{"id":8663,"date":"2025-02-21T17:30:15","date_gmt":"2025-02-21T09:30:15","guid":{"rendered":"https:\/\/fanyiming.life\/?p=8663"},"modified":"2025-12-21T01:04:00","modified_gmt":"2025-12-20T17:04:00","slug":"mrna%e7%9a%84%e8%b4%9f%e5%8f%8d%e9%a6%88%e8%b0%83%e8%8a%82","status":"publish","type":"post","link":"https:\/\/fanyiming.life\/?p=8663","title":{"rendered":"mRNA\u7684\u8d1f\u53cd\u9988\u8c03\u8282"},"content":{"rendered":"\n

[ez-toc]<\/p>\n\n\n\n

2006 PNAS<\/h1>\n\n\n\n

Small dsRNAs induce transcriptional activation in human cells<\/p>\n\n\n\n

\u8fd9\u7bc7\u8bba\u6587\u8bd5\u56fe\u89e3\u51b3\u4ec0\u4e48\u95ee\u9898\uff1f<\/h2>\n\n\n\n

\u8be5\u8bba\u6587\u8bd5\u56fe\u63ed\u793a\u5c0f\u53cc\u94feRNA\uff08small dsRNAs\uff09\u662f\u5426\u53ef\u4ee5\u5728\u4eba\u7c7b\u7ec6\u80de\u4e2d\u6fc0\u6d3b\u57fa\u56e0\u8868\u8fbe\u3002\u4f20\u7edf\u4e0a\uff0cdsRNAs\u88ab\u8ba4\u4e3a\u4e3b\u8981\u7528\u4e8e\u57fa\u56e0\u6c89\u9ed8\uff0c\u4f46\u672c\u7814\u7a76\u63a2\u7d22\u4e86\u5b83\u4eec\u5728\u8f6c\u5f55\u6c34\u5e73\u4e0a\u6fc0\u6d3b\u57fa\u56e0\u7684\u53ef\u80fd\u6027\u3002<\/p>\n\n\n\n

\u4e3b\u8981\u7814\u7a76\u5185\u5bb9\u548c\u7ed3\u8bba<\/h2>\n\n\n\n
    \n
  1. \u5b9e\u9a8c\u8bbe\u8ba1<\/strong>\uff1a\u7814\u7a76\u4eba\u5458\u8bbe\u8ba1\u5e76\u5408\u6210\u4e86\u9488\u5bf9E-cadherin\u3001p21WAF1\/CIP1(p21) \u548c VEGF \u57fa\u56e0\u542f\u52a8\u5b50\u533a\u57df\u768421-nt dsRNAs\u3002<\/li>\n\n\n\n
  2. \u7ed3\u679c<\/strong>\uff1a\n
      \n
    • E-cadherin<\/strong>\uff1a\u5728PC-3\u548cDU-145\u7ec6\u80de\u4e2d\uff0cdsRNAs\u663e\u8457\u8bf1\u5bfc\u4e86E-cadherin\u7684mRNA\u548c\u86cb\u767d\u8d28\u8868\u8fbe\uff0c\u5e76\u4e14\u8fd9\u79cd\u6548\u5e94\u53ef\u4ee5\u6301\u7eed\u81f3\u5c1113\u5929\u3002<\/li>\n\n\n\n
    • p21<\/strong>\uff1adsP21\u2013322\u5728\u591a\u79cd\u7ec6\u80de\u7cfb\u4e2d\u663e\u8457\u8bf1\u5bfc\u4e86p21\u7684\u8868\u8fbe\u3002<\/li>\n\n\n\n
    • VEGF<\/strong>\uff1adsVEGF-706\u5728HeLa\u7ec6\u80de\u4e2d\u8bf1\u5bfc\u4e86VEGF\u7684\u8868\u8fbe\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n
    • \u673a\u5236\u63a2\u8ba8<\/strong>\uff1a\n
        \n
      • dsRNA\u8bf1\u5bfc\u7684\u57fa\u56e0\u6fc0\u6d3b\u4f9d\u8d56\u4e8eArgonaute 2 (Ago2)\u86cb\u767d\u3002<\/li>\n\n\n\n
      • dsRNA\u8bf1\u5bfc\u7684\u57fa\u56e0\u6fc0\u6d3b\u4e0e\u7ec4\u86cb\u767dH3\u7b2c9\u4f4d\u8d56\u6c28\u9178\u7532\u57fa\u5316\u51cf\u5c11\u6709\u5173\u3002<\/li>\n\n\n\n
      • dsRNA\u76845’\u7aef\u201c\u79cd\u5b50\u201d\u5e8f\u5217\u5bf9\u4e8e\u6fc0\u6d3b\u9776\u57fa\u56e0\u81f3\u5173\u91cd\u8981\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n
      • \u7279\u5f02\u6027\u9a8c\u8bc1<\/strong>\uff1a\u901a\u8fc7\u7a81\u53d8\u5206\u6790\u3001\u5bf9\u7167\u5b9e\u9a8c\u53ca\u5e72\u6270\u7d20\u53cd\u5e94\u68c0\u6d4b\uff0c\u8bc1\u5b9e\u4e86dsRNA\u4ecb\u5bfc\u7684\u57fa\u56e0\u6fc0\u6d3b\u662f\u5e8f\u5217\u7279\u5f02\u6027\u7684\u3002<\/li>\n<\/ol>\n\n\n\n

