tRNA ligase的发现

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这篇文献笔记聚焦于tRNA连接酶RtcB的发现。该酶作为一种3′-PO₄/5′-OH RNA连接酶,其功能在细菌、古菌乃至哺乳动物中相继得到鉴定。作者梳理了其在大肠杆菌和人类细胞中的不同作用机制与复合物组成。

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RtcB, a 3′-PO4/5′-OH RNA ligase, has recently been identified in bacteria, archaea, and mammals (Englert et al., 2011; Popow et al., 2011; Tanaka and Shuman, 2011).

A Synthetic Biology Approach Identifies the Mammalian UPR RNA Ligase RtcB: Molecular Cell

Ecoli中:

RtcB Is the RNA Ligase Component of an Escherichia coli RNA Repair Operon* - Journal of Biological Chemistry
RtcB Is the RNA Ligase Component of an Escherichia coli RNA Repair Operon* - Journal of Biological Chemistry

Human中:

HSPC117 Is the Essential Subunit of a Human tRNA Splicing Ligase Complex | Science
HSPC117 Is the Essential Subunit of a Human tRNA Splicing Ligase Complex | Science

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