{"id":958,"date":"2024-03-02T00:21:51","date_gmt":"2024-03-01T16:21:51","guid":{"rendered":"https:\/\/fanyiming.life\/?p=958"},"modified":"2025-12-21T01:06:02","modified_gmt":"2025-12-20T17:06:02","slug":"%e7%bb%84%e8%9b%8b%e7%99%bd%e7%94%b2%e5%9f%ba%e5%8c%96%e5%92%8c%e4%b9%99%e9%85%b0%e5%8c%96%e4%bf%ae%e9%a5%b0","status":"publish","type":"post","link":"https:\/\/fanyiming.life\/?p=958","title":{"rendered":"\u7ec4\u86cb\u767d\u7532\u57fa\u5316\u548c\u4e59\u9170\u5316\u4fee\u9970"},"content":{"rendered":"\n

\u7ec4\u86cb\u767d\u7532\u57fa\u5316\u548c\u4e59\u9170\u5316\u4fee\u9970\u52a8\u6001\u8c03\u63a7\uff1a<\/h4>\n\n\n\n

\u7ec4\u86cb\u767d\u7532\u57fa\u5316\u9176\uff08KMT\uff09\u548c\u7ec4\u86cb\u767d\u53bb\u7532\u57fa\u5316\u9176\uff08KDM\uff09\u8c03\u63a7\u7ec4\u86cb\u767d\u7532\u57fa\u5316\u3002<\/p>\n\n\n\n

\u7ec4\u86cb\u767d\u4e59\u9170\u5316\u9176\uff08HAT\uff09\u548c\u7ec4\u86cb\u767d\u53bb\u4e59\u9170\u5316\u9176\uff08HDAC\uff09\u8c03\u63a7\u7ec4\u86cb\u767d\u4e59\u9170\u5316\u3002<\/p>\n\n\n\n

\u7ec4\u86cb\u767d\u4fee\u9970\u7684\u4f4d\u7f6e\u548c\u57fa\u56e0\u8868\u8fbe\u5173\u7cfb\uff1a<\/h4>\n\n\n\n

H3K4me1\u548cH3K27ac\u901a\u5e38\u7528\u4e8e\u6807\u8bb0\u6d3b\u5316\u6001\u589e\u5f3a\u5b50\u533a\u57df\u3002<\/p>\n\n\n\n

H3K4me1\u6307\u793a\u589e\u5f3a\u5b50\uff0cH3K4me3\u6307\u793a\u542f\u52a8\u5b50\u3002<\/p>\n\n\n\n

H3K36\u548cH3K4\u7684\u7532\u57fa\u5316\u548c\u4e59\u9170\u5316\u90fd\u53c2\u4e0e\u8f6c\u5f55\u6fc0\u6d3b\uff0c\u4e59\u9170\u5316\u4f5c\u7528\u591a\u53d1\u751f\u5728\u542f\u52a8\u5b50\uff0c\u800cH3K4\u7532\u57fa\u5316\u591a\u5728\u8f6c\u5f55\u8d77\u59cb\u4f4d\u70b9\uff0cH3K36\u7532\u57fa\u5316\u5219\u5728\u7f16\u7801\u533a\u57df\u3002<\/p>\n\n\n\n

\u5e38\u67d3\u8272\u8d28\u548c\u5f02\u67d3\u8272\u8d28\u7684\u7ec4\u86cb\u767d\u6807\u5fd7\uff1a<\/h4>\n\n\n\n

\u5e38\u67d3\u8272\u8d28\u5177\u6709\u9ad8\u6c34\u5e73\u7684\u4e59\u9170\u5316\u548cH3K4, H3K36, H4K20\u7684\u4e09\u7532\u57fa\u5316\u3002<\/p>\n\n\n\n

\u5f02\u67d3\u8272\u8d28\u5177\u6709\u4f4e\u6c34\u5e73\u7684\u4e59\u9170\u5316\u548cH3K9, H3K27, H4K20\u7684\u9ad8\u6c34\u5e73\u7532\u57fa\u5316\u3002<\/p>\n\n\n\n

\u5e38\u89c1\u7532\u57fa\u8f6c\u79fb\u9176\u548c\u53bb\u7532\u57fa\u5316\u9176\uff1a<\/h4>\n\n\n\n