        \u8bba\u6587\u7684\u8d21\u732e<\/h2>\n\n\n\n
          \n
        1. \u9996\u6b21\u8bc1\u660e\u4e86dsRNAs\u53ef\u4ee5\u5728\u4eba\u7c7b\u7ec6\u80de\u4e2d\u6fc0\u6d3b\u57fa\u56e0\u8868\u8fbe\uff0c\u800c\u4e0d\u4ec5\u4ec5\u662f\u6291\u5236\u3002<\/li>\n\n\n\n
        2. \u63ed\u793a\u4e86dsRNA\u4ecb\u5bfc\u7684\u8f6c\u5f55\u6fc0\u6d3b\uff08RNAa\uff09\u7684\u65b0\u673a\u5236\uff0c\u4e3a\u7406\u89e3\u5c0fRNA\u5206\u5b50\u5728\u57fa\u56e0\u8868\u8fbe\u8c03\u63a7\u4e2d\u7684\u591a\u6837\u6027\u63d0\u4f9b\u4e86\u65b0\u89c6\u89d2\u3002<\/li>\n\n\n\n
        3. \u63d0\u51fa\u4e86dsRNA\u4f5c\u4e3a\u6f5c\u5728\u6cbb\u7597\u5de5\u5177\u7528\u4e8e\u9776\u5411\u57fa\u56e0\u6fc0\u6d3b\u7684\u53ef\u80fd\u6027\u3002<\/li>\n<\/ol>\n\n\n\n

          \u7814\u7a76\u610f\u4e49<\/h2>\n\n\n\n

          \u8fd9\u9879\u7814\u7a76\u4e0d\u4ec5\u6269\u5c55\u4e86\u6211\u4eec\u5bf9\u5c0fRNA\u529f\u80fd\u7684\u7406\u89e3\uff0c\u8fd8\u4e3a\u5f00\u53d1\u57fa\u4e8edsRNA\u7684\u65b0\u578b\u6cbb\u7597\u65b9\u6cd5\u63d0\u4f9b\u4e86\u7406\u8bba\u57fa\u7840\u3002\u7279\u522b\u662f\u5bf9\u4e8e\u90a3\u4e9b\u56e0\u8868\u89c2\u9057\u4f20\u6c89\u9ed8\u800c\u5bfc\u81f4\u7684\u75be\u75c5\uff08\u5982\u764c\u75c7\uff09\uff0cdsRNA\u53ef\u80fd\u6210\u4e3a\u4e00\u79cd\u6709\u6548\u7684\u6cbb\u7597\u624b\u6bb5\u3002<\/p>\n\n\n\n

          \u672a\u6765\u7684\u7814\u7a76\u65b9\u5411<\/h2>\n\n\n\n
            \n
          1. \u8fdb\u4e00\u6b65\u63a2\u7d22dsRNA\u4ecb\u5bfc\u7684\u57fa\u56e0\u6fc0\u6d3b\u7684\u5177\u4f53\u5206\u5b50\u673a\u5236\u3002<\/li>\n\n\n\n
          2. \u7814\u7a76\u5176\u4ed6\u7c7b\u578b\u7684\u5c0fRNA\u662f\u5426\u4e5f\u5177\u6709\u7c7b\u4f3c\u7684\u529f\u80fd\u3002<\/li>\n\n\n\n
          3. \u5f00\u53d1\u66f4\u9ad8\u6548\u7684dsRNA\u9012\u9001\u7cfb\u7edf\u4ee5\u63d0\u9ad8\u5176\u4e34\u5e8a\u5e94\u7528\u6f5c\u529b\u3002<\/li>\n\n\n\n
          4. \u6df1\u5165\u7814\u7a76\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u4e2ddsRNA\u54cd\u5e94\u5dee\u5f02\u7684\u539f\u56e0\u3002<\/li>\n<\/ol>\n\n\n\n

