Archive: nuclear actins

Rebert Grosse实验室对nuclear actins有多年研究。

他们实验室2024年最新的综述：Ulferts S, Lopes M, Miyamoto K, Grosse R. Nuclear actin dynamics and functions at a glance. J Cell Sci. 2024 Mar 15;137(6):jcs261630. doi: 10.1242/jcs.261630. Epub 2024 Apr 2. PMID: 38563209.

他们还写过一篇针对nuclear actin Visualization的综述：Melak M, Plessner M, Grosse R. Actin visualization at a glance. J Cell Sci. 2017 Feb 1;130(3):525-530. doi: 10.1242/jcs.189068. Epub 2017 Jan 12. Erratum in: J Cell Sci. 2017 May 1;130(9):1688. doi: 10.1242/jcs.204487. PMID: 28082420.

另一篇其他实验室2022年对nuclear actin功能方面的综述：Huang Y, Zhang S, Park JI. Nuclear Actin Dynamics in Gene Expression, DNA Repair, and Cancer. Results Probl Cell Differ. 2022;70:625-663. doi: 10.1007/978-3-031-06573-6_23. PMID: 36348125; PMCID: PMC9677682.

研究nulcear actin定位的困难之处：

Nuclear actin filaments and their specific functions are an emerging topic in the field of actin research. However, there are several reasons why the visualization of actin filaments in the nucleus is particularly difficult.

First, the concentration of actin in the nucleus is much lower than in the cytoplasm (Baarlink et al., 2013).

Second, the assembly of nuclear actin filaments is only triggered by specific signaling cues, for example in response to extracellular signals, such as serum factors (Baarlink et al., 2013) or DNA damage (Belin et al., 2015), or in the context of integrin-based cellular adhesion and mechanotransduction (Plessner et al., 2015).

Finally, actin, as well as most of the actin-regulatory proteins found in mammalian cell nuclei, dynamically shuttles between the cytoplasm and the nuclear compartment (Kristó et al., 2016).

Actin visualization at a glance | Journal of Cell Science | The Company of Biologists