LINE-1 enhancer

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这篇笔记梳理了关于LINE-1逆转录转座子作为增强子的关键研究。从早期胚胎发育中调控染色质可及性,到建立干细胞多能性网络,再到介导长距离基因激活,一系列前沿工作揭示了这类“垃圾DNA”深刻且保守的顺式调控功能。

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Jachowicz JW, Bing X, Pontabry J, Bošković A, Rando OJ, Torres-Padilla ME. LINE-1 activation after fertilization regulates global chromatin accessibility in the early mouse embryo. Nat Genet. 2017 Oct;49(10):1502-1510. doi: 10.1038/ng.3945. Epub 2017 Aug 28. PMID: 28846101.

Percharde M, Lin CJ, Yin Y, Guan J, Peixoto GA, Bulut-Karslioglu A, Biechele S, Huang B, Shen X, Ramalho-Santos M. A LINE1-Nucleolin Partnership Regulates Early Development and ESC Identity. Cell. 2018 Jul 12;174(2):391-405.e19. doi: 10.1016/j.cell.2018.05.043. Epub 2018 Jun 21. PMID: 29937225; PMCID: PMC6046266.

Meng, S. et al. Young LINE-1 transposon 5′ UTRs marked by elongation factor ELL3 function as enhancers to regulate naïve pluripotency in embryonic stem cells. Nat. Cell Biol. 25, 1319–1331 (2023)​.

Pal, D. et al. H4K16ac activates the transcription of transposable elements and contributes to their cis-regulatory function. Nat. Struct. Mol. Biol. 30, 935–947 (2023)​.

Li X et al. LINE-1 transcription activates long-range gene expression. Nature Genetics(2024)

有话这里说 ↓