            \u76f8\u5173\u6587\u732e\u5f15\u7528<\/h2>\n\n\n\n

            \u4ee5\u4e0b\u6587\u732e\u6d89\u53caRTCB\u6216RNA\u8fde\u63a5\uff08RNA ligation\uff09\u76f8\u5173\u5185\u5bb9\uff1a<\/p>\n\n\n\n

              \n
            • Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T (2001) Nature 411:494\u2013498.<\/li>\n\n\n\n
            • Meister G, Landthaler M, Patkaniowska A, Dorsett Y, Teng G, Tuschl T (2004) Mol Cell 15:185\u2013197.<\/li>\n\n\n\n
            • Reynolds A, Leake D, Boese Q, Scaringe S, Marshall WS, Khvorova A (2004) Nat Biotechnol 22:326\u2013330.<\/li>\n<\/ul>\n\n\n\n

              \u4ee5\u4e0a\u5f15\u7528\u6587\u732e\u867d\u7136\u6ca1\u6709\u76f4\u63a5\u63d0\u5230RTCB\u6216RNA ligation\uff0c\u4f46\u5728siRNA\u8bbe\u8ba1\u89c4\u5219\u548cRNAi\u673a\u5236\u65b9\u9762\u63d0\u4f9b\u4e86\u91cd\u8981\u80cc\u666f\u4fe1\u606f\u3002<\/p>\n\n\n\n

              2013 Cell<\/h1>\n\n\n\n

              Gene Expression Is Circular: Factors for mRNA Degradation Also Foster mRNA Synthesis<\/p>\n\n\n\n

              \u8fd9\u7bc7\u8bba\u6587\u8bd5\u56fe\u89e3\u51b3\u4ec0\u4e48\u95ee\u9898\uff1f<\/h2>\n\n\n\n

              \u8fd9\u7bc7\u8bba\u6587\u8bd5\u56fe\u63ed\u793amRNA\u964d\u89e3\u56e0\u5b50\u5728\u57fa\u56e0\u8868\u8fbe\u4e2d\u7684\u53cc\u91cd\u89d2\u8272\uff1a\u4e0d\u4ec5\u53c2\u4e0emRNA\u7684\u964d\u89e3\uff0c\u8fd8\u4fc3\u8fdb\u5176\u5408\u6210\u3002\u5177\u4f53\u6765\u8bf4\uff0c\u5b83\u63a2\u8ba8\u4e86\u8fd9\u4e9b\u56e0\u5b50\u5982\u4f55\u901a\u8fc7\u6838\u8d28\u7a7f\u68ad\u5f71\u54cd\u8f6c\u5f55\uff0c\u5e76\u89e3\u91ca\u4e86\u8fd9\u79cd\u673a\u5236\u5982\u4f55\u4f7f\u57fa\u56e0\u8868\u8fbe\u6210\u4e3a\u4e00\u4e2a\u5faa\u73af\u8fc7\u7a0b\u3002<\/p>\n\n\n\n