\u7532\u57fa\u8f6c\u79fb\u9176Suv39h1, Suv39h2, SETDB1\u7684\u5e95\u7269\u90fd\u662fH3K9\uff0c\u4f46\u5177\u4f53\u529f\u80fd\u7565\u6709\u4e0d\u540c\u3002<\/p>\n\n\n\n

PRC2\u590d\u5408\u7269\u8d1f\u8d23\u50ac\u5316H3K27\u7684\u7532\u57fa\u5316\u3002<\/p>\n\n\n\n

LSD1\/KDM1\u662f\u7b2c\u4e00\u4e2a\u53d1\u73b0\u7684\u7ec4\u86cb\u767d\u53bb\u7532\u57fa\u5316\u9176<\/p>\n\n\n\n

\u7ec4\u86cb\u767d\u53bb\u7532\u57fa\u5316\u9176\u547d\u540d\uff1a<\/h4>\n\n\n\n

2007\u5e74\uff0c\u5b66\u672f\u754c\u5bf9\u7ec4\u86cb\u767d\u53bb\u7532\u57fa\u5316\u9176\u8fdb\u884c\u89c4\u8303\u5316\u547d\u540d\uff0cLSD1\u79f0\u4f5cKDM1A(Lysine(K<\/strong>) D<\/strong>em<\/strong>ethylase 1A)\uff0cLSD2\u79f0\u4e3aKDM1B\uff0c\u540e\u7eed\u53d1\u73b0\u7684\u5176\u4ed6\u7ec4\u86cb\u767d\u53bb\u7532\u57fa\u5316\u9176\u53ebKDM2, KDM3, \u2026<\/p>\n\n\n\n

\u5e38\u89c1\u4e59\u9170\u5316\u9176\u548c\u53bb\u4e59\u9170\u5316\u9176\uff1a<\/h4>\n\n\n\n

H3K27ac\u7531p300\/CBP\u50ac\u5316\u3002<\/p>\n\n\n\n

\u5728\u4eba\u4f53\u4e2d\uff0c\u5df2\u7ecf\u786e\u5b9a\u7684\u53bb\u4e59\u9170\u5316\u9176\u670918\u79cd\uff0c\u5206\u522b\u662fHDAC1~11<\/strong>\u548cSIRT1~7<\/strong>\u3002<\/p>\n\n\n\n

\u7ec4\u86cb\u767d\u4fee\u9970\u7684\u7814\u7a76\u65b9\u6cd5\uff1a<\/h4>\n\n\n\n

ChIP-seq<\/p>\n","protected":false},"excerpt":{"rendered":"

\u8fd9\u7bc7\u7b14\u8bb0\u7cfb\u7edf\u68b3\u7406\u4e86\u8868\u89c2\u9057\u4f20\u5b66\u4e2d\u7684\u6838\u5fc3\u673a\u5236\uff1a\u7ec4\u86cb\u767d\u7532\u57fa\u5316\u4e0e\u4e59\u9170\u5316\u4fee\u9970\u3002\u6587\u7ae0\u8be6\u7ec6\u9610\u8ff0\u4e86\u5176\u52a8\u6001\u8c03\u63a7\u7684\u9176\u5b66\u57fa\u7840\u3001\u4e0d\u540c\u4fee\u9970\u4f4d\u70b9\u4e0e\u57fa\u56e0\u8868\u8fbe\u72b6\u6001\u7684\u5173\u8054\uff0c\u5e76\u5f52\u7eb3\u4e86\u5e38\/\u5f02\u67d3\u8272\u8d28\u7684\u6807\u5fd7\u6027\u4fee\u9970\u7279\u5f81\u3002<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-958","post","type-post","status-publish","format-standard","hentry","category-note"],"_links":{"self":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts\/958","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=958"}],"version-history":[{"count":2,"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts\/958\/revisions"}],"predecessor-version":[{"id":14122,"href":"https:\/\/fanyiming.life\/index.php?rest_route=\/wp\/v2\/posts\/958\/revisions\/14122"}],"wp:attachment":[{"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=958"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=958"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fanyiming.life\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=958"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}