\u8bef\u6740\uff1b\u7528\u751f\u7269\u65b9\u6cd5\u5c31\u662f\u52a0NLS\uff0c\u4f46\u662f\u600e\u6837\u5171\u4ef7\u8fde\u63a5\u4e00\u4e2a\u591a\u80bd\u548c\u4e00\u4e2a\u5316\u5b66\u5c0f\u5206\u5b50\uff0c\u5bf9\u6b64\u6211\u4e00\u65e0\u6240\u77e5\u3002<\/li>\n<\/ol>\n\n\n\n

    \u8fd9\u4e2a\u6280\u672f\u76f8\u6bd4\u4e8eDegron\u7684\u4f18\u70b9\u663e\u800c\u6613\u89c1\uff1a<\/p>\n\n\n\n

      \n
    • \u4e0d\u9700\u8981\u7ed9\u86cb\u767d\u672c\u8eab\u52a0\u6807\u7b7e\uff0c\u4e0d\u4f1a\u56e0\u4e3a\u6807\u7b7e\u6539\u53d8\u539f\u6709\u7684\u86cb\u767d\u7ed3\u6784<\/li>\n<\/ul>\n\n\n\n
      \n\n\n\n

      \u8fd8\u63d0\u5230\u4e00\u4e2a\u65b9\u6cd5\u662f\u80f6\u4f53\u91d1\u900f\u5c04\u7535\u955c\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

      \u8fd9\u7bc7\u7b14\u8bb0\u63a2\u8ba8\u4e86PROTAC\uff08\u86cb\u767d\u964d\u89e3\u9776\u5411\u5d4c\u5408\u5206\u5b50\uff09\u6280\u672f\uff0c\u4f5c\u8005\u5728\u5f15\u7528\u5176\u6838\u5fc3\u673a\u5236\u540e\uff0c\u7ed3\u5408\u4e0e\u5b5f\u9662\u58eb\u7684\u8ba8\u8bba\uff0c\u5206\u6790\u4e86\u5c06\u5176\u5e94\u7528\u4e8e\u9009\u62e9\u6027\u964d\u89e3\u6838\u5185\u808c\u52a8\u86cb\u767d\uff08nuclear actin\uff09\u7684\u6784\u60f3\u3002\u6587\u4e2d\u91cd\u70b9\u5256\u6790\u4e86\u8be5\u8bbe\u60f3\u9762\u4e34\u7684\u4e24\u5927\u6311\u6218\uff1a\u9776\u5411\u914d\u4f53\u8bbe\u8ba1\u7684\u96be\u5ea6\u4e0e\u5b9e\u73b0\u7ec6\u80de\u6838\u7279\u5f02\u6027\u9012\u9001\u7684\u969c\u788d\uff0c\u5e76\u4e0eDegron\u6280\u672f\u8fdb\u884c\u4e86\u7b80\u8981\u6bd4\u8f83\u3002<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-5978","post","type-post","status-publish","format-standard","hentry","category-note"],"_links":{"self":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts\/5978","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5978"}],"version-history":[{"count":2,"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts\/5978\/revisions"}],"predecessor-version":[{"id":13935,"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts\/5978\/revisions\/13935"}],"wp:attachment":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5978"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5978"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5978"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}