              \u4e3b\u8981\u7814\u7a76\u5185\u5bb9\u548c\u7ed3\u8bba<\/h2>\n\n\n\n

              \u4e3b\u8981\u7814\u7a76\u5185\u5bb9<\/h3>\n\n\n\n
                \n
              1. mRNA\u6c34\u5e73\u7684\u7a33\u5b9a\u6027<\/strong>\uff1a\u7814\u7a76\u53d1\u73b0\u5927\u591a\u6570\u9175\u6bcdmRNA\u901a\u8fc7\u7ec6\u80de\u8d28\u4e2d\u76845’\u52303’\u9014\u5f84\uff08\u5373\u201c\u964d\u89e3\u4f53\u201d\uff09\u88ab\u964d\u89e3\u3002\u7136\u800c\uff0c\u8fd9\u4e9bmRNA\u7684\u6c34\u5e73\u5bf9\u964d\u89e3\u9014\u5f84\u7684\u6270\u52a8\u975e\u5e38\u7a33\u5b9a\uff0c\u56e0\u4e3a\u7f3a\u9677\u5bfc\u81f4\u8f6c\u5f55\u4e0b\u8c03\u3002<\/li>\n\n\n\n
              2. \u964d\u89e3\u56e0\u5b50\u7684\u6838\u8d28\u7a7f\u68ad<\/strong>\uff1a\u8fd9\u4e9b\u56e0\u5b50\u5728\u7ec6\u80de\u8d28\u548c\u7ec6\u80de\u6838\u4e4b\u95f4\u6765\u56de\u79fb\u52a8\uff0c\u4f9d\u8d56\u4e8e\u6b63\u786e\u7684mRNA\u964d\u89e3\u3002\u5728\u7ec6\u80de\u6838\u4e2d\uff0c\u5b83\u4eec\u4f18\u5148\u7ed3\u5408\u5230\u8f6c\u5f55\u8d77\u59cb\u4f4d\u70b9\u4e0a\u6e38\u7ea630bp\u5904\u5e76\u76f4\u63a5\u523a\u6fc0\u8f6c\u5f55\u542f\u52a8\u548c\u5ef6\u4f38\u3002<\/li>\n\n\n\n
              3. \u8f6c\u5f55\u4e0emRNA\u964d\u89e3\u7684\u8054\u7cfb<\/strong>\uff1a\u964d\u89e3\u4f53\u5728\u8f6c\u5f55\u4e2d\u7684\u4f5c\u7528\u4e0e\u5176\u5728\u7ec6\u80de\u8d28\u4e2dmRNA\u964d\u89e3\u7684\u4f5c\u7528\u662f\u76f8\u4e92\u5173\u8054\u7684\uff0c\u8fd9\u79cd\u5173\u8054\u4f3c\u4e4e\u53d6\u51b3\u4e8e\u5176\u7ec4\u5206\u7684\u6b63\u786e\u7a7f\u68ad\u3002<\/li>\n\n\n\n
              4. \u5b9e\u9a8c\u9a8c\u8bc1<\/strong>\uff1a\u901a\u8fc7\u57fa\u56e0\u6572\u9664\u3001\u8367\u5149\u539f\u4f4d\u6742\u4ea4\uff08FISH\uff09\u3001\u67d3\u8272\u8d28\u514d\u75ab\u6c89\u6dc0\uff08ChIP\uff09\u7b49\u6280\u672f\u9a8c\u8bc1\u4e86\u4e0a\u8ff0\u53d1\u73b0\u3002<\/li>\n<\/ol>\n\n\n\n

                \u5173\u952e\u7ed3\u8bba<\/h3>\n\n\n\n
                  \n
                • \u57fa\u56e0\u8868\u8fbe\u8fc7\u7a0b\u662f\u5faa\u73af\u7684\uff0c\u5176\u4e2dmRNA\u5408\u6210\u7684\u7b2c\u4e00\u9636\u6bb5\u548c\u6700\u540e\u9636\u6bb5\u76f8\u4e92\u8fde\u63a5\u3002<\/li>\n\n\n\n
                • mRNA\u964d\u89e3\u56e0\u5b50\u4e0d\u4ec5\u8d1f\u8d23mRNA\u7684\u964d\u89e3\uff0c\u8fd8\u5728\u8f6c\u5f55\u8fc7\u7a0b\u4e2d\u626e\u6f14\u91cd\u8981\u89d2\u8272\u3002<\/li>\n\n\n\n
                • Xrn1p\u7b49\u964d\u89e3\u56e0\u5b50\u7684\u6d3b\u6027\u4e0e\u5176\u5728\u7ec6\u80de\u5185\u7684\u5b9a\u4f4d\u5bc6\u5207\u76f8\u5173\uff0c\u5f71\u54cd\u7740\u8f6c\u5f55\u6548\u7387\u3002<\/li>\n<\/ul>\n\n\n\n

                  \u8bba\u6587\u7684\u8d21\u732e<\/h2>\n\n\n\n

                  \u672c\u6587\u9996\u6b21\u63d0\u51fa\u4e86mRNA\u964d\u89e3\u56e0\u5b50\u5177\u6709\u4fc3\u8fdb\u8f6c\u5f55\u7684\u529f\u80fd\uff0c\u6539\u53d8\u4e86\u4f20\u7edf\u4e0a\u8ba4\u4e3a\u8fd9\u4e9b\u56e0\u5b50\u4ec5\u53c2\u4e0e\u964d\u89e3\u7684\u89c2\u70b9\u3002\u6b64\u5916\uff0c\u7814\u7a76\u63ed\u793a\u4e86\u57fa\u56e0\u8868\u8fbe\u8c03\u63a7\u7684\u65b0\u673a\u5236\uff0c\u5373mRNA\u964d\u89e3\u4e0e\u5408\u6210\u4e4b\u95f4\u7684\u7d27\u5bc6\u8054\u7cfb\uff0c\u4e3a\u7406\u89e3\u771f\u6838\u751f\u7269\u57fa\u56e0\u8868\u8fbe\u63d0\u4f9b\u4e86\u65b0\u7684\u89c6\u89d2\u3002<\/p>\n\n\n\n

                  \u7814\u7a76\u610f\u4e49<\/h2>\n\n\n\n

                  \u8fd9\u9879\u7814\u7a76\u5bf9\u5b66\u672f\u754c\u6709\u91cd\u8981\u610f\u4e49\uff0c\u56e0\u4e3a\u5b83\u63ed\u793a\u4e86\u4e00\u4e2a\u5168\u65b0\u7684\u57fa\u56e0\u8868\u8fbe\u8c03\u63a7\u6a21\u5f0f\uff0c\u5373mRNA\u964d\u89e3\u548c\u5408\u6210\u5e76\u4e0d\u662f\u5b64\u7acb\u7684\u8fc7\u7a0b\uff0c\u800c\u662f\u76f8\u4e92\u4f9d\u5b58\u7684\u6574\u4f53\u7cfb\u7edf\u7684\u4e00\u90e8\u5206\u3002\u8fd9\u4e00\u53d1\u73b0\u6709\u52a9\u4e8e\u6df1\u5165\u7406\u89e3\u57fa\u56e0\u8868\u8fbe\u8c03\u63a7\u7684\u590d\u6742\u6027\uff0c\u5e76\u53ef\u80fd\u4e3a\u5f00\u53d1\u65b0\u7684\u6cbb\u7597\u7b56\u7565\u63d0\u4f9b\u7406\u8bba\u4f9d\u636e\u3002<\/p>\n\n\n\n

                  \u672a\u6765\u7684\u7814\u7a76\u65b9\u5411<\/h2>\n\n\n\n

                  \u4f5c\u8005\u5efa\u8bae\u672a\u6765\u53ef\u4ee5\u8fdb\u4e00\u6b65\u63a2\u7d22\u4ee5\u4e0b\u51e0\u4e2a\u65b9\u9762\uff1a<\/p>\n\n\n\n

                    \n
                  • \u63a2\u8ba8\u4e0d\u540c\u7c7b\u578b\u7684mRNA\u964d\u89e3\u56e0\u5b50\u5728\u8f6c\u5f55\u8c03\u63a7\u4e2d\u7684\u5177\u4f53\u673a\u5236\u3002<\/li>\n\n\n\n
                  • \u7814\u7a76\u5176\u4ed6\u7269\u79cd\u4e2d\u662f\u5426\u5b58\u5728\u7c7b\u4f3c\u7684\u57fa\u56e0\u8868\u8fbe\u5faa\u73af\u73b0\u8c61\u3002<\/li>\n\n\n\n
                  • \u6df1\u5165\u89e3\u6790\u964d\u89e3\u56e0\u5b50\u5982\u4f55\u7cbe\u786e\u5730\u8c03\u8282\u7279\u5b9a\u57fa\u56e0\u7684\u8868\u8fbe\u3002<\/li>\n<\/ul>\n\n\n\n

                    \u76f8\u5173\u6587\u732e\u5f15\u7528<\/h2>\n\n\n\n

                    \u6587\u4e2d\u5f15\u7528\u4e86\u591a\u9879\u5173\u4e8emRNA\u964d\u89e3\u53ca\u8f6c\u5f55\u8c03\u63a7\u7684\u7ecf\u5178\u7814\u7a76\uff0c\u4f46\u5e76\u672a\u7279\u522b\u63d0\u53ca\u4e0eRTCB\u6216RNA ligation\u76f8\u5173\u7684\u6587\u732e\u3002\u4ee5\u4e0b\u662f\u90e8\u5206\u76f8\u5173\u5f15\u7528\uff1a<\/p>\n\n\n\n

                      \n
                    • Anderson, J.S., and Parker, R.P. (1998). EMBO J. 17, 1497\u20131506.<\/li>\n\n\n\n
                    • Coller, J., and Parker, R. (2004). Annu. Rev. Biochem. 73, 861\u2013890.<\/li>\n\n\n\n
                    • He, F., et al. (2003). Mol. Cell 12, 1439\u20131452.<\/li>\n\n\n\n
                    • Komili, S., and Silver, P.A. (2008). Nat. Rev. Genet. 9, 38\u201348.<\/li>\n\n\n\n
                    • Parker, R. (2012). Genetics 191, 671\u2013702.<\/li>\n\n\n\n
                    • P\u00e9rez-Ort\u00edn, J.E., et al. (2013). J. Mol. Biol. Published online March 4, 2013.<\/li>\n<\/ul>\n\n\n\n